Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

abstract：PURPOSE:Endothelin (ET)-1 is known to inhibit active NaK transport by as much as 50% in kidney tubule and other tissues. The presence of low levels of ET-1 in aqueous humor combined with the potential for release of ET-1 from ciliary processes suggests that the lens could be exposed to ET-1 in vivo. In this study, expe...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Delamere NA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Growth factors act through high-affinity cell surface receptors expressed by target cells and are critical modulators of cell function. Because aqueous humor is known to contain growth factors, these molecules may play a key role in maintaining the normal function of the human trabecular meshwork (HTM). Alterna...

journal_title：Investigative ophthalmology & visual science

authors： Wordinger RJ,Clark AF,Agarwal R,Lambert W,Wilson SE

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS:This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (C...

journal_title：Investigative ophthalmology & visual science

authors： Yang D,Fu J,Hou R,Liu K,Jonas JB,Wang H,Chen W,Li Z,Sang J,Zhang Z,Liu S,Cao Y,Xie X,Ren R,Lu Q,Weinreb RN,Wang N

更新日期：2014-04-15 00:00:00

abstract：Purpose:Mesopic flash electroretinography (fERG) as a tool to identify N-methyl-d-aspartate receptor (NMDAR) hypofunction in subjects with schizophrenia shows great potential. We report the first fERG study in a genetic mouse model of schizophrenia characterized by NMDAR hypofunction from gene silencing of serine racem...

journal_title：Investigative ophthalmology & visual science

authors： Torres Jimenez N,Lines JW,Kueppers RB,Kofuji P,Wei H,Rankila A,Coyle JT,Miller RF,McLoon LK

更新日期：2020-02-07 00:00:00

abstract：:Ocular ultraviolet radiation (UVR) exposure was assessed in three occupational groups: fisherman, landscape workers and construction workers. The ratio of ocular exposure to ambient exposure was determined by placing UV-sensitive film (295-320 nm) between the eyes of the subjects and in a nearby open field. The mean o...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal FS,Phoon C,Bakalian AE,Taylor HR

更新日期：1988-04-01 00:00:00

abstract：PURPOSE:To determine the concentration of group II phospholipase (PL) A(2), an antimicrobial molecule, in tears of normal subjects in different age and sex groups. METHODS:PLA(2) content of tears was measured in 122 healthy volunteers with ages ranging from 20 to 89 years (mean, 49.5 years) by a time-resolved fluoroim...

journal_title：Investigative ophthalmology & visual science

authors： Saari KM,Aho V,Paavilainen V,Nevalainen TJ

更新日期：2001-02-01 00:00:00

abstract：:PURPOSE. To investigate morphologic photoreceptor layer abnormalities and their correlation with visual function in occult macular dystrophy (OMD), by using spectral-domain optical coherence tomography (SD-OCT). METHODS. This observational case series included 18 eyes of 9 patients with OMD. All patients underwent an ...

journal_title：Investigative ophthalmology & visual science

authors： Park SJ,Woo SJ,Park KH,Hwang JM,Chung H

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To map the disease locus in a four-generation, consanguineous Pakistani family affected by autosomal dominant congenital nuclear cataract (adNCat). All affected individuals had early onset of bilateral nuclear cataract. METHODS:Genomic DNA from family members was typed for alleles at more than 300 known polymo...

journal_title：Investigative ophthalmology & visual science

authors： Khaliq S,Hameed A,Ismail M,Anwar K,Mehdi SQ

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To test whether a diet supplemented with coenzyme Q10 (CoQ10) ameliorates glutamate excitotoxicity and oxidative stress-mediated retinal ganglion cell (RGC) degeneration by preventing mitochondrial alterations in the retina of glaucomatous DBA/2J mice. METHODS:Preglaucomatous DBA/2J and age-matched control DBA...

journal_title：Investigative ophthalmology & visual science

authors： Lee D,Shim MS,Kim KY,Noh YH,Kim H,Kim SY,Weinreb RN,Ju WK

更新日期：2014-02-18 00:00:00

abstract：PURPOSE:This study focuses on the identification of regulatory elements that contribute to lens-specific expression of the human CP49 gene within the 5'-flanking DNA sequences. METHODS:The DNA sequence upstream of the human CP49 coding region was subcloned as a set of 5' and 3' deletion series. The constructs were tra...

journal_title：Investigative ophthalmology & visual science

authors： DePianto DJ,Hess JF,Blankenship TN,FitzGerald PG

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To investigate the impact of ambient room lighting on the magnitude of flicker light-induced retinal vasodilations in healthy individuals. METHODS:Twenty healthy nonsmokers participated in a balanced 2 × 2 crossover study. Retinal vascular imaging was performed with the dynamic vessel analyzer under reduced or...

journal_title：Investigative ophthalmology & visual science

authors： Noonan JE,Dusting GJ,Nguyen TT,Man RE,Best WJ,Lamoureux EL

更新日期：2014-08-07 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：:Previous research has demonstrated that distinct, gender-related differences exist in the morphology of the rat lacrimal gland. The purpose of the present study was to determine whether this sexual dimorphism is unique to the rat, or extends as well to other species. Lacrimal glands were collected from adult male and ...

journal_title：Investigative ophthalmology & visual science

authors： Cornell-Bell AH,Sullivan DA,Allansmith MR

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To determine the relationship between changes in contrast sensitivity, if any, after glaucoma therapy and the test-retest reliability of the CSV-1000 contrast sensitivity test. METHODS:Patients with primary open angle glaucoma (N = 16) were retrospectively evaluated to determine changes in visual function, as ...

