A comparison of the laser flare cell meter and fluorophotometry in assessment of the blood-aqueous barrier.

abstract：PURPOSE:To investigate the relationship between long-term glycemic control and photopic negative response (PhNR) changes in the blue flash ERG in adolescents with type 1 diabetes (T1D) without diabetic retinopathy (DR). METHODS:After light adaptation, ERG responses to 1.60 cd·s/m(2) blue (420 nm) flashes (blue flash E...

journal_title：Investigative ophthalmology & visual science

authors： McFarlane M,Wright T,Stephens D,Nilsson J,Westall CA

更新日期：2012-02-13 00:00:00

abstract：PURPOSE:Extremely low gestational age neonates (ELGANs) requiring oxygen therapy often experience frequent episodes of intermittent hypoxia (IH) and are at high risk for severe retinopathy of prematurity (ROP). Using an established model for oxygen-induced retinopathy (OIR), we examined the hypothesis that there is a c...

journal_title：Investigative ophthalmology & visual science

authors： Beharry KD,Cai CL,Sharma P,Bronshtein V,Valencia GB,Lazzaro DR,Aranda JV

更新日期：2013-11-19 00:00:00

abstract：:The capacities of porcine choroidal fibroblasts, retinal glial cells, and retinal pigment epithelial cells to contract collagen gels in vitro were compared. Experiments with varied cell numbers indicated that glial cells are the most effective, followed by choroidal fibroblasts and retinal pigment epithelial cells. An...

journal_title：Investigative ophthalmology & visual science

authors： Guidry C,McFarland RJ,Morris R,Witherspoon CD,Hook M

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal dominant retinitis pigmentosa in a Chinese Family. METHODS:Families were ascertained and patients underwent complete ophthalmic examinations. Blood samples were collected and DNA was extracted. A linkage scan of genomic regions containing known ...

journal_title：Investigative ophthalmology & visual science

authors： Li N,Mei H,MacDonald IM,Jiao X,Hejtmancik JF

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To validate velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model. METHODS:A 30-mL syringe filled with skim milk was inserted into a syringe pump. Intravenous (i.v.) tubing connected the syringe within the pump to a glass capillary tube (inter...

journal_title：Investigative ophthalmology & visual science

authors： Kagemann L,Wollstein G,Ishikawa H,Townsend KA,Schuman JS

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:The main purpose of this study was to develop a cell culture model of immortalized epithelium from the human cornea for drug permeability testing. METHODS:Immortalized human corneal epithelial (HCE) cells were grown on filters, with various filter materials and coating procedures. In the optimal case, HCE cell...

journal_title：Investigative ophthalmology & visual science

authors： Toropainen E,Ranta VP,Talvitie A,Suhonen P,Urtti A

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To assess the impact of amblyopia, strabismus and glasses on subjective visual and psychological function among amblyopes. METHODS:Questionnaires were administered to 120 teenagers with amblyopia (cases), with residual amblyopia after treatment, or with or without strabismus and 120 control subjects (controls)...

journal_title：Investigative ophthalmology & visual science

authors： Sabri K,Knapp CM,Thompson JR,Gottlob I

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To assess the retinal macrophage response to cannulation of the anterior chamber (AC) and acute elevation of intraocular pressure (IOP) in adult mice. METHODS:Eyes from 12-month-old C57BL/6J WT mice were subject to IOP increase (50 mm Hg for 30 minutes) by direct cannulation of the AC. Fellow eyes were either ...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chrysostomou V,Trounce IA,McMenamin PG,Crowston JG

更新日期：2013-04-30 00:00:00

abstract：PURPOSE:To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery. METHODS:A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was incr...

