Cone visual cell degeneration in ground squirrel retina: disruption of morphology and cyclic nucleotide metabolism by lodoacetic acid.

abstract：PURPOSE:To investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro. METHODS:A standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice t...

journal_title：Investigative ophthalmology & visual science

authors： Grimaldo S,Yuen D,Ecoiffier T,Chen L

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To understand the pathophysiology of human retinal degenerations caused by mutations in the peripherin/RDS gene. METHODS:Three families with autosomal dominant retinal degeneration were found to have mutations in the peripherin/RDS gene. There were two frameshift mutations: a 1-base pair (bp) insertion at codo...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Kemp CM,Sheffield VC,Stone EM

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:To assess the suitability of human donor corneas maintained in long-term organ culture for the isolation and expansion of viable and functional corneal stromal stem cells (CSSCs). These cells display properties similar to mesenchymal stem cells and demonstrate the ability to reproduce an organized matrix in vit...

journal_title：Investigative ophthalmology & visual science

authors： Kureshi AK,Funderburgh JL,Daniels JT

更新日期：2014-10-21 00:00:00

abstract：PURPOSE:This study was undertaken to improve understanding of the defective lens developmental changes induced by the transgenic overexpression of the Rho GDP dissociation inhibitor RhoGDIalpha. The study was focused on a single differentially expressed gene encoding ponsin, a cell adhesion interacting signaling adapto...

journal_title：Investigative ophthalmology & visual science

authors： Rao PV,Maddala R

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Regulatory CD4+ T cells (T regs) arise in the spleens of mice with anterior chamber-associated immune deviation (ACAID), an eye-derived tolerance evoked by injection of antigen into the ocular anterior chamber (AC). The current study was conducted to investigate the possibility that these T regs express CD25 an...

journal_title：Investigative ophthalmology & visual science

authors： Keino H,Takeuchi M,Kezuka T,Hattori T,Usui M,Taguchi O,Streilein JW,Stein-Streilein J

更新日期：2006-03-01 00:00:00

abstract：:Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 +/- 0.8 to 7.1 +/- 1.4 mm Hg (P less than 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the ...

journal_title：Investigative ophthalmology & visual science

authors： Toris CB,Pederson JE

更新日期：1985-12-01 00:00:00

abstract：PURPOSE:To determine the mechanism that leads to the UVA light-dependent loss of glutathione reductase (GR) activity in human lens (HL). METHODS:Both the HL water-soluble (WS) fraction and yeast GR were irradiated with UVA light (200 mW/(cm(2). h) for 1 hour at +20 degrees C, and the specific activity (SA) was observe...

journal_title：Investigative ophthalmology & visual science

authors： Linetsky M,Hill JM,Chemoganskiy VG,Hu F,Ortwerth BJ

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:To compare current imaging methods with respect to their ability to detect the condition of the fovea in patients with geographic atrophy (GA). METHODS:The retinas of 176 eyes with GA were imaged using two spectral-domain optical coherence tomography (SD-OCT) systems, Cirrus HD-OCT and Spectralis HRA+OCT, and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayegh RG,Zotter S,Roberts PK,Kandula MM,Sacu S,Kreil DP,Baumann B,Pircher M,Hitzenberger CK,Schmidt-Erfurth U

更新日期：2015-08-01 00:00:00

abstract：:Dopamine, cis-flupenthixol, and dibutyryl cAMP affected the standing potential and light-evoked responses of the perfused cat eye in vitro. At micromolar concentrations, dopamine, a retinal neurotransmitter, increased the standing potential of the eye. At slightly higher concentrations, dopamine abolished the "light p...

journal_title：Investigative ophthalmology & visual science

authors： Dawis SM,Niemeyer G

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthal...

journal_title：Investigative ophthalmology & visual science

authors： Jekle A,Abdul Rani S,Celeri C,Zuck M,Xu P,Wang L,Najafi-Tagol K,Anderson M,Stroman D,Debabov D

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:The objective of this study was to investigate whether leakage of aquaporin 5 (AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models. METHODS:Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)...

journal_title：Investigative ophthalmology & visual science

authors： Hirai S,Ishida N,Watanabe K,Mita S

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To define the retinal phenotype in patients with the Bardet-Biedl syndrome and mutations in the BBS1 gene. METHODS:Ten patients (age range, 16-48 years), representing eight pedigrees, with BBS1 gene mutations were studied clinically and with kinetic perimetry, chromatic static perimetry, electroretinography (E...

journal_title：Investigative ophthalmology & visual science

authors： Azari AA,Aleman TS,Cideciyan AV,Schwartz SB,Windsor EA,Sumaroka A,Cheung AY,Steinberg JD,Roman AJ,Stone EM,Sheffield VC,Jacobson SG

更新日期：2006-11-01 00:00:00

abstract：Purpose:To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels. Methods:A total of 522 eyes of 327 patients with POAG (mean age ± SD, 54.1 ± 12.4 years) and 375 eyes of 204 patients with PACG (67.3 ± 8.9 ye...

journal_title：Investigative ophthalmology & visual science

authors： Yousefi S,Sakai H,Murata H,Fujino Y,Garway-Heath D,Weinreb R,Asaoka R

更新日期：2018-03-01 00:00:00

abstract：Purpose:The purpose of this study was to clarify the interactions between macrophages (MPs) and RPE cells in coculture systems to investigate the functional plasticity of RPE cells. Methods:Adherent peritoneal cells or murine MP cell line Raw 264.7 was cocultured with primary RPE cells taken from C57BL/6 mice, with or...

