Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.

abstract：Purpose:We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D) and in the retina of rats with T1D. Methods:Retinas from T1D (n = 7), T2D (n = 13)...

journal_title：Investigative ophthalmology & visual science

authors： Hu P,Hunt NH,Arfuso F,Shaw LC,Uddin MN,Zhu M,Devasahayam R,Adamson SJ,Benson VL,Chan-Ling T,Grant MB

更新日期：2017-10-01 00:00:00

abstract：Purpose:In many individuals with pattern strabismus, the vertical misalignment varies with horizontal eye position. It has been proposed that these cross-axis effects result from abnormal cross-talk between brainstem structures that would normally encode horizontal and vertical eye position and velocity. The nucleus pr...

journal_title：Investigative ophthalmology & visual science

authors： Pallus A,Walton MMG

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:Evidence suggests that capillary degeneration in early diabetic retinopathy results from chronic inflammation, and leukotrienes have been implicated in this process. The authors investigated the cellular sources of leukotriene biosynthesis in diabetic retinas and the effects of hyperglycemia on leukotriene prod...

journal_title：Investigative ophthalmology & visual science

authors： Talahalli R,Zarini S,Sheibani N,Murphy RC,Gubitosi-Klug RA

更新日期：2010-03-01 00:00:00

abstract：:Various noninvasive test procedures were used to evaluate retinal function in a patient who had become night blind following vincristine chemotherapy. The results obtained were strikingly similar to those reported previously in subjects with recessively inherited stationary night blindness; the dark-adaptation curve w...

journal_title：Investigative ophthalmology & visual science

authors： Ripps H,Carr RE,Siegel IM,Greenstein VC

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transdu...

journal_title：Investigative ophthalmology & visual science

authors： Binley K,Widdowson P,Loader J,Kelleher M,Iqball S,Ferrige G,de Belin J,Carlucci M,Angell-Manning D,Hurst F,Ellis S,Miskin J,Fernandes A,Wong P,Allikmets R,Bergstrom C,Aaberg T,Yan J,Kong J,Gouras P,Prefontaine A,

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:The anatomy of individual myofibers within the orbicularis oculi muscle was examined to determine individual myofiber lengths in the different regions of the muscle. A wide variety of eyelid conditions require eyelid surgery or drug injections directly into the eyelid. Knowledge of regional myofiber anatomy and...

journal_title：Investigative ophthalmology & visual science

authors： Lander T,Wirtschafter JD,McLoon LK

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To determine the fate of donor epithelial, stromal, and endothelial cells after corneal transplantation in humans. METHODS:Fifty-two transplanted corneal buttons were explanted over a 2-year period from patients who required regrafting and had received corneas from donors of opposite sex. Fluorescence in situ ...

journal_title：Investigative ophthalmology & visual science

authors： Lagali N,Stenevi U,Claesson M,Fagerholm P,Hanson C,Weijdegård B,Swedish Society of Corneal Surgeons.

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To evaluate goblet cell density (GCD) on conjunctiva and cornea in patients with ocular chemical burns by in vivo laser scanning confocal microscopy (LSCM) and impression cytology (IC) and to explore the correlation between two methods. METHODS:Fifty-four patients (58 eyes) with chemical burn were enrolled in ...

journal_title：Investigative ophthalmology & visual science

authors： Le QH,Wang WT,Hong JX,Sun XH,Zheng TY,Zhu WQ,Xu JJ

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To describe a method for quantitative mapping of metamorphopsia and abnormalities of oculocentric direction in subjects with epiretinal membranes. METHODS:Binocular correspondence perimetry was performed using red and green dichoptic stimuli applied in a rectangular grid pattern. The study included 9 healthy s...

journal_title：Investigative ophthalmology & visual science

authors： Krøyer K,Jensen OM,Larsen M

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To explore the effect of lateral tension as a survival factor for retinal explants in vitro. The central nervous system (CNS) resides in a highly mechanical milieu. However, the importance of biomechanical homeostasis for normal CNS function has not been extensively explored. Diseases in which normal mechanical...

journal_title：Investigative ophthalmology & visual science

authors： Taylor L,Moran D,Arnér K,Warrant E,Ghosh F

更新日期：2013-03-13 00:00:00

abstract：PURPOSE:To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS:Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; m...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Giudiceandrea A,Vaiano AS,Caputo CG,Gullà F,Salgarello T

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Folic acid is essential for DNA, RNA, and protein synthesis, and deficiencies in folate can lead to nutritional amblyopia and optic neuropathy. The transport of folate from the choroidal blood supply to the retina is only now beginning to be understood. The reduced-folate transporter was reported recently to be...

journal_title：Investigative ophthalmology & visual science

authors： Smith SB,Kekuda R,Gu X,Chancy C,Conway SJ,Ganapathy V

更新日期：1999-04-01 00:00:00

abstract：:Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 +/- 0.8 to 7.1 +/- 1.4 mm Hg (P less than 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the ...

journal_title：Investigative ophthalmology & visual science

authors： Toris CB,Pederson JE

更新日期：1985-12-01 00:00:00

abstract：PURPOSE:To explore differences in optic disc tilt and torsion between normal control and glaucoma subjects, and to determine whether the direction of optic disc tilt is consistent with the initial location of glaucomatous visual field (VF) defect. METHODS:Glaucoma patients with isolated superior or inferior hemifield ...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Shin HY,Park CK

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To assess the effect of group B streptococcal (GBS) meningitis on retinal blood flow (RetBF) and choroidal blood flow (ChBF) autoregulation in sedated newborn piglets (1 to 5 days of age). METHODS:Fourteen study animals injected with 0.5 ml heat-killed GBS (10(9)) were compared to 10 control animals injected w...

