Dopamine influences the light peak in the perfused mammalian eye.

abstract：PURPOSE:Gangliosides are normal components of cell membranes, contribute to structural rigidity and membrane function, and have been shown to protect against various insults to the brain. This study evaluates the effect of exogenously administered monosialoganglioside GM1 on retinal damage induced by transient retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Weber M,Mohand-Said S,Hicks D,Dreyfus H,Sahel JA

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:To study in an infant rat model of retinopathy of prematurity, the rod photoreceptors, which are known to have attenuated photoresponses. METHODS:Rhodopsin was extracted from whole retinas, the thickness of the rod outer segment (ROS) layer was measured, large phagosomes were counted, and the ROS ultrastructur...

journal_title：Investigative ophthalmology & visual science

authors： Fulton AB,Reynaud X,Hansen RM,Lemere CA,Parker C,Williams TP

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Sildenafil (Viagra), a cGMP-specific phosphodiesterase type 5 inhibitor, is widely used for the treatment of erectile dysfunction and pulmonary hypertension. Clinical studies have reported transient visual impairments in patients after single-dose sildenafil use, suggesting neural involvement in several retinal...

journal_title：Investigative ophthalmology & visual science

authors： Martins J,Kolomiets B,Caplette R,Sahel JA,Castelo-Branco M,Ambrósio AF,Picaud S

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:There is no consensus as how to calculate orbital soft tissue volume based on CT or MRI scans. The authors sought to validate their technique and to assess the intraobserver and interobserver variability of their calculations of bony orbital volume (OV), orbital fat volume (FV), and extraocular muscle volume (M...

journal_title：Investigative ophthalmology & visual science

authors： Regensburg NI,Kok PH,Zonneveld FW,Baldeschi L,Saeed P,Wiersinga WM,Mourits MP

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:The pathway linking late-life malnutrition to greater risk of cardiovascular disease is unclear. Microcirulatory changes assessed by retinal vascular caliber have been linked with increased risk of stroke and coronary heart disease. The purpose of this study was to examine whether retinal vascular calibers are ...

journal_title：Investigative ophthalmology & visual science

authors： Daien V,Carriere I,Kawasaki R,Cristol JP,Villain M,Fesler P,Ritchie K,Delcourt C,POLA Study Group.

更新日期：2014-05-27 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy caused by the chronic and progressive death of retinal ganglion cells (RGCs), resulting in irreversible blindness. Ocular hypertension is a major risk factor, but RGC death often continues after ocular hypertension is normalized, and can take place with normal tension. Continuous...

journal_title：Investigative ophthalmology & visual science

authors： Bai Y,Sivori D,Woo SB,Neet KE,Lerner SF,Saragovi HU

更新日期：2011-07-15 00:00:00

abstract：:The metabolic disorder in diabetics often results in progressive retinopathy with severe visual impairment. Changes in metabolism can influence corneal autofluorescence. This has led to speculation that diabetic retinopathy might be associated with changes in corneal autofluorescence. Corneal autofluorescence of both ...

journal_title：Investigative ophthalmology & visual science

authors： Stolwijk TR,van Best JA,Oosterhuis JA,Swart W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To characterize reticular pseudodrusen (RPD) by using a point-to-point comparison of the reticular pattern on infrared reflectance (IR), autofluorescence (AF), and red-free (RF) images registered with en face sections of the choroid from spectral domain optical coherence tomography (SD-OCT) scans. METHODS:A cr...

journal_title：Investigative ophthalmology & visual science

authors： Sohrab MA,Smith RT,Salehi-Had H,Sadda SR,Fawzi AA

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:Age-related nuclear cataracts involve denaturation and aggregation of intracellular proteins. We have documented age-dependent changes in membrane transport in the mouse lens to see what might initiate changes in the intracellular milieu. METHODS:Microelectrode-based intracellular impedance studies of intact l...

journal_title：Investigative ophthalmology & visual science

authors： Gao J,Wang H,Sun X,Varadaraj K,Li L,White TW,Mathias RT

更新日期：2013-11-01 00:00:00

abstract：Purpose:To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months. Methods:We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at ba...

journal_title：Investigative ophthalmology & visual science

authors： Ng WY,Ting DS,Agrawal R,Khandelwal N,Htoon HM,Lee SY,Wong TY,Cheung GC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 m...

journal_title：Investigative ophthalmology & visual science

authors： Wallace DJ,Shen D,Reed GF,Miyanaga M,Mochizuki M,Sen HN,Dahr SS,Buggage RR,Nussenblatt RB,Chan CC

更新日期：2006-07-01 00:00:00

abstract：Purpose:The purpose of this work was to test whether palisade endings express structural and molecular features of exocytotic machinery, and are associated with acetylcholine receptors, and enzymes for neurotransmitter breakdown. Methods:Extraocular rectus muscles from six cats were studied. Whole-mount preparations o...

journal_title：Investigative ophthalmology & visual science

authors： Blumer R,Streicher J,Carrero-Rojas G,Calvo PM,de la Cruz RR,Pastor AM

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:To provide a clinical and genetic description of a patient cohort with Stargardt disease (STGD1) with identifiable foveal sparing. METHODS:Patients with retinal atrophy (defined as an absence of autofluorescence) that surrounded the fovea by at least 180° and did not include the fovea were defined as having fo...

journal_title：Investigative ophthalmology & visual science

authors： van Huet RA,Bax NM,Westeneng-Van Haaften SC,Muhamad M,Zonneveld-Vrieling MN,Hoefsloot LH,Cremers FP,Boon CJ,Klevering BJ,Hoyng CB

