Functional abnormalities in vincristine-induced night blindness.

abstract：:The characterization of beta-adrenergic receptors on cultured human trabecular cells and trabecular meshwork from human autopsy eyes was carried out by radioligand binding utilizing (125I)-iodopindolol. In cultured cells, the observed binding of (125I)-iodopindolol was of high affinity (Kd = 43 pM) and saturable. Scat...

journal_title：Investigative ophthalmology & visual science

authors： Wax MB,Molinoff PB,Alvarado J,Polansky J

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To characterize the spectrum of mutations in the OPA1 gene in a large international panel of patients with autosomal dominant optic atrophy (adOA), to improve understanding of the range of functional deficits attributable to sequence variants in this gene, and to assess any genotype-phenotype correlations. MET...

journal_title：Investigative ophthalmology & visual science

authors： Thiselton DL,Alexander C,Taanman JW,Brooks S,Rosenberg T,Eiberg H,Andreasson S,Van Regemorter N,Munier FL,Moore AT,Bhattacharya SS,Votruba M

更新日期：2002-06-01 00:00:00

abstract：:Recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing the shedding of herpes simplex virus type-1 (HSV-1) induced by 6-hydroxydopamine iontophoresis followed by topical epinephrine application in previously infected rabbit corneas. A treatment schedule of RIFN alpha D, two drops QID was...

journal_title：Investigative ophthalmology & visual science

authors： Mayers M,Matli M,Okumoto M,Samy M,Smolin G

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：:In 150 retinoblastomas the authors found a uniform thickness of the cuff of viable retinoblastoma cells that surrounds blood vessels. The mean thickness was 98.7 microns with a standard deviation of 11.9 microns. The cross-sectional area of the cuff was negatively correlated with the mitotic activity in the cuff and p...

journal_title：Investigative ophthalmology & visual science

authors： Burnier MN,McLean IW,Zimmerman LE,Rosenberg SH

更新日期：1990-10-01 00:00:00

abstract：:Chloride ion (Cl-) secretion by the rabbit corneal epithelium involves a catecholamine-stimulated Cl- conductance at the apical membrane, but the characteristics of the ion channel(s) responsible are unknown. A primary cell culture system was developed that induces stratified epithelial differentiation of rat and rabb...

journal_title：Investigative ophthalmology & visual science

authors： Marshall WS,Hanrahan JW

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:Floppy eyelid syndrome (FES) is an acquired hyperelasticity disorder affecting the upper eyelid. The tarsal plate becomes hyperelastic with a loss of intrinsic rigidity. As a result, the eyelid is subjected to cyclic mechanical stress. This condition was used as a model to investigate changes in dynamic fibrobl...

journal_title：Investigative ophthalmology & visual science

authors： Ezra DG,Ellis JS,Beaconsfield M,Collin R,Bailly M

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To investigate the effect of etomidate (ET) on axonal regeneration of retinal ganglion cells (RGCs) in adult rats. METHODS:The optic nerve was transected intraorbitally at 1 mm from the optic disc, and an autologous peripheral nerve was transplanted onto the ocular ON stump in adult rats. Then the animals were...

journal_title：Investigative ophthalmology & visual science

authors： Xu ZX,Qin SZ,Xu GZ,Hu JM,Ma LT

更新日期：2011-10-11 00:00:00

abstract：:A simple method for the culture of human retinal capillary endothelial cells in vitro is described in this report. Through a process of gentle mechanical disruption and sieving, a sufficient yield of retinal microvessels was obtained from one or two human eyes to allow the culture of endothelial cells in abundance. Th...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Gillies MC

更新日期：1992-09-01 00:00:00

abstract：:Laser densitometric analysis of immunoperoxidase stained tissue was used to quantitate class I HLA (HLA-A,B,C) antigen expression by human corneal epithelium. Frozen sections of human donor corneas stored in modified McCarey-Kaufman medium for less than 24 hr were evaluated for class I HLA antigen by an indirect immun...

journal_title：Investigative ophthalmology & visual science

authors： Dreizen NG,Whitsett CF,Austin GE,Stulting RD

更新日期：1986-06-01 00:00:00

abstract：:Purpose: To compare efficacy and safety between subconjunctival and intrascleral methods of mitomycin C (MMC) application during trabeculectomy Methods: This retrospective study included 165 eyes treated by trabeculectomy and compared clinical outcomes between eyes that received subconjunctival MMC (Group 1, 80 eyes, ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang M,Li B,Wang J,Liu W,Wu X

更新日期：2014-07-21 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) ocular shedding and recurrent corneal epithelial lesions were assessed following an intravenous injection of cyclophosphamide (75 mg/kg) and 24 hr later an intravenous injection of dexamethasone (4 mg/kg) in 24 eyes of 15 rabbits latently infected with HSV-1 strain McKrae. Sampling ...

