Exocytic clearing of degraded membrane material from pigment epithelial cells in frog retina.

abstract：:Flow cytometry (FCM) was used to investigate antigenic expression and modulation during the cell cycle of Y-79 and WERI-Rb1 tissue cultured retinoblastoma cell lines using a polyclonal anti-Y-79 antibody and fluorescein conjugated lectins. Several Y-79 resting cell populations were identified by FCM analysis of antibo...

journal_title：Investigative ophthalmology & visual science

authors： Felberg NT,Augsburger JJ,Shields JA,Goldschmidt J,Pronesti G,Haimowitz A

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:To characterize the possible role of transducin Gtβγ-complex in modulating the signaling properties of photoactivated rhodopsin and its lifetime in rod disc membranes and intact rods. METHODS:Rhodopsin photolysis was studied using UV-visible spectroscopy and rapid scanning spectroscopy in the presence of hydro...

journal_title：Investigative ophthalmology & visual science

authors： Lomonosova E,Kolesnikov AV,Kefalov VJ,Kisselev OG

更新日期：2012-03-09 00:00:00

abstract：:The authors used a psychophysical method to measure lens transmission of young, type I diabetic patients and normal controls. The results from normal controls agreed with previously published reports of decreasing lens transmission with age, and those from diabetic subjects suggested that lenses of young, type I diabe...

journal_title：Investigative ophthalmology & visual science

authors： Lutze M,Bresnick GH

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：Purpose:To investigate the optimal procedures for multichannel visually evoked potentials (VEPs) to detect misrouting in albinism subjects. Methods:Investigations were done in a phenotypically heterogeneous group of 180 albinism subjects and 187 controls with and without ocular pathology. We retrospectively compared s...

journal_title：Investigative ophthalmology & visual science

authors： Kruijt CC,de Wit GC,Talsma HE,Schalij-Delfos NE,van Genderen MM

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:To validate velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model. METHODS:A 30-mL syringe filled with skim milk was inserted into a syringe pump. Intravenous (i.v.) tubing connected the syringe within the pump to a glass capillary tube (inter...

journal_title：Investigative ophthalmology & visual science

authors： Kagemann L,Wollstein G,Ishikawa H,Townsend KA,Schuman JS

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:MicroRNAs (miRNAs) are small, stable, noncoding RNA molecules with regulatory function and marked tissue specificity that posttranscriptionally regulate gene expression. However, their role in fungal keratitis remains unknown. The purpose of this study was to identify the miRNA profile and its regulatory role i...

journal_title：Investigative ophthalmology & visual science

authors： Boomiraj H,Mohankumar V,Lalitha P,Devarajan B

更新日期：2015-12-01 00:00:00

abstract：:Monkeys eyes were fixed with glutaraldehyde in vivo at positive intraocular pressure of 35 or 25 mm Hg and compared with eyes fixed without a positive pressure gradient, with the use of light microscopy and transmission and scanning electron microscopy. The entire endothelial lining of the inner wall of Schlemm's cana...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone MA

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:Dysregulation of the extracellular matrix (ECM) plays an important role in the pathogenesis of age-related macular degeneration (AMD). Elastin is a fibrous protein constituent of the ECM, degradation of which may be detected by the presence of serum elastin-derived peptides (S-EDPs) in circulation. This study w...

journal_title：Investigative ophthalmology & visual science

authors： Sivaprasad S,Chong NV,Bailey TA

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Amino-amide or amino-ester local anesthetics, which are currently used for topical ocular anesthesia, are short acting and may delay corneal healing with long-term use. In contrast, site 1 sodium channel blockers (S1SCBs) are potent local anesthetics with minimal adverse tissue reaction. In this study, we exami...

journal_title：Investigative ophthalmology & visual science

authors： McAlvin JB,Zhan C,Dohlman JC,Kolovou PE,Salvador-Culla B,Kohane DS

更新日期：2015-06-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) inoculated directly into the anterior chamber of the mouse eye induced an acute inflammatory process in both the injected eye and its uninjected (contralateral) counterpart. In the former, a rapid intense inflammatory reaction developed in the anterior segment (cornea, anterior cham...

journal_title：Investigative ophthalmology & visual science

authors： Whittum JA,McCulley JP,Niederkorn JY,Streilein JW

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight pro...

journal_title：Investigative ophthalmology & visual science

authors： Weber BH,Lin B,White K,Kohler K,Soboleva G,Herterich S,Seeliger MW,Jaissle GB,Grimm C,Reme C,Wenzel A,Asan E,Schrewe H

更新日期：2002-08-01 00:00:00

abstract：Purpose:Mesopic flash electroretinography (fERG) as a tool to identify N-methyl-d-aspartate receptor (NMDAR) hypofunction in subjects with schizophrenia shows great potential. We report the first fERG study in a genetic mouse model of schizophrenia characterized by NMDAR hypofunction from gene silencing of serine racem...

journal_title：Investigative ophthalmology & visual science

authors： Torres Jimenez N,Lines JW,Kueppers RB,Kofuji P,Wei H,Rankila A,Coyle JT,Miller RF,McLoon LK

更新日期：2020-02-07 00:00:00

abstract：Purpose:To enumerate the ocular surface fungal microbiome of healthy human eyes by using next-generation sequencing (NGS). Methods:Tarsal and fornix conjunctiva from the lower and upper lids of both eyes of healthy individuals were swabbed in duplicate separately. A total of 34 samples were collected from both the eye...

