Retinoblastoma: tissue culture lines and monoclonal antibody studies.

abstract：PURPOSE:To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS:Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of ...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Siemers E,Abel LA,Yee RD

更新日期：2000-07-01 00:00:00

abstract：:The definition and diagnostic criteria of dry eye disease (DED) proposed by the Japan Dry Eye Society and other countries are reviewed. The first definition and criteria of DED in Japan were proposed in 1995. In that report, DED was considered a disease of tears, which subsequently damaged ocular epithelia. The presen...

journal_title：Investigative ophthalmology & visual science

authors： Shimazaki J

更新日期：2018-11-01 00:00:00

abstract：:We tested the state of retinal correspondence at different positions in the visual field of ten observers with strabismic and/or anisometropic amblyopia, four strabismic subjects with alternating fixation and three normal controls. Correspondence was evaluated by the subjective displacement of dichoptic stimuli; to es...

journal_title：Investigative ophthalmology & visual science

authors： Sireteanu R,Fronius M

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:Alkali burning of the rabbit cornea is a well-established model for the study of anterior surface inflammation, neovascularization, and wound-healing processes. 12-hydroxyeicosanoids have been implicated as mediators of such responses. 12(S)-hydroxyeicosatetraenoic acid (12[S]-HETE) is a lipoxygenase-derived ar...

journal_title：Investigative ophthalmology & visual science

authors： Conners MS,Urbano F,Vafeas C,Stoltz RA,Dunn MW,Schwartzman ML

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To describe lacrimal gland involvement in a murine model of acute graft-versus-host disease (GVHD). METHODS:Histopathologic examination was performed on lacrimal glands of mice affected by GVHD at 1, 2, 4, and 6 weeks after allogeneic bone marrow transplantation (BMT). Histopathologic scoring, based on charact...

journal_title：Investigative ophthalmology & visual science

authors： Hassan AS,Clouthier SG,Ferrara JL,Stepan A,Mian SI,Ahmad AZ,Elner VM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:Vitreous degeneration contributes to several age-related eye diseases, including retinal detachment, macular hole, macular traction syndrome, and nuclear cataracts. Remarkably little is understood about the molecular interactions responsible for maintaining vitreous structure. The purpose of this study was to m...

journal_title：Investigative ophthalmology & visual science

authors： Filas BA,Zhang Q,Okamoto RJ,Shui YB,Beebe DC

更新日期：2014-01-03 00:00:00

abstract：PURPOSE:To determine whether the human retinal oxygenation response (deltaPO2) to a hyperoxic provocation is abnormal in patients with type I diabetes. METHODS:Magnetic resonance imaging (MRI) was used to measure deltaPO2 during 100% oxygen breathing in patients with type I diabetes who had either no clinically detect...

journal_title：Investigative ophthalmology & visual science

authors： Trick GL,Edwards P,Desai U,Berkowitz BA

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) and early-onset severe retinal dystrophy (EOSRD) are genetically heterogeneous, with 11 genes currently implicated. The LCA chip may be used to interrogate many variants in one hybridization reaction. The purpose of this study was to assess the utility of this technology. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Henderson RH,Waseem N,Searle R,van der Spuy J,Russell-Eggitt I,Bhattacharya SS,Thompson DA,Holder GE,Cheetham ME,Webster AR,Moore AT

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To assess the role of vitamin E (VE) in age-related changes in the retinal tissues by using a mouse model of severe VE deficiency. METHODS:Pups of alpha-tocopherol transfer protein null (a-TTP(-)(/)(-)) mice were fed a VE-deficient diet for 4 or 18 months (VE (-) group). Wild-type C57BL/6 mice were fed a 0.002...

journal_title：Investigative ophthalmology & visual science

authors： Tanito M,Yoshida Y,Kaidzu S,Chen ZH,Cynshi O,Jishage K,Niki E,Ohira A

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To investigate the alterations in gene expression when human retinal pigment epithelial (RPE) cells in culture are treated with vitreous as a model for the changes that occur in proliferative vitreoretinopathy. METHODS:Human RPE cells were cultured with or without human vitreous or collagen. RNA was extracted ...

journal_title：Investigative ophthalmology & visual science

authors： Parapuram SK,Ganti R,Hunt RC,Hunt DM

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:To evaluate the intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV), the hydrolysis product of HDP-cyclic-CDV, a long-lasting intravitreal cidofovir prodrug for cytomegalovirus (CMV) retinitis. METHODS:HDP-cyclic-CDV was suspended in phosphate-buffered saline (PBS) at 37°C and for...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Chhablani J,Freeman WR,Beadle JR,Hostetler KY,Hartmann K,Conner L,Aldern KA,Pearson L,Cheng L

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:Acute optic neuritis (ON) is often followed by recovery of visual function. Although this recovery is mainly attributable to resolution of the acute inflammation, the redistribution of ion channels along the demyelinated membrane, and subsequent remyelination, part of it may be the result of neural plasticity. ...

journal_title：Investigative ophthalmology & visual science

authors： Klistorner A,Arvind H,Garrick R,Graham SL,Paine M,Yiannikas C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Oxidative stress and cellular senescence are known to contribute to the development of AMD; however, the mechanism is not fully understood. This study investigated the role of TGF-β-activated kinase 1 (TAK1) in the senescence of RPE cells as a model for the development of dry AMD. METHODS:Cultured human RPE ce...

journal_title：Investigative ophthalmology & visual science

authors： Dvashi Z,Green Y,Pollack A

更新日期：2014-08-12 00:00:00

abstract：PURPOSE:Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study. METHODS:C57BL/6(B6), FasL (CD95L)-deficient B6-...

