Corneal sensitivity following lacrimal gland excision in the rat.

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：PURPOSE:Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthal...

journal_title：Investigative ophthalmology & visual science

authors： Jekle A,Abdul Rani S,Celeri C,Zuck M,Xu P,Wang L,Najafi-Tagol K,Anderson M,Stroman D,Debabov D

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:To obtain quantitative data on the optic disc excavation in children affected by cerebral visual impairment (CVI) by using the Heidelberg Retinal Tomograph (HRT)-II (Heidelberg Engineering, Heidelberg, Germany). METHODS:A total of 24 subjects affected by CVI (mean age, 7.28 years) were examined: 16 in alert co...

journal_title：Investigative ophthalmology & visual science

authors： Ruberto G,Salati R,Milano G,Bertone C,Tinelli C,Fazzi E,Guagliano R,Signorini S,Borgatti R,Bianchi A,Bianchi PE

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Neuronal and glial alterations precede the overt vascular change that characterizes diabetic retinopathy. Because retinal astrocytes modulate neuronal and vascular function, this study investigated the time course of astrocyte, Müller cell, and neuronal change during diabetes to determine whether astrocytes may...

journal_title：Investigative ophthalmology & visual science

authors： Ly A,Yee P,Vessey KA,Phipps JA,Jobling AI,Fletcher EL

更新日期：2011-12-02 00:00:00

abstract：Purpose:Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls. Methods:Nine patients (...

journal_title：Investigative ophthalmology & visual science

authors： Gao TY,Ledgeway T,Lie AL,Anstice N,Black J,McGraw PV,Thompson B

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degenerat...

journal_title：Investigative ophthalmology & visual science

authors： Marc RE,Jones BW,Anderson JR,Kinard K,Marshak DW,Wilson JH,Wensel T,Lucas RJ

更新日期：2007-07-01 00:00:00

abstract：:Specimens for chlamydial isolation culture and direct fluorescent antibody cytology (DFA) were collected from 1671 women and children from a trachoma-endemic area in Central Tanzania. Trachoma was graded using the new World Health Organization grading scheme, and 54% of the children and 9% of the women had inflammator...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Rapoza PA,West S,Johnson S,Munoz B,Katala S,Mmbaga BB

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:Tissues derived from immune-privileged sites sometimes possess special characteristics that promote their own survival when transplanted to a nonprivileged site. This study was undertaken to evaluate whether retinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly....

journal_title：Investigative ophthalmology & visual science

authors： Wenkel H,Streilein JW

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To characterize retinal functional consequences of elevated intraocular pressure (IOP) in a rat model of experimental glaucoma. METHODS:Unilateral elevation of IOP was produced by hypertonic saline injection into an episcleral vein in 20 adult male Brown-Norway rats. IOP was measured in both eyes of awake anim...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Bui BV,Morrison JC,Johnson EC,Dong J,Cepurna WO,Jia L,Barber S,Cioffi GA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To test whether retinal pigment epithelial (RPE) cells are able to induce myeloid-derived suppressor cell (MDSC) differentiation from bone marrow (BM) progenitors. METHODS:BM cells were cocultured with or without RPE cells in the presence of GM-CSF and IL-4. Numbers of resultant MDSCs were assessed by flow cyt...

journal_title：Investigative ophthalmology & visual science

authors： Tu Z,Li Y,Smith D,Doller C,Sugita S,Chan CC,Qian S,Fung J,Caspi RR,Lu L,Lin F

更新日期：2012-02-23 00:00:00

abstract：PURPOSE:Diabetic complications are associated with hypoglycemia and hyperglycemia. The purpose of this study was to investigate the effect of both glucose deprivation and hyperglycemia on the induction of endoplasmic reticulum (ER) stress and the subsequent activation of the unfolded protein response (UPR) that results...

journal_title：Investigative ophthalmology & visual science

authors： Mulhern ML,Madson CJ,Danford A,Ikesugi K,Kador PF,Shinohara T

更新日期：2006-09-01 00:00:00

abstract：:Five immunosuppressive and anti-inflammatory agents were tested for their effects on development of experimental autoimmune uveoretinitis (EAU) and immune responses to S-antigen in rats immunized with this retinal antigen. When administered daily from day 0-14 after immunization, cyclosporine at 5-20 mg/Kg was nontoxi...

journal_title：Investigative ophthalmology & visual science

authors： Mochizuki M,Nussenblatt RB,Kuwabara T,Gery I

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS:MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline....

journal_title：Investigative ophthalmology & visual science

authors： Sasamoto Y,Gomi F,Sawa M,Sakaguchi H,Tsujikawa M,Nishida K

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:Extremely low gestational age neonates (ELGANs) requiring oxygen therapy often experience frequent episodes of intermittent hypoxia (IH) and are at high risk for severe retinopathy of prematurity (ROP). Using an established model for oxygen-induced retinopathy (OIR), we examined the hypothesis that there is a c...

journal_title：Investigative ophthalmology & visual science

authors： Beharry KD,Cai CL,Sharma P,Bronshtein V,Valencia GB,Lazzaro DR,Aranda JV

更新日期：2013-11-19 00:00:00

abstract：PURPOSE:Monkeys reared under conditions of alternating monocular occlusion during their first few months of life show large horizontal strabismus, "A" patterns, and dissociated vertical deviation. "A" patterns manifest as an inappropriate horizontal component in the deviated eye during vertical eye movements (cross-axi...

