Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.

abstract：PURPOSE:To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. METHODS:TM specimens were collected from 146 patie...

journal_title：Investigative ophthalmology & visual science

authors： Fernández-Durango R,Fernández-Martínez A,García-Feijoo J,Castillo A,de la Casa JM,García-Bueno B,Pérez-Nievas BG,Fernández-Cruz A,Leza JC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To determine variations in eye volume, surface area, and shape with refractive error in young children using a three-dimensional magnetic resonance imaging (MRI) model. METHODS:A subset of Singaporean Chinese boys enrolled in the population-based Strabismus, Amblyopia, and Refractive Error in Singapore (STARS)...

journal_title：Investigative ophthalmology & visual science

authors： Lim LS,Yang X,Gazzard G,Lin X,Sng C,Saw SM,Qiu A

更新日期：2011-11-17 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To determine the intergrader reproducibility for computer-assisted grading of optical coherence tomography (OCT) images in eyes with neovascular age-related macular degeneration (AMD), by using a standardized grading procedure. METHODS:Sixty OCT image sets (of six radial lines each) were independently analyzed...

journal_title：Investigative ophthalmology & visual science

authors： Joeres S,Tsong JW,Updike PG,Collins AT,Dustin L,Walsh AC,Romano PW,Sadda SR

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To evaluate the absolute blood flow rate in a single choroidal vessel using Doppler optical coherence tomography (OCT). METHODS:Three choroidal vessels were selected in the right eye of three normal subjects, and were measured with Doppler OCT at a 1020-nm probe wavelength. The pulsatile change of the blood fl...

journal_title：Investigative ophthalmology & visual science

authors： Miura M,Makita S,Iwasaki T,Yasuno Y

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Macular drusen are hallmarks of age-related maculopathy (ARM), but these focal extracellular lesions also appear with age in the peripheral retina. The present study was conducted to determine regional differences in morphology that contribute to the higher vulnerability of the macula to advanced disease. METH...

journal_title：Investigative ophthalmology & visual science

authors： Rudolf M,Clark ME,Chimento MF,Li CM,Medeiros NE,Curcio CA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Previous studies assessed the associations between Helicobacter pylori infection and open-angle glaucoma (OAG) and produced inconsistent results. Therefore, we performed a meta-analysis to evaluate the effects of H. pylori infection on OAG risk. METHODS:Relevant studies that reported the associations between H...

journal_title：Investigative ophthalmology & visual science

authors： Zeng J,Liu H,Liu X,Ding C

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To obtain quantitative data on the optic disc excavation in children affected by cerebral visual impairment (CVI) by using the Heidelberg Retinal Tomograph (HRT)-II (Heidelberg Engineering, Heidelberg, Germany). METHODS:A total of 24 subjects affected by CVI (mean age, 7.28 years) were examined: 16 in alert co...

journal_title：Investigative ophthalmology & visual science

authors： Ruberto G,Salati R,Milano G,Bertone C,Tinelli C,Fazzi E,Guagliano R,Signorini S,Borgatti R,Bianchi A,Bianchi PE

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：:Checkerboard reversal stimuli were used to evoke transient pattern electroretinograms (P-ERGs) from the eyes of 14 patients with amblyopia and 14 normal subjects. In the control group, and in normal eyes of patients, pattern electroretinograms were obtained with monocular central fixation. Amblyopic eyes were examined...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Welge-Lüssen L

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of retinal eccentricity on the phenomenon of dichoptic suppression of the mfVEP amplitude and to examine the relationship between the degree of simulated unilateral visual impairment and the possible release of dichoptic suppression in the contralateral eye. METHOD:Eight subjects with...

journal_title：Investigative ophthalmology & visual science

authors： Leaney J,Klistorner A,Arvind H,Graham SL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：Purpose:The measurement of achromatic sensitivity has been an important tool for monitoring subtle changes in vision as the result of disease or response to therapy. In this study, we aimed to provide a normative data set for achromatic and chromatic contrast sensitivity functions within a common cone contrast space us...

journal_title：Investigative ophthalmology & visual science

authors： Kim YJ,Reynaud A,Hess RF,Mullen KT

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To investigate morphological characteristics of optic nerve head and peripapillary region with myopia and glaucoma. METHODS:Ten normal and 17 glaucomatous myopic participants were imaged with a custom 1060-nm swept-source optical coherence tomography system. The three-dimensional images were processed and segm...

journal_title：Investigative ophthalmology & visual science

authors： Lee S,Han SX,Young M,Beg MF,Sarunic MV,Mackenzie PJ

更新日期：2014-06-03 00:00:00

abstract：PURPOSE:We investigated the therapeutic effect of liposomal doxorubicin (Lipo-dox) on experimental proliferative vitreoretinopathy (PVR). METHODS:The toxicity of Lipo-dox was determined in vitro in cultured rabbit retinal pigment epithelium (RPE) cells by tetrazolium-based (MTT) assay for cell viability performed 48 a...

journal_title：Investigative ophthalmology & visual science

authors： Kuo HK,Chen YH,Wu PC,Wu YC,Huang F,Kuo CW,Lo LH,Shiea J

更新日期：2012-06-29 00:00:00

abstract：PURPOSE:Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European populati...

journal_title：Investigative ophthalmology & visual science

authors： Beatty S,Murray IJ,Henson DB,Carden D,Koh H,Boulton ME

更新日期：2001-02-01 00:00:00

abstract：:Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4....

journal_title：Investigative ophthalmology & visual science

authors： Braakman R,van der Valk P,van Delft JL,de Wolff-Rouendaal D,Oosterhuis JA

