Origins of Pupillary Hippus in the Autonomic Nervous System.

abstract：PURPOSE:Mice rendered hypoglycemic by a null mutation in the glucagon receptor gene Gcgr display late-onset retinal degeneration and loss of retinal sensitivity. Acute hyperglycemia induced by dextrose ingestion does not restore their retinal function, which is consistent with irreversible loss of vision. The goal of t...

journal_title：Investigative ophthalmology & visual science

authors： Umino Y,Cuenca N,Everhart D,Fernandez-Sanchez L,Barlow RB,Solessio E

更新日期：2012-02-21 00:00:00

abstract：Purpose:Global analyses using mean deviation (MD) assess visual field progression, but can miss localized changes. Pointwise analyses are more sensitive to localized progression, but more variable so require confirmation. This study assessed whether cluster trend analysis, averaging information across subsets of locati...

journal_title：Investigative ophthalmology & visual science

authors： Gardiner SK,Mansberger SL,Demirel S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To assess presbyopic spectacle coverage, willingness to pay, and the impact of correcting uncorrected presbyopia in individuals 40 years of age and older in Zanzibar and whether assessment of presbyopia can be incorporated into Rapid Assessment of Blindness (RAAB) surveys. METHODS:A cross-sectional, population...

journal_title：Investigative ophthalmology & visual science

authors： Laviers HR,Omar F,Jecha H,Kassim G,Gilbert C

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To determine the effect of intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) on optic disc movement and lamina cribrosa displacement using confocal scanning laser tomography (CSLT). METHODS:The anterior chamber and lateral ventricles were cannulated in mixed-breed dogs (n = 8) to allow modulat...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Chauhan BC,Yu DY,Cringle SJ,Alder VA,House PH

更新日期：2002-10-01 00:00:00

abstract：:Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outsi...

journal_title：Investigative ophthalmology & visual science

authors： Panda S,Jonas JB

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To investigate the discrepancy between grating and optotype visual acuity in children with visual impairment due to brain and/or ocular abnormalities. METHODS:Better eye acuity at 114 cm was studied in 81 patients (ages, 5-24 years) attending special schools for the visually handicapped. Fourteen patients had ...

journal_title：Investigative ophthalmology & visual science

authors： Stiers P,Vanderkelen R,Vandenbussche E

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. METHODS:A series of birth, anthropometric, and 13 ocular biometric traits were ...

journal_title：Investigative ophthalmology & visual science

authors： Sanfilippo PG,Medland SE,Hewitt AW,Kearns LS,Ruddle JB,Sun C,Hammond CJ,Young TL,Martin NG,Mackey DA

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:As the number of cases of Acanthamoeba spp. keratitis (AK) is constantly growing, new diagnostic tools are needed to confirm and guide ophthalmologists in this clinically problematic diagnosis. Molecular diagnosis is particularly well adapted, although only a few real-time PCR techniques have been described rec...

journal_title：Investigative ophthalmology & visual science

authors： Maubon D,Dubosson M,Chiquet C,Yera H,Brenier-Pinchart MP,Cornet M,Savy O,Renard E,Pelloux H

更新日期：2012-05-14 00:00:00

abstract：Purpose:To investigate the application of optical coherence tomography angiography (OCT-A) in evaluation of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Methods:Patients with GA were prospectively enrolled and studied with blue fundus autofluorescence (FAF), en face structural OCT, and ...

journal_title：Investigative ophthalmology & visual science

authors： Corbelli E,Sacconi R,Rabiolo A,Mercuri S,Carnevali A,Querques L,Bandello F,Querques G

更新日期：2017-10-01 00:00:00

abstract：:Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized b...

journal_title：Investigative ophthalmology & visual science

authors： Iso T,Uda K,Yamauchi H,Nakajima N,Suda H

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a ...

