Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis.

abstract：Purpose:To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A). Methods:In this case-control retrospective observational study, patients with atrophic NAION (at least 3 months after onset of sy...

journal_title：Investigative ophthalmology & visual science

authors： Augstburger E,Zéboulon P,Keilani C,Baudouin C,Labbé A

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:By their control of membrane potential and intracellular free Ca(2+) ([Ca(2+)](i)), K(+) currents are pivotal in the regulation of arterial smooth muscle tone. The goal of the present study was to identify and characterize the A-type K(+) current in retinal microvascular smooth muscle (MVSM) and to examine its ...

journal_title：Investigative ophthalmology & visual science

authors： McGahon MK,Dawicki JM,Scholfield CN,McGeown JG,Curtis TM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To examine the waveform characteristics of 37 subjects with manifest latent nystagmus (MLN) and determine the manner in which visual feedback influences the nature of the waveform. METHODS:Binocular recordings of the eye movements of all subjects were undertaken using an infrared tracking system. Subjects view...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Scallan CJ

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four...

journal_title：Investigative ophthalmology & visual science

authors： Keller KE,Kelley MJ,Acott TS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To assess whether saccadic eye movements show distinct changes in patients with early active Graves' ophthalmopathy (GO), which could serve as a diagnostic tool for early detection and treatment. METHODS:Each of two prospective studies included 10 patients with early acute GO and 10 age- and sex-matched contro...

journal_title：Investigative ophthalmology & visual science

authors： Schworm HD,Heufelder AE,Kunze A,Welge E,Boergen KP

更新日期：2000-06-01 00:00:00

abstract：:Docosapentaenoic acid (22:5 omega 6), a minor constituent (less than 4%) of photoreceptor outer segment membranes in all vertebrate species examined to date, comprises 23% of the fatty acids in total lipids from rabbit outer segment membranes. This fatty acid is a significant constituent of each of the three major pho...

journal_title：Investigative ophthalmology & visual science

authors： Nielsen JC,Maude MB,Hughes H,Anderson RE

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:To investigate the relationship between long-term glycemic control and photopic negative response (PhNR) changes in the blue flash ERG in adolescents with type 1 diabetes (T1D) without diabetic retinopathy (DR). METHODS:After light adaptation, ERG responses to 1.60 cd·s/m(2) blue (420 nm) flashes (blue flash E...

journal_title：Investigative ophthalmology & visual science

authors： McFarlane M,Wright T,Stephens D,Nilsson J,Westall CA

更新日期：2012-02-13 00:00:00

abstract：PURPOSE:Ischemia is a risk factor for eye diseases like ocular vein occlusion or glaucoma. To investigate effects of ischemia-reperfusion (I/R) a lot of different animal models are used, studying one or two different cell types, which creates heterogeneity of data. The aim of this study was to investigate the function ...

journal_title：Investigative ophthalmology & visual science

authors： Schmid H,Renner M,Dick HB,Joachim SC

更新日期：2014-04-28 00:00:00

abstract：:Five immunosuppressive and anti-inflammatory agents were tested for their effects on development of experimental autoimmune uveoretinitis (EAU) and immune responses to S-antigen in rats immunized with this retinal antigen. When administered daily from day 0-14 after immunization, cyclosporine at 5-20 mg/Kg was nontoxi...

journal_title：Investigative ophthalmology & visual science

authors： Mochizuki M,Nussenblatt RB,Kuwabara T,Gery I

更新日期：1985-02-01 00:00:00

abstract：:Previous research has demonstrated that distinct, gender-related differences exist in the morphology of the rat lacrimal gland. The purpose of the present study was to determine whether this sexual dimorphism is unique to the rat, or extends as well to other species. Lacrimal glands were collected from adult male and ...

journal_title：Investigative ophthalmology & visual science

authors： Cornell-Bell AH,Sullivan DA,Allansmith MR

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:The stratified squamous epithelial covering of the cornea provides one of the first physical and immunological lines of defense. A breach in its integrity results in a wound healing response that resolves quickly. However, under certain conditions-for example, when migrating cells are unable to adhere to the ba...

