Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis.

abstract：:Long-term S-antigen (S-Ag) specific T lymphocyte lines can induce experimental autoimmune uveoretinitis (EAU) when transferred into naive rats systemically or intravitreally. The uveitogenic lymphocyte line (ThS) stains positively for the ART 18 (IL-2 receptor) and W3/25 (T helper/inducer); negatively for OX6 (RT1B) a...

journal_title：Investigative ophthalmology & visual science

authors： Chan CC,Caspi RR,Roberge FG,Nussenblatt RB

更新日期：1988-03-01 00:00:00

abstract：:Five immunosuppressive and anti-inflammatory agents were tested for their effects on development of experimental autoimmune uveoretinitis (EAU) and immune responses to S-antigen in rats immunized with this retinal antigen. When administered daily from day 0-14 after immunization, cyclosporine at 5-20 mg/Kg was nontoxi...

journal_title：Investigative ophthalmology & visual science

authors： Mochizuki M,Nussenblatt RB,Kuwabara T,Gery I

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:To determine whether complement-derived SC5b-9, the soluble nonlytic-fluid phase of the membrane attack complex, can be generated in normal human corneas when they are injured with lipopolysaccharide (LPS), ribitol teichoic acid (RTA) immune complexes, acid, or alkali. METHODS:The experimental cornea of each d...

journal_title：Investigative ophthalmology & visual science

authors： Mondino BJ,Chou HJ,Sumner HL

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:A pilot study of human neural retinal transplantation was undertaken to investigate three major issues: whether a safe surgical procedure could be devised for transplantation of neural retinal tissue into the subretinal space, whether the transplant would be accepted in the subretinal space, and whether an impr...

journal_title：Investigative ophthalmology & visual science

authors： Humayun MS,de Juan E Jr,del Cerro M,Dagnelie G,Radner W,Sadda SR,del Cerro C

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:meso-Zeaxanthin is a carotenoid that is rarely encountered in nature outside of the vertebrate eye. It is not a constituent of a normal human diet, yet this carotenoid comprises one-third of the primate macular pigment. In the current study, we undertook a systematic approach to biochemically characterize the p...

journal_title：Investigative ophthalmology & visual science

authors： Gorusupudi A,Shyam R,Li B,Vachali P,Subhani YK,Nelson K,Bernstein PS

更新日期：2016-04-01 00:00:00

abstract：:Cone electroretinograms were elicited with a full-field red flash after-45 min of dark adaptation from 16 patients with retinitis pigmentosa and from 17 normal subjects. The average latency and implicit time of the cone a-waves recorded from the patients were each significantly delayed (p less than 0.005) compared wit...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Sullivan PL,Berson EL

更新日期：1981-11-01 00:00:00

abstract：PURPOSE:To define the inductive pathways leading to rat tear IgA antibody responses. METHODS:Fluoresceinated dinitrophenylated bovine serum albumin was encapsulated in poly(lactide-co-glycolide) microparticles and was administered by intranasal, ocular topical, or gastrointestinal routes. Histologic methods were used ...

journal_title：Investigative ophthalmology & visual science

authors： Ridley Lathers DM,Gill RF,Montgomery PC

更新日期：1998-05-01 00:00:00

abstract：Purpose:Epithelial to mesenchymal transition (EMT) is a cause of anterior and posterior subcapsular cataracts. Central to EMT is the formation of actin stress fibers. Selective targeting of actin stress fiber-associated tropomyosin (Tpm) in epithelial cells may be a means to prevent stress fiber formation and repress l...

journal_title：Investigative ophthalmology & visual science

authors： Parreno J,Amadeo MB,Kwon EH,Fowler VM

更新日期：2020-06-03 00:00:00

abstract：PURPOSE:To assess presbyopic spectacle coverage, willingness to pay, and the impact of correcting uncorrected presbyopia in individuals 40 years of age and older in Zanzibar and whether assessment of presbyopia can be incorporated into Rapid Assessment of Blindness (RAAB) surveys. METHODS:A cross-sectional, population...