journal_title：Investigative ophthalmology & visual science

authors： Joshi AC,Das VE

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in re...

journal_title：Investigative ophthalmology & visual science

authors： Bynoe LA,Gottsch JD,Sadda SR,Panton RW,Haller EM,Gleason CA

更新日期：1993-09-01 00:00:00

abstract：:Growth of the embryonic chick cornea was directly related to, and coordinated with, overall eye growth. During normal development, the size of the embryonic chick cornea increased in three linear phases of diametric growth. Corneal diameter increased at a rate of 216 microns per day between embryonic day 4 (E4) and E7...

journal_title：Investigative ophthalmology & visual science

authors： Bee JA,Roche SM

更新日期：1992-11-01 00:00:00

abstract：:Three methods of corneal epithelial preparation for subsequent analysis of epithelial glycogen and DNA content were compared: scraping, lamellar stripping, and in situ freezing. All three methods gave good recovery of these substances. However, there was incomplete recovery of the sample using the in situ freezing met...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kiorpes T,Kinoshita S

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:Primary open angle glaucoma-associated mutations in myocilin (MYOC) cause protein "nonsecretion," rendering secreted MYOC difficult to detect using conventional techniques. This study focused on developing and using an assay that can quickly and easily detect mutant MYOC secretion. METHODS:We fused Gaussia luc...

journal_title：Investigative ophthalmology & visual science

authors： Zadoo S,Nguyen A,Zode G,Hulleman JD

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To determine the sensitivity to change and specificity achieved when published test-retest variability (TRV) data are used to determine whether measured changes in ETDRS logarithm of the minimum angle of resolution (logMAR) visual acuity reflect true clinical change or are attributable to measurement error alon...

journal_title：Investigative ophthalmology & visual science

authors： Rosser DA,Cousens SN,Murdoch IE,Fitzke FW,Laidlaw DA

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：:Cellular retinol binding protein (CRBP) was localized in the rat retina by means of light and electron microscopic immunocytochemistry. The peroxidase-antiperoxidase (PAP) method employed at the light microscopic level showed that CRBP is sharply localized to the retinal pigment epithelium (RPE). None was detectable i...

journal_title：Investigative ophthalmology & visual science

authors： Bok D,Ong DE,Chytil F

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:Identification of causative mutations for retinal blinding disorders is often limited by restricted understanding of gene expression and underlying molecular mechanisms that trigger degenerative processes. This study was conducted to develop a catalog of canine retina-expressed genes that would provide a unique...

journal_title：Investigative ophthalmology & visual science

authors： Zangerl B,Sun Q,Pillardy J,Johnson JL,Schweitzer PA,Hernandez AG,Liu L,Acland GM,Aguirre GD

更新日期：2006-06-01 00:00:00

abstract：:A stimulus consisting of 96 red LEDs mounted in the rear of a ganzfeld bowl was used to elicit focal electroretinograms (FERG) from the central 9 degrees of the retina in human subjects. The luminance of the stimulus was driven sinusoidally at frequencies from 10-60 Hz. The temporal responsiveness and response phase l...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM,Carr RE,Mayron C

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:To map the disease locus in a four-generation, consanguineous Pakistani family affected by autosomal dominant congenital nuclear cataract (adNCat). All affected individuals had early onset of bilateral nuclear cataract. METHODS:Genomic DNA from family members was typed for alleles at more than 300 known polymo...

journal_title：Investigative ophthalmology & visual science

authors： Khaliq S,Hameed A,Ismail M,Anwar K,Mehdi SQ

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:This study investigated, using high-resolution magnetic resonance imaging (MRI), inferior oblique muscle (IO) position relative to the adnexa in normal controls, subjects with and without vertical strabismus following lower lid blepharoplasty, and subjects with other hypertropia. METHODS:Sagittal plane MRI was...

journal_title：Investigative ophthalmology & visual science

authors： Shin SY,Demer JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To evaluate the utility of baseline Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) retinal nerve fiber layer (RNFL) normative classification in the prediction of future visual field (VF) loss. METHODS:Eighty-eight eyes with suspected glaucoma with abnormal RNFL classification by Str...

journal_title：Investigative ophthalmology & visual science

authors： Sung KR,Kim S,Lee Y,Yun SC,Na JH

更新日期：2011-04-22 00:00:00

abstract：PURPOSE:The authors took advantage of the Oa1 mutant mouse in combination with other albinism mouse models (i.e., Tyrosinase and membrane-associated transporter protein [Matp]) to study the function of Oa1, the gene mutated in ocular albinism type 1, in the RPE during development and after birth. METHODS:Enzyme activi...

journal_title：Investigative ophthalmology & visual science

authors： Cortese K,Giordano F,Surace EM,Venturi C,Ballabio A,Tacchetti C,Marigo V

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:To develop and characterize a feline model of retinal degeneration induced by intravitreal injection of adenosine triphosphate (ATP). METHODS:Nineteen normally sighted adult cats received 100 μL intravitreal injections of ATP with a final concentration of 11, 22, or 55 mM at the retina. Four animals were eutha...

journal_title：Investigative ophthalmology & visual science

authors： Aplin FP,Luu CD,Vessey KA,Guymer RH,Shepherd RK,Fletcher EL

更新日期：2014-11-25 00:00:00