Isolation and characterization of the human CP49 gene promoter.

abstract：PURPOSE:To investigate the effects of retinoic acid, retinol, and 11-cis retinaldehyde on proliferation, differentiation, and survival of cultured embryonic chick neural retina cells; to describe the metabolic transformations of these retinoids by the cultured cells. METHODS:Retinoids were added to glia-free, low-dens...

journal_title：Investigative ophthalmology & visual science

authors： Stenkamp DL,Gregory JK,Adler R

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:We assessed whether partial occlusion of the nonamblyopic eye with Bangerter filters can immediately reduce suppression and promote binocular summation of contrast in observers with amblyopia. METHODS:In Experiment 1, suppression was measured for 22 observers (mean age, 20 years; range, 14-32 years; 10 females...

journal_title：Investigative ophthalmology & visual science

authors： Chen Z,Li J,Thompson B,Deng D,Yuan J,Chan L,Hess RF,Yu M

更新日期：2014-10-28 00:00:00

abstract：:The effects of oral immunization with a recombinant vaccine expressing chlamydial lipopolysaccharide (LPS) on subsequent ocular challenge with Chlamydia trachomatis were studied in cynomolgus monkeys. Groups of four or five monkeys were given an oral vaccine containing 5 X 10(8) parent or recombinant Escherichia coli ...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Prendergast RA

更新日期：1987-10-01 00:00:00

abstract：:Newborn stump-tail monkeys were continuously exposed to 400 f-c of cool, white, fluorescent light for periods varying from 12 hr to 7 days. The right eye of each monkey was occluded by a patch of black velour material to serve as a control. The protected eyes retained normal ultrastructure; the exposed eyes showed pro...

journal_title：Investigative ophthalmology & visual science

authors： Messner KH,Maisels MJ,Leure-DuPree AE

更新日期：1978-02-01 00:00:00

abstract：PURPOSE:To compare directly the robustness of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), frequency-doubling perimetry (FDP), and grating-resolution perimetry (GRP) stimuli to different degrees of intraocular stray light induced by commercially available opacity-containing filters. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RS,Redmond T,McDowell DR,Breslin KM,Zlatkova MB

更新日期：2009-08-01 00:00:00

abstract：Purpose:Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined in a large historical cohort of Japanese patients with diabetes mellitus. Methods:We evaluated the effects of ov...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto M,Fujihara K,Ishizawa M,Osawa T,Kaneko M,Ishiguro H,Matsubayashi Y,Seida H,Yamanaka N,Tanaka S,Kodama S,Hasebe H,Sone H

更新日期：2019-06-03 00:00:00

abstract：Purpose:Endophthalmitis models have reported the virulent role of Panton-Valentine leucocidin (PVL) secreted by Staphylococcus aureus on the retina. PVL targets retinal ganglion cells (RGCs), expressing PVL membrane receptor C5aR. Interactions between PVL and retinal cells lead to glial activation, retinal inflammation...

journal_title：Investigative ophthalmology & visual science

authors： Wurtz M,Ruhland E,Liu X,Namer IJ,Mazzoleni V,Lipsker D,Keller D,Prévost G,Gaucher D

更新日期：2021-01-04 00:00:00

abstract：Purpose:The prevalence of age-related macular degeneration (AMD) increases dramatically with age. This large collaborative study investigates the effects of 51 late-AMD-associated genetic variants in different ages, focusing on individuals above the age of 90 years. Methods:The study included 27,996 individuals of the...

journal_title：Investigative ophthalmology & visual science

authors： Schick T,Lorés-Motta L,Altay L,Fritsche LG,den Hollander AI,Fauser S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS:There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion cri...

journal_title：Investigative ophthalmology & visual science

authors： Hiraoka T,Kakita T,Okamoto F,Takahashi H,Oshika T

更新日期：2012-06-22 00:00:00

abstract：PURPOSE:To analyze whether insulin receptor substrate (IRS-1) is involved in lymphatic vessel development and whether IRS-1 blockade can inhibit lymphangiogenesis in vivo. METHODS:The impact of IRS-1 blockade by GS-101 (Aganirsen), an antisense oligonucleotide against IRS-1, on lymphatic endothelial cell (LEC) prolife...

journal_title：Investigative ophthalmology & visual science

authors： Hos D,Regenfuss B,Bock F,Onderka J,Cursiefen C

更新日期：2011-07-29 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Evidence suggests oxidative stress plays a role in the disease. To assess the potential contribution of epigenetic regulation of antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, a tissue-specifi...

journal_title：Investigative ophthalmology & visual science

authors： Hunter A,Spechler PA,Cwanger A,Song Y,Zhang Z,Ying GS,Hunter AK,Dezoeten E,Dunaief JL

更新日期：2012-04-24 00:00:00

abstract：PURPOSE:To investigate the molecular basis of hereditary lattice corneal dystrophy (LCD) type IIIA associated with corneal amyloid deposits afflicting several members of a four-generation family. METHODS:Histologic, immunohistochemical and biochemical studies were performed on corneal tissue samples obtained after per...

journal_title：Investigative ophthalmology & visual science

authors： Stix B,Leber M,Bingemer P,Gross C,Rüschoff J,Fändrich M,Schorderet DF,Vorwerk CK,Zacharias M,Roessner A,Röcken C

更新日期：2005-04-01 00:00:00

abstract：Purpose:To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels. Methods:A total of 522 eyes of 327 patients with POAG (mean age ± SD, 54.1 ± 12.4 years) and 375 eyes of 204 patients with PACG (67.3 ± 8.9 ye...