journal_title：Investigative ophthalmology & visual science

authors： Yamawaki T,Ito E,Mukai A,Ueno M,Yamada J,Sotozono C,Kinoshita S,Hamuro J

更新日期：2016-11-01 00:00:00

abstract：:Retinal leukocyte velocity and density were estimated using blue-field entoptic imaging techniques in a controlled double-masked study to determine the relative effects of oxygen and carbon dioxide on perimacular hemodynamics in single eyes of ten normal human subjects. Mild hypoxia (inspiration of 16% O2) did not sig...

journal_title：Investigative ophthalmology & visual science

authors： Sponsel WE,DePaul KL,Zetlan SR

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the changes in tumor burden and hypoxia in the LH(BETA)T(AG) retinal tumors after treatment with a focal, single-modality, and combination therapy using periocular carboplatin and 2-deoxy-d-glucose (2-DG). METHODS:Seventeen-week-old LH(BETA)T(AG) transgenic mice (n = 25) w...

journal_title：Investigative ophthalmology & visual science

authors： Piña Y,Houston SK,Murray TG,Boutrid H,Celdran M,Feuer W,Shi W,Hernandez E,Lampidis TJ

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Previous studies have shown that binocular coordination during saccadic eye movement is affected in humans with large strabismus. The purpose of this study was to examine the conjugacy of saccadic eye movements in monkeys with sensory strabismus. METHODS:The authors recorded binocular eye movements in four str...

journal_title：Investigative ophthalmology & visual science

authors： Fu L,Tusa RJ,Mustari MJ,Das VE

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To evaluate the change in ocular function by eye in patients with unilateral pigmentary retinopathy. METHODS:Longitudinal regression was used to estimate mean exponential rates of change in Goldmann visual field area (V4e white test light) and in full-field electroretinogram (ERG) amplitudes to 0.5- and 30-Hz ...

journal_title：Investigative ophthalmology & visual science

authors： Potsidis E,Berson EL,Sandberg MA

更新日期：2011-11-29 00:00:00

abstract：PURPOSE:To investigate the alterations in gene expression when human retinal pigment epithelial (RPE) cells in culture are treated with vitreous as a model for the changes that occur in proliferative vitreoretinopathy. METHODS:Human RPE cells were cultured with or without human vitreous or collagen. RNA was extracted ...

journal_title：Investigative ophthalmology & visual science

authors： Parapuram SK,Ganti R,Hunt RC,Hunt DM

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：Purpose:To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods:A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human ...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Liao A,Robinson HS,Palejwala NV,Sprehe N

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Activation of complement has been implicated as one of the major causes of age-related macular degeneration (AMD). Evidence is accumulating for a role of complement in other retinal diseases, such as diabetic retinopathy and proliferative vitreoretinopathy. Because of the paucity of animal models that directly ...

journal_title：Investigative ophthalmology & visual science

authors： Cashman SM,Desai A,Ramo K,Kumar-Singh R

更新日期：2011-05-18 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：:Although intravitreal injection of antibiotics is being used more widely in treatment of bacterial endophthalmitis, the pharmacokinetic principles that underlie such therapy have been derived exclusively from experiments in the rabbit. Therefore, we studied several representative antibiotics in normal eyes of rhesus m...

journal_title：Investigative ophthalmology & visual science

authors： Barza M,Kane A,Baum J

更新日期：1983-12-01 00:00:00

abstract：PURPOSE:Conjunctiva-associated lymphoid tissue (CALT) is assumed to be a key location for the generation of adaptive immune mechanisms of the ocular surface, but functional studies of CALT are still lacking. The purpose of this study was to establish an animal model that enables functional analysis of immune mechanisms...

journal_title：Investigative ophthalmology & visual science

authors： Steven P,Rupp J,Hüttmann G,Koop N,Lensing C,Laqua H,Gebert A

更新日期：2008-04-01 00:00:00

abstract：Purpose:Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods:This ca...

journal_title：Investigative ophthalmology & visual science

authors： Ono M,Takano Y,Haida M

更新日期：2018-09-04 00:00:00

abstract：Purpose:Basement membrane degradation and macrophage aggregation at the optic fissure margins are crucial to optic fissure closure during normal murine eye development. Basement membrane degradation is also an essential step in cancer development, and matrix metalloproteinases (MMPs) play an important role. In this stu...

journal_title：Investigative ophthalmology & visual science

authors： Tsuji N,Matsuura T,Narama I,Yoshiki A,Ozaki K

更新日期：2018-03-01 00:00:00

abstract：Purpose:Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined in a large historical cohort of Japanese patients with diabetes mellitus. Methods:We evaluated the effects of ov...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto M,Fujihara K,Ishizawa M,Osawa T,Kaneko M,Ishiguro H,Matsubayashi Y,Seida H,Yamanaka N,Tanaka S,Kodama S,Hasebe H,Sone H

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:Placental growth factor (PlGF) has been implicated as a contributor to resistance against anti-VEGF therapy. The purpose of the present study was to analyze the systemic levels of PlGF, VEGF-A, and VEGF-B in patients with neovascular age-related macular degeneration (AMD) after treatment with aflibercept, ranib...

journal_title：Investigative ophthalmology & visual science

authors： Zehetner C,Bechrakis NE,Stattin M,Kirchmair R,Ulmer H,Kralinger MT,Kieselbach GF

更新日期：2015-05-01 00:00:00