Optotype and grating visual acuity in patients with ocular and cerebral visual impairment.

Abstract:

PURPOSE:To investigate the discrepancy between grating and optotype visual acuity in children with visual impairment due to brain and/or ocular abnormalities. METHODS:Better eye acuity at 114 cm was studied in 81 patients (ages, 5-24 years) attending special schools for the visually handicapped. Fourteen patients had a brain abnormality, 48 had an ocular disorder, and 19 had both. Three acuity tasks were administered: detecting gratings in one of two positions, discriminating the orientation of single gratings, and discriminating the orientation of uncrowded Landolt-C optotypes. The three paradigms were similar in stimulus contrast, luminance, presentation mode, and psychophysical procedure. RESULTS:Overall, grating acuity was better than optotype acuity, and the disparity increased with poorer optotype acuity. The largest discrepancies occurred in patients with brain abnormality, but disparities were also large in patients with optic nerve disorder. In patients with ocular and brain abnormality, grating acuities were only mildly better and not different from patients with only ocular abnormality. Grating orientation and grating detection tasks yielded similar thresholds, except in patients with cerebral visual impairment and with optic nerve disorder, whose grating detection acuity was better than grating orientation acuity. CONCLUSIONS:Grating-to-optotype acuity superiority is typically large in visual disorders involving the brain. The closely matched test paradigms point to stimulus characteristics as the explanation. However, because the discrepancy decreased with grating orientation acuity instead of grating detection acuity, the complexity of the response required also plays a role.

authors

Stiers P,Vanderkelen R,Vandenbussche E

doi

10.1167/iovs.03-0822

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

4333-9

issue

12

eissn

0146-0404

issn

1552-5783

pii

45/12/4333

journal_volume

45

pub_type

杂志文章
  • Objective concurrent measures of open-loop accommodation and vergence under photopic conditions.

    abstract:PURPOSE:To investigate the relationship between photopic open-loop accommodation and vergence and the effect of mental effort on these positions. METHODS:Twenty subjects (11 men and 9 women) viewed monocularly a photopic (25 cdm-2), high-contrast (90%) Maltese cross-target for 3 minutes, through a 0.5-mm pinhole drill...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Gray LS,Winn B,Gilmartin B,Eadie AS

    更新日期:1993-09-01 00:00:00

  • Interrelationship of optical coherence tomography and multifocal visual-evoked potentials after optic neuritis.

    abstract:PURPOSE:Acute optic neuritis (ON) is often followed by recovery of visual function. Although this recovery is mainly attributable to resolution of the acute inflammation, the redistribution of ion channels along the demyelinated membrane, and subsequent remyelination, part of it may be the result of neural plasticity. ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-4577

    authors: Klistorner A,Arvind H,Garrick R,Graham SL,Paine M,Yiannikas C

    更新日期:2010-05-01 00:00:00

  • A new noninvasive tear stability analysis system for the assessment of dry eyes.

    abstract:PURPOSE:This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS:The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.03-0712

    authors: Kojima T,Ishida R,Dogru M,Goto E,Takano Y,Matsumoto Y,Kaido M,Ohashi Y,Tsubota K

    更新日期:2004-05-01 00:00:00

  • Glaucoma filtration surgery using amniotic membrane transplantation.

    abstract:PURPOSE:To investigate the potential use of amniotic membrane transplantation (AMT) in the construction of glaucoma filtering blebs. METHODS:Twenty-four albino rabbits underwent glaucoma filtration surgery in one eye. In alternate cases, the conjunctival flap was replaced with AMT. Postoperative examination data were ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Barton K,Budenz DL,Khaw PT,Tseng SC

    更新日期:2001-07-01 00:00:00

  • Influence of intraocular pressure on aqueous outflow facility in enucleated eyes of different mammals.