journal_title：Investigative ophthalmology & visual science

authors： Laviers HR,Omar F,Jecha H,Kassim G,Gilbert C

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To identify the mutation leading to syndromic choroideremia (CHM) in two families and to define fundus autofluorescence (FAF) in CHM carriers. METHODS:The ophthalmic and clinical phenotype was investigated including FAF, neuropediatric, otorhinolaryngologic, cardiologic, and nephrologic examinations of three m...

journal_title：Investigative ophthalmology & visual science

authors： Poloschek CM,Kloeckener-Gruissem B,Hansen LL,Bach M,Berger W

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Recent evidence suggests that platelets play a major role in ischemia-reperfusion injury, not only through thrombus formation but also through participation in inflammatory reactions with leukocytes. This study was designed to investigate the contribution of platelets in leukocyte recruitment to inflamed region...

journal_title：Investigative ophthalmology & visual science

authors： Nishijima K,Kiryu J,Tsujikawa A,Miyamoto K,Honjo M,Tanihara H,Nonaka A,Yamashiro K,Katsuta H,Miyahara S,Honda Y,Ogura Y

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:We described the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). METHODS:Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteri...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Fung S,Karampelas M,Sadda SR,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2014-01-21 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：:Herpetic stromal disease often is treated with combinations of antiviral agents and corticosteroids. The addition of steroids to the antiviral treatment regimen frequently increases the efficacy of therapy in patients; however, many complications may arise as a result of corticosteroid therapy. Using a rabbit model, t...

journal_title：Investigative ophthalmology & visual science

authors： O'Brien WJ,Taylor JL

更新日期：1991-08-01 00:00:00

abstract：:Accurate assessment of ocular alignment in monkeys is difficult because typical clinical methods require extensive cooperation by the subject or provide only a rough estimate of the misalignment. Recently, Brodie derived a geometrical model for determining the Hirschberg ratio in humans, and validated it photographica...

journal_title：Investigative ophthalmology & visual science

authors： Quick MW,Boothe RG

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:We evaluated the relationship between cone photoreceptor packing density and outer nuclear layer (ONL) thickness within the central 15 degrees. METHODS:Individual differences for healthy subjects in cone packing density and ONL thickness were examined in 8 younger and 8 older subjects, mean age 27.2 versus 56....

journal_title：Investigative ophthalmology & visual science

authors： Chui TY,Song H,Clark CA,Papay JA,Burns SA,Elsner AE

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:To investigate the effect of ABCA4 mutation status on lipofuscin-related quantitative autofluorescence (qAF) in humans and on bisretinoid accumulation in mice. METHODS:Genotyped parents (n = 26; age 37-64 years) of patients with biallelic ABCA4-related retinopathy underwent in-depth retinal phenotyping includi...

journal_title：Investigative ophthalmology & visual science

authors： Müller PL,Gliem M,Mangold E,Bolz HJ,Finger RP,McGuinness M,Betz C,Jiang Z,Weber BH,MacLaren RE,Holz FG,Radu RA,Charbel Issa P

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Scleral proteoglycans were characterized from human donor eyes aged 2 months to 94 years to identify age-related changes in the synthesis and/or accumulation of these extracellular matrix components. METHODS:Newly synthesized proteoglycans (previously radiolabeled with 35SO4) and total accumulated scleral prot...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Achen VR,Penugonda S,Schmidt RW,Mount BA

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:Although the presence of IgG autoantibodies in the vitreous of spontaneous cases of equine recurrent uveitis (ERU) has been demonstrated, the potential role of IgM reactivities during ERU pathogenesis remains unexplored. The purpose of this study was to examine the presence of IgM autoantibodies in vitreous spe...

journal_title：Investigative ophthalmology & visual science

authors： Swadzba ME,Hirmer S,Amann B,Hauck SM,Deeg CA

更新日期：2012-01-25 00:00:00

abstract：PURPOSE:To determine the effect of age on the proportion of apoptotic cells in the RPE and cellular density in human eyes in situ. METHODS:RPE flatmounts prepared from 22 adult human cadaver eyes (11 pairs; ages 19-87) were stained for apoptotic cells by a TUNEL technique. The density of RPE cells was also measured. T...