journal_title：Investigative ophthalmology & visual science

authors： Haruta Y,Rootman DS,Xie LX,Kiritoshi A,Hill JM

更新日期：1989-03-01 00:00:00

abstract：:Five immunosuppressive and anti-inflammatory agents were tested for their effects on development of experimental autoimmune uveoretinitis (EAU) and immune responses to S-antigen in rats immunized with this retinal antigen. When administered daily from day 0-14 after immunization, cyclosporine at 5-20 mg/Kg was nontoxi...

journal_title：Investigative ophthalmology & visual science

authors： Mochizuki M,Nussenblatt RB,Kuwabara T,Gery I

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:To determine global mRNA expression levels in corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression. METHODS:cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide arra...

journal_title：Investigative ophthalmology & visual science

authors： Turner HC,Budak MT,Akinci MA,Wolosin JM

更新日期：2007-05-01 00:00:00

abstract：:Purpose. To understand the barriers facing primary care providers (PCPs), including nurse practitioners (NPs) and physician assistants (PAs), in the current referral-to-eye-care process and to solicit suggestions from PCPs on how to improve the current referral system. Methods. Four focus groups were conducted with a ...

journal_title：Investigative ophthalmology & visual science

authors： Holley CD,Lee PP

更新日期：2010-04-01 00:00:00

abstract：:In recent years, there has been great interest in recording the pattern electroretinogram (PERG) in glaucomatous and diabetic populations. The Dawson, Trick, and Litzkow thread electrode (DTLTE) and the gold foil electrode (GFE), commonly used for recording PERGs, were compared for variations in amplitude of response,...

journal_title：Investigative ophthalmology & visual science

authors： Prager TC,Saad N,Schweitzer FC,Garcia CA,Arden GB

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:Invasion of tumor cells into blood vessels is essential for metastasis of uveal melanoma. The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients. METHODS:Between 1972 and 2007, 643 eyes primarily enucleated fo...

journal_title：Investigative ophthalmology & visual science

authors： Ly LV,Odish OF,Wolff-Rouendaal Dd,Missotten GS,Luyten GP,Jager MJ

更新日期：2010-02-01 00:00:00

abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

journal_title：Investigative ophthalmology & visual science

authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:To determine whether the lipid peroxidation inhibitor tirilazad mesylate can block the death of retinal ganglion cells induced by the inhibition of oxidative phosphorylation and glycolysis. METHODS:Rat retinal ganglion cells were labeled retrogradely with the fluorescent tracer DiI, and mixed cultures were pre...

journal_title：Investigative ophthalmology & visual science

authors： Levin LA,Clark JA,Johns LK

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:Reports of lymphatics in the posterior human uvea are contradictory. We systematically analyzed the choroid by combining various lymphatic markers, following recently established guidelines for the immunohistochemical detection of ocular lymphatics. METHODS:Human choroids were prepared for flat mount serial cr...

journal_title：Investigative ophthalmology & visual science

authors： Schrödl F,Kaser-Eichberger A,Trost A,Strohmaier C,Bogner B,Runge C,Motloch K,Bruckner D,Laimer M,Heindl LM,Reitsamer HA

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To characterize the molecular properties, cellular distribution, and subcellular distribution of bovine rom-1 and its interaction with peripherin/rds in photoreceptor cells as an important step toward elucidating the role of rom-1 in photoreceptor outer segment structure-function relationships and in inherited ...

journal_title：Investigative ophthalmology & visual science

authors： Moritz OL,Molday RS

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:The inhibition of angiogenesis by angiostatic steroids has been demonstrated in a variety of systems, including rabbit and rat cornea. There is considerable interest in the therapeutic potential of this class of compounds for angiogenic ocular conditions such as diabetic retinopathy, macular degeneration, and r...

journal_title：Investigative ophthalmology & visual science

authors： Penn JS,Rajaratnam VS,Collier RJ,Clark AF

更新日期：2001-01-01 00:00:00

abstract：Purpose:We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods:The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography,...

journal_title：Investigative ophthalmology & visual science

authors： Alassane S,Binquet C,Arnould L,Fleck O,Acar N,Delcourt C,Bretillon L,Bron AM,Creuzot-Garcher C

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Compensatory eye movements (CEM) maintain a stable image on the retina by minimizing retinal slip. The optokinetic reflex (OKR) and vestibulo-ocular reflex (VOR) compensate for low and high velocity stimuli, respectively. The OKR system is known to be highly nonlinear. The VOR is generally modeled as a linear s...

journal_title：Investigative ophthalmology & visual science

authors： Sibindi TM,Holland PJ,van der Geest JN,Donchin O,Frens MA

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To learn whether locally