Mydriasis induced by tetrahydrocannabinol (THC) in rats.

abstract：PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characteriz...

journal_title：Investigative ophthalmology & visual science

authors： Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

更新日期：2015-02-26 00:00:00

abstract：PURPOSE:Persistent hyperplastic primary vitreous (PHPV) is an idiopathic developmental eye disease associated with failed involution of the hyaloid vasculature. The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease. METHODS:Ophthalmoscopic and histologic...

journal_title：Investigative ophthalmology & visual science

authors： Martin AC,Thornton JD,Liu J,Wang X,Zuo J,Jablonski MM,Chaum E,Zindy F,Skapek SX

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To correlate the morphologic characteristics of choroidal neovascular lesions (CNV) in age-related macular degeneration (AMD) using raster scanning high-definition optical coherence tomography (HD-OCT) and conventional fluorescein angiography (FA). METHODS:In this comparative clinical study, 37 consecutive pat...

journal_title：Investigative ophthalmology & visual science

authors： Malamos P,Sacu S,Georgopoulos M,Kiss C,Pruente C,Schmidt-Erfurth U

更新日期：2009-10-01 00:00:00

abstract：:The retinal blood vessels serve for nutrition of the retinal ganglion cells and their axons. This study was undertaken to evaluate the vessel diameter in normal and glaucoma eyes. The calibers of the superior temporal and inferior temporal retinal artery and vein were measured at the optic disc border and at a distanc...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nguyen XN,Naumann GO

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To characterize the expression patterns of myosin heavy chain (MyHC) isoforms in mouse extraocular muscles (EOMs) during postnatal development. METHODS:MyHC isoform expression in mouse EOMs from postnatal day (P)0 to 3 months was evaluated by quantitative polymerase chair reaction (qPCR) and immunohistochemist...

journal_title：Investigative ophthalmology & visual science

authors： Zhou Y,Liu D,Kaminski HJ

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Although L-type Ca2+ channels are known to play a key role in the myogenic reactivity of retinal arterial vessels, the involvement of other types of voltage-gated Ca2+ channels in this process remains unknown. In the present study we have investigated the contribution of T-type Ca2+ channels to myogenic signali...

journal_title：Investigative ophthalmology & visual science

authors： Fernández JA,McGahon MK,McGeown JG,Curtis TM

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To compare action spectra for visual discomfort in the fovea and the parafovea and to determine the effect of macular pigment (MP). METHODS:Visual discomfort thresholds to lights from 440 to 600 nm were obtained for six young (<35 y), visually normal subjects with a wide range of MP densities (0.10-0.71 at 30'...

journal_title：Investigative ophthalmology & visual science

authors： Stringham JM,Snodderly DM

更新日期：2013-09-19 00:00:00

abstract：PURPOSE:To study the survival of adult retinal grafts prepared in a physiologically optimized way. METHODS:Twenty-three rabbits received an adult full-thickness rabbit retinal transplant positioned under the host retina, using a vitrectomy technique. The transplants were prepared using a procedure based on a previousl...

journal_title：Investigative ophthalmology & visual science

authors： Wassélius J,Ghosh F

更新日期：2001-10-01 00:00:00

abstract：:Reduced quality of life and financial burden due to visual impairment and blindness begin to increase dramatically when individuals reach the age of 40. The major causes of age-related vision loss can be traced to changes to the structure and function of the lens, one of the tissues responsible for focusing light on t...

journal_title：Investigative ophthalmology & visual science

authors： Petrash JM

更新日期：2013-12-13 00:00:00

abstract：PURPOSE:α-Crystallins are small heat shock proteins that regulate cellular damage and cell survival. Expression of the proteins of the crystallin superfamily in the retina and their role in neuronal cell survival were investigated in two animal models of diabetes and retinal neurons in culture. METHODS:Crystallin expr...

journal_title：Investigative ophthalmology & visual science

authors： Losiewicz MK,Fort PE

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:As in human populations, in which founder mutations have been identified in groups of families, a number of founder mutations have been observed across strains in mice. In this report, we provide a phenotype and genotype survey of three common eye diseases in the collection of JAX mice strains at The Jackson La...

journal_title：Investigative ophthalmology & visual science

authors： Chang B,Hurd R,Wang J,Nishina P

更新日期：2013-07-24 00:00:00

abstract：PURPOSE:During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina. Because gangliosides play an important role in neuronal cell differentiation and proliferation, this change in ganglioside profile may indicate retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Park EJ,Suh M,Clandinin MT

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

journal_title：Investigative ophthalmology & visual science

authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To examine the possibility that ocular surface epithelial cells might be grown in culture for use as grafts. METHODS:The proliferative capacity of epithelial cells cultured from the conjunctiva, limbus, and central cornea of normal human eyes was compared. Single cells disaggregated from approximately 1 mm2 bi...

journal_title：Investigative ophthalmology & visual science

authors： Lindberg K,Brown ME,Chaves HV,Kenyon KR,Rheinwald JG

更新日期：1993-08-01 00:00:00

abstract：Purpose:We assessed changes in age-specific prevalence of refractive error at the time of starting school, by comparing preschool and school age cohorts in Shanghai, China. Methods:A cross-sectional study was done in Jiading District, Shanghai during November and December 2013. We randomly selected 7 kindergartens and...