journal_title：Investigative ophthalmology & visual science

authors： Stuart PM,Pan F,Plambeck S,Ferguson TA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Keratoconus disease or post-LASIK corneal ectasia are increasingly treated using UV-A/riboflavin-induced corneal collagen cross-linking (CXL). However, this treatment suffers from a lack of techniques to provide an assessment in real-time of the CXL effects. Here, we investigated the potential interest of corne...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen TM,Aubry JF,Touboul D,Fink M,Gennisson JL,Bercoff J,Tanter M

更新日期：2012-08-31 00:00:00

abstract：PURPOSE:It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can...

journal_title：Investigative ophthalmology & visual science

authors： Wang S,Lu B,Girman S,Holmes T,Bischoff N,Lund RD

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To investigate corneal sensitivity to selective mechanical, chemical, heat, and cold stimulation in patients with fibromyalgia (FM). METHODS:Twenty patients with FM (18 women, 2 men; 51.9 +/- 2.3 years old) and 18 control subjects (16 women, 2 men; 51.7 +/- 2.4 years) participated voluntarily in the study. Sub...

journal_title：Investigative ophthalmology & visual science

authors： Gallar J,Morales C,Freire V,Acosta MC,Belmonte C,Duran JA

更新日期：2009-09-01 00:00:00

abstract：:Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively u...

journal_title：Investigative ophthalmology & visual science

authors： Peng H,Park JK,Lavker RM

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS:MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline....

journal_title：Investigative ophthalmology & visual science

authors： Sasamoto Y,Gomi F,Sawa M,Sakaguchi H,Tsujikawa M,Nishida K

更新日期：2011-02-16 00:00:00

abstract：:Sixteen patients with osteogenesis imperfecta (OI) have undergone a thorough eye examination. These patients had statistically significantly lower ocular rigidity measurements than a group of normal volunteers matched on age, sex, and refractive error. In addition, the corneal diameter and length of the eyeball was sm...

journal_title：Investigative ophthalmology & visual science

authors： Kaiser-Kupfer MI,McCain L,Shapiro JR,Podgor MJ,Kupfer C,Rowe D

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:To determine whether blur adaptation influences blur sensitivity and blur discrimination thresholds in young adult myopes and emmetropes. In addition, to determine whether there is a differential effect of blur adaptation on blur sensitivity and discrimination between refractive error groups. METHODS:Proximal ...

journal_title：Investigative ophthalmology & visual science

authors： Cufflin MP,Mankowska A,Mallen EA

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Activity in regions of the visual cortex corresponding to central scotomas in subjects with macular degeneration (MD) is considered evidence for functional reorganization in the brain. Three unresolved issues related to cortical activity in subjects with MD were addressed: Is the cortical response to stimuli pr...

journal_title：Investigative ophthalmology & visual science

authors： Liu T,Cheung SH,Schuchard RA,Glielmi CB,Hu X,He S,Legge GE

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling. METHODS:The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, re...

journal_title：Investigative ophthalmology & visual science

authors： Faralli JA,Newman JR,Sheibani N,Dedhar S,Peters DM

更新日期：2011-03-25 00:00:00

abstract：Purpose:To assess interocular delays in amblyopes with stereopsis and to evaluate the relationship between interocular delays and the clinical characteristics. Methods:Twenty amblyopes with stereopsis (median, 400 arcseconds) and 20 controls with normal or corrected to normal visual acuity (≤0 logMAR) and normal stere...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Reynaud A,Tao C,Mao Y,He Z,Zhou J,Hess RF

更新日期：2020-03-09 00:00:00

abstract：:Docosapentaenoic acid (22:5 omega 6), a minor constituent (less than 4%) of photoreceptor outer segment membranes in all vertebrate species examined to date, comprises 23% of the fatty acids in total lipids from rabbit outer segment membranes. This fatty acid is a significant constituent of each of the three major pho...

journal_title：Investigative ophthalmology & visual science

authors： Nielsen JC,Maude MB,Hughes H,Anderson RE

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:To characterize the signaling pathways used by hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) in human corneal epithelial cells. METHODS:Cultures of SV40 large T antigen-transfected human corneal epithelial cells were treated with recombinant human HGF or KGF at 50 ng/ml to 100 ng/ml for 5...

journal_title：Investigative ophthalmology & visual science

authors： Liang Q,Mohan RR,Chen L,Wilson SE

更新日期：1998-07-01 00:00:00

abstract：:We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on...

journal_title：Investigative ophthalmology & visual science

authors： Grunwald JE

更新日期：1990-03-01 00:00:00

abstract：:The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes wer...

journal_title：Investigative ophthalmology & visual science

authors： Wolffsohn JS,Kollbaum PS,Berntsen DA,Atchison DA,Benavente A,Bradley A,Buckhurst H,Collins M,Fujikado T,Hiraoka T,Hirota M,Jones D,Logan NS,Lundström L,Torii H,Read SA,Naidoo K

更新日期：2019-02-28 00:00:00

abstract：Purpose:Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts....

journal_title：Investigative ophthalmology & visual science

authors： Futakuchi A,Inoue T,Fujimoto T,Kuroda U,Inoue-Mochita M,Takahashi E,Ohira S,Tanihara H

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Antimicrobial peptides (AMPs) are multifunctional host defense molecules. Human beta-defensin 9 (HBD9) has previously been shown to be downregulated during ocular surface (OS) infection or inflammation. Here, the authors aimed to study localization of HBD9 protein in different OS regions and to determine the ro...

journal_title：Investigative ophthalmology & visual science

authors： Mohammed I,Suleman H,Otri AM,Kulkarni BB,Chen P,Hopkinson A,Dua HS

更新日期：2010-09-01 00:00:00