Accommodation-convergence relationships and age.

abstract：PURPOSE:To investigate the induction of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) gene expression by prostaglandin E2 (PGE2) in cultured rat Müller cells and to study the mechanism of the induction. METHODS:Müller cells were obtained from neonatal Sprague-Dawley rat retinas an...

journal_title：Investigative ophthalmology & visual science

authors： Cheng T,Cao W,Wen R,Steinberg RH,LaVail MM

更新日期：1998-03-01 00:00:00

abstract：Purpose:To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether risk factor effect sizes vary depending on children's position in the refractive error distribution. Methods:Refractive error was assessed in participants from two birth cohort...

journal_title：Investigative ophthalmology & visual science

authors： Pozarickij A,Enthoven CA,Ghorbani Mojarrad N,Plotnikov D,Tedja MS,Haarman AEG,Tideman JWL,Polling JR,Northstone K,Williams C,Klaver CCW,Guggenheim JA

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:To examine the distribution of human heat shock proteins (HSPs) HSP90, inducible HSP70 (iHSP70), constitutive and inducible HSP70 (cHSP70), HSP65, and human HSP27 in conjunctival biopsy specimens of ocular cicatricial pemphigoid (OCP), atopic keratoconjunctivitis, and healthy persons with cataract. METHODS:Usi...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Dutt JE,Nouri M,Foster CS

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To evaluate the influence of a control group on the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) in early glaucoma. METHODS:In a diagnostic, case-control study, 119 eyes of 60 normal subjects with no findings suspicious for glaucoma (control cohort 1); 76 eyes of 41 subjects ref...

journal_title：Investigative ophthalmology & visual science

authors： Rao HL,Kumbar T,Addepalli UK,Bharti N,Senthil S,Choudhari NS,Garudadri CS

更新日期：2012-02-29 00:00:00

abstract：Purpose:We examined the pattern and extent of connective tissue distribution in the extraocular muscles (EOMs) and determined the ability of the interconnected connective tissues to disseminate force laterally. Methods:Human EOMs were examined for collagens I, III, IV, and VI; fibronectin; laminin; and elastin using i...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Vicente A,Fitzpatrick KR,Lindström M,Pedrosa Domellöf F

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：:This study was undertaken to observe the effect on the differential light sensitivity in glaucoma suspects produced by a long-term reduction in intraocular pressure (IOP) with timolol maleate. The results are taken from an ongoing 6 year follow-up study of glaucoma suspects randomly selected for treatment and nontreat...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:The authors took advantage of the Oa1 mutant mouse in combination with other albinism mouse models (i.e., Tyrosinase and membrane-associated transporter protein [Matp]) to study the function of Oa1, the gene mutated in ocular albinism type 1, in the RPE during development and after birth. METHODS:Enzyme activi...

journal_title：Investigative ophthalmology & visual science

authors： Cortese K,Giordano F,Surace EM,Venturi C,Ballabio A,Tacchetti C,Marigo V

更新日期：2005-12-01 00:00:00

abstract：Purpose:To validate widefield autofluorescence (AF) in vivo imaging of the retina in mice expressing green fluorescent protein (gfp) in microglia, and to monitor retinal microglia reconstitution in vivo after lethal irradiation and bone marrow transplantation. Methods:Transgenic Cx3cr1gfp/gfp and wildtype Balb/c mice ...

journal_title：Investigative ophthalmology & visual science

authors： Kokona D,Schneider N,Giannakaki-Zimmermann H,Jovanovic J,Ebneter A,Zinkernagel M

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice. METHODS:To ...

journal_title：Investigative ophthalmology & visual science

authors： Tang Y,Liu X,Zoltoski RK,Novak LA,Herrera RA,Richard I,Kuszak JR,Kumar NM

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To investigate the effect of hydrogen peroxide on the epithelial cells of cultured rabbit lenses. METHODS:Lenses were cultured in minimum essential medium containing a single dose of 0.03, 0.1, or 0.2 mM H2O2. Three hours later the medium was replaced with peroxide-free minimum essential medium. Lenses were al...

journal_title：Investigative ophthalmology & visual science

authors： Reddan JR,Giblin FJ,Dziedzic DC,Wirebaugh BM,Peters JL

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：:One hypothesized cause of low-tension glaucoma is chronic or intermittent ischemia of the optic nerve. Since the optic nerve and brain are both parts of the central nervous system and share a common blood supply, the authors wondered if patients with low-tension glaucoma might also have clinical or radiographic eviden...

journal_title：Investigative ophthalmology & visual science

authors： Corbett JJ,Phelps CD,Eslinger P,Montague PR

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:Local first-order multifocal electroretinogram (mfERG) implicit time (K1-IT) delays have proved to be important and predictive indicators of retinal function in diabetes. To better understand the nature of these delays, the authors examined the spatial association between K1-IT and second-order amplitudes (K2-S...

journal_title：Investigative ophthalmology & visual science

authors： Bronson-Castain KW,Bearse MA Jr,Han Y,Schneck ME,Barez S,Adams AJ

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS:We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), ...