journal_title：Investigative ophthalmology & visual science

authors： Bottoli I,Beharry K,Modanlou HD,Norris K,Ling E,Noya F,Amato MM,Aranda JV

更新日期：1995-06-01 00:00:00

abstract：Purpose:We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model. Methods:Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], ...

journal_title：Investigative ophthalmology & visual science

authors： Cui RZ,Wang L,Qiao SN,Wang YC,Wang X,Yuan F,Weng SJ,Yang XL,Zhong YM

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:To evaluate changes in the multifocal electroretinogram (mfERG) in patients with neovascular age-related macular degeneration (nAMD) undergoing ranibizumab treatment. METHODS:This was an observational, longitudinal, prospective study. Treatment-naive patients with nAMD who met the inclusion and exclusion crite...

journal_title：Investigative ophthalmology & visual science

authors： Campa C,Hagan R,Sahni JN,Brown MC,Beare NA,Heimann H,Harding SP

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To investigate, using multifocal electroretinography (mfERG) and optical coherence tomography (OCT), potential spatial associations between local neuroretinal function and local retinal thickness in patients with diabetes. METHODS:Forty-five patients without retinopathy (10 with Type 1 diabetes; 35 with Type 2...

journal_title：Investigative ophthalmology & visual science

authors： Dhamdhere KP,Bearse MA Jr,Harrison W,Barez S,Schneck ME,Adams AJ

更新日期：2012-09-12 00:00:00

abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

journal_title：Investigative ophthalmology & visual science

authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS:Two genome-wide associatio...

journal_title：Investigative ophthalmology & visual science

authors： Burdon KP,Macgregor S,Bykhovskaya Y,Javadiyan S,Li X,Laurie KJ,Muszynska D,Lindsay R,Lechner J,Haritunians T,Henders AK,Dash D,Siscovick D,Anand S,Aldave A,Coster DJ,Szczotka-Flynn L,Mills RA,Iyengar SK,Taylor KD,

更新日期：2011-10-31 00:00:00

abstract：:Ultrastructural cytochemistry was used to analyze the polarized distribution of alkaline phosphatase (AP) on the plasma membranes of normal and regenerating retinal pigment epithelium (RPE) and the ciliary body epithelium in rabbits. The AP activity was concentrated on the basolateral plasma membrane in normal RPE. In...

journal_title：Investigative ophthalmology & visual science

authors： Korte GE,Rappa E,Andracchi S

更新日期：1991-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:To determine the contribution of copy number variation (CNV) in glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) to the susceptibility to age-related cataract (ARC) and its subtypes in a Han Chinese population. METHODS:ARC cases (n = 279) and controls (n = 145) were included from a...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Hu J,Guan H

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

journal_title：Investigative ophthalmology & visual science

authors： Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Vitreoretinal disorders are frequently characterized by increased vitreous levels of cellular mediators, including cytokines, chemokines, and growth factors. The study was conducted to investigate whether multiplex bead analysis could identify disease-specific profiles of these mediators in a variety of vitreor...

journal_title：Investigative ophthalmology & visual science

authors： Banerjee S,Savant V,Scott RA,Curnow SJ,Wallace GR,Murray PI

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate tumor control efficacy of paclitaxel in the treatment of retinal tumors harbored by the LH beta-Tag murine transgenic model of retinoblastoma. METHODS:LH beta-Tag-positive mice (n = 5) 10 weeks of age received two 20-microL subconjunctival injections delivered with ...

journal_title：Investigative ophthalmology & visual science

authors： Suárez F,Jockovich ME,Hernandez E,Feuer W,Parel JM,Murray TG

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To examine the cross-sectional relationship between blood pressure, perfusion pressure, and prevalence of open angle glaucoma (OAG) in an adult Latino population. METHODS:Participants aged 40 years and older (N = 6130) from the Los Angeles Latino Eye Study (LALES), a large, population-based study of self-ident...

journal_title：Investigative ophthalmology & visual science

authors： Memarzadeh F,Ying-Lai M,Chung J,Azen SP,Varma R,Los Angeles Latino Eye Study Group.

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Dysregulation of the extracellular matrix (ECM) plays an important role in the pathogenesis of age-related macular degeneration (AMD). Elastin is a fibrous protein constituent of the ECM, degradation of which may be detected by the presence of serum elastin-derived peptides (S-EDPs) in circulation. This study w...

journal_title：Investigative ophthalmology & visual science

authors： Sivaprasad S,Chong NV,Bailey TA

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:The role of VEGF-A in the normal ciliary body is largely unexplored. The ciliary body is similar in many respects to the choroid plexus of the brain, and we demonstrated previously the importance of VEGF-A in maintenance of choroid plexus vasculature and ependymal cells. Therefore, the role of VEGF-A in ciliary...

journal_title：Investigative ophthalmology & visual science

authors： Ford KM,Saint-Geniez M,Walshe TE,D'Amore PA

更新日期：2012-11-07 00:00:00

abstract：PURPOSE:Microsaccades could indicate the place where our mind is unconsciously focusing, although our gaze is directed elsewhere. Many studies report the importance of microsaccades in visual scene perception, but none of them has addressed their relationship with the perception of a dynamic action and the prediction o...

journal_title：Investigative ophthalmology & visual science

authors： Piras A,Raffi M,Lanzoni IM,Persiani M,Squatrito S

更新日期：2015-07-01 00:00:00