当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension.

Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension.

Abstract：

PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characterized by in vivo optical coherence tomography (OCT) and immunohistochemistry. Retinal dysfunction was also monitored by the full-field ERG. Retinal ganglion cell light responses were recorded using a 256-channel multielectrode array (MEA), and RGC subtypes were characterized by noncentered spike-triggered covariance (STC-NC) analysis. Single-unit extracellular recordings from superficial layers of the superior colliculus (SC) were performed to examine the receptive field (RF) properties of SC neurons. RESULTS:The elevation of intraocular pressure (IOP) lasted 4 months in mice treated with a combination of laser photocoagulation and microbead injection. Progressive RGC loss and functional degeneration were confirmed in ocular hypertensive (OHT) mice. These mice had fewer visually responsive RGCs than controls. Using the STC-NC analysis, we classified RGCs into ON, OFF, and ON-OFF functional subtypes. We showed that ON and OFF RGCs were more susceptible to the IOP elevation than ON-OFF RGCs. Furthermore, SC neurons of OHT mice had weakened responses to visual stimulation and exhibited mismatched ON and OFF subfields and irregular RF structure. CONCLUSIONS:We demonstrated that the functional degeneration of RGCs is subtype-dependent and that the ON and OFF pathways from the retina to the SC were disrupted. Our study provides a foundation to investigate the mechanisms underlying the progressive vision loss in experimental glaucoma.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

doi

10.1167/iovs.14-15691

subject

Has Abstract

pub_date

2015-02-26 00:00:00

pages

1971-84

issue

3

eissn

0146-0404

issn

1552-5783

pii

iovs.14-15691

journal_volume

56

pub_type

杂志文章

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Osteopontin expression and serum levels in metastatic uveal melanoma: a pilot study.

    abstract：PURPOSE:This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS:Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tis...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0422

    authors： Kadkol SS,Lin AY,Barak V,Kalickman I,Leach L,Valyi-Nagy K,Majumdar D,Setty S,Maniotis AJ,Folberg R,Pe'er J

    更新日期：2006-03-01 00:00:00

  • The Roles of PAX6 and SOX2 in Myopia: lessons from the 1958 British Birth Cohort.

    abstract：PURPOSE:Myopia is a common complex trait that affects up to 60% of some populations. Its development is influenced by multiple genes and environmental factors. PAX6 and SOX2 are genes with fundamental roles in ocular growth and development, and they have been linked with myopia in a recent linkage study. The authors in...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-0231

    authors： Simpson CL,Hysi P,Bhattacharya SS,Hammond CJ,Webster A,Peckham CS,Sham PC,Rahi JS

    更新日期：2007-10-01 00:00:00

  • Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope.

    abstract：PURPOSE:To evaluate the feasibility and reliability of a standardized approach for quantitative measurements of fundus autofluorescence (AF) in images obtained with a confocal scanning laser ophthalmoscope (cSLO). METHODS:AF images (30°) were acquired in 34 normal subjects (age range, 20-55 years) with two different c...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8319

    authors： Delori F,Greenberg JP,Woods RL,Fischer J,Duncker T,Sparrow J,Smith RT

    更新日期：2011-12-09 00:00:00

  • Physical activity and the 15-year incidence of age-related macular degeneration.

    abstract：PURPOSE:There is uncertainty in the published literature as to whether physical activity should be advocated for age-related macular degeneration (AMD) prevention. We aimed to assess prospectively the association between physical activity and the 15-year incidence of AMD in older adults. METHODS:We assessed AMD from r...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-15575

    authors： Gopinath B,Liew G,Burlutsky G,Mitchell P

    更新日期：2014-11-11 00:00:00

  • Differential expression and function of survivin during the progress of pterygium.

    abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-15715

    authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

    更新日期：2014-12-02 00:00:00

  • IPSC-Derived Corneal Endothelial-like Cells Act as an Appropriate Model System to Assess the Impact of SLC4A11 Variants on Pre-mRNA Splicing.