journal_title：Investigative ophthalmology & visual science

authors： Ma Y,Qu X,Zhu X,Xu X,Zhu J,Sankaridurg P,Lin S,Lu L,Zhao R,Wang L,Shi H,Tan H,You X,Yuan H,Sun S,Wang M,He X,Zou H,Congdon N

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD. METHODS:Fifty-seven Chinese subjects with clinically diagnosed FCD and 121 normal control subjects were recruited. Genomic DNA was extr...

journal_title：Investigative ophthalmology & visual science

authors： Thalamuthu A,Khor CC,Venkataraman D,Koh LW,Tan DT,Aung T,Mehta JS,Vithana EN

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:This study was conducted to validate a recently described technique for measuring the rates of visual field (VF) decay in glaucoma. METHODS:A pointwise exponential regression (PER) model was used to calculate average rates of faster and slower deteriorating VF components, and that of the entire VF. Rapid progr...

journal_title：Investigative ophthalmology & visual science

authors： Azarbod P,Mock D,Bitrian E,Afifi AA,Yu F,Nouri-Mahdavi K,Coleman AL,Caprioli J

更新日期：2012-08-09 00:00:00

abstract：PURPOSE:To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). METHODS:We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who underwent both fluorescein angiography (FA) and volu...

journal_title：Investigative ophthalmology & visual science

authors： Hariri A,Heussen FM,Nittala MG,Sadda SR

更新日期：2013-12-09 00:00:00

abstract：PURPOSE:We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS:We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), ...

journal_title：Investigative ophthalmology & visual science

authors： Akashi A,Kanamori A,Nakamura M,Fujihara M,Yamada Y,Negi A

更新日期：2013-07-10 00:00:00

abstract：PURPOSE:To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes. METHODS:Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monosco...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Hutchison DM,Artes PH,Caprioli J,Jonas JB,LeBlanc RP,Nicolela MT

更新日期：2009-04-01 00:00:00

abstract：Purpose:Previous studies have reported a possible link between low bone mineral density and AMD. The aim of the present study was to investigate the association between osteoporosis and AMD in a South Korean cohort. Methods:This cross-sectional, nationwide study included 3496 women and 2789 men who had participated in...

journal_title：Investigative ophthalmology & visual science

authors： Yoo TK,Kim SH,Kwak J,Kim HK,Rim TH

更新日期：2018-03-20 00:00:00

abstract：PURPOSE:Methylenetetrahydrofolate reductase (Mthfr) is a key enzyme in homocysteine-methionine metabolism. We investigated Mthfr expression in retina and asked whether mild hyperhomocysteinemia, due to Mthfr deficiency, alters retinal neurovascular structure and function. METHODS:Expression of Mthfr was investigated a...

journal_title：Investigative ophthalmology & visual science

authors： Markand S,Saul A,Roon P,Prasad P,Martin P,Rozen R,Ganapathy V,Smith SB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting oxidative stress-induced damage to RPE...

journal_title：Investigative ophthalmology & visual science

authors： He Y,Leung KW,Ren Y,Pei J,Ge J,Tombran-Tink J

更新日期：2014-09-11 00:00:00

abstract：PURPOSE:To identify the risk factors for having advanced glaucomatous visual field loss on the first visit at three hospital eye services. METHODS:This was a hospital-based, case-control study involving patients newly diagnosed with glaucoma at first visit to one of three ophthalmic departments in the United Kingdom. ...

journal_title：Investigative ophthalmology & visual science

authors： Fraser S,Bunce C,Wormald R

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To determine the involvement of calpain in ovine cataractogenesis by measuring calcium, calpain activity, proteolysis, and the effect of calpain inhibition. METHODS:Sheep with genetic cataracts were examined for cataract severity. Calcium in normal and cataract lenses was measured. The presence of calpain was ...

journal_title：Investigative ophthalmology & visual science

authors： Robertson LJ,Morton JD,Yamaguchi M,Bickerstaffe R,Shearer TR,Azuma M

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Christian JC,Abel LA,Yee RD

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to examine the roles of signaling pathways potentially activated by TGFbeta (i.e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation of cell migration and proliferation of healing mouse corneal epithelium. METHODS:Activation of Smads or p38MAPK was evaluated by im...

journal_title：Investigative ophthalmology & visual science

authors： Saika S,Okada Y,Miyamoto T,Yamanaka O,Ohnishi Y,Ooshima A,Liu CY,Weng D,Kao WW

更新日期：2004-01-01 00:00:00

abstract：:Intracameral perfusion with 4 to 6 mM Na2EDTA or 4 mM EGTA for 40 to 80 min caused a very large increase in gross outflow facility. This effect was partly reversible when followed by perfusion with mock aqueous humor. Eyes perfused with Na2EDTA were studied morphologically. In the trabecular meshwork the cells separat...

journal_title：Investigative ophthalmology & visual science

authors： Bill A,Lütjen-Drecoll E,Svedbergh B

更新日期：1980-05-01 00:00:00

abstract：PURPOSE:To investigate the efficacy of an endoscopic vitrectomy in Seoul-type keratoprosthesis (S-Kpro) exchange procedures. METHODS:Nine S-Kpro-implanted rabbit eyes were enrolled in the S-Kpro exchange. Six eyes underwent an antecedent vitrectomy by an endoscopic system and then the S-Kpro exchange (endoscopy group)...

journal_title：Investigative ophthalmology & visual science

authors： Lee SM,Kim MK,Oh JY,Heo JW,Shin MS,Lee MS,Wee WR,Lee JH

更新日期：2008-10-01 00:00:00