更新日期：2014-10-16 00:00:00

abstract：PURPOSE:This study describes the effects of the cyclic adenosine monophosphate (cAMP) pathway on the tight junctional barrier of the corneal endothelium, which plays a critical role in maintaining the corneal stroma in an underhydrated, transparent state. METHODS:Subcultured bovine corneal endothelial cells grown on f...

journal_title：Investigative ophthalmology & visual science

authors： Le Varlet B,Ducroc R,Dagonet FB,Pouliquen Y,Vandewalle A,Hirsch M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS:There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion cri...

journal_title：Investigative ophthalmology & visual science

authors： Hiraoka T,Kakita T,Okamoto F,Takahashi H,Oshika T

更新日期：2012-06-22 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:We investigated the therapeutic effect of liposomal doxorubicin (Lipo-dox) on experimental proliferative vitreoretinopathy (PVR). METHODS:The toxicity of Lipo-dox was determined in vitro in cultured rabbit retinal pigment epithelium (RPE) cells by tetrazolium-based (MTT) assay for cell viability performed 48 a...

journal_title：Investigative ophthalmology & visual science

authors： Kuo HK,Chen YH,Wu PC,Wu YC,Huang F,Kuo CW,Lo LH,Shiea J

更新日期：2012-06-29 00:00:00

abstract：PURPOSE:To examine the prognostic relevance of expression of the chemokine receptors CCR7 and CXCR4 and its ligand CXCL12 in uveal melanoma in nonmetastatic and metastatic patients with correlation to liver metastasis and overall survival. METHODS:Primary uveal melanoma specimens from 19 patients with correlating live...

journal_title：Investigative ophthalmology & visual science

authors： van den Bosch T,Koopmans AE,Vaarwater J,van den Berg M,de Klein A,Verdijk RM

更新日期：2013-11-08 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:Injury to the adult optic nerve, caused mechanically or by diseases, is still not reparable because the retinal ganglion cells (RGCs) are not allowed to regrow their axons and die retrogradely, although they possess the intrinsic propensity to regenerate axons in experimental conditions. METHODS:In vitro propa...

journal_title：Investigative ophthalmology & visual science

authors： Charalambous P,Hurst LA,Thanos S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine the details of the mechanism of K-115's neuroprotective effect in vivo and in vitro. METHODS:ROCK inhibitors, including K-115 and fasud...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto K,Maruyama K,Himori N,Omodaka K,Yokoyama Y,Shiga Y,Morin R,Nakazawa T

更新日期：2014-10-02 00:00:00

abstract：PURPOSE:We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS:The resistance to unidirectional transverse shear ...

journal_title：Investigative ophthalmology & visual science

authors： Søndergaard AP,Ivarsen A,Hjortdal J

更新日期：2013-07-26 00:00:00

abstract：Purpose:To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD). Methods:In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained tw...

journal_title：Investigative ophthalmology & visual science

authors： Tan R,Guymer RH,Luu CD

更新日期：2018-08-01 00:00:00

abstract：:Vitreous and macrophage samples were tested for the ability to stimulate proliferation and cell migration in cultured rabbit retinal pigment epithelium (RPE). A macrophage invasion was elicited by the intravitreal injection of latex particles in rabbits and after 3 days the vitreal macrophages were collected. The macr...

journal_title：Investigative ophthalmology & visual science

authors： Burke JM,Twining SS

更新日期：1987-07-01 00:00:00

abstract：:Previous studies have shown that aqueous humor of calf and human eyes contains about 25 microM hydrogen peroxide. We have studied the removal of hydrogen peroxide by the outflow pathway of intact, freshly enucleated, calf eyes. Eyes were immersed under silicone oil that had a density greater than water and medium cont...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen KP,Chung ML,Anderson PJ,Johnson M,Epstein DL

更新日期：1988-06-01 00:00:00

abstract：PURPOSE:To map the gene for autosomal dominant cataracts (ADC) in an American white family of European descent. METHODS:Ophthalmic examinations and linkage analyses using a variety of polymorphisms were performed; two-point lod scores calculated. RESULTS:Affected individuals (14 studied) exhibited variable expressivi...

journal_title：Investigative ophthalmology & visual science

authors： Bateman JB,Johannes M,Flodman P,Geyer DD,Clancy KP,Heinzmann C,Kojis T,Berry R,Sparkes RS,Spence MA

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To determine the mechanism that leads to the UVA light-dependent loss of glutathione reductase (GR) activity in human lens (HL). METHODS:Both the HL water-soluble (WS) fraction and yeast GR were irradiated with UVA light (200 mW/(cm(2). h) for 1 hour at +20 degrees C, and the specific activity (SA) was observe...

journal_title：Investigative ophthalmology & visual science

authors： Linetsky M,Hill JM,Chemoganskiy VG,Hu F,Ortwerth BJ

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:To use a theoretical model of the observer on the Farnsworth-Munsell 100-hue test to estimate the magnitude of random variation in 100-Hue test error scores. METHODS:The model was based upon classical signal detection theory. Results from the model were obtained by computer simulation. RESULTS:There is a fair...

journal_title：Investigative ophthalmology & visual science

authors： Craven BJ

更新日期：1993-03-01 00:00:00

abstract：:Intravitreal membranes from patients with proliferative vitreoretinopathy (PVR) consist partly of retinal glial (RG) and retinal pigment epithelial (RPE) cells surrounded by varying amounts of extracellular matrix (ECM). The contribution of the ECM to the growth of PVR membranes is unknown. This study was undertaken t...

journal_title：Investigative ophthalmology & visual science

authors： Williams DF,Burke JM

更新日期：1990-09-01 00:00:00