Vitreous macrophage elicitation: generation of stimulants for pigment epithelium in vitro.

abstract：PURPOSE:Previous studies have shown that insulin-like growth factor-binding protein (IGFBP)-2 is markedly upregulated in senescent RPE cells in vitro, and might therefore be a marker of senescent cells in vivo. This study was conducted to determine whether IGFBP-2 expression in human RPE cells from the macula and perip...

journal_title：Investigative ophthalmology & visual science

authors： Miyamura N,Mishima K,Honda S,Aotaki-Keen AE,Morse LS,Handa JT,Hjelmeland LM

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:To study the distribution and predominant orientations of fibrillar collagen at different depths throughout the entire thickness of the human cornea. This information will form the basis of a full three-dimensional reconstruction of the preferred orientations of corneal lamellae. METHODS:Femtosecond laser tech...

journal_title：Investigative ophthalmology & visual science

authors： Abahussin M,Hayes S,Knox Cartwright NE,Kamma-Lorger CS,Khan Y,Marshall J,Meek KM

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To determine whether the Ganzfeld ERG photopic negative response (PhNR), an assay of inner retinal activity, is altered in childhood optic glioma (OPG). METHODS:Seventeen pediatric patients with a diagnosis of OPG, established on neuro-ophthalmologic and brain/orbit magnetic resonance imaging (MRI) criteria, w...

journal_title：Investigative ophthalmology & visual science

authors： Abed E,Piccardi M,Rizzo D,Chiaretti A,Ambrosio L,Petroni S,Parrilla R,Dickmann A,Riccardi R,Falsini B

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To determine the prevalence and incidence of epiretinal membranes (ERM) in eyes with inactive extramacular cytomegalovirus (CMV) retinitis in patients with acquired immune deficiency syndrome (AIDS). METHODS:A case-control report from a longitudinal multicenter observational study by the Studies of the Ocular ...

journal_title：Investigative ophthalmology & visual science

authors： Kozak I,Vaidya V,Van Natta ML,Pak JW,May KP,Thorne JE,Studies of the Ocular Complications of AIDS Research Group.

更新日期：2014-06-12 00:00:00

abstract：PURPOSE:Noise field campimetry, performed according to Aulhorn and Köst, confronts patients with a large field of irregularly flickering dots, and many patients immediately perceive their visual field defects. The original method had a somewhat low specificity and sensitivity, especially for patients with visual field ...

journal_title：Investigative ophthalmology & visual science

authors： Bachmann G,Fahle M

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To examine the effects of methylcobalamin on glutamate-induced neurotoxicity in the cultured retinal neurons. METHODS:Primary cultures obtained from the fetal rat retina (gestation days 16 to 19) were used for the experiment. The neurotoxicity was assessed quantitatively using the trypan blue exclusion method....

journal_title：Investigative ophthalmology & visual science

authors： Kikuchi M,Kashii S,Honda Y,Tamura Y,Kaneda K,Akaike A

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) has features of chronic low-grade inflammation. The purpose of our study was to investigate whether the presence of inflammatory cells in fibrovascular membranes (FVMs) from patients with proliferative diabetic retinopathy (PDR) is associated with the activity of PDR and visual acuity ...

journal_title：Investigative ophthalmology & visual science

authors： Urbančič M,Štunf Š,Milutinović Živin A,Petrovič D,GlobočnikPetrovič M

更新日期：2014-11-25 00:00:00

abstract：PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

journal_title：Investigative ophthalmology & visual science

authors： Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To determine the accommodative accuracy of infants and young children before they had had any form of clinical intervention or treatment, in an attempt to determine the difference between 'normal' and 'abnormal' visual experience for these individuals. METHODS:Nott retinoscopy was performed on 111 subjects in ...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Gray KH,Hohenbary CC,Lyon DW

更新日期：2012-01-17 00:00:00

abstract：PURPOSE:Bicarbonate transport plays a role in aqueous humor (AH) secretion. The authors examined bicarbonate transport mechanisms and carbonic anhydrase (CA) in porcine nonpigmented ciliary epithelium (NPE). METHODS:Cytoplasmic pH (pH(i)) was measured in cultured porcine NPE loaded with BCECF. Anion exchanger (AE), so...

journal_title：Investigative ophthalmology & visual science

authors： Shahidullah M,To CH,Pelis RM,Delamere NA

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV). METHODS:PDT was performed in monkey and Brown Norway rats with laser-induced CNV. L-NAME, a NOS inhibitor, or saline wa...

journal_title：Investigative ophthalmology & visual science

authors： She H,Nakazawa T,Matsubara A,Hisatomi T,Young TA,Michaud N,Connolly E,Hafezi-Moghadam A,Gragoudas ES,Miller JW

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To investigate the residual stereo function of a group of 15 patients with strabismic amblyopia, by using motion-in-depth stimuli that allow discrimination of contributions from local disparity as opposed to those from local velocity mechanisms as a function of the rate of depth change. METHODS:The stereo perf...

journal_title：Investigative ophthalmology & visual science

authors： Hess RF,Mansouri B,Thompson B,Gheorghiu E

更新日期：2009-10-01 00:00:00

abstract：:Critical flicker frequency (CFF) was measured for stimuli varying in chromaticity only and in luminance only for patients with multiple sclerosis (MS) and for matched normal controls. The two CFF measurements showed different underlying linear interdependencies for the two groups, consistent with a greater loss of tem...

journal_title：Investigative ophthalmology & visual science

authors： Mason RJ,Snelgar RS,Foster DH,Heron JR,Jones RE

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:Diabetes mellitus has been shown to be associated with and complicated by dry eye syndrome. We sought to examine and compare the tear film proteome of type 2 diabetic patients with or without dry eye syndrome and normal subjects using two-dimensional nano-liquid chromatography coupled with tandem mass spectrome...