journal_title：Investigative ophthalmology & visual science

authors： Shivaji S,Jayasudha R,Sai Prashanthi G,Kalyana Chakravarthy S,Sharma S

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:To evaluate and compare the use of the Kowa laser flare cell meter and intravenous anterior chamber fluorophotometry in assessment of the blood-aqueous barrier after cataract surgery. METHOD:Laser flare and cell measurements and fluorophotometry were performed at 1 and 3 months after surgery in 48 eyes of 44 p...

journal_title：Investigative ophthalmology & visual science

authors： Shah SM,Spalton DJ,Allen RJ,Smith SE

更新日期：1993-10-01 00:00:00

abstract：Purpose:IFT81, a core component of the IFT-B complex, involved in the bidirectional transport of ciliary proteins, has been recently implicated in syndromic ciliopathies. However, none of the IFT-B core complex proteins have been associated with nonsyndromic retinal dystrophies. Given the importance of ciliary transpor...

journal_title：Investigative ophthalmology & visual science

authors： Dharmat R,Liu W,Ge Z,Sun Z,Yang L,Li Y,Wang K,Thomas K,Sui R,Chen R

更新日期：2017-05-01 00:00:00

abstract：Purpose:To investigate the association of microRNA (miRNA) copy number variants (CNVs) with acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) and to assess underlying disease mechanisms. Methods:This study included 768 patients with AAU+AS+ or AAU+AS- and 660 controls from a Chinese Han populati...

journal_title：Investigative ophthalmology & visual science

authors： Yang L,Du L,Yue Y,Huang Y,Zhou Q,Cao S,Qi J,Liang L,Wu L,Wang C,Ye Z,Tian Y,Kijlstra A,Hou S,Yang P

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:The organization of scleral collagen helps to determine the eye's biomechanical response to intraocular pressure (IOP), and may therefore be important in glaucoma. This study provides a quantitative assessment of changes in scleral collagen fibril organization in bead-induced murine experimental glaucoma. METH...

journal_title：Investigative ophthalmology & visual science

authors： Pijanka JK,Kimball EC,Pease ME,Abass A,Sorensen T,Nguyen TD,Quigley HA,Boote C

更新日期：2014-09-16 00:00:00

abstract：PURPOSE:Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular gl...

journal_title：Investigative ophthalmology & visual science

authors： Vorwerk CK,Naskar R,Schuettauf F,Quinto K,Zurakowski D,Gochenauer G,Robinson MB,Mackler SA,Dreyer EB

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To investigate the biometric characteristics of eyes with idiopathic central serous chorioretinopathy (CSC). METHODS:Medical records of 52 consecutive patients with unilateral CSC were reviewed. Central serous chorioretinopathy was diagnosed using spectral-domain optical coherence tomography (SD-OCT) and fluor...

journal_title：Investigative ophthalmology & visual science

authors： Oh JH,Oh J,Togloom A,Kim SW,Huh K

更新日期：2014-03-13 00:00:00

abstract：PURPOSE:Endocannabinoids are important modulators of synaptic transmission and plasticity throughout the central nervous system. The cannabinoid receptor type 1 (CB1R) is extensively expressed in the adult retina of rodents, while CB2R mRNA and protein expression have been only recently demonstrated in retinal tissue. ...

journal_title：Investigative ophthalmology & visual science

authors： Cécyre B,Zabouri N,Huppé-Gourgues F,Bouchard JF,Casanova C

更新日期：2013-12-11 00:00:00

abstract：Purpose:The purpose of this study was to investigate the acute effects of caffeine on retinal hemodynamics during dark to light adaptation using optical coherence tomography angiography (OCTA). Methods:Thirteen healthy individuals (13 eyes) underwent OCTA imaging after dark adaptation and at repeated intervals during ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang YS,Lee HE,Kwan CC,Schwartz GW,Fawzi AA

更新日期：2020-04-09 00:00:00

abstract：PURPOSE:Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degenerat...

journal_title：Investigative ophthalmology & visual science

authors： Marc RE,Jones BW,Anderson JR,Kinard K,Marshak DW,Wilson JH,Wensel T,Lucas RJ

更新日期：2007-07-01 00:00:00

abstract：:Cataracts were produced in cultured rat lenses by either 10 microM calcium ionophore A23187, 25 microM sodium selenite, or 30 mM xylose. E64, an inhibitor of cysteine proteases, such as calpain (EC, 3.4.22.17), reduced severity of cataract and proteolysis of crystallins when included at a 500 microM concentration in t...

journal_title：Investigative ophthalmology & visual science

authors： Shearer TR,Azuma M,David LL,Murachi T

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:Perinatal inflammatory stress in preterm babies is associated with increased rates of severe retinopathy of prematurity (ROP) and adverse neurological dysfunction. In this study, we set out to determine the consequences of severe systemic inflammatory stress on developmental retinal vascularization and evaluate...

journal_title：Investigative ophthalmology & visual science

authors： Tremblay S,Miloudi K,Chaychi S,Favret S,Binet F,Polosa A,Lachapelle P,Chemtob S,Sapieha P

更新日期：2013-12-17 00:00:00

abstract：PURPOSE:To test whether in an animal model of proliferative vitreoretinopathy (PVR) the Müller glial cells displayed an upregulation of purinergic P2 receptor-mediated responses. METHODS:PVR was induced by intravitreal injection of the proteolytic enzyme, dispase, in the eyes of adult rabbits. The developing PVR was e...

journal_title：Investigative ophthalmology & visual science

authors： Francke M,Weick M,Pannicke T,Uckermann O,Grosche J,Goczalik I,Milenkovic I,Uhlmann S,Faude F,Wiedemann P,Reichenbach A,Bringmann A

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS:An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Kaur K,Rao KN,Mandal AK,Kaur I,Parikh RS,Thomas R

更新日期：2009-01-01 00:00:00