更新日期：1989-05-01 00:00:00

abstract：:Intravitreal membranes from patients with proliferative vitreoretinopathy (PVR) consist partly of retinal glial (RG) and retinal pigment epithelial (RPE) cells surrounded by varying amounts of extracellular matrix (ECM). The contribution of the ECM to the growth of PVR membranes is unknown. This study was undertaken t...

journal_title：Investigative ophthalmology & visual science

authors： Williams DF,Burke JM

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:This study determined whether adenovirus-mediated transfer of the murine interferon-beta (AdCMVIFN-beta) gene protects against liver metastases arising from intraocular melanomas in mice. METHODS:A replication-deficient adenovirus vector (AdCMVIFN-beta) was used for the in vivo transfer of the murine IFN-beta ...

journal_title：Investigative ophthalmology & visual science

authors： Alizadeh H,Howard K,Mellon J,Mayhew E,Rusciano D,Niederkorn JY

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To investigate in vitro the cell toxicity and antioxidant effects of two major tear substitutes, hyaluronic acid and a widely used carbomer, with and without preservative. METHODS:Chang conjunctival cells were treated with different concentrations of unpreserved or preserved carbomer 934P (0.03% and 0.3%), unp...

journal_title：Investigative ophthalmology & visual science

authors： Debbasch C,De La Salle SB,Brignole F,Rat P,Warnet JM,Baudouin C

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To investigate the effect of nerve growth factor (NGF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a rabbit model after PRK and correlate the findings with functional tear test. METHODS:Unilateral PRK was performed on 21 New Zealand albino rabbits. Three groups, each consist...

journal_title：Investigative ophthalmology & visual science

authors： Esquenazi S,Bazan HE,Bui V,He J,Kim DB,Bazan NG

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Modalities for inhibiting neovascularization may be one avenue to the development of effective therapies for retinopathy. The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model. METHODS:OIR was induced in C57BL6 mice by a 5-day exposure to 75...

journal_title：Investigative ophthalmology & visual science

authors： Higgins RD,Sanders RJ,Yan Y,Zasloff M,Williams JI

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:The role of macular pigment (MP) in age-related maculopathy (ARM) is still not clearly understood. Recent studies have reported on variations in the spatial distribution of MP optical density (MPOD) including a secondary peak ("ring") in the slope of the MPOD profile. The authors investigated in a cross-section...

journal_title：Investigative ophthalmology & visual science

authors： Dietzel M,Zeimer M,Heimes B,Pauleikhoff D,Hense HW

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transdu...

journal_title：Investigative ophthalmology & visual science

authors： Binley K,Widdowson P,Loader J,Kelleher M,Iqball S,Ferrige G,de Belin J,Carlucci M,Angell-Manning D,Hurst F,Ellis S,Miskin J,Fernandes A,Wong P,Allikmets R,Bergstrom C,Aaberg T,Yan J,Kong J,Gouras P,Prefontaine A,

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To study heterogeneity for chromosome 3 copy number in mixed choroidal melanoma with discrete populations of spindle and epithelioid cells using chromosome in situ hybridization (CISH) and to correlate chromosomal loss with cell type. METHODS:Twenty-two archival cases of choroidal melanoma with discrete popula...

journal_title：Investigative ophthalmology & visual science

authors： Sandinha T,Farquharson M,McKay I,Roberts F

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To study reading acuity in children and assess the reliability of its measurement using the Italian version of the MNREAD reading chart. METHODS:One hundred sixteen children from grades 3 to 8 with normal near vision were tested at a pediatric eye care institution in northeastern Italy. Visual acuity was evalu...

journal_title：Investigative ophthalmology & visual science

authors： Virgili G,Cordaro C,Bigoni A,Crovato S,Cecchini P,Menchini U

更新日期：2004-09-01 00:00:00

abstract：Purpose:To determine the long-term safety and efficacy of WST-D/near-infrared (NIR) corneal stiffening. Methods:One eye of 23 New Zealand White rabbits was de-epithelialized mechanically followed by topical application of 2.5 mg/mL WST11, combined with dextran-500 (WST-D) for 20 minutes. Subsequently, samples were irr...

journal_title：Investigative ophthalmology & visual science

authors： Brekelmans J,Goz A,Dickman MM,Brandis A,Sui X,Wagner HD,Nuijts RMMA,Scherz A,Marcovich AL

更新日期：2017-08-01 00:00:00

abstract：:The visual field of normal infants was assessed using a perimeter with LED stimuli and a forced-choice observation procedure. Central fixation was elicited by four central, pulsing LEDs and maintained with the aid of auditory stimuli. Field extent was derived from the four-alternative, forced-choice judgments of an ad...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Cummings MF

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:Air puff systems have been presented recently to measure corneal biomechanical properties in vivo. In our study we tested the influence of several factors on corneal deformation to an air puff: IOP, corneal rigidity, dehydration, presence of sclera, and in vivo versus in vitro conditions. METHODS:We used 14 fr...

journal_title：Investigative ophthalmology & visual science

authors： Kling S,Marcos S

更新日期：2013-07-26 00:00:00

abstract：PURPOSE:Sildenafil increases ocular blood flow. Thus, the authors investigated if it also increases anterior chamber (AC) refilling after paracentesis. METHODS:Corriedale sheep and albino rabbits were used as animal models. Intraocular pressure (IOP) was measured, paracentesis performed on one eye, and AC refilling fo...

journal_title：Investigative ophthalmology & visual science

authors： Gerometta R,Alvarez LJ,Candia OA

更新日期：2012-02-01 00:00:00