Low ocular rigidity in patients with osteogenesis imperfecta.

abstract：:Photoreceptor degeneration was induced in the cone-dominant retina of the ground squirrel by intracardiac injection of iodoacetic acid. Morphology was examined and cyclic nucleotide levels were determined in retinas taken at various times between 35 min and 11 days after injection. Degenerating cone cells were first d...

journal_title：Investigative ophthalmology & visual science

authors： Farber DB,Souza DW,Chase DG

更新日期：1983-09-01 00:00:00

abstract：PURPOSE:To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. METHODS:The retinas of cyclic-light-reared, pigmented arrestin knockout mice and wild-type littermate control mice were examined histologically for photoreceptor ce...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Simon MI,Matthes MT,Yasumura D,LaVail MM

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects. METHODS:Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey ...

journal_title：Investigative ophthalmology & visual science

authors： Tham YC,Cheng CY,Zheng Y,Aung T,Wong TY,Cheung CY

更新日期：2013-11-05 00:00:00

abstract：:Angiotensin II (A2) is a vasoconstrictor generated by the renin-angiotensin system. A2 appears to act also as an angiogenic factor. Recent evidence suggests that renin is synthesized at many tissue sites and may generate A2 locally. Local A2 may have important functions in the normal and diseased eye. We examined eigh...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Day RP,Ehrlich EN

更新日期：1988-11-01 00:00:00

abstract：Purpose:To investigate diurnal variation in the length of mouse rod outer segments in vivo. Methods:The lengths of rod inner and outer segments (RIS, ROS) of dark-adapted albino mice maintained on a 12-hour dark:12-hour light cycle with light onset 7 AM were measured at prescribed times (6:30 AM, 11 AM, 3:30 PM) durin...

journal_title：Investigative ophthalmology & visual science

authors： Zhang P,Shibata B,Peinado G,Zawadzki RJ,FitzGerald P,Pugh EN Jr

更新日期：2020-03-09 00:00:00

abstract：:Lenses from young rhesus monkeys were incubated in the presence of H2O2 or oxygen radical generating systems to determine their suitability as a model for investigating lenticular oxidative stress. Additionally, direct comparisons were made between the effects found with the monkey lenses and those observed with cultu...

journal_title：Investigative ophthalmology & visual science

authors： Zigler JS Jr,Lucas VA,Du XY

更新日期：1989-10-01 00:00:00

abstract：PURPOSE:To compare the mydriatic effect and the short-term corneal endothelial safety of intracamerally injected N-methyl-3,4-dihydroxyphenylamine (epinine) to phenylephrine in a porcine eye model. METHODS:One hundred twelve eyes from newly slaughtered pigs were used in this study. After pretreatment with 20 mg intrac...

journal_title：Investigative ophthalmology & visual science

authors： Lundberg B,Behndig A

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To identify if whole-body hydration plays an important role in dry eye (DE). We hypothesized that individuals classified as DE have higher plasma osmolality (Posm), indicating suboptimal hydration, compared with those classified as non-DE. METHODS:Using a hospital-based observational cross-sectional design, as...

journal_title：Investigative ophthalmology & visual science

authors： Walsh NP,Fortes MB,Raymond-Barker P,Bishop C,Owen J,Tye E,Esmaeelpour M,Purslow C,Elghenzai S

更新日期：2012-09-25 00:00:00

abstract：PURPOSE:To examine the effects of oxidized low-density lipoproteins (oxLDL) on phagocytosis and processing of photoreceptor outer segments (OS) by retinal pigment epithelial (RPE) cells. METHODS:Confluent cultures of RPE-J cells were pretreated with oxLDL or LDL, and the effects of such treatment on the processing of ...

journal_title：Investigative ophthalmology & visual science

authors： Hoppe G,Marmorstein AD,Pennock EA,Hoff HF

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Recent studies demonstrated that short peptides derived from activity-dependent neurotrophic factor (ADNF) and activity-dependent neuroprotective protein (ADNP) are neuroprotective at femtomolar concentrations. We evaluated these findings in cultures of purified rat retinal ganglion cells (RGCs) using two such ...