journal_title：Investigative ophthalmology & visual science

authors： Akashi A,Kanamori A,Nakamura M,Fujihara M,Yamada Y,Negi A

更新日期：2013-07-10 00:00:00

abstract：PURPOSE:To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Lee KM,Kim H,Kim TW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Invasion of tumor cells into blood vessels is essential for metastasis of uveal melanoma. The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients. METHODS:Between 1972 and 2007, 643 eyes primarily enucleated fo...

journal_title：Investigative ophthalmology & visual science

authors： Ly LV,Odish OF,Wolff-Rouendaal Dd,Missotten GS,Luyten GP,Jager MJ

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Although much is now understood about the molecular structure of tight junctions (TJs), little is known about the regulation of their function during neural inflammatory disease processes in vivo. The mechanisms by which leukocytes transmigrate the blood-retina barrier (BRB) without affecting endothelial permea...

journal_title：Investigative ophthalmology & visual science

authors： Xu H,Dawson R,Crane IJ,Liversidge J

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a major cause of visual impairment in developed countries. While DR has been described classically as a microvascular disease, recent evidence suggests that changes to retinal microglia are an early feature of retinopathy. In our study, we assessed changes in microglial distribution...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chen X,Rakoczy EP,McMenamin PG

更新日期：2013-01-30 00:00:00

abstract：PURPOSE:To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. METHODS:Osmotic mini-pum...

journal_title：Investigative ophthalmology & visual science

authors： Overby DR,Bertrand J,Tektas OY,Boussommier-Calleja A,Schicht M,Ethier CR,Woodward DF,Stamer WD,Lütjen-Drecoll E

更新日期：2014-07-15 00:00:00

abstract：:The rhodopsin content of the human retina was determined spectrophotometrically. Retinas were removed completely by using an in vitro technique based on a simulation of retinal detachment. This method provides a total recovery of rod outer segments which contain the rhodopsin visual pigment or its apoprotein, opsin. U...

journal_title：Investigative ophthalmology & visual science

authors： van Kuijk FJ,Lewis JW,Buck P,Parker KR,Kliger DS

更新日期：1991-06-01 00:00:00

abstract：PURPOSE:To investigate the protective effect of pioglitazone on the rat retina after ischemia/reperfusion (I/R) injury and to explore its possible mechanisms. METHODS:Retinal ischemia was induced by increasing the intraocular pressure to 110 mm Hg for 60 minutes, and pioglitazone was delivered 3 hours before the I/R. ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang XY,Xiao YQ,Zhang Y,Ye W

更新日期：2013-06-06 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：PURPOSE:To compare action spectra for visual discomfort in the fovea and the parafovea and to determine the effect of macular pigment (MP). METHODS:Visual discomfort thresholds to lights from 440 to 600 nm were obtained for six young (<35 y), visually normal subjects with a wide range of MP densities (0.10-0.71 at 30'...

journal_title：Investigative ophthalmology & visual science

authors： Stringham JM,Snodderly DM

更新日期：2013-09-19 00:00:00

abstract：Purpose:To ascertain cellular constituents within islands of preserved retina in choroideremia (CHM) by multimodal imaging. Methods:CHM probands (16) and female carriers (9) of CHM were studied. Near-infrared autofluorescence (NIR-AF; 787-nm excitation; emission, >830 nm), short-wavelength autofluorescence (SW-AF; 488...

journal_title：Investigative ophthalmology & visual science

authors： Paavo M,Carvalho JRL Jr,Lee W,Sengillo JD,Tsang SH,Sparrow JR

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To understand the pathophysiology of human retinal degenerations caused by mutations in the peripherin/RDS gene. METHODS:Three families with autosomal dominant retinal degeneration were found to have mutations in the peripherin/RDS gene. There were two frameshift mutations: a 1-base pair (bp) insertion at codo...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Kemp CM,Sheffield VC,Stone EM

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:To create a binocular statistical eye model based on previously measured ocular biometric data. METHODS:Thirty-nine parameters were determined for a group of 127 healthy subjects (37 male, 90 female; 96.8% Caucasian) with an average age of 39.9 ± 12.2 years and spherical equivalent refraction of -0.98 ± 1.77 D...

journal_title：Investigative ophthalmology & visual science

authors： Rozema JJ,Atchison DA,Tassignon MJ

更新日期：2011-06-23 00:00:00

abstract：PURPOSE:To ablate retina and vitreous membranes using the 193-nm argon fluoride excimer laser in a fluid medium. METHODS:A special delivery system for the 193-nm excimer laser was developed that enabled the delivery of the laser into high-absorption liquid environments. The system was tested on the retina in an in vit...

journal_title：Investigative ophthalmology & visual science

authors： Palanker D,Hemo I,Turovets I,Zauberman H,Fish G,Lewis A

更新日期：1994-10-01 00:00:00

abstract：:Exposure of adult male and female albino rats to high-intensity illumination for 17.5 hr results in a marked, transient exophthalmos, which persists for approximately 48 hr after the light exposure. Upon examination of the Harderian glands in these rats, a significant glandular weight increase was observed up to 2 day...

journal_title：Investigative ophthalmology & visual science

authors： Johnson DD,Rudeen PK,O'Steen WK

更新日期：1979-12-01 00:00:00