    abstract：Purpose:To report molecular genetic findings in six probands with congenital hereditary endothelial dystrophy (CHED) variably associated with hearing loss (also known as Harboyan syndrome). Furthermore, we developed a cellular model to determine if disease-associated variants induce aberrant SLC4A11 pre-mRNA splicing. ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.19-26930

    authors： Brejchova K,Dudakova L,Skalicka P,Dobrovolny R,Masek P,Putzova M,Moosajee M,Tuft SJ,Davidson AE,Liskova P

    更新日期：2019-07-01 00:00:00

  • Genotype-phenotype correlation of mouse pde6b mutations.

    abstract：PURPOSE:To identify the underlying molecular defects causing retinal degeneration in seven N-ethyl-N-nitrosourea (ENU) induced mutant alleles of the Pde6b gene and to analyze the timescale of retinal degeneration in these new models of retinitis pigmentosa. METHODS:Conformation sensitive capillary electrophoresis and ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0254

    authors： Hart AW,McKie L,Morgan JE,Gautier P,West K,Jackson IJ,Cross SH

    更新日期：2005-09-01 00:00:00

  • Quality of life in patients with leber hereditary optic neuropathy.

    abstract：PURPOSE:Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial optic neuropathy characterized by bilateral, severe loss of central vision. In this study, the first formal assessment was conducted of visual disability in affected and unaffected individuals from molecularly confirmed LHON pedigrees. METH...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.08-3166

    authors： Kirkman MA,Korsten A,Leonhardt M,Dimitriadis K,De Coo IF,Klopstock T,Griffiths PG,Hudson G,Chinnery PF,Yu-Wai-Man P

    更新日期：2009-07-01 00:00:00

  • Synthesis of group II phospholipase A2 and lysozyme in lacrimal glands.

    abstract：PURPOSE:The aim of this study was to demonstrate the synthesis and cellular distribution of group II phospholipase A2 and lysozyme in the main and accessory lacrimal glands. METHODS:The authors studied samples of normal main lacrimal glands of seven autopsied subjects and accessory lacrimal glands of eight patients wh...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Aho HJ,Saari KM,Kallajoki M,Nevalainen TJ

    更新日期：1996-08-01 00:00:00

  • Origins of Pupillary Hippus in the Autonomic Nervous System.

    abstract：Purpose:The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus. Methods:We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (T...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-20785

    authors： Turnbull PR,Irani N,Lim N,Phillips JR

    更新日期：2017-01-01 00:00:00

  • Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy.

    abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) is a major cause of serosanguinous maculopathy in Chinese patients with age-related macular degeneration (AMD). Variants in the CFH and HTRA1/LOC387715 genes are strongly associated with AMD in Caucasians and Chinese. Variants in the C2 and BF genes have been found to con...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-0860

    authors： Lee KY,Vithana EN,Mathur R,Yong VH,Yeo IY,Thalamuthu A,Lee MW,Koh AH,Lim MC,How AC,Wong DW,Aung T

    更新日期：2008-06-01 00:00:00

  • Effects of prostaglandins F2 alpha, A2, and their esters in glaucomatous monkey eyes.

    abstract：:The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. Dose-response testing and baseline IOP measurements were done. For multiple dose testing, 5 micrograms in 25 microliters (0.02%) o...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Wang RF,Camras CB,Lee PY,Podos SM,Bito LZ

    更新日期：1990-11-01 00:00:00

  • Decreased photoreceptor count in human eyes with secondary angle-closure glaucoma.

    abstract：:Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outsi...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Panda S,Jonas JB

    更新日期：1992-07-01 00:00:00

  • Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies.

    abstract：PURPOSE:To investigate whether a recently described retinal ganglion cell (RGC) marker Rbpms (RNA binding protein with multiple splicing) could be used for RGC quantification in various models of RGC degeneration. METHODS:Optic nerve crush, excitotoxicity, and elevated intraocular pressure (IOP) rat models were used. ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-7869

    authors： Kwong JM,Quan A,Kyung H,Piri N,Caprioli J

    更新日期：2011-12-28 00:00:00

  • Anti-TNFalpha therapy modulates the phenotype of peripheral blood CD4+ T cells in patients with posterior segment intraocular inflammation.