journal_title：Investigative ophthalmology & visual science

authors： Li B,Sheng M,Xie L,Liu F,Yan G,Wang W,Lin A,Zhao F,Chen Y

更新日期：2014-01-09 00:00:00

abstract：PURPOSE:To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS:MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline....

journal_title：Investigative ophthalmology & visual science

authors： Sasamoto Y,Gomi F,Sawa M,Sakaguchi H,Tsujikawa M,Nishida K

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:To investigate in vitro the cell toxicity and antioxidant effects of two major tear substitutes, hyaluronic acid and a widely used carbomer, with and without preservative. METHODS:Chang conjunctival cells were treated with different concentrations of unpreserved or preserved carbomer 934P (0.03% and 0.3%), unp...

journal_title：Investigative ophthalmology & visual science

authors： Debbasch C,De La Salle SB,Brignole F,Rat P,Warnet JM,Baudouin C

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To characterize the cellular expression patterns of antiangiogenic factors differentially regulated in the fetal human macula. METHODS:RNA was extracted from macular, nasal, and surround biopsies of three human fetal retinas at midgestation. Relative levels of expression of pigment epithelium-derived factor (P...

journal_title：Investigative ophthalmology & visual science

authors： Kozulin P,Natoli R,Bumsted O'Brien KM,Madigan MC,Provis JM

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00

abstract：:The authors used a psychophysical method to measure lens transmission of young, type I diabetic patients and normal controls. The results from normal controls agreed with previously published reports of decreasing lens transmission with age, and those from diabetic subjects suggested that lenses of young, type I diabe...

journal_title：Investigative ophthalmology & visual science

authors： Lutze M,Bresnick GH

更新日期：1991-01-01 00:00:00

abstract：Purpose:To examine the associations between nighttime driving performance of older drivers and photopic, mesopic, and glare-based tests of visual function. Methods:Participants included 26 older drivers (71.8 ± 6.3 years), with minimal or no eye disease, but who reported vision-related nighttime driving difficulties. ...

journal_title：Investigative ophthalmology & visual science

authors： Kimlin JA,Black AA,Wood JM

更新日期：2017-05-01 00:00:00

abstract：:The anterior chamber of the eye is an immunosuppressive microenvironment as shown experimentally by immune privilege, anterior chamber-associated immune deviation, and inability to display local delayed-type hypersensitivity responses. It recently was reported that both the aqueous humor and the cells of the iris and ...

journal_title：Investigative ophthalmology & visual science

authors： Streilein JW,Bradley D

更新日期：1991-09-01 00:00:00

abstract：:We describe a new technique for the separation and isolation of nonpigmented ciliary body epithelial cells from rabbit. Excised ciliary body is incubated in a medium buffered with EGTA to a free-Ca2+ concentration of 10(-8) M, and the nonpigmented cell layer is separated from the pigmented layer by microdissection und...

journal_title：Investigative ophthalmology & visual science

authors： Fain GL,Cilluffo MC,Fain MJ,Lee DA

更新日期：1988-05-01 00:00:00

abstract：:PURPOSE. Simple sphingolipids control crucial cellular processes in several cell types. Previous work demonstrated that sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate, are key mediators in the regulation of survival, differentiation, and proliferation of retina photoreceptors. Ceramide-1-pho...

journal_title：Investigative ophthalmology & visual science

authors： Miranda GE,Abrahan CE,Agnolazza DL,Politi LE,Rotstein NP

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:Imaging studies suggest that the choroidal vasculature may be altered in central serous chorioretinopathy. Little is known, however, about the regulation of ocular blood flow in patients with central serous chorioretinopathy (CSC). The hypothesis for the present study was that choroidal blood flow changes durin...

journal_title：Investigative ophthalmology & visual science

authors： Tittl M,Maar N,Polska E,Weigert G,Stur M,Schmetterer L

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:To investigate the relationship between percentage of body fat and macular pigment (MP) optical density. METHODS:One hundred healthy subjects of ages between 22 and 60 years volunteered to participate in this study. MP optical density was measured psychophysically, serum lutein and zeaxanthin were quantified b...

journal_title：Investigative ophthalmology & visual science

authors： Nolan J,O'Donovan O,Kavanagh H,Stack J,Harrison M,Muldoon A,Mellerio J,Beatty S

更新日期：2004-11-01 00:00:00

abstract：:The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with 125[I]-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bi...

journal_title：Investigative ophthalmology & visual science

authors： Stern WH,Heath TD,Lewis GP,Guerin CJ,Erickson PA,Lopez NG,Hong KL

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To clarify the functions of a specific subtype of thyroid hormone receptor (TR), TRbeta2, and photoreceptor cell-specific nuclear receptor (PNR) in the development of cone photoreceptors. METHODS:The expression of short (S)- and medium (M)-wavelength cone opsins was analyzed by reverse transcription polymerase...

journal_title：Investigative ophthalmology & visual science

authors： Yanagi Y,Takezawa S,Kato S

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:The serum- and glucocorticoid-inducible kinase SGK1 regulates several epithelial channels and transporters, the related protein kinase B (PKB) regulates glucose transport. SGK1 is expressed in the brain and could thus regulate glial and/or neuronal transport processes. The present study explores whether SGK1 is...

journal_title：Investigative ophthalmology & visual science

authors： Schniepp R,Kohler K,Ladewig T,Guenther E,Henke G,Palmada M,Boehmer C,Rothstein JD,Bröer S,Lang F

更新日期：2004-05-01 00:00:00