journal_title：Investigative ophthalmology & visual science

authors： Lagrèze WA,Pielen A,Steingart R,Schlunck G,Hofmann HD,Gozes I,Kirsch M

更新日期：2005-03-01 00:00:00

abstract：Purpose:Ocular lens fiber cell elongation, differentiation, and compaction are associated with extensive reorganization of cell adhesive interactions and cytoskeleton; however, our knowledge of proteins critical to these events is still evolving. This study characterizes the distribution pattern of neuronal-specific α-...

journal_title：Investigative ophthalmology & visual science

authors： Maddala R,Rao PV

更新日期：2017-07-01 00:00:00

abstract：:Tunicamycin (TM), a selective inhibitor of dolichylphosphate-dependent oligosaccharide biosynthesis, effectively blocks glycosylation, but not synthesis, of opsin, the rod visual pigment apoglycoprotein. In parallel with this inhibition, vesicular membrane material accumulates in the compartment between rod inner and ...

journal_title：Investigative ophthalmology & visual science

authors： Defoe DM,Besharse JC,Fliesler SJ

更新日期：1986-11-01 00:00:00

abstract：PURPOSE:Rabbits are used commonly for the evaluation of drugs and surgery to lower intraocular pressure (IOP). The authors compared the accuracy and variability of three tonometers for measuring IOP in rabbits. METHODS:The anterior chamber of adult rabbits was cannulated with a 25-gauge needle connected to an elevated...

journal_title：Investigative ophthalmology & visual science

authors： Abrams LS,Vitale S,Jampel HD

更新日期：1996-04-01 00:00:00

abstract：Purpose:To determine whether high glucose (HG) or diabetes alters mitochondrial morphology and promotes mitochondrial fragmentation in retinal vascular cells and thereby triggers apoptosis associated with diabetic retinopathy. Methods:To assess whether diabetes promotes mitochondrial fragmentation and thereby triggers...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Roy S

更新日期：2020-08-03 00:00:00

abstract：:Interocular differences in apparent size (aniseikonia) are typically associated with interocular differences in refractive error (anisometropia). Aniseikonia is generally thought to reflect disparities in retinal image size that often accompany anisometropia. This assumption was examined with seven highly anisometropi...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Rabin J,Freeman RD

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS:Two genome-wide associatio...

journal_title：Investigative ophthalmology & visual science

authors： Burdon KP,Macgregor S,Bykhovskaya Y,Javadiyan S,Li X,Laurie KJ,Muszynska D,Lindsay R,Lechner J,Haritunians T,Henders AK,Dash D,Siscovick D,Anand S,Aldave A,Coster DJ,Szczotka-Flynn L,Mills RA,Iyengar SK,Taylor KD,

更新日期：2011-10-31 00:00:00

abstract：PURPOSE:Vitamin D3 is a secosteroid mainly synthesized from the conversion of the skin precursor 7-dehydrocholesterol (7DHC) to vitamin D3 by ultraviolet (UV) B sunlight. Extrarenal synthesis of vitamin D3 has been reported in many tissues and cells, including barrier sites. This study characterizes the expression of c...

journal_title：Investigative ophthalmology & visual science

authors： Alsalem JA,Patel D,Susarla R,Coca-Prados M,Bland R,Walker EA,Rauz S,Wallace GR

更新日期：2014-04-07 00:00:00

abstract：PURPOSE:To examine the accommodative accuracy and amplitude in children with Down syndrome. Accommodation is usually assumed to be good in children and is rarely measured. METHODS:A dynamic retinoscopy technique was developed that allows rapid and reliable measures of accuracy and amplitude of accommodation in infants...

journal_title：Investigative ophthalmology & visual science

authors： Woodhouse JM,Meades JS,Leat SJ,Saunders KJ

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To determine the size variation of the X-chromosomal human red and green visual pigment gene array in the general population using pulsed field gel electrophoresis and Southern blotting. METHODS:Peripheral blood lymphocytes were prepared from 67 anonymous males. The cells were embedded in agarose and the genom...

journal_title：Investigative ophthalmology & visual science

authors： Macke JP,Nathans J

更新日期：1997-04-01 00:00:00

abstract：:Using a freezing point depression method, requiring volumes of only 200 nanoliters, the osmolalities of 324 tear samples collected at consecutive 10-minute intervals throughout 8.5-hour periods from each of six healthy young adults were measured. The population mean was found to be 318 mOsm/kg, with a population media...

