Macrophage-Associated Gelatinase Degrades Basement Membrane at the Optic Fissure Margins During Normal Ocular Development in Mice.

abstract：PURPOSE:To investigate the human disease due to CRB1 mutations and compare results with the Crb1-mutant rd8 mouse. METHODS:Twenty-two patients with CRB1 mutations were studied. Function was assessed with perimetry and electroretinography (ERG) and retinal structure with optical coherence tomography (OCT). Cortical str...

journal_title：Investigative ophthalmology & visual science

authors： Aleman TS,Cideciyan AV,Aguirre GK,Huang WC,Mullins CL,Roman AJ,Sumaroka A,Olivares MB,Tsai FF,Schwartz SB,Vandenberghe LH,Limberis MP,Stone EM,Bell P,Wilson JM,Jacobson SG

更新日期：2011-08-29 00:00:00

abstract：:Critical flicker frequency (CFF) was measured for stimuli varying in chromaticity only and in luminance only for patients with multiple sclerosis (MS) and for matched normal controls. The two CFF measurements showed different underlying linear interdependencies for the two groups, consistent with a greater loss of tem...

journal_title：Investigative ophthalmology & visual science

authors： Mason RJ,Snelgar RS,Foster DH,Heron JR,Jones RE

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:To characterize the spatial and temporal expression of key structural and phototransduction cascade proteins in the monkey cone outer segment (OS). METHODS:Retinas from Macaca monkeys from ages fetal day (Fd) 89 through adulthood were double labeled using immunofluorescence for short (S) or long/medium (L/M) w...

journal_title：Investigative ophthalmology & visual science

authors： Sears S,Erickson A,Hendrickson A

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Amphibian retinas regenerate after injury, making them ideal for studying the mechanisms of retinal regeneration, but this leaves their value as models of retinal degeneration in question. The authors asked whether the initial cellular changes after rod loss in the regenerative model Xenopus laevis mimic those ...

journal_title：Investigative ophthalmology & visual science

authors： Choi RY,Engbretson GA,Solessio EC,Jones GA,Coughlin A,Aleksic I,Zuber ME

更新日期：2011-01-21 00:00:00

abstract：:The adhesion complex of the corneal epithelium consists of the hemidesmosome and its associated structures, such as anchoring filaments, lamina densa of the basement membrane, and anchoring fibrils. It contributes to the adhesion of the corneal epithelium to Bowman's layer. To understand the adhesion complex better, a...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Kurpakus MA,Sambol B,Jones JC

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS:The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in ...

journal_title：Investigative ophthalmology & visual science

authors： Kojima T,Ishida R,Dogru M,Goto E,Takano Y,Matsumoto Y,Kaido M,Ohashi Y,Tsubota K

更新日期：2004-05-01 00:00:00

abstract：:In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Foley KM,Rismondo V

更新日期：1986-08-01 00:00:00

abstract：PURPOSE:Recent studies on ocular shape have raised increased interest in the peripheral characteristics of the eye, as it potentially triggers changes in the central vision. Current techniques are, however, not capable of accurately measuring the three-dimensional shape of the retina. We describe a new magnetic resonan...

journal_title：Investigative ophthalmology & visual science

authors： Beenakker JW,Shamonin DP,Webb AG,Luyten GP,Stoel BC

更新日期：2015-01-15 00:00:00

abstract：:After a careful dissection of trabecular tissue from recent postmortem specimens, human trabecular cells were established in tissue culture with 250 ng/ml fibroblast growth factor (FGF), Dulbecco's modified Eagle's medium (DME), and 10% human serum. These conditions have allowed propagation of human trabecular cells f...

journal_title：Investigative ophthalmology & visual science

authors： Polansky JR,Weinreb RN,Baxter JD,Alvarado J

更新日期：1979-10-01 00:00:00

abstract：PURPOSE:To determine the effects of blocking substance P (SP) interactions with its major receptor (NK1-R) using the antagonist spantide I in susceptible mice infected with Pseudomonas aeruginosa. METHODS:Immunohistochemistry and enzyme immunosorbent assay (EIA) tested levels of SP in the cornea of B6 and BALB/c mice....

journal_title：Investigative ophthalmology & visual science

authors： Hazlett LD,McClellan SA,Barrett RP,Liu J,Zhang Y,Lighvani S

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:To assess the range of macular pigment optical density (MPOD) in a healthy group of young adults of South Asian origin; to investigate whether any dietary factors or personal characteristics were related to intersubject variations in MPOD; and to compare the mean MPOD of the South Asian group with the mean MPOD...

journal_title：Investigative ophthalmology & visual science

authors： Howells O,Eperjesi F,Bartlett H

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:We investigated the phenotype of macrophages infiltrating rejected corneal allografts. METHODS:We performed allogeneic or syngeneic corneal transplantation in mice, and humanely killed animals at day 28 during allograft rejection when 60% of corneal allografts were rejected. We divided allografts into two grou...