    abstract::Freshly enucleated monkey, calf, and human eyes were quantitatively perfused with mock aqueous humor through the anterior chamber by a constant pressure technique. After baseline perfusion at 15 mm Hg, intraocular pressure was raised to 45 mm Hg and later reduced back to 15 mm Hg. Calf and human (both adult and infant...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Hashimoto JM,Epstein DL

    更新日期:1980-12-01 00:00:00

  • Antianaphylactic effects of dipivalyl epinephrine and related compounds in rat conjunctiva.

    abstract::Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized b...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Iso T,Uda K,Yamauchi H,Nakajima N,Suda H

    更新日期:1980-07-01 00:00:00

  • Aberrant cell and basement membrane architecture contribute to sidestream smoke-induced choroidal endothelial dysfunction.

    abstract:PURPOSE:Environmental tobacco smoke (ETS) is widely regarded as a major modifiable risk factor for age-related macular degeneration (AMD). Yet, precisely how it exerts its pathologic effects is poorly understood. Since early-stage AMD is characterized by choroidal capillary loss, this study examined the effect of sides...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-13659

    authors: Yang X,Scott HA,Ardekani S,Williams M,Talbot P,Ghosh K

    更新日期:2014-04-08 00:00:00

  • Quantification of deficits in spatial visual function of mouse models for glaucoma.

    abstract:PURPOSE:DBA/2J mice are a standard preclinical glaucoma model, which spontaneously developed mutations resulting in chronic age-related pigmentary glaucoma. The goals of this study were to identify the degree of visual impairment in DBA/2J mice before and after disease onset by quantifying the optokinetic reflex respon...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.10-7106

    authors: Burroughs SL,Kaja S,Koulen P

    更新日期:2011-06-01 00:00:00

  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling.

    abstract:PURPOSE:This study was undertaken to improve understanding of the defective lens developmental changes induced by the transgenic overexpression of the Rho GDP dissociation inhibitor RhoGDIalpha. The study was focused on a single differentially expressed gene encoding ponsin, a cell adhesion interacting signaling adapto...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-2909

    authors: Rao PV,Maddala R

    更新日期:2009-04-01 00:00:00

  • Relation of cholesterol-stimulated Staphylococcus aureus growth to chronic blepharitis.

    abstract:PURPOSE:Many types of chronic blepharitis have been believed to be primarily microbial in origin; however, it was proposed that differences and changes in lipid composition of meibomian secretion may be the initiating factor in some of these. It was recently reported that there are two subgroups of normals, those whose...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Shine WE,Silvany R,McCulley JP

    更新日期:1993-06-01 00:00:00

  • Preferential looking acuity obtained with a staircase procedure in pediatric patients.

    abstract::Visual acuity of infants and young children with ophthalmologic disorders was assessed by adapting a transformed up-down staircase to preferential looking (PL) procedures. Eighty-five percent of pediatric patients between 11 days and 5 years of age were tested successfully. Acuity of infants and young children with no...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Mayer DL,Fulton AB,Hansen RM

    更新日期:1982-10-01 00:00:00

  • Decrease of anterior ciliary arterial pressure with increased ocular pressure.

    abstract::The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Sakimoto G,Schwartz B

    更新日期:1984-08-01 00:00:00

  • Localization of S-100 protein in Müller cells of the retina--2. Electron microscopical immunocytochemistry.

    abstract::The cellular and subcellular distribution of S-100 protein was investigated at the ultrastructural level in the rat retina by the immunocytochemical PAP method. S-100 appeared to be localized in the cytoplasm and nucleus of Müller cells, offering conclusive evidence that in the mammalian retina, the protein is confine...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Cocchia D,Polak JM,Terenghi G,Battaglia F,Stolfi V,Gangitano C,Michetti F

    更新日期:1983-07-01 00:00:00

  • Glaucoma filtration surgery in nonhuman primates using taxol and etoposide in polyanhydride carriers.

    abstract:PURPOSE:To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. METHODS:Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subc...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Jampel HD,Thibault D,Leong KW,Uppal P,Quigley HA

