Normal pattern electroretinograms in amblyopia.

abstract：PURPOSE:To describe an in vivo mouse model for the study of recurrent corneal erosion syndrome (RCES) in mice and to characterize the changes in alpha9 integrin expression during wound healing. METHODS:Corneal epithelial debridement wounds of two sizes (1.5 and 2.5 mm) were made on the ocular surface of BALB/c mice an...

journal_title：Investigative ophthalmology & visual science

authors： Pal-Ghosh S,Pajoohesh-Ganji A,Brown M,Stepp MA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To compare the effects of early, mid, and late subconjunctival injection of bevacizumab on corneal neovascularization (NV) and conjunctivalization in a rabbit limbal insufficiency model. METHODS:Limbal insufficiency was created surgically, and subconjunctival injections of 2.5 mg bevacizumab twice weekly for 1...

journal_title：Investigative ophthalmology & visual science

authors： Lin CT,Hu FR,Kuo KT,Chen YM,Chu HS,Lin YH,Chen WL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether human corneal epithelial cells and keratocytes synthesize both the soluble and membrane forms of the type II IL-1 receptor (IL-1RII). METHODS:Primary cell cultures of human corneal epithelial cells and keratocytes were established from human corneas. RT-PCR wa...

journal_title：Investigative ophthalmology & visual science

authors： Cubitt CL,Lausch RN,Oakes JE

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:We characterized fluorescent bone marrow cells (YFP(+) BMCs) in the thy1-YFP mouse and determine if they promote trigeminal ganglion (TG) cell neurite growth. METHODS:Excimer laser annular keratectomy was performed in thy1-YFP mice, and corneas were imaged. BMCs were harvested from femur and tibia, and the exp...

journal_title：Investigative ophthalmology & visual science

authors： Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S

更新日期：2013-09-03 00:00:00

abstract：PURPOSE:To evaluate diurnal intraocular pressure (DIOP) among individuals with primary angle closure (PAC) or primary angle-closure suspect (PACS). Additionally, the hypothesis that greater DIOP fluctuation is related to smaller angle parameters was investigated. METHODS:Forty Caucasian newly referred untreated patien...

journal_title：Investigative ophthalmology & visual science

authors： Sanchez-Parra L,Pardhan S,Buckley RJ,Parker M,Bourne RR

更新日期：2015-05-01 00:00:00

abstract：:The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated via a reduction in aqueous outflow through the conventional (trabecular meshwork and Schlemm's canal) outflow pathway. Current IOP lowering pharmacological strategies target the uveoscleral (nonconventional) outflow pathway or ...

journal_title：Investigative ophthalmology & visual science

authors： Cavet ME,Vittitow JL,Impagnatiello F,Ongini E,Bastia E

更新日期：2014-08-14 00:00:00

abstract：Purpose:To validate the prediction accuracy of variational Bayes linear regression (VBLR) with two datasets external to the training dataset. Method:The training dataset consisted of 7268 eyes of 4278 subjects from the University of Tokyo Hospital. The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG) da...

journal_title：Investigative ophthalmology & visual science

authors： Murata H,Zangwill LM,Fujino Y,Matsuura M,Miki A,Hirasawa K,Tanito M,Mizoue S,Mori K,Suzuki K,Yamashita T,Kashiwagi K,Shoji N,Asaoka R

更新日期：2018-04-01 00:00:00

abstract：Purpose:To examine the impact of small pupils and light levels on reading performance of distance-corrected presbyopes. To determine whether small pupils would enable presbyopes to read at near even at low light levels. Methods:To establish the lower range of text luminances, we quantified the space-averaged luminance...

journal_title：Investigative ophthalmology & visual science

authors： Xu R,Gil D,Dibas M,Hare W,Bradley A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To quantify the role of anterior zonular tension on the optomechanical lens response during simulation of accommodation in primates. METHODS:Postmortem cynomolgus monkey eyes (n = 14; age range, 3.0-11.5 years) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, ...

