The insensitivity of the chicken eye to the inflammatory effects of x-rays in contrast to its sensitivity to other inflammatory agents.

abstract：PURPOSE:Children with cortical or cerebral visual impairment (CVI) often experience photophobia. In a study conducted to test whether this clinical phenomenon affects visual function, the sweep visual evoked potential (VEP) was used to evaluate cortical responses to grating stimuli in two luminance conditions: low and ...

journal_title：Investigative ophthalmology & visual science

authors： Good WV,Hou C

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice. METHODS:To ...

journal_title：Investigative ophthalmology & visual science

authors： Tang Y,Liu X,Zoltoski RK,Novak LA,Herrera RA,Richard I,Kuszak JR,Kumar NM

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Somatostatin (SST) analogues have been used to treat proliferative diabetic retinopathy, pseudotumor cerebri, thyroid orbitopathy, and cystoid macular edema. There is a paucity of published data in regards to cell-specific distribution of SST receptors (SSTR) in normal human eye tissues. Gene expression for all...

journal_title：Investigative ophthalmology & visual science

authors： Klisovic DD,O'Dorisio MS,Katz SE,Sall JW,Balster D,O'Dorisio TM,Craig E,Lubow M

更新日期：2001-09-01 00:00:00

abstract：Purpose:There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanic...

journal_title：Investigative ophthalmology & visual science

authors： Blackburn BJ,Gu S,Ford MR,de Stefano V,Jenkins MW,Dupps WJ Jr,Rollins AM

更新日期：2019-01-02 00:00:00

abstract：Purpose:Ocular structural and functional changes, collectively termed spaceflight-associated neuro-ocular syndrome (SANS), have been described in astronauts undergoing long-duration missions in the microgravity environment of the International Space Station. We tested the hypothesis that retinal vascular remodeling, pa...

journal_title：Investigative ophthalmology & visual science

authors： Vyas RJ,Young M,Murray MC,Predovic M,Lim S,Jacobs NM,Mason SS,Zanello SB,Taibbi G,Vizzeri G,Parsons-Wingerter P

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characteriz...

journal_title：Investigative ophthalmology & visual science

authors： Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

更新日期：2015-02-26 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:The transdifferentiation of Tenon fibroblasts to myofibroblasts is a pivotal step in filtering bleb scarring. It is mediated by the cytokine TGF-beta, Rho-dependent contractility, and cell-matrix interactions in an interdependent fashion. HMG-CoA-reductase inhibitors (statins) have been shown to inhibit Rho-GTP...

journal_title：Investigative ophthalmology & visual science

authors： Meyer-Ter-Vehn T,Katzenberger B,Han H,Grehn F,Schlunck G

更新日期：2008-09-01 00:00:00

abstract：Purpose:To investigate the effect of reducing high glucose (HG)-induced lysyl oxidase (LOX) overexpression and increased activity on retinal endothelial cell apoptosis. Methods:Rat retinal endothelial cells (RRECs) were grown in normal (N) or HG (30 mM glucose) medium for 7 days. In parallel, RRECs were grown in HG me...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Mecham RP,Trackman PC,Roy S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：Purpose:To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT). Methods:Fifty-six myopic patients on ocular hypotensive therapy with the diagnose ...

journal_title：Investigative ophthalmology & visual science

authors： Kim YC,Koo YH,Jung KI,Park CK

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may indicate a degenerative and attempted regenerative response of nerve fibers to diabetes. The purpose of this study was to define alterations...

journal_title：Investigative ophthalmology & visual science

authors： Kallinikos P,Berhanu M,O'Donnell C,Boulton AJ,Efron N,Malik RA

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:To examine the expression of matrix metalloproteinases (MMPs) and their inhibitors during the development of retinal neovascularization (NV) in a mouse model. METHODS:A well-characterized murine model of retinal NV was used to study the expression of specific MMPs (MMP-2, MMP-9, and MT1-MMP) and tissue inhibit...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire P,Colombo S,Das A

更新日期：2001-01-01 00:00:00

abstract：Purpose:To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods:Wide-field spectral-domain OCT scans, including the disc and mac...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Tsamis E,Bommakanti NK,Joiner DB,Al-Aswad LL,Blumberg DM,Cioffi GA,Liebmann JM,De Moraes CG

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS:There were two study days in an open design. On the first day, OPP was varied by elevating IOP during ...

journal_title：Investigative ophthalmology & visual science

authors： Polska E,Simader C,Weigert G,Doelemeyer A,Kolodjaschna J,Scharmann O,Schmetterer L

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To explore the roles of ZO-1 in corneal fibroblasts and myofibroblasts in a model of wounding. METHODS:Antibodies were used to identify ZO-1 in cultured rabbit corneal fibroblasts by immunocytochemistry, Western blot analysis, and immunoprecipitation. For colocalization studies, antibodies to beta-catenin, cad...