    更新日期:1993-10-01 00:00:00

  • Light and electron microscopy of the anterior chamber angle structures following surgical disinsertion of the ciliary muscle in the cynomolgus monkey.

    abstract::Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Lütjen-Drecoll E,Kaufman PL,Bárány EH

    更新日期:1977-03-01 00:00:00

  • Erosive vitreoretinopathy and wagner disease are caused by intronic mutations in CSPG2/Versican that result in an imbalance of splice variants.

    abstract:PURPOSE:Linkage intervals for erosive vitreoretinopathy (ERVR) and Wagner disease previously were found to overlap at 5q14.3. In a Japanese family with Wagner disease, a CSPG2/Versican splice site mutation (c.4004-2A-->G) was recently reported that resulted in a 39-nucleotide exon 8 in-frame deletion. We investigated w...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0141

    authors: Mukhopadhyay A,Nikopoulos K,Maugeri A,de Brouwer AP,van Nouhuys CE,Boon CJ,Perveen R,Zegers HA,Wittebol-Post D,van den Biesen PR,van der Velde-Visser SD,Brunner HG,Black GC,Hoyng CB,Cremers FP

    更新日期:2006-08-01 00:00:00

  • Instantaneous flow rate of vitreous cutter probes.

    abstract:PURPOSE:We report on instantaneous volumetric flow rate of vitreous cutters measured by means of particle image velocimetry (PIV). METHODS:In an in vitro experimental study, vitreous cutters mounting a regular blade (RB) or modified Twedge blade (TB) engineered for higher flow were connected to a console machine equip...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-15467

    authors: Rossi T,Querzoli G,Angelini G,Rossi A,Malvasi C,Iossa M,Ripandelli G

    更新日期:2014-11-20 00:00:00

  • Effect of age on individual retinal layer thickness in normal eyes as measured with spectral-domain optical coherence tomography.

    abstract:PURPOSE:To determine the effect of age on the thickness of individual retinal layers, measured with spectral-domain optical coherence tomography (SD-OCT), in a population of healthy Caucasians. METHODS:One hundred and twenty subjects with an age ranging between 18 and 81 years were examined with SD-OCT. Mean layer thi...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-11913

    authors: Demirkaya N,van Dijk HW,van Schuppen SM,Abràmoff MD,Garvin MK,Sonka M,Schlingemann RO,Verbraak FD

    更新日期:2013-07-22 00:00:00

  • Spatial Distribution of Macular Pigment in an Elderly French Population: The Montrachet Study.

    abstract:Purpose:We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods:The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography,...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章,多中心研究

    doi:10.1167/iovs.16-19958

    authors: Alassane S,Binquet C,Arnould L,Fleck O,Acar N,Delcourt C,Bretillon L,Bron AM,Creuzot-Garcher C

    更新日期:2016-08-01 00:00:00

  • Effects of prostaglandins F2 alpha, A2, and their esters in glaucomatous monkey eyes.

    abstract::The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. Dose-response testing and baseline IOP measurements were done. For multiple dose testing, 5 micrograms in 25 microliters (0.02%) o...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Wang RF,Camras CB,Lee PY,Podos SM,Bito LZ

    更新日期:1990-11-01 00:00:00

  • Prostaglandin F2alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle.

    abstract:PURPOSE:To determine the mechanisms underlying prostaglandin (PG) F(2)alpha-(,) carbachol (CCh)-, or latanoprost (a PGF(2)alpha analogue)-induced contraction of the pig iris sphincter muscle. METHODS:Effects of these agents on myofilament Ca(2+) sensitivity were evaluated and compared with the use of receptor-coupled ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.05-1518

    authors: Hasegawa Y,Nishimura J,Niiro N,Hirano K,Ishibashi T,Kanaide H

    更新日期:2006-11-01 00:00:00

  • Conventional pattern-reversal VEPs are not equivalent to summed multifocal VEPs.