journal_title：Investigative ophthalmology & visual science

authors： Nankivil D,Manns F,Arrieta-Quintero E,Ziebarth N,Borja D,Amelinckx A,Bernal A,Ho A,Parel JM

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To compare the mydriatic effect and the short-term corneal endothelial safety of intracamerally injected N-methyl-3,4-dihydroxyphenylamine (epinine) to phenylephrine in a porcine eye model. METHODS:One hundred twelve eyes from newly slaughtered pigs were used in this study. After pretreatment with 20 mg intrac...

journal_title：Investigative ophthalmology & visual science

authors： Lundberg B,Behndig A

更新日期：2009-11-01 00:00:00

abstract：:The first heritable model of retinoblastoma was established by retina-specific expression of simian virus 40 T-antigen (SV40 T-ag) in transgenic mice. Bilateral, multifocal ocular tumors were observed in 100% of transgene-bearing mice. Central nervous system neoplasms occurred at a lower rate (27%) and represented the...

journal_title：Investigative ophthalmology & visual science

authors： Marcus DM,Carpenter JL,O'Brien JM,Kivela T,Brauner E,Tarkkanen A,Virtanen I,Albert DM

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:To assess the impact on visual function of community glaucoma screening in an African American population using spectral-domain optical coherence tomography (SD-OCT). METHODS:Using a Monte Carlo microsimulation model with a 10-year time horizon, we analyzed the efficacy of SD-OCT screening on visual field outc...

journal_title：Investigative ophthalmology & visual science

authors： Blumberg DM,Vaswani R,Nong E,Al-Aswad L,Cioffi GA

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. METHODS:The binding affinities and agonistic activities of ONO-AG-367, a carboxy...

journal_title：Investigative ophthalmology & visual science

authors： Yamane S,Karakawa T,Nakayama S,Nagai K,Moriyuki K,Neki S,Suto F,Kambe T,Hirota Y,Kawabata K

更新日期：2015-04-01 00:00:00

abstract：:Docosapentaenoic acid (22:5 omega 6), a minor constituent (less than 4%) of photoreceptor outer segment membranes in all vertebrate species examined to date, comprises 23% of the fatty acids in total lipids from rabbit outer segment membranes. This fatty acid is a significant constituent of each of the three major pho...

journal_title：Investigative ophthalmology & visual science

authors： Nielsen JC,Maude MB,Hughes H,Anderson RE

更新日期：1986-02-01 00:00:00

abstract：:Posterior eye cups of the frog Rana ridibunda were prefixed in the presence of tannic acid, osmicated and stained en bloc with uranyl acetate. Electron microscopy revealed the following features of membrane traffic in cells of the retinal pigment epithelium (RPE): (1) intracellular membranes with increased electron de...

journal_title：Investigative ophthalmology & visual science

authors： Rungger-Brändle E,Englert U,Leuenberger PM

更新日期：1987-12-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur i...

journal_title：Investigative ophthalmology & visual science

authors： Sotozono C,Ueta M,Yokoi N

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:MicroRNAs (miRNAs) are small, stable, noncoding RNA molecules with regulatory function and marked tissue specificity that posttranscriptionally regulate gene expression. However, their role in fungal keratitis remains unknown. The purpose of this study was to identify the miRNA profile and its regulatory role i...

journal_title：Investigative ophthalmology & visual science

authors： Boomiraj H,Mohankumar V,Lalitha P,Devarajan B

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To identify major gangliosides - the sialated glycolipids - of corneal epithelium; to determine which specific gangliosides, if any, are synthesized in a higher amount or are downregulated during corneal epithelial cell migration; and to determine what role, if any, they play in the modulation of corneal epithe...

journal_title：Investigative ophthalmology & visual science

authors： Yang Z,Zhao Z,Panjwani N

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：PURPOSE:The increase of nerve growth factor (NGF) plasma levels in vernal keratoconjunctivitis (VKC) patients has been demonstrated previously. Results of numerous studies in vitro and in vivo have shown that NGF modulates the synthesis of substance P (SP), a neuropeptide involved in the pathogenesis of human allergic ...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Micera A,Tirassa P,Magrini L,Bonini S,Aloe L

