The cellular expression of antiangiogenic factors in fetal primate macula.

abstract：PURPOSE:To assess the repeatability, intersession and interobserver reproducibility, and agreement of central corneal thickness (CCT) measurements obtained by scanning-slit topography (SST) and noncontact specular microscopy (NCSM) after advanced surface ablation (ASA). METHODS:To analyze repeatability, one examiner m...

journal_title：Investigative ophthalmology & visual science

authors： López-Miguel A,Martínez-Almeida L,Mateo ME,Coco-Martín MB,Alió JL,Maldonado MJ

更新日期：2013-02-05 00:00:00

abstract：:Fibroblasts in the retroocular connective tissue appear to play a central role in the pathogenesis of Graves' ophthalmopathy (GO). We hypothesize that specific attributes, differentiating normal from GO retroocular fibroblasts, may render the latter more vulnerable to the ongoing immunopathological process in GO. We i...

journal_title：Investigative ophthalmology & visual science

authors： Heufelder AE,Wenzel BE,Bahn RS

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:To identify factors associated prospectively with increased cataract surgical rate (CSR) in rural Chinese hospitals. METHODS:Annual cataract surgical output was obtained at baseline and 24 months later from operating room records at 42 rural, county-level hospitals. Total local CSR (cases/million population/y)...

journal_title：Investigative ophthalmology & visual science

authors： Chen T,Jin L,Zhou Z,Huang Y,Yan X,Liu T,Ong EL,Liu B,Huang W,Iezzi B,He M,Friedman DS,Congdon NG

更新日期：2015-02-03 00:00:00

abstract：PURPOSE:To assess the reactive changes of the corneal epithelial thickness (ET) profile induced by small incision lenticule extraction (SMILE) for treatment of myopia. METHODS:This prospective observational study included 46 eyes of 23 patients that were scheduled for myopic SMILE. High-resolution spectral-domain opti...

journal_title：Investigative ophthalmology & visual science

authors： Luft N,Ring MH,Dirisamer M,Mursch-Edlmayr AS,Kreutzer TC,Pretzl J,Bolz M,Priglinger SG

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:The authors investigated whether trigeminal sensitization occurs in response to bright light with the retina disconnected from the rest of the central nervous system by optic nerve section. METHODS:In urethane-anesthetized rats, trigeminal reflex blinks were evoked with air puff stimuli directed at the cornea ...

journal_title：Investigative ophthalmology & visual science

authors： Dolgonos S,Ayyala H,Evinger C

更新日期：2011-10-04 00:00:00

abstract：PURPOSE:The scarified cornea keratitis model was modified to study Pseudomonas aeruginosa infection of healing corneal epithelium. The new model was then used to study the role of ExsA, a transcriptional activator of P. aeruginosa, in bacterial penetration through injured and healing corneal epithelia. METHODS:Scratch...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Evans DJ,Fleiszig SM

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:To compare EyeCam (Clarity Medical Systems, Pleasanton, CA) imaging with gonioscopy for detecting angle closure. METHODS:In this prospective, hospital-based study, subjects underwent gonioscopy by a single observer and EyeCam imaging by a different operator. EyeCam images were graded by two masked observers. T...

journal_title：Investigative ophthalmology & visual science

authors： Perera SA,Baskaran M,Friedman DS,Tun TA,Htoon HM,Kumar RS,Aung T

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：:Cataracts in cultured rabbit lenses were produced by elevation of internal calcium. Experimental procedures were successful in increasing levels of total and bound Ca++, often without significant changes in sodium, potassium, or water content. Although the excess in calcium was predominantly associated with water-solu...

journal_title：Investigative ophthalmology & visual science

authors： Hightower KR,Reddy VN

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

journal_title：Investigative ophthalmology & visual science

authors： Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

更新日期：2015-09-01 00:00:00

abstract：:A single injection of an aqueous suspension of group A streptococcal peptidoglycan-polysaccharide complexes (PG-PS) when injected intraperitoneally into Lewis rats induced a self-limiting bilateral uveitis with associated perpetuating polyarthritis. The uveitis was characterized clinically during the first 72 h by iri...

journal_title：Investigative ophthalmology & visual science

authors： Wells A,Pararajasegaram G,Baldwin M,Yang CH,Hammer M,Fox A

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS:This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (C...

journal_title：Investigative ophthalmology & visual science

authors： Yang D,Fu J,Hou R,Liu K,Jonas JB,Wang H,Chen W,Li Z,Sang J,Zhang Z,Liu S,Cao Y,Xie X,Ren R,Lu Q,Weinreb RN,Wang N

更新日期：2014-04-15 00:00:00

abstract：Purpose:To investigate the underlying mechanisms for how the mouse Cx50-R205G point mutation, a homologue of the human Cx50-R198W mutation that is linked to cataract-microcornea syndrome, affects proper lens growth and fiber cell differentiation to lead to severe lens phenotypes. Methods:EdU labeling, immunostaining, ...

journal_title：Investigative ophthalmology & visual science

authors： Tjahjono N,Xia CH,Li R,Chu S,Wang J,Gong X

更新日期：2020-03-09 00:00:00

abstract：:Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively u...

journal_title：Investigative ophthalmology & visual science

authors： Peng H,Park JK,Lavker RM

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas. METHODS:This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); form...