    abstract:PURPOSE:To compare conventional pattern-reversal visual evoked potentials (cVEPs) with multifocal VEPs (mfVEPs). METHODS:mfVEPs and cVEPs were recorded during the same session in 12 normal subjects with an active electrode at Oz referenced to the inion (Oz-In) or to a midfrontal position, Fz (Oz-Fz). The mfVEP stimulu...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.02-0441

    authors: Fortune B,Hood DC

    更新日期:2003-03-01 00:00:00

  • Mutations in ASCC3L1 on 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese family.

    abstract:PURPOSE:To localize and identify the gene and mutations causing autosomal dominant retinitis pigmentosa in a Chinese Family. METHODS:Families were ascertained and patients underwent complete ophthalmic examinations. Blood samples were collected and DNA was extracted. A linkage scan of genomic regions containing known ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-3725

    authors: Li N,Mei H,MacDonald IM,Jiao X,Hejtmancik JF

    更新日期:2010-02-01 00:00:00

  • Inhibition of TNF-alpha-induced sickle RBC retention in retina by a VLA-4 antagonist.

    abstract:PURPOSE:Patients with sickle cell disease have elevated circulating levels of cytokines including tumor necrosis factor (TNF) alpha. TNF-alpha stimulates expression by endothelial cells of adhesion molecules, including vascular cell adhesion molecule (VCAM) 1. Others have demonstrated that VLA-4 (alpha(4)beta(1)), a li...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Lutty GA,Taomoto M,Cao J,McLeod DS,Vanderslice P,McIntyre BW,Fabry ME,Nagel RL

    更新日期:2001-05-01 00:00:00

  • Heterogeneity of collagens in rabbit cornea: type VI collagen.

    abstract::Normal adult rabbit corneas were digested with 5% pepsin and their collagens extracted with acetic acid. Collagen extracts were fractionated by differential salt precipitation. The 2.5 M NaCl fraction was then redissolved with tris buffer and precipitated with sodium acetate. The precipitate contained a high-molecular...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Cintron C,Hong BS

    更新日期:1988-05-01 00:00:00

  • Occludin independently regulates permeability under hydrostatic pressure and cell division in retinal pigment epithelial cells.

    abstract:PURPOSE:The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. METHODS:Occludin expression was inhibited in the human retina...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.07-1204

    authors: Phillips BE,Cancel L,Tarbell JM,Antonetti DA

    更新日期:2008-06-01 00:00:00

  • Endothelial nitric oxide synthase-related mechanotransduction changes in aged porcine angular aqueous plexus cells.

    abstract:PURPOSE:To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress. METHODS:The AAP cells were isolated differentially from porcine outflow tissues using puromycin ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-14992

    authors: Lei Y,Stamer WD,Wu J,Sun X

    更新日期:2014-11-06 00:00:00

  • Detection and subcellular localization of two 15S-lipoxygenases in human cornea.

    abstract:PURPOSE:There are two human 15-lipoxygenases (LOX), 15-LOX-1 and -2, which convert arachidonic acid to 15S-hydroxyeicosatetraenoic acid (15S-HETE). The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium. METHODS:Human corneal epithelia from donor c...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.04-1166

    authors: Chang MS,Schneider C,Roberts RL,Shappell SB,Haselton FR,Boeglin WE,Brash AR

    更新日期:2005-03-01 00:00:00

  • Effect of acute intraocular pressure challenge on rat retinal and cortical function.

    abstract:PURPOSE:The global or gross response index of visual performance measured from the eye does not necessarily translate to global responses measured from the brain. A better understanding of this relationship would facilitate the monitoring of disease models that affect the visual pathway. We consider whether rod- and co...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-13003

    authors: Tsai TI,Bui BV,Vingrys AJ

    更新日期:2014-02-20 00:00:00

  • Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland.

    abstract:PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-7210

    authors: Dartt DA,Hodges RR

    更新日期:2011-05-01 00:00:00