A new noninvasive tear stability analysis system for the assessment of dry eyes.

abstract：PURPOSE:There is uncertainty in the published literature as to whether physical activity should be advocated for age-related macular degeneration (AMD) prevention. We aimed to assess prospectively the association between physical activity and the 15-year incidence of AMD in older adults. METHODS:We assessed AMD from r...

journal_title：Investigative ophthalmology & visual science

authors： Gopinath B,Liew G,Burlutsky G,Mitchell P

更新日期：2014-11-11 00:00:00

abstract：PURPOSE:To investigate the effect of tear hyperosmolarity and signs of clinical ocular surface pathology on conjunctival goblet cell population. METHODS:111 participants were assessed using tear osmolarity (TO) measurements and a comprehensive selection of clinical ophthalmic tests. The resultant clinical database was...

journal_title：Investigative ophthalmology & visual science

authors： Moore JE,Vasey GT,Dartt DA,McGilligan VE,Atkinson SD,Grills C,Lamey PJ,Leccisotti A,Frazer DG,Moore TC

更新日期：2011-08-03 00:00:00

abstract：PURPOSE:The objective of the study was to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on the multifocal electroretinogram (mfERG) following an induced branch retinal vein occlusion (BRVO) in pigs. METHODS:Electrophysiological examination of the retina was performed in 20 pigs with stan...

journal_title：Investigative ophthalmology & visual science

authors： Ejstrup R,Cour Ml,Kyhn MV,Heegaard S,Kiilgaard JF

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To examine the expression and localization of the neuroplastins (np), two synapse-enriched members of the immunoglobulin (Ig) superfamily of cell-adhesion molecules, in the developing and adult retina and optic nerve. METHODS:Expressions of the two isoforms np55 and np65 and carboxyl-terminal splice variants w...

journal_title：Investigative ophthalmology & visual science

authors： Kreutz MR,Langnaese K,Dieterich DC,Seidenbecher CI,Zuschratter W,Beesley PW,Gundelfinger ED

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to deepen our knowledge on the basis of intrafamilial genetic heterogeneity of inherited retinal dystrophies (RD) to further discern the contribution of individual alleles to the pathology. METHODS:Families with intrafamilial locus and/or allelic heterogeneity were selected from a coh...

journal_title：Investigative ophthalmology & visual science

authors： Sánchez-Alcudia R,Cortón M,Ávila-Fernández A,Zurita O,Tatu SD,Pérez-Carro R,Fernandez-San Jose P,Lopez-Martinez MÁ,del Castillo FJ,Millan JM,Blanco-Kelly F,García-Sandoval B,Lopez-Molina MI,Riveiro-Alvarez R,Ayuso C

更新日期：2014-10-23 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：:The pattern reversal visual evoked response (VER) was recorded under conditions of artificially unbalanced visual input between two eyes, an aniseikonia induced by size lenses that alter the perceived retinal image size without changing refraction. At 3.0% aniseikonia binocular summation started to decrease, and at 5....

journal_title：Investigative ophthalmology & visual science

authors： Katsumi O,Tanino T,Hirose T

更新日期：1986-04-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the acute effects of caffeine on retinal hemodynamics during dark to light adaptation using optical coherence tomography angiography (OCTA). Methods:Thirteen healthy individuals (13 eyes) underwent OCTA imaging after dark adaptation and at repeated intervals during ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang YS,Lee HE,Kwan CC,Schwartz GW,Fawzi AA

更新日期：2020-04-09 00:00:00

abstract：PURPOSE:To model the photochemical kinetics of corneal cross-linking with riboflavin (Rf) and confirm the model through measured oxygen concentration experiments under varying energy input conditions by UV-A irradiance and temperature modulation in ex vivo porcine cornea. METHODS:A theoretical model was developed to d...

journal_title：Investigative ophthalmology & visual science

authors： Kamaev P,Friedman MD,Sherr E,Muller D

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:The purposes of the present study were to assess the effect of a sympathetic inhibitory pharmacologic agent, timolol maleate, on the magnitude of nearwork-induced transient myopia (NITM) and its decay in different refractive groups for an extended near task duration and to determine the proportion of the young ...