journal_title：Investigative ophthalmology & visual science

authors： Minguini N,Monteiro de Carvalho KM,Akaishi PM,De Luca IM

更新日期：2000-10-01 00:00:00

abstract：Purpose:To investigate the effects of tear film instability (TFI) induced by sustained tear exposure (STARE) on sensory responses to corneal cold, mechanical, and chemical stimuli. Methods:Fifteen normal subjects were enrolled. TFI was induced during 10 repeated trials of STARE. Pneumatic cold, mechanical, and chemica...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Begley CG,Simpson TL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To establish, using adaptive optics scanning laser ophthalmoscopy (AOSLO), that the retinal parafoveal capillary network is altered before the onset of diabetic retinopathy in adult patients with type 2 diabetes. METHODS:AOSLO videos were acquired in the parafoveal region of one eye from control subjects and f...

journal_title：Investigative ophthalmology & visual science

authors： Tam J,Dhamdhere KP,Tiruveedhula P,Manzanera S,Barez S,Bearse MA Jr,Adams AJ,Roorda A

更新日期：2011-11-29 00:00:00

abstract：PURPOSE:To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS:All family members underwent ophthalmic examination. Linkage analysis of candidate retinal dystrophy loci and a whole genome scan were perfo...

journal_title：Investigative ophthalmology & visual science

authors： van Lith-Verhoeven JJ,Hoyng CB,van den Helm B,Deutman AF,Brink HM,Kemperman MH,de Jong WH,Kremer H,Cremers FP

更新日期：2004-01-01 00:00:00

abstract：:Previous studies have shown that aqueous humor of calf and human eyes contains about 25 microM hydrogen peroxide. We have studied the removal of hydrogen peroxide by the outflow pathway of intact, freshly enucleated, calf eyes. Eyes were immersed under silicone oil that had a density greater than water and medium cont...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen KP,Chung ML,Anderson PJ,Johnson M,Epstein DL

更新日期：1988-06-01 00:00:00

abstract：:Photoreceptors can segregate inner segment proteins from outer segment proteins. It is uncertain whether such a sorting process occurs during disc morphogenesis in rods, thereby resulting in an outer segment plasma membrane which differs compositionally from the discs. In this study, the plasma membranes of intact, pu...

journal_title：Investigative ophthalmology & visual science

authors： Polans AS,Burton MD

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:To investigate the role of N-cadherin and hepatocyte growth factor (HGF) in the invasion of collagen type I by human retinal pigment epithelial (RPE) cells. METHODS:RPE sheets from eight human eyes were used for characterization through Western blot analysis of the expression of cadherin in total lysates or af...

journal_title：Investigative ophthalmology & visual science

authors： Van Aken EH,De Wever O,Van Hoorde L,Bruyneel E,De Laey JJ,Mareel MM

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To determine the relationship between optical coherence tomography (OCT) images of the retina and retinal substructure in vitro and in vivo. METHODS:In vitro, OCT images of human and bovine retina were acquired after sequential excimer laser ablation of the inner retinal layers. Measurements of bands in the OC...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan DS,Marshall J

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To explore connexin43 (Cx43) knockdown as an efficient treatment for corneal endothelial injury in an in vivo rat corneal scrape injury model. METHODS:Scrape injury was induced in the corneal endothelium, and immunolabeling (ZO-1, alpha-SMA, Cx43) was performed to analyze changes in Cx43 expression during woun...

journal_title：Investigative ophthalmology & visual science

authors： Nakano Y,Oyamada M,Dai P,Nakagami T,Kinoshita S,Takamatsu T

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Nystagmus, head nodding, and anomalous head position are symptoms of spasmus nutans. This disorder appears in early childhood and is thought to be self-limited. However, the visual outcome of patients with spasmus nutans is unclear. The resolution of nystagmus has not been proven with quantitative eye movement ...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Wizov SS,Reinecke RD

更新日期：1995-12-01 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:MicroRNAs (miRNAs) are small, stable, noncoding RNA molecules with regulatory function and marked tissue specificity that posttranscriptionally regulate gene expression. However, their role in fungal keratitis remains unknown. The purpose of this study was to identify the miRNA profile and its regulatory role i...