journal_title：Investigative ophthalmology & visual science

authors： Taliana L,Benezra M,Greenberg RS,Masur SK,Bernstein AM

更新日期：2005-01-01 00:00:00

abstract：Purpose:Applying CNGA3 gene augmentation therapy to cure a novel causative mutation underlying achromatopsia (ACHM) in sheep. Methods:Impaired vision that spontaneously appeared in newborn lambs was characterized by behavioral, electroretinographic (ERG), and histologic techniques. Deep-sequencing reads of an affected...

journal_title：Investigative ophthalmology & visual science

authors： Gootwine E,Abu-Siam M,Obolensky A,Rosov A,Honig H,Nitzan T,Shirak A,Ezra-Elia R,Yamin E,Banin E,Averbukh E,Hauswirth WW,Ofri R,Seroussi E

更新日期：2017-03-01 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a history of cataract and cataract surgery (self-report and for a sibling), and to determine which demographic, cognitive, and medical factors are predictive of an accurate history. METHODS:All participants in the Salisbury Eye Evaluation (SEE) project and their locally resident si...

journal_title：Investigative ophthalmology & visual science

authors： Bowie H,Congdon NG,Lai H,West SK

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:As part of a systematic elucidation of the pharmacology of prostaglandin's (PG) effects on intraocular pressure in the monkey, the prototypical selective prostanoid EP(4) receptor agonist (3,7-dithia PGE(1)) was examined. It was found to be highly efficacious in nonhuman primates, and its mechanism of ocular hy...

journal_title：Investigative ophthalmology & visual science

authors： Woodward DF,Nilsson SF,Toris CB,Kharlamb AB,Nieves AL,Krauss AH

更新日期：2009-07-01 00:00:00

abstract：:The authors used a psychophysical method to measure lens transmission of young, type I diabetic patients and normal controls. The results from normal controls agreed with previously published reports of decreasing lens transmission with age, and those from diabetic subjects suggested that lenses of young, type I diabe...

journal_title：Investigative ophthalmology & visual science

authors： Lutze M,Bresnick GH

更新日期：1991-01-01 00:00:00

abstract：Purpose:To compare the phenotype of blue cone monochromacy (BCM) caused by large deletion mutations with those having the C203R missense mutation. Methods:BCM patients with large deletion mutations (n = 21; age range, 5-60 years), and with the C203R missense mutation (n = 13; age range, 5-70 years), were studied with ...

journal_title：Investigative ophthalmology & visual science

authors： Sumaroka A,Garafalo AV,Cideciyan AV,Charng J,Roman AJ,Choi W,Saxena S,Aksianiuk V,Kohl S,Wissinger B,Jacobson SG

更新日期：2018-12-03 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Previous studies have shown that adenosine induces relaxation of isolated retinal arterioles mediated by the A2A receptor, but the contributions to tone regulation of adenosine receptors located both in and around the vascular wall have not been studied in detail. METHODS:Porcine retinal arterioles with preser...

journal_title：Investigative ophthalmology & visual science

authors： Riis-Vestergaard MJ,Misfeldt MW,Bek T

更新日期：2014-03-19 00:00:00

abstract：PURPOSE:Dry eye disease (DED) produces ocular pain and irritation, yet a detailed characterization of ocular sensitivity in a preclinical model of DED is lacking. The aim of the present study was to assess nociceptive behaviors in an aqueous tear deficiency model of DED in the rat. METHODS:Spontaneous blinking, cornea...

journal_title：Investigative ophthalmology & visual science

authors： Meng ID,Barton ST,Mecum NE,Kurose M

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of varying levels of ocular surface stimulation on the timing and amplitude of the blink and tear secretion. METHODS:Following instillation of fluorescein dye, increasing levels of air flow were directed toward the central corneas of 10 healthy subjects. Interblink interval (IBI), tea...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Begley CG,Port N,Bradley A,Braun R,King-Smith E

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To evaluate the pharmacokinetics of ciliary neurotrophic factor (CNTF) delivered over a period of up to 2 years by an intraocular encapsulated cell technology (ECT) implant in patients with retinitis pigmentosa (RP) and geographic atrophy (GA). METHODS:Patients from phase 1 RP (CNTF1); phase 2 GA (CNTF2); and ...

journal_title：Investigative ophthalmology & visual science

authors： Kauper K,McGovern C,Sherman S,Heatherton P,Rapoza R,Stabila P,Dean B,Lee A,Borges S,Bouchard B,Tao W

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL...

journal_title：Investigative ophthalmology & visual science

authors： Hidalgo-de-Quintana J,Evans RJ,Cheetham ME,van der Spuy J

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To examine retinal function using the full-field electroretinogram (ERG) during and after acute intraocular pressure (IOP) elevation in wild-type mice. METHODS:IOP was elevated by anterior chamber cannulation in wild-type C57/BL6 mice. The pressure-function relationship was determined by IOP elevation in steps...

journal_title：Investigative ophthalmology & visual science

authors： Kong YX,Crowston JG,Vingrys AJ,Trounce IA,Bui VB

更新日期：2009-12-01 00:00:00