journal_title：Investigative ophthalmology & visual science

authors： Vasudevan B,Ciuffreda KJ,Gilmartin B

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Point and null mutations in interphotoreceptor retinoid-binding protein (IRBP) cause retinal dystrophy in affected patients and IRBP-deficient mice with unknown mechanism. This study investigated whether IRBP protects cells from damages induced by all-trans-retinal (atRAL), which was increased in the Irbp(-/-) ...

journal_title：Investigative ophthalmology & visual science

authors： Lee M,Li S,Sato K,Jin M

更新日期：2016-04-01 00:00:00

abstract：:The glycosaminoglycans (GAGs) extractable from the trabecular meshworks (TM) of human and non-human primate eye have been analyzed by sequential enzymatic degradation and cellulose acetate electrophoresis. For comparison, similar extracts of the cornea, sclera, iris, and ciliary body have also been analyzed. The distr...

journal_title：Investigative ophthalmology & visual science

authors： Acott TS,Westcott M,Passo MS,Van Buskirk EM

更新日期：1985-10-01 00:00:00

abstract：PURPOSE:It is known that the pattern electroretinogram (PERG) of normal subjects is reduced temporarily after short-term elevation of intraocular pressure (IOP). The authors evaluated PERG changes in ocular hypertension during and after transient IOP elevation. METHODS:Steady state (8 Hz) PERGs to sinusoidal gratings ...

journal_title：Investigative ophthalmology & visual science

authors： Colotto A,Falsini B,Salgarello T,Buzzonetti L,Cermola S,Porrello G

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS:The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats a...

journal_title：Investigative ophthalmology & visual science

authors： LeDoux MS,Zhou Q,Murphy RB,Greene ML,Ryan P

更新日期：2001-10-01 00:00:00

abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Kimsey RA

更新日期：1981-04-01 00:00:00

abstract：PURPOSE:To evaluate the effect of disease severity and optic disc size on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular parameters with RTVue (Optovue, Fremont, CA) spectral domain optical coherence tomography (SDOCT) in glaucoma. METHODS:110 eyes of 62 normal subje...

journal_title：Investigative ophthalmology & visual science

authors： Rao HL,Leite MT,Weinreb RN,Zangwill LM,Alencar LM,Sample PA,Medeiros FA

更新日期：2011-03-10 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy caused by the chronic and progressive death of retinal ganglion cells (RGCs), resulting in irreversible blindness. Ocular hypertension is a major risk factor, but RGC death often continues after ocular hypertension is normalized, and can take place with normal tension. Continuous...

journal_title：Investigative ophthalmology & visual science

authors： Bai Y,Sivori D,Woo SB,Neet KE,Lerner SF,Saragovi HU

更新日期：2011-07-15 00:00:00

abstract：PURPOSE:To describe and evaluate a new experimental reference plane for measuring rim area in scanning laser tomography. METHODS:The experimental reference plane was positioned so that (1) it always lay entirely below the margin of the optic nerve head (ONH), (2) it remained at a set z-axis distance below the ONH in i...

journal_title：Investigative ophthalmology & visual science

authors： Tan JC,Hitchings RA

更新日期：2003-03-01 00:00:00

abstract：Purpose:The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus. Methods:We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (T...

journal_title：Investigative ophthalmology & visual science

authors： Turnbull PR,Irani N,Lim N,Phillips JR

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To determine the role of the small guanosine triphosphate (GTP)-binding protein Rho in the migration of corneal epithelial cells. METHODS:The presence of the Rho target proteins Rho-associated coiled coil-containing protein kinase (ROCK)-1 and ROCK-2 in rabbit cornea was examined by immunohistochemical analysi...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura M,Nagano T,Chikama T,Nishida T

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Loss-of-function mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa. Other mutant alleles o...