journal_title：Investigative ophthalmology & visual science

authors： Yousefi S,Sakai H,Murata H,Fujino Y,Garway-Heath D,Weinreb R,Asaoka R

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Previous studies assessed the associations between Helicobacter pylori infection and open-angle glaucoma (OAG) and produced inconsistent results. Therefore, we performed a meta-analysis to evaluate the effects of H. pylori infection on OAG risk. METHODS:Relevant studies that reported the associations between H...

journal_title：Investigative ophthalmology & visual science

authors： Zeng J,Liu H,Liu X,Ding C

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Children with idiopathic infantile nystagmus (IIN) exhibit visual acuity deficits that have been modeled in terms of foveation characteristics of the nystagmus waveform. Here we present evidence for an additional component of acuity loss associated with the deprivation experienced during the sensitive period of...

journal_title：Investigative ophthalmology & visual science

authors： Felius J,Muhanna ZA

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:To determine whether people with central visual field loss (CFL) show a smaller visual contribution to posture stabilization than people with normal vision and to determine the visual factors that predict the magnitude of visual stabilization in people with central visual field loss. METHODS:Posture informatio...

journal_title：Investigative ophthalmology & visual science

authors： Turano KA,Dagnelie G,Herdman SJ

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:To identify the underlying molecular defects causing retinal degeneration in seven N-ethyl-N-nitrosourea (ENU) induced mutant alleles of the Pde6b gene and to analyze the timescale of retinal degeneration in these new models of retinitis pigmentosa. METHODS:Conformation sensitive capillary electrophoresis and ...

journal_title：Investigative ophthalmology & visual science

authors： Hart AW,McKie L,Morgan JE,Gautier P,West K,Jackson IJ,Cross SH

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To determine whether ciliary neurotrophic factor (CNTF) or brain-derived neurotrophic factor (BDNF) treatment leads to long-term photoreceptor survival in hereditary retinal degeneration. METHODS:An autosomal dominant feline model of rod-cone dystrophy was used throughout the study with two normal animals. In ...

journal_title：Investigative ophthalmology & visual science

authors： Chong NH,Alexander RA,Waters L,Barnett KC,Bird AC,Luthert PJ

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To reveal the effects of minocycline, an anti-inflammatory and neuroprotective agent, on the viability and physiological properties of retinal pigment epithelial (RPE) cells and to compare the effects with those of triamcinolone acetonide. METHODS:The proliferation of human RPE cells in vitro was investigated ...

journal_title：Investigative ophthalmology & visual science

authors： Hollborn M,Wiedemann P,Bringmann A,Kohen L

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Ocular side effects in patients using eye drops may be due to intolerance to the vector used in eye drops. Castor oil is the commonly used lipophilic vector but has been shown to be cytotoxic. Effects on cells of four oils (olive, camelina, Aleurites moluccana, maize) were compared with those of castor oil in h...

journal_title：Investigative ophthalmology & visual science

authors： Said T,Dutot M,Christon R,Beaudeux JL,Martin C,Warnet JM,Rat P

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Previous reports indicated that pregnancy and corneal injury (CI) trigger alterations of lacrimal gland (LG) growth factor expression and redistributions of lymphocytes from periductal foci to acini. The purpose of this study was to test our hypothesis that pregnancy would exacerbate the changes induced by CI. ...

journal_title：Investigative ophthalmology & visual science

authors： Ding C,Chang N,Fong YC,Wang Y,Trousdale MD,Mircheff AK,Schechter JE

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：PURPOSE:To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP). METHODS:Paired explants were used as control versus VIP (10 nM)-treated before storage in corne...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Gloria D,Molloy J

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To examine the extent to which the two major determinants of refractive error, corneal curvature and axial length, are scaled relative to one another by shared genetic variants, along with their relationship to the genetic scaling of height. METHODS:Corneal curvature, axial length, and height were measured in ...

journal_title：Investigative ophthalmology & visual science

authors： Guggenheim JA,Zhou X,Evans DM,Timpson NJ,McMahon G,Kemp JP,St Pourcain B,Northstone K,Ring SM,Fan Q,Wong TY,Cheng CY,Khor CC,Aung T,Saw SM,Williams C

更新日期：2013-03-07 00:00:00

abstract：PURPOSE:Downregulation of melanoma-associated antigens (MAAs), against which natural cytolytic T lymphocytes (CTLs) exist in humans, is one of the mechanisms that aids in evasion of immune surveillance. In view of putative re-expression strategies for MAAs during immunotherapy, this study was conducted to investigate M...

journal_title：Investigative ophthalmology & visual science

authors： van Dinten LC,Pul N,van Nieuwpoort AF,Out CJ,Jager MJ,van den Elsen PJ

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To report the impact of intravitreous bevacizumab therapy on contrast sensitivity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a prospective, multicenter, double-masked, randomized, controlled trial of 131 patients with nAMD. The patients with nAMD had received intravi...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Chen FK,Da Cruz L,Rubin GS,Tufail A,ABC Trial Study Group.

更新日期：2011-05-11 00:00:00

abstract：:Retinoblastoma patients have cellular and humoral reactivity towards antigens expressed on retinoblastoma cells. We report the ultrastructural, cytogenetic, and immunologic features of four new retinoblastoma derived tissue culture cell lines. Studies with hybridoma produced monoclonal antibodies demonstrate that thes...

journal_title：Investigative ophthalmology & visual science

authors： Char DH,Wood IS,Huhta K,Rand N,Morita CT,Howes EL Jr

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells. METHODS:Six mutations known to be responsible for autosomal dominant corneal dystrophies linked to chromosome 5 were generated in a BIGH3 expression vector and transfected in HeLa and HCE cells. The ex...

journal_title：Investigative ophthalmology & visual science

authors： Morand S,Buchillier V,Maurer F,Bonny C,Arsenijevic Y,Munier FL,Schorderet DF

更新日期：2003-07-01 00:00:00