journal_title：Investigative ophthalmology & visual science

authors： Pomerance GN,Evans DW

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To evaluate a fully automated local fractal dimension method to quantify vessel density and foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images. METHODS:Fifty-two healthy Asian Indian eyes underwent imaging prospectively with OCTA system. Superficial and deep retinal vasc...

journal_title：Investigative ophthalmology & visual science

authors： Gadde SG,Anegondi N,Bhanushali D,Chidambara L,Yadav NK,Khurana A,Sinha Roy A

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00

abstract：PURPOSE:To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress. METHODS:The AAP cells were isolated differentially from porcine outflow tissues using puromycin ...

journal_title：Investigative ophthalmology & visual science

authors： Lei Y,Stamer WD,Wu J,Sun X

更新日期：2014-11-06 00:00:00

abstract：:To determine whether glaucoma selectively injures a particular size of optic nerve fiber (and its cell body), we induced chronic experimental glaucoma in one eye each of ten monkeys. With automated image analysis, the number and diameter of optic nerve fibers were compared between each glaucomatous eye and its normal ...

journal_title：Investigative ophthalmology & visual science

authors： Quigley HA,Sanchez RM,Dunkelberger GR,L'Hernault NL,Baginski TA

更新日期：1987-06-01 00:00:00

abstract：Purpose:To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods:We extended a previously published numerical model of the ONH to include 24 factors representing tissue anato...

journal_title：Investigative ophthalmology & visual science

authors： Hua Y,Voorhees AP,Sigal IA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:We investigated the phenotype of macrophages infiltrating rejected corneal allografts. METHODS:We performed allogeneic or syngeneic corneal transplantation in mice, and humanely killed animals at day 28 during allograft rejection when 60% of corneal allografts were rejected. We divided allografts into two grou...

journal_title：Investigative ophthalmology & visual science

authors： Oh JY,Lee HJ,Ko AY,Ko JH,Kim MK,Wee WR

更新日期：2013-11-21 00:00:00

abstract：PURPOSE:Estimates of the incidences of severe visual impairment and blindness (SVI/B) and their causes are key to good health service planning. Thus, the database of Germany's largest state's blind registry was used to estimate current incidence rates (IR) and to project rates for Germany in 2010 and 2030. METHODS:The...

journal_title：Investigative ophthalmology & visual science

authors： Finger RP,Fimmers R,Holz FG,Scholl HP

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:Sildenafil (Viagra; Pfizer, New York, NY), a selective phosphodiesterase type-5 (PDE5) inhibitor, is widely used to treat impotence by improving penile blood flow via elevation of cGMP. However, its effect on ocular circulation is controversial and whether retinal arterioles are responsive to this drug remains ...

journal_title：Investigative ophthalmology & visual science

authors： Yuan Z,Hein TW,Rosa RH Jr,Kuo L

更新日期：2008-02-01 00:00:00

abstract：:Interocular differences in apparent size (aniseikonia) are typically associated with interocular differences in refractive error (anisometropia). Aniseikonia is generally thought to reflect disparities in retinal image size that often accompany anisometropia. This assumption was examined with seven highly anisometropi...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Rabin J,Freeman RD

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To investigate thickness profile changes of the corneal epithelium and Bowman's layer at the vertical and horizontal meridians with overnight myopia orthokeratology (OK) lenses. METHODS:Twenty subjects (age range: 19-33 years) wore reverse-geometry rigid gas-permeable OK lenses in both eyes for 30 days. Before...

journal_title：Investigative ophthalmology & visual science

authors： Lian Y,Shen M,Jiang J,Mao X,Lu P,Zhu D,Chen Q,Wang J,Lu F

更新日期：2013-01-23 00:00:00

abstract：PURPOSE:The fibrotic lens disorder posterior capsule opacification (PCO) develops in millions of patients following cataract surgery. PCO characteristics are extensive extracellular matrix (ECM) production and contraction of the posterior lens capsule, resulting in light-scattering ECM modification (wrinkling). The pro...

journal_title：Investigative ophthalmology & visual science

authors： Eldred JA,Hodgkinson LM,Dawes LJ,Reddan JR,Edwards DR,Wormstone IM

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:To identify major gangliosides - the sialated glycolipids - of corneal epithelium; to determine which specific gangliosides, if any, are synthesized in a higher amount or are downregulated during corneal epithelial cell migration; and to determine what role, if any, they play in the modulation of corneal epithe...

journal_title：Investigative ophthalmology & visual science

authors： Yang Z,Zhao Z,Panjwani N

更新日期：1996-03-01 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:To compare current imaging methods with respect to their ability to detect the condition of the fovea in patients with geographic atrophy (GA). METHODS:The retinas of 176 eyes with GA were imaged using two spectral-domain optical coherence tomography (SD-OCT) systems, Cirrus HD-OCT and Spectralis HRA+OCT, and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayegh RG,Zotter S,Roberts PK,Kandula MM,Sacu S,Kreil DP,Baumann B,Pircher M,Hitzenberger CK,Schmidt-Erfurth U

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To use a theoretical model of the observer on the Farnsworth-Munsell 100-hue test to estimate the magnitude of random variation in 100-Hue test error scores. METHODS:The model was based upon classical signal detection theory. Results from the model were obtained by computer simulation. RESULTS:There is a fair...

journal_title：Investigative ophthalmology & visual science

authors： Craven BJ

更新日期：1993-03-01 00:00:00