journal_title：Investigative ophthalmology & visual science

authors： Chow S,Di Girolamo N

更新日期：2014-09-18 00:00:00

abstract：PURPOSE:To characterize the interleukin (IL)-4 receptor (IL-4R) complex in human corneal fibroblasts. METHODS:The presence of IL-4R subunit mRNAs and proteins in cultured human corneal fibroblasts was examined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. The interaction of 125I-...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Fujitsu Y,Kumagai N,Nishida T

更新日期：2002-01-01 00:00:00

abstract：:Dog corneas were studied by indirect immunofluorescence with antibodies specific for pemphigus and pemphigoid antigens, laminin, and type IV collagen. The distribution of these antigens was similar to that observed in other squamous epithelia and skin. This study provides further evidence for close immunochemical simi...

journal_title：Investigative ophthalmology & visual science

authors： Cowen SJ,Anhalt GJ,Wicha MS,Sugar A,Labib RS,Diaz LA

更新日期：1981-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to demonstrate the synthesis and cellular distribution of group II phospholipase A2 and lysozyme in the main and accessory lacrimal glands. METHODS:The authors studied samples of normal main lacrimal glands of seven autopsied subjects and accessory lacrimal glands of eight patients wh...

journal_title：Investigative ophthalmology & visual science

authors： Aho HJ,Saari KM,Kallajoki M,Nevalainen TJ

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To study the effect of pars plana vitrectomy (PPV) on vitreous oxygenation (pO2) using magnetic resonance imaging (MRI). METHODS:Patients due to undergo PPV for either macular hole or epiretinal membrane were recruited. MRI scanning was performed 1 week before and at least 3 months after PPV. MRI T1 mapping wa...

journal_title：Investigative ophthalmology & visual science

authors： Simpson AR,Dowell NG,Jackson TL,Tofts PS,Hughes EH

更新日期：2013-03-21 00:00:00

abstract：PURPOSE:MRL/MpJ-+/+ (MRL/+) and MRL/MpJ-lpr/lpr (MRL/lpr) mice show spontaneous development of a T-cell-driven lacrimal gland inflammation that is a model for Sjögren syndrome. The lacrimal gland lesions in these mice were evaluated by quantitative RT-PCR for selected cytokine mRNA for the relative contributions of T-h...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Prendergast RA,Rorer EM,Hudson AP,Whittum-Hudson JA

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To test the association between elevated proportions of CD1c+ myeloid dendritic cells (mDCs) and disease activation/reactivation in noninfectious uveitis. METHODS:Noninfectious uveitis patients (n = 89) and healthy controls (n = 111) were recruited. The proportion of CD1c+ mDCs in the total dendritic cell (DC)...

journal_title：Investigative ophthalmology & visual science

authors： Chen P,Urzua CA,Knickelbein JE,Kim JS,Li Z,Hannes S,Kuo D,Chaigne-Delalande B,Armbrust K,Tucker W,Liu B,Agrón E,Sen HN,Nussenblatt RB

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To investigate the effects of an imaginary and a visual target on torsional optokinetic nystagmus (tOKN) and directional symmetry of tOKN. METHODS:Torsional OKN was induced by a rotating random dot pattern (52 degrees in diameter, constant angular velocity: +/-30 deg/sec to +/-52 deg/sec) with an imaginary or ...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki Y,Shinmei Y,Nara H,Ifukube T

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To determine the mechanism by which IL-1beta induces FGF-2 and to elucidate the signaling pathways of IL-1beta-induced FGF-2 in corneal endothelial cells (CECs). METHODS:Expression and/or activation of FGF-2, p38, ERK1/2, and Akt was analyzed by immunoblot analysis. Cell proliferation was measured by MTT assay...

journal_title：Investigative ophthalmology & visual science

authors： Lee JG,Kay EP

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:The Rd4/+ mouse inherits an autosomal dominant retinal degeneration that cosegregates with a large inversion spanning nearly all of mouse chromosome 4 (Chr 4). This inversion is homozygous lethal. The hypothesis for the study was that disruption of a gene at one of the two breakpoints in the Rd4 chromosome is r...