journal_title：Investigative ophthalmology & visual science

authors： Saad A,Gatinel D

更新日期：2012-05-17 00:00:00

abstract：PURPOSE:To assess whether tonometric measurements of the drop in intraocular pressure (IOP) induced by 0.005% latanoprost are modified after photorefractive keratectomy (PRK). METHODS:Data from 24 randomly selected eyes of 24 patients (12 men and 12 women, mean age +/- SD: 31.7 +/- 6.2 years) who were undergoing bilat...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Vaiano AS,Salgarello T,Caputo CG,Scullica L

更新日期：2004-03-01 00:00:00

abstract：:Sixteen patients with osteogenesis imperfecta (OI) have undergone a thorough eye examination. These patients had statistically significantly lower ocular rigidity measurements than a group of normal volunteers matched on age, sex, and refractive error. In addition, the corneal diameter and length of the eyeball was sm...

journal_title：Investigative ophthalmology & visual science

authors： Kaiser-Kupfer MI,McCain L,Shapiro JR,Podgor MJ,Kupfer C,Rowe D

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery. METHODS:A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After ...

journal_title：Investigative ophthalmology & visual science

authors： Jee JP,Choung HK,Kim CK,Hwang JM

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To determine the order and components of the signaling pathway utilized by epidermal growth factor (EGF) to stimulate conjunctival goblet cell proliferation. METHODS:Goblet cells from rat bulbar and forniceal conjunctiva and human bulbar conjunctiva were grown in organ culture. Goblet cells (GCs) were serum st...

journal_title：Investigative ophthalmology & visual science

authors： Li D,Shatos MA,Hodges RR,Dartt DA

更新日期：2013-08-21 00:00:00

abstract：PURPOSE:To assess whether saccadic eye movements show distinct changes in patients with early active Graves' ophthalmopathy (GO), which could serve as a diagnostic tool for early detection and treatment. METHODS:Each of two prospective studies included 10 patients with early acute GO and 10 age- and sex-matched contro...

journal_title：Investigative ophthalmology & visual science

authors： Schworm HD,Heufelder AE,Kunze A,Welge E,Boergen KP

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal recessive retinitis pigmentosa in three consanguineous Pakistani families. METHODS:Blood samples were collected and DNA was extracted. A genome-wide scan was performed by using 382 polymorphic microsatellite markers on genomic DNA from affected ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Zulfiqar F,Zhang Q,Sergeev YV,Qazi ZA,Husnain T,Caruso R,Riazuddin S,Sieving PA,Hejtmancik JF

更新日期：2005-07-01 00:00:00

abstract：Purpose:Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (B...

journal_title：Investigative ophthalmology & visual science

authors： Jolly JK,Xue K,Edwards TL,Groppe M,MacLaren RE

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To develop a stable antimicrobial contact lens, which is effective against the International Organization for Standardization (ISO) panel microorganisms, Acanthamoeba castellanii and drug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. METHODS:Melimine was covalently incorporated into et...

journal_title：Investigative ophthalmology & visual science

authors： Dutta D,Cole N,Kumar N,Willcox MD

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:To determine whether polyamines are present in corneal cells, whether corneal cell polyamines can be depleted by blocking the first rate-limiting enzyme in the polyamine synthesis pathway, ornithine decarboxylase (ODC), and whether polyamines are required for proliferation in all three corneal cell types. METH...

journal_title：Investigative ophthalmology & visual science

authors： Du H,Viar MJ,Johnson LR,Watsky MA

更新日期：2003-06-01 00:00:00

abstract：:The retinae of a monkey, cat, rat and mouse were examined for FMRF-amide immunoreactivity, a marker for efferent fibers in the retinae of lower vertebrates. No FMRF-amide immunoreactive retinal fibers were found despite their presence in the rat CNS. Therefore, we conclude that efferent fibers, if present in mammalian...

journal_title：Investigative ophthalmology & visual science

authors： Rusoff AC,Hendrickson AE

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:To study retinal microstructure in Usher Syndrome type 1B (USH1B) caused by MYO7A mutations as a prelude to treatment initiatives. METHODS:Patients with MYO7A-USH1B (n=17; ages 5-61) were studied with optical coherence tomography. Retinal laminae across horizontal and vertical meridians were measured. Colocali...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Aleman TS,Sumaroka A,Cideciyan AV,Roman AJ,Windsor EA,Schwartz SB,Rehm HL,Kimberling WJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Glial cells are structurally and functionally linked to neuronal tissues. Pathologically, the cells may be activated and characterized by increased size and number and altered cellular properties. In glaucoma, pathologic mechanisms within the anterior optic nerve may include glial activation. This study examine...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Cioffi GA,Cull G,Dong J,Fortune B

更新日期：2002-04-01 00:00:00

abstract：:The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes wer...

journal_title：Investigative ophthalmology & visual science

authors： Wolffsohn JS,Kollbaum PS,Berntsen DA,Atchison DA,Benavente A,Bradley A,Buckhurst H,Collins M,Fujikado T,Hiraoka T,Hirota M,Jones D,Logan NS,Lundström L,Torii H,Read SA,Naidoo K

更新日期：2019-02-28 00:00:00

abstract：PURPOSE:To determine the earliest changes that occur in the retina after the onset of ectopic expression of vascular endothelial growth factor (VEGF) by photoreceptors in transgenic mice, to characterize the development of neovascularization (NV), and to determine the feasibility of using these mice to test the efficac...

journal_title：Investigative ophthalmology & visual science

authors： Tobe T,Okamoto N,Vinores MA,Derevjanik NL,Vinores SA,Zack DJ,Campochiaro PA

更新日期：1998-01-01 00:00:00