    abstract：PURPOSE:Posterior segment intraocular inflammation (PSII) is a putative Th1 CD4+ cell mediated autoimmune disorder. In experimental autoimmune uveoretinitis, neutralization of tumor necrosis factor (TNF)-alpha induces suppression of Th1 cells, macrophage activation, and target organ damage. Previous studies implicated ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 临床试验,杂志文章

    doi：10.1167/iovs.03-0659

    authors： Greiner K,Murphy CC,Willermain F,Duncan L,Plskova J,Hale G,Isaacs JD,Forrester JV,Dick AD

    更新日期：2004-01-01 00:00:00

  • Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation.

    abstract：PURPOSE:Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Loss-of-function mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa. Other mutant alleles o...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1470

    authors： Radu RA,Yuan Q,Hu J,Peng JH,Lloyd M,Nusinowitz S,Bok D,Travis GH

    更新日期：2008-09-01 00:00:00

  • Immunohistochemical properties of human optic nerve glioma. Evidence of type 1 astrocyte origin.

    abstract：:The peroxidase-antiperoxidase method was used to study ten surgically obtained human optic nerve gliomas (pilocytic astrocytomas). All tissues were formalin fixed and paraffin embedded. Primary antisera included glial fibrillary acidic protein (GFAP), HNK-1 (type 1 astrocyte precursor marker), A2B5 (type 2 astrocyte p...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Cutarelli PE,Roessmann UR,Miller RH,Specht CS,Grossniklaus HE

    更新日期：1991-08-01 00:00:00

  • Modulation of corneal epithelial innate immune response to pseudomonas infection by flagellin pretreatment.

    abstract：PURPOSE:A prior study showed that Toll-like receptor (TLR)-5 recognizes Pseudomonas aeruginosa flagellin and triggers the production of proinflammatory cytokines in human corneal epithelial cells (HCECs). The present study was conducted to determine how the inflammatory response is modulated after TLR activation in HCE...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-0473

    authors： Kumar A,Yin J,Zhang J,Yu FS

    更新日期：2007-10-01 00:00:00

  • Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentin.

    abstract：PURPOSE:To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity. METHODS:Retinal detachments were created in mice deficient for GFAP and vimentin (GFAP(-/-)vim(-/-)) and age-matched wild-type (wt) mice. The reactivity of the retina was studied by immunofluorescence and e...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1474

    authors： Verardo MR,Lewis GP,Takeda M,Linberg KA,Byun J,Luna G,Wilhelmsson U,Pekny M,Chen DF,Fisher SK

    更新日期：2008-08-01 00:00:00

  • Selective interactions of lymphocytes with neonatal and adult lacrimal gland tissues.

    abstract：:The lacrimal gland is a functional part of the mucosal immune system and is populated by lymphoid cells that begin to appear early in neonatal development. To define the events controlling the accumulation of these cells, an in vitro adherence assay was used to investigate the interactions of lymphocyte populations wi...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： O'Sullivan NL,Montgomery PC

    更新日期：1990-08-01 00:00:00

  • Sunitinib inhibits inflammatory corneal lymphangiogenesis.

    abstract：PURPOSE:To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sunitinib in corneal neovascularization (NV). METHODS:Inflammatory corneal NV was induced by thermal cauterization applied in the central cornea of mice, to which sunitinib malate was daily administered by gavage or not. At...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.12-10856

    authors： Detry B,Blacher S,Erpicum C,Paupert J,Maertens L,Maillard C,Munaut C,Sounni NE,Lambert V,Foidart JM,Rakic JM,Cataldo D,Noël A

    更新日期：2013-05-03 00:00:00

  • Individualized compensation of anterior segment birefringence during scanning laser polarimetry.