journal_title：Investigative ophthalmology & visual science

authors： Boomiraj H,Mohankumar V,Lalitha P,Devarajan B

更新日期：2015-12-01 00:00:00

abstract：:Topical application of Prostaglandin F2 alpha (PGF2 alpha) to the eye reduces intraocular pressure (IOP) in all mammalian species studied thus far, including humans. The L-isopropylester derivative is currently the one most commonly used in experimental and clinical studies. Dose-response relationships were determined...

journal_title：Investigative ophthalmology & visual science

authors： Crawford KS,Kaufman PL

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To evaluate the dynamic changes in refraction during the accommodative facility test in myopes and emmetropes. METHODS:Ten myopes and 10 emmetropes participated in the study. All were young adults, and refractive error in the myopes was corrected with soft contact lenses. Monocular accommodative facility measu...

journal_title：Investigative ophthalmology & visual science

authors： Radhakrishnan H,Allen PM,Charman WN

更新日期：2007-09-01 00:00:00

abstract：Purpose:Basement membrane degradation and macrophage aggregation at the optic fissure margins are crucial to optic fissure closure during normal murine eye development. Basement membrane degradation is also an essential step in cancer development, and matrix metalloproteinases (MMPs) play an important role. In this stu...

journal_title：Investigative ophthalmology & visual science

authors： Tsuji N,Matsuura T,Narama I,Yoshiki A,Ozaki K

更新日期：2018-03-01 00:00:00

abstract：:Bovine rod outer segments (ROS) specifically stimulate DNA synthesis in lymphocyte cultures from guinea pigs preimmunized with ROS. At doses above 10 microgram/ml protein, however, preparations of ROS inhibit DNA and RNA synthesis by the sensitized lymphocytes or by normal lymphocytes reacting to mitogens. The inhibti...

journal_title：Investigative ophthalmology & visual science

authors： Gery I

更新日期：1980-07-01 00:00:00

abstract：:Various noninvasive test procedures were used to evaluate retinal function in a patient who had become night blind following vincristine chemotherapy. The results obtained were strikingly similar to those reported previously in subjects with recessively inherited stationary night blindness; the dark-adaptation curve w...

journal_title：Investigative ophthalmology & visual science

authors： Ripps H,Carr RE,Siegel IM,Greenstein VC

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:The serum- and glucocorticoid-inducible kinase SGK1 regulates several epithelial channels and transporters, the related protein kinase B (PKB) regulates glucose transport. SGK1 is expressed in the brain and could thus regulate glial and/or neuronal transport processes. The present study explores whether SGK1 is...

journal_title：Investigative ophthalmology & visual science

authors： Schniepp R,Kohler K,Ladewig T,Guenther E,Henke G,Palmada M,Boehmer C,Rothstein JD,Bröer S,Lang F

更新日期：2004-05-01 00:00:00

abstract：Purpose:To examine the early glial reactivity and neuron damage in response to short-term cerebrospinal fluid pressure (CSFp) reduction, as compared with intraocular pressure (IOP) elevation. Methods:The experiment included 54 male Sprague-Dawley rats with elevated translaminar cribrosa pressure difference (TLPD), def...

journal_title：Investigative ophthalmology & visual science

authors： Li XX,Zhang Z,Zeng HY,Wu S,Liu L,Zhang JX,Liu Q,Yang DY,Wang NL

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To measure high-resolution eye-specific displacements and deformations induced within the human LC microstructure by an acute increase in IOP. METHODS:Six eyes from donors aged 23 to 82 were scanned using second harmonic-generated (SHG) imaging at various levels of IOP from 10 to 50 mm Hg. An image registratio...

journal_title：Investigative ophthalmology & visual science

authors： Sigal IA,Grimm JL,Jan NJ,Reid K,Minckler DS,Brown DJ

更新日期：2014-01-02 00:00:00

abstract：PURPOSE:To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS:The type IV collagen chains present in the normal retina were determined immunohistoche...

journal_title：Investigative ophthalmology & visual science

authors： Savige J,Liu J,DeBuc DC,Handa JT,Hageman GS,Wang YY,Parkin JD,Vote B,Fassett R,Sarks S,Colville D

更新日期：2010-03-01 00:00:00