journal_title：Investigative ophthalmology & visual science

authors： Kumar M,Hill JM,Clement C,Varnell ED,Thompson HW,Kaufman HE

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Sildenafil increases ocular blood flow. Thus, the authors investigated if it also increases anterior chamber (AC) refilling after paracentesis. METHODS:Corriedale sheep and albino rabbits were used as animal models. Intraocular pressure (IOP) was measured, paracentesis performed on one eye, and AC refilling fo...

journal_title：Investigative ophthalmology & visual science

authors： Gerometta R,Alvarez LJ,Candia OA

更新日期：2012-02-01 00:00:00

abstract：:Purpose. To use optical coherence tomography (OCT) to evaluate the effect of punctal occlusion on tear meniscus volume in dry eye patients. Methods. Occlusion of both upper and lower puncta with collagen plugs was performed on one eye each in 20 dry eye patients and 20 normal subjects. The upper and lower tear menisci...

journal_title：Investigative ophthalmology & visual science

authors： Chen F,Shen M,Chen W,Wang J,Li M,Yuan Y,Lu F

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH). METHODS:A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH. Demographic and clinical differe...

journal_title：Investigative ophthalmology & visual science

authors： Nakao K,Abematsu N,Mizushima Y,Sakamoto T

更新日期：2012-04-18 00:00:00

abstract：:The effects of x-rays and three chemical agents, known to cause intraocular inflammation in mammalian eyes, were studied on the chicken eye because this species was reported to be insensitive to the cataractogenic effects of x-rays. Intravitreal injection of Shigella endotoxin and topical and/or intravitreal administr...

journal_title：Investigative ophthalmology & visual science

authors： Stetz DE,Bito LZ

更新日期：1978-05-01 00:00:00

abstract：PURPOSE:A prior study showed that Toll-like receptor (TLR)-5 recognizes Pseudomonas aeruginosa flagellin and triggers the production of proinflammatory cytokines in human corneal epithelial cells (HCECs). The present study was conducted to determine how the inflammatory response is modulated after TLR activation in HCE...

journal_title：Investigative ophthalmology & visual science

authors： Kumar A,Yin J,Zhang J,Yu FS

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations. METHODS:Thirty-six subjects (19 male, 17 female; mean SD, age 51 13 years) were recruited into this single-masked placebo-controlled study, and were ...

journal_title：Investigative ophthalmology & visual science

authors： Loughman J,Nolan JM,Howard AN,Connolly E,Meagher K,Beatty S

更新日期：2012-11-29 00:00:00

abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

journal_title：Investigative ophthalmology & visual science

authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To investigate corneal sensitivity to selective mechanical, chemical, heat, and cold stimulation in patients with fibromyalgia (FM). METHODS:Twenty patients with FM (18 women, 2 men; 51.9 +/- 2.3 years old) and 18 control subjects (16 women, 2 men; 51.7 +/- 2.4 years) participated voluntarily in the study. Sub...

journal_title：Investigative ophthalmology & visual science

authors： Gallar J,Morales C,Freire V,Acosta MC,Belmonte C,Duran JA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:When intraocular pressure (IOP) was monitored in supine healthy young adults throughout a 24-hour period, a diurnal-to-nocturnal elevation of IOP was observed. This study was undertaken to investigate whether a similar elevation of IOP can be detected when experimental subjects are in the sitting position. MET...

journal_title：Investigative ophthalmology & visual science

authors： Liu JH,Bouligny RP,Kripke DF,Weinreb RN

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:In Graves' orbitopathy (GO), inflammation and expansion of the retrobulbar tissue are the result of a pathophysiologic process in which orbital fibroblasts (GO-Fs) are considered the central cell type. However, in a previous study we observed that GO-Fs expressed some of the consensus surface markers described ...

journal_title：Investigative ophthalmology & visual science

authors： Brandau S,Bruderek K,Hestermann K,Görtz GE,Horstmann M,Mattheis S,Lang S,Eckstein A,Berchner-Pfannschmidt U