journal_title：Investigative ophthalmology & visual science

authors： Benjamin WJ,Hill RM

更新日期：1983-12-01 00:00:00

abstract：:Using isochromatic luminance gratings and isoluminant red-green color gratings, examined luminance and color discrimination in amblyopia were examined. Complete color and luminance contrast sensitivity functions were measured monocularly from each eye of six normal and six amblyopic observers. Similar spatial frequenc...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Dahlman C,Switkes E,De Valois K

更新日期：1986-09-01 00:00:00

abstract：:An ultrasonic pachometer was used to measure the central, mid-peripheral, and peripheral thickness in 17 locations across the corneas of 12 adult New Zealand Albino rabbit eyes. The mean thickness at each location was entered into a microcomputer to generate a three-dimensional plot of corneal thickness. The rabbit co...

journal_title：Investigative ophthalmology & visual science

authors： Chan T,Payor S,Holden BA

更新日期：1983-10-01 00:00:00

abstract：PURPOSE:To quantitate in vivo retinal ganglion cell (RGC) survival after transient periods of pressure-induced ischemia of the rat retina and after different survival intervals. METHODS:In adult rats, RGCs were labeled with fluorogold applied to their main targets in the brain. Seven days later, in several groups of r...

journal_title：Investigative ophthalmology & visual science

authors： Sellés-Navarro I,Villegas-Pérez MP,Salvador-Silva M,Ruiz-Gómez JM,Vidal-Sanz M

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy...

journal_title：Investigative ophthalmology & visual science

authors： van Essen TH,Bronkhorst IH,Maat W,Verduyn W,Roelen DL,Luyten GP,Jager MJ

更新日期：2012-05-04 00:00:00

abstract：PURPOSE:To make the first quantitative assessment of the rate of oxygen consumption in high oxygen-consuming layers of both the outer and inner retina of the rat in vivo. METHODS:Oxygen-sensitive microelectrodes were used to measure the oxygen tension as a function of depth through the retina in anesthetized rats. Ind...

journal_title：Investigative ophthalmology & visual science

authors： Cringle SJ,Yu DY,Yu PK,Su EN

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:We described the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). METHODS:Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteri...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Fung S,Karampelas M,Sadda SR,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2014-01-21 00:00:00

abstract：:The morphology of the apical surface of rabbit retinal pigment epithelium was studied by scanning electron microscopy from the first minute to several hours after making small nonrhegmatogenous retinal detachments (blebs). From 0 to 5 min, there were only slight changes in the homogeneous, dense mat of filamentous mic...

journal_title：Investigative ophthalmology & visual science

authors： Immel J,Negi A,Marmor MF

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the optimal conditions for prolonging corneal allograft survival by inducing anergy with the superantigen staphylococcal enterotoxin B (SEB). METHODS:A rat model of penetrating keratoplasty, whereby Fisher344 donor corneas are implanted into Lewis recipients, was used...

journal_title：Investigative ophthalmology & visual science

authors： Pan Z,Chen Y,Zhang W,Jie Y,Li N,Wu Y

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate tumor control efficacy of paclitaxel in the treatment of retinal tumors harbored by the LH beta-Tag murine transgenic model of retinoblastoma. METHODS:LH beta-Tag-positive mice (n = 5) 10 weeks of age received two 20-microL subconjunctival injections delivered with ...

journal_title：Investigative ophthalmology & visual science

authors： Suárez F,Jockovich ME,Hernandez E,Feuer W,Parel JM,Murray TG

更新日期：2007-08-01 00:00:00

abstract：Purpose:Age-related macular degeneration (AMD) is a progressive disease with multifactorial etiology. There is a need to identify clinical features that are harbingers of advanced disease. We evaluated morphologic features of the retina and choroid on optical coherence tomography (OCT) to determine if they predict prog...

journal_title：Investigative ophthalmology & visual science

authors： Ferrara D,Silver RE,Louzada RN,Novais EA,Collins GK,Seddon JM

更新日期：2017-07-01 00:00:00