journal_title：Investigative ophthalmology & visual science

authors： Kitamura E,Danciger M,Yamashita C,Rao NP,Nusinowitz S,Chang B,Farber DB

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Downregulation of melanoma-associated antigens (MAAs), against which natural cytolytic T lymphocytes (CTLs) exist in humans, is one of the mechanisms that aids in evasion of immune surveillance. In view of putative re-expression strategies for MAAs during immunotherapy, this study was conducted to investigate M...

journal_title：Investigative ophthalmology & visual science

authors： van Dinten LC,Pul N,van Nieuwpoort AF,Out CJ,Jager MJ,van den Elsen PJ

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The endothelium produces nitric oxide and endothelin (ET). This study was designed to investigate the endothelium-dependent regulation of the porcine ophthalmic microcirculation. METHODS:Isolated porcine eyes were perfused with a modified Langendorff setup (Hugo Sachs Elektronik KG, Freiburg, Germany) at a per...

journal_title：Investigative ophthalmology & visual science

authors： Meyer P,Flammer J,Lüscher TF

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:Many retinal imaging instruments use infrared wavelengths to reduce the risk of light damage. However, we have discovered that exposure to infrared illumination causes a long-lasting reduction in infrared autofluorescence (IRAF). We have characterized the dependence of this effect on radiant exposure and invest...

journal_title：Investigative ophthalmology & visual science

authors： Masella BD,Williams DR,Fischer WS,Rossi EA,Hunter JJ

更新日期：2014-05-20 00:00:00

abstract：PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

journal_title：Investigative ophthalmology & visual science

authors： Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Tubby-like proteins (TULPs) are a family of four proteins, two of which have been linked to neurosensory disease phenotypes. TULP1 is a photoreceptor-specific protein that is mutated in retinitis pigmentosa, an inherited retinal disease characterized by the degeneration of rod and cone photoreceptor cells. To i...

journal_title：Investigative ophthalmology & visual science

authors： Xi Q,Pauer GJ,Ball SL,Rayborn M,Hollyfield JG,Peachey NS,Crabb JW,Hagstrom SA

更新日期：2007-06-01 00:00:00

abstract：:The uveal absorption of aqueous humor at two different intraocular pressures was measured in rhesus monkeys by sampling vortex vein blood during anterior chamber perfusion of Ringer's solution containing both fluorescein and 125I albumin. At 20 mm. Hg, an excess of fluorescein equivalent in amount to 0.45 microliter/m...

journal_title：Investigative ophthalmology & visual science

authors： Pederson JE,Gaasterland DE,MacLellan HM

更新日期：1977-11-01 00:00:00

abstract：:Selenium toxicity was investigated in cultured rabbit lenses to provide further information about the role of Ca++ in Se cataract. At a dose of 0.1 mM for 20 hr, Se induces a 10% change in Na levels within 6 hr, a 30% increase after 20 hr, and a three-fold increase within 48 hr of subsequent culture after removal of S...

journal_title：Investigative ophthalmology & visual science

authors： Hightower KR,McCready JP

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). The present study we conducted to assess whether these genes were associated with primary open-angle glaucoma (POAG),...

journal_title：Investigative ophthalmology & visual science

authors： Mabuchi F,Sakurada Y,Kashiwagi K,Yamagata Z,Iijima H,Tsukahara S

更新日期：2011-06-28 00:00:00

abstract：:Experimental esotropia was produced surgically in infant rhesus monkeys (Macaca mulatta) for brief periods of time. Electrophysiological studies of the visual cortex showed that esotropia of only 2 weeks duration in an infant monkey is sufficient to cause a marked shift of dominance in favor of the fixating eye and to...

journal_title：Investigative ophthalmology & visual science

authors： Crawford ML,von Noorden GK

更新日期：1979-05-01 00:00:00

abstract：PURPOSE:To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. METHODS:TM specimens were collected from 146 patie...

journal_title：Investigative ophthalmology & visual science

authors： Fernández-Durango R,Fernández-Martínez A,García-Feijoo J,Castillo A,de la Casa JM,García-Bueno B,Pérez-Nievas BG,Fernández-Cruz A,Leza JC

更新日期：2008-06-01 00:00:00