journal_title：Investigative ophthalmology & visual science

authors： Oh JY,Lee HJ,Ko AY,Ko JH,Kim MK,Wee WR

更新日期：2013-11-21 00:00:00

abstract：:Long-term S-antigen (S-Ag) specific T lymphocyte lines can induce experimental autoimmune uveoretinitis (EAU) when transferred into naive rats systemically or intravitreally. The uveitogenic lymphocyte line (ThS) stains positively for the ART 18 (IL-2 receptor) and W3/25 (T helper/inducer); negatively for OX6 (RT1B) a...

journal_title：Investigative ophthalmology & visual science

authors： Chan CC,Caspi RR,Roberge FG,Nussenblatt RB

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:To compare the diagnostic value of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT) in patients with ocular hypertension, preperimetric, and perimetric glaucoma. METHODS:One hundred eighty-one eyes consisting of 40 healthy controls, 41 ocular hypertensive sub...

journal_title：Investigative ophthalmology & visual science

authors： Gmeiner JM,Schrems WA,Mardin CY,Laemmer R,Kruse FE,Schrems-Hoesl LM

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:In several retinal complications, such as age-dependent macular degeneration (AMD), oxidative stress is increased and cytokine level is elevated. These are shown to alter the activation and expression of matrix metalloproteinase (MMP) both in human primary and immortalized retinal pigment epithelial (RPE) cells...

journal_title：Investigative ophthalmology & visual science

authors： Juuti-Uusitalo K,Nieminen M,Treumer F,Ampuja M,Kallioniemi A,Klettner A,Skottman H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Since central corneal thickness may inversely influence the amount and rate of progression of glaucomatous optic nerve damage and because lamina cribrosa thickness may be of importance in susceptibility to glaucoma, it was the purpose of the present study to evaluate whether central corneal thickness is related...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Holbach L

更新日期：2005-04-01 00:00:00

abstract：Purpose:During development, the corneal epithelium (CE) and the conjunctiva are derived from the surface ectoderm. Here we have examined how, during development, the cells of these two issues become isolated from each other. Methods:Epithelia from the anterior eyes of chicken embryos were labeled with the fluorescent,...

journal_title：Investigative ophthalmology & visual science

authors： Kubilus JK,Zapater I Morales C,Linsenmayer TF

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:China has among the lowest cataract surgical rates in Asia. This study was conducted to identify barriers to cataract surgery in rural China. METHODS:All subjects having undergone cataract surgery and persons with presenting visual acuity or=1 eye due to nons...

journal_title：Investigative ophthalmology & visual science

authors： Yin Q,Hu A,Liang Y,Zhang J,He M,Lam DS,Ge J,Wang N,Friedman DS,Zhao J,Congdon N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To develop a stable antimicrobial contact lens, which is effective against the International Organization for Standardization (ISO) panel microorganisms, Acanthamoeba castellanii and drug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. METHODS:Melimine was covalently incorporated into et...

journal_title：Investigative ophthalmology & visual science

authors： Dutta D,Cole N,Kumar N,Willcox MD

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS:An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Kaur K,Rao KN,Mandal AK,Kaur I,Parikh RS,Thomas R

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：:Flicker sensitivity was measured in groups of younger and older adult observers to assess its mean values and the test-retest variability both between sessions and in a single session. Test-retest sensitivities differed by less than 15% but tended to decrease slightly in a session and increase slightly between session...

journal_title：Investigative ophthalmology & visual science

authors： Tyler CW

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:To evaluate the kinetics, receptor specificity, molecular basis, and site selectivity of the endocrine and neural regulation of secretory component (SC) synthesis by rat lacrimal gland acinar cells. METHODS:Acinar cells from the rat lacrimal and submandibular glands, as well as epithelial cells (IEC-6) from th...

journal_title：Investigative ophthalmology & visual science

authors： Lambert RW,Kelleher RS,Wickham LA,Vaerman JP,Sullivan DA

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To identify proteins secreted by the retinal pigment epithelium (RPE) and to analyze their cellular distribution in normal and pathologic rat retinas at various stages of eye development. METHODS:A cDNA library was constructed with RNA isolated from porcine RPE sheets and screened by using the yeast signal seq...

journal_title：Investigative ophthalmology & visual science

authors： Van Den Berghe L,Sainton K,Gogat K,Marchant D,Dufour E,Bonnel S,Gadin S,Menasche M,Abitbol M

更新日期：2004-05-01 00:00:00

abstract：:The vestibulo-ocular reflex of normal monkeys was tested by a modified Bárány spinning test (B-test) and by sinosoidal rotation. The two tests gave concordant estimates of the time constant and corner frequency. Deviation from concordance was caused largely by modification of the reflex during the testing procedures. ...

journal_title：Investigative ophthalmology & visual science

authors： Blair S,Gavin M

更新日期：1979-10-01 00:00:00

abstract：Purpose:To investigate the optimal procedures for multichannel visually evoked potentials (VEPs) to detect misrouting in albinism subjects. Methods:Investigations were done in a phenotypically heterogeneous group of 180 albinism subjects and 187 controls with and without ocular pathology. We retrospectively compared s...

journal_title：Investigative ophthalmology & visual science

authors： Kruijt CC,de Wit GC,Talsma HE,Schalij-Delfos NE,van Genderen MM

更新日期：2019-09-03 00:00:00