journal_title：Investigative ophthalmology & visual science

authors： Del Priore LV,Kuo YH,Tezel TH

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. METHODS:Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose,...

journal_title：Investigative ophthalmology & visual science

authors： Fleming AD,Philip S,Goatman KA,Olson JA,Sharp PF

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To determine the effect of pyrrolidine dithiocarbamate (PDTC), a nuclear factor (NF)-kappaB inhibitor, on chemokine and chemokine receptor expression and thus elucidate the role of NF-kappaB in the pathogenesis of experimental autoimmune anterior uveitis (EAAU). METHODS:Uveitis was induced in Lewis rats with t...

journal_title：Investigative ophthalmology & visual science

authors： Yang CH,Fang IM,Lin CP,Yang CM,Chen MS

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:This study describes the expression and distribution of arrestin, phosducin, and recoverin in the cone-dominant retina of the ground squirrel Spermophilus tridecemlineatus. METHODS:mRNA expression was studied by blot hybridization of ground squirrel retinal RNA, with human and murine RNA as controls. The distr...

journal_title：Investigative ophthalmology & visual science

authors： von Schantz M,Szél A,van Veen T,Farber DB

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:To determine whether cultured retinal pigment epithelial (RPE) cells implanted in the subconjunctival space induce an immune response against autoantigens and whether an active downregulation is achieved by RPE grafts placed in the anterior chamber and within the subretinal space. METHODS:Cultured RPE cells fr...

journal_title：Investigative ophthalmology & visual science

authors： Grisanti S,Ishioka M,Kosiewicz M,Jiang LQ

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:Cataract is the most common cause of blindness in the world today, and yet there is no generally accepted treatment other than surgical intervention. Studies in rodent models designed to increase understanding of the molecular basis of cataract have shown that transforming growth factor (TGF)-beta induces morph...

journal_title：Investigative ophthalmology & visual science

authors： Hales AM,Chamberlain CG,McAvoy JW

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To examine the signal transduction pathways involved in the activation of orbital fibroblast effector functions relevant to the pathogenesis of Graves' ophthalmopathy (GO). To determine, using antisense technology, whether the c-myc protooncogene is involved in cell proliferation and glycosaminoglycan (GAG) syn...

journal_title：Investigative ophthalmology & visual science

authors： Heufelder AE,Bahn RS

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:This study was designed to examine whether retinal function can be rescued by allogeneic normal retinal pigment epithelial (RPE) grafts in Royal College of Surgeons (RCS) with retinal degeneration and, if so, whether this rescued function can be measured and followed by recording the corneal electroretinogram (...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Hamasaki D

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:To compare visual function assessment, optic disc evaluation by indirect ophthalmoscopy, and retinal nerve fiber layer analysis by optical coherence tomography (OCT) for the screening of optic pathway gliomas in pediatric patients (2-15 years old) affected by neurofibromatosis type 1. METHODS:Fifty-seven conse...

journal_title：Investigative ophthalmology & visual science

authors： Parrozzani R,Clementi M,Kotsafti O,Miglionico G,Trevisson E,Orlando G,Pilotto E,Midena E

更新日期：2013-12-17 00:00:00

abstract：PURPOSE:This study determined whether adenovirus-mediated transfer of the murine interferon-beta (AdCMVIFN-beta) gene protects against liver metastases arising from intraocular melanomas in mice. METHODS:A replication-deficient adenovirus vector (AdCMVIFN-beta) was used for the in vivo transfer of the murine IFN-beta ...

journal_title：Investigative ophthalmology & visual science

authors： Alizadeh H,Howard K,Mellon J,Mayhew E,Rusciano D,Niederkorn JY

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To investigate the dynamic effect of tear lipocalins (TLs), the major lipid-binding protein in tears, at aqueous-cornea and lipid-aqueous interfaces, and their potential contribution to surface tension in the tear film. METHODS:Human apo- and holo-TLs were applied to the aqueous subphase in a Langmuir trough, ...

journal_title：Investigative ophthalmology & visual science

authors： Glasgow BJ,Marshall G,Gasymov OK,Abduragimov AR,Yusifov TN,Knobler CM

更新日期：1999-12-01 00:00:00