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To investigate the pharmacologic effect of tetramethylpyrazine (TMP) on human Tenon's fibroblasts (HTFs), the cells implicated in scarring after filtration surgery. METHODS:Transforming growth factor-β2 (TGF-β2) was used to stimulate a fibrotic phenotype in primary HTFs, and the influence of TMP on the fibroti...

journal_title：Investigative ophthalmology & visual science

authors： Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To determine whether changes in the retinal blood flow in light and darkness occur in humans. METHODS; The systolic and diastolic flow velocities were measured by color Doppler in the ophthalmic and the central retinal arteries in 12 healthy individuals in light and darkness. RESULTS:In the ophthalmic artery t...

journal_title：Investigative ophthalmology & visual science

authors： Havelius U,Hansen F,Hindfelt B,Krakau T

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:We attempted to reproduce published studies that evaluated whether the following factors influence choroidal neovascularization (CNV) induced by laser photocoagulation in murine retinas: small interfering RNA (siRNA), cobra venom factor, complement factors C3 and C5, and complement receptor C5aR. In addition, w...

journal_title：Investigative ophthalmology & visual science

authors： Poor SH,Qiu Y,Fassbender ES,Shen S,Woolfenden A,Delpero A,Kim Y,Buchanan N,Gebuhr TC,Hanks SM,Meredith EL,Jaffee BD,Dryja TP

更新日期：2014-09-09 00:00:00

abstract：PURPOSE:To describe and evaluate a new experimental reference plane for measuring rim area in scanning laser tomography. METHODS:The experimental reference plane was positioned so that (1) it always lay entirely below the margin of the optic nerve head (ONH), (2) it remained at a set z-axis distance below the ONH in i...

journal_title：Investigative ophthalmology & visual science

authors： Tan JC,Hitchings RA

更新日期：2003-03-01 00:00:00

abstract：:The glycosaminoglycans (GAGs) extractable from the trabecular meshworks (TM) of human and non-human primate eye have been analyzed by sequential enzymatic degradation and cellulose acetate electrophoresis. For comparison, similar extracts of the cornea, sclera, iris, and ciliary body have also been analyzed. The distr...

journal_title：Investigative ophthalmology & visual science

authors： Acott TS,Westcott M,Passo MS,Van Buskirk EM

更新日期：1985-10-01 00:00:00

abstract：PURPOSE:To evaluate the role of TIMP-1 in inherited retinal degeneration. METHODS:The genomic structure of the TIMP-1 gene was established and male patients with x-linked retinitis pigmentosa 2 from five families were screened for sequence alterations by direct sequencing in all exons, exon-intron boundaries, and the ...

journal_title：Investigative ophthalmology & visual science

authors： Hardcastle AJ,Thiselton DL,Nayudu M,Hampson RM,Bhattacharya SS

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:Elevated levels of C-reactive protein (CRP), a proinflammatory marker, are associated with systemic vascular disorders. In addition, clinical studies have implicated that elevated CRP is an independent risk factor for diabetic retinopathy and age-related macular degeneration. However, the direct effect of CRP o...

journal_title：Investigative ophthalmology & visual science

authors： Nagaoka T,Kuo L,Ren Y,Yoshida A,Hein TW

更新日期：2008-05-01 00:00:00

abstract：:Collagen deposition is largely responsible for scar information, an undesirable outcome of glaucoma filtering surgery. Because interferon-gamma (IFN-gamma) has been reported to inhibit collagen synthesis in a variety of cells, the authors examined its effect on collagen synthesis by Tenon's capsule fibroblasts culture...

journal_title：Investigative ophthalmology & visual science

authors： Low SQ,Kitada S,Lee DA

更新日期：1991-10-01 00:00:00

abstract：PURPOSE:To test the validity of the color component subtraction method, a new objective technique of measuring nuclear cataract, and to correlate the tangent values of the different degrees of nuclear opacities to their corresponding subjective nuclear cataract grading using the Lens Opacities Classification System II ...

journal_title：Investigative ophthalmology & visual science

authors： Khu PM,Kashiwagi T

更新日期：1993-01-01 00:00:00