    abstract：PURPOSE:To describe a method for assessment and individualized compensation of anterior segment birefringence with scanning laser polarimetry. METHODS:A scanning laser polarimeter (GDx Nerve Fiber Analyzer; Laser Diagnostic Technologies, Inc., San Diego, CA) was modified to accommodate a variable compensator. The magn...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Zhou Q,Weinreb RN

    更新日期：2002-07-01 00:00:00

  • Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds.

    abstract：PURPOSE:To establish mouse models for RPGR-associated diseases by generating and characterizing an Rpgr mutation (in-frame deletion of exon 4) in two different genetic backgrounds (BL/6 and BALB/c). METHODS:Gene targeting in embryonic stem (ES) cells was performed to introduce a in-frame deletion of exon 4 in the Rpgr...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.08-2742

    authors： Brunner S,Skosyrski S,Kirschner-Schwabe R,Knobeloch KP,Neidhardt J,Feil S,Glaus E,Luhmann UF,Rüther K,Berger W

    更新日期：2010-02-01 00:00:00

  • Cell penetration peptides for enhanced entry of αB-crystallin into lens cells.

    abstract：PURPOSE:The prevalence of cataract increases with age. Conversely, the abundance of native α-crystallin diminishes with age and cataract development. We hypothesize replenishing lens α-crystallin may delay or prevent cataract. Herein we investigated the ability of cell penetration peptides (CPP) to enhance entry of α-c...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.12-10947

    authors： Mueller NH,Ammar DA,Petrash JM

    更新日期：2013-01-02 00:00:00

  • Secondary mtDNA defects do not cause optic nerve dysfunction in a mouse model of dominant optic atrophy.

    abstract：PURPOSE:The majority of patients with autosomal dominant optic atrophy (DOA) harbor pathogenic OPA1 mutations and certain missense mutations, mostly within the GTPase domain, have recently been shown to cause multiple mitochondrial DNA (mtDNA) deletions in skeletal muscle. This raises the possibility that the optic neu...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.09-3634

    authors： Yu-Wai-Man P,Davies VJ,Piechota MJ,Cree LM,Votruba M,Chinnery PF

    更新日期：2009-10-01 00:00:00

  • Repeatability and reproducibility of corneal thickness measurements by optical coherence tomography.

    abstract：PURPOSE:To assess the repeatability and interoperator and intersession reproducibility of central corneal thickness (CCT) measurements made by a commercially available optical coherence tomography (OCT) system. METHODS:Intersession and interoperator reproducibility and repeatability were defined according to the guide...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Muscat S,McKay N,Parks S,Kemp E,Keating D

    更新日期：2002-06-01 00:00:00

  • A psychophysical investigation of ocular expansion in human eyes.

    abstract：PURPOSE:To investigate spatial anisotropies in the peripheral visual field of axially myopic eyes, in an attempt to distinguish between models of isotropic and anisotropic ocular stretching. METHODS:Stimuli consisted of two high-contrast Gaussian patches presented in one of four orientations (90 degrees, 180 degrees, ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.04-0127

    authors： Vera-Diaz FA,McGraw PV,Strang NC,Whitaker D

    更新日期：2005-02-01 00:00:00

  • Angiography and multifocal electroretinography show that blood supply to the pig retina may be both ipsilateral and contralateral.

    abstract：PURPOSE:We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-12376

    authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

    更新日期：2013-09-09 00:00:00

  • Topographic localization of macular retinal ganglion cell loss associated with localized peripapillary retinal nerve fiber layer defect.

    abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-13925

    authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

    更新日期：2014-05-06 00:00:00

  • Accommodation-convergence relationships and age.

    abstract：PURPOSE:The objective of this study was to determine if there are differences in accommodative-convergence/accommodation (AC/A) and convergence-accommodation/convergence (CA/C) ratios in subjects with increasing age. The authors aimed to relate the findings to the present theories of the development of presbyopia. MET...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Bruce AS,Atchison DA,Bhoola H

    更新日期：1995-02-01 00:00:00