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:Retinal ganglion cells die by apoptosis during development and after trauma such as axonal damage and exposure to excitotoxins. Apoptosis is associated with changes in the expression of genes that regulate this process. The genes that regulate apoptosis in retinal ganglion cells have not been characterized prim...

journal_title：Investigative ophthalmology & visual science

authors： Li Y,Schlamp CL,Nickells RW

更新日期：1999-04-01 00:00:00

abstract：:Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outsi...

journal_title：Investigative ophthalmology & visual science

authors： Panda S,Jonas JB

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To assess structural, functional, and visual behavioral relationships in mutant rhodopsin transgenic (Tg) rats and to determine whether early optokinetic tracking (OKT) visual experience, known to permanently elevate visual thresholds in normal rats, can enhance vision in rats with photoreceptor degeneration. ...

journal_title：Investigative ophthalmology & visual science

authors： McGill TJ,Prusky GT,Douglas RM,Yasumura D,Matthes MT,Lowe RJ,Duncan JL,Yang H,Ahern K,Daniello KM,Silver B,LaVail MM

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To determine whether complement-derived SC5b-9, the soluble nonlytic-fluid phase of the membrane attack complex, can be generated in normal human corneas when they are injured with lipopolysaccharide (LPS), ribitol teichoic acid (RTA) immune complexes, acid, or alkali. METHODS:The experimental cornea of each d...

journal_title：Investigative ophthalmology & visual science

authors： Mondino BJ,Chou HJ,Sumner HL

更新日期：1996-07-01 00:00:00

abstract：Purpose:To investigate the application of optical coherence tomography angiography (OCT-A) in evaluation of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Methods:Patients with GA were prospectively enrolled and studied with blue fundus autofluorescence (FAF), en face structural OCT, and ...

journal_title：Investigative ophthalmology & visual science

authors： Corbelli E,Sacconi R,Rabiolo A,Mercuri S,Carnevali A,Querques L,Bandello F,Querques G

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD), the most common cause of incurable blindness in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells cu...

journal_title：Investigative ophthalmology & visual science

authors： Songstad AE,Wiley LA,Duong K,Kaalberg E,Flamme-Wiese MJ,Cranston CM,Riker MJ,Levasseur D,Stone EM,Mullins RF,Tucker BA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Diabetes mellitus has been shown to be associated with and complicated by dry eye syndrome. We sought to examine and compare the tear film proteome of type 2 diabetic patients with or without dry eye syndrome and normal subjects using two-dimensional nano-liquid chromatography coupled with tandem mass spectrome...

journal_title：Investigative ophthalmology & visual science

authors： Li B,Sheng M,Xie L,Liu F,Yan G,Wang W,Lin A,Zhao F,Chen Y

更新日期：2014-01-09 00:00:00

abstract：PURPOSE:To assess the prevalence, distribution, and demographic associations of refractive error in an urban population in southern India. METHODS:Two thousand five hundred twenty-two subjects of all ages, representative of the Hyderabad population, were examined in the population-based Andhra Pradesh Eye Disease Stud...

journal_title：Investigative ophthalmology & visual science

authors： Dandona R,Dandona L,Naduvilath TJ,Srinivas M,McCarty CA,Rao GN

更新日期：1999-11-01 00:00:00

abstract：:Retinal leukocyte velocity and density were estimated using blue-field entoptic imaging techniques in a controlled double-masked study to determine the relative effects of oxygen and carbon dioxide on perimacular hemodynamics in single eyes of ten normal human subjects. Mild hypoxia (inspiration of 16% O2) did not sig...

journal_title：Investigative ophthalmology & visual science

authors： Sponsel WE,DePaul KL,Zetlan SR

更新日期：1992-05-01 00:00:00