journal_title：Investigative ophthalmology & visual science

authors： Radu RA,Yuan Q,Hu J,Peng JH,Lloyd M,Nusinowitz S,Bok D,Travis GH

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To determine a time window in the rhodopsin knockout (Rho(-/-)) mouse during which retinal function is already sufficiently developed but cone degeneration is not yet substantial, thus representing an all-cone retina. METHODS:Electroretinograms (ERGs) were obtained from 14 homozygous Rho(-/-) mice and eight C5...

journal_title：Investigative ophthalmology & visual science

authors： Jaissle GB,May CA,Reinhard J,Kohler K,Fauser S,Lütjen-Drecoll E,Zrenner E,Seeliger MW

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:To describe hereditary macular degeneration observed in the cynomolgus monkey (Macaca fascicularis), which shares phenotypic features with age-related macular degeneration in humans, and to test the involvement of candidate gene loci by mutation screening and linkage analysis. METHODS:Ophthalmic examinations w...

journal_title：Investigative ophthalmology & visual science

authors： Umeda S,Ayyagari R,Allikmets R,Suzuki MT,Karoukis AJ,Ambasudhan R,Zernant J,Okamoto H,Ono F,Terao K,Mizota A,Yoshikawa Y,Tanaka Y,Iwata T

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Although the murine alphaA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao H,Yang Y,Rizo CM,Overbeek PA,Robinson ML

更新日期：2004-06-01 00:00:00

abstract：Purpose:To assess the presence of binocular gain in macular telangiectasia type 2 (MacTel) and its correlation to paracentral scotomas. Methods:Sixty-eight patients with MacTel were consecutively recruited for a cross-sectional analysis. Best-corrected visual acuity (BCVA), reading acuity, and reading speed were teste...

journal_title：Investigative ophthalmology & visual science

authors： Tzaridis S,Herrmann P,Charbel Issa P,Degli Esposti S,Wagner SK,Fruttiger M,Egan C,Rubin G,Holz FG,Heeren TFC

更新日期：2019-09-03 00:00:00

abstract：Purpose:This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods:A total of 64 eyes (45 ED, 19 ...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Yang H,Reynaud J,Burgoyne CF,Smith B,Wang L,Downs JC

更新日期：2017-07-01 00:00:00

abstract：Purpose:To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether risk factor effect sizes vary depending on children's position in the refractive error distribution. Methods:Refractive error was assessed in participants from two birth cohort...

journal_title：Investigative ophthalmology & visual science

authors： Pozarickij A,Enthoven CA,Ghorbani Mojarrad N,Plotnikov D,Tedja MS,Haarman AEG,Tideman JWL,Polling JR,Northstone K,Williams C,Klaver CCW,Guggenheim JA

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:To visualize changes in deep optic nerve head (ONH) structures following glaucoma surgery using (3-dimensional [3D]) swept-source optical coherence tomography (SS-OCT) and to determine the clinical and structural factors associated with postoperative lamina cribrosa (LC) and prelaminar neural tissue (PLT) chang...

journal_title：Investigative ophthalmology & visual science

authors： Yoshikawa M,Akagi T,Hangai M,Ohashi-Ikeda H,Takayama K,Morooka S,Kimura Y,Nakano N,Yoshimura N

更新日期：2014-01-23 00:00:00

abstract：PURPOSE:To examine the possibility that ocular surface epithelial cells might be grown in culture for use as grafts. METHODS:The proliferative capacity of epithelial cells cultured from the conjunctiva, limbus, and central cornea of normal human eyes was compared. Single cells disaggregated from approximately 1 mm2 bi...

journal_title：Investigative ophthalmology & visual science

authors： Lindberg K,Brown ME,Chaves HV,Kenyon KR,Rheinwald JG

更新日期：1993-08-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the disease-causing mutations for retinitis pigmentosa (RP) patients and function of mutations. Methods:We recruited RP families and sporadic RP patients, and performed whole-exome sequencing (WES) to screen for sequence variations. Subsequently, we investigated the...

journal_title：Investigative ophthalmology & visual science

authors： Xiao X,Cao Y,Zhang Z,Xu Y,Zheng Y,Chen LJ,Pang CP,Chen H

更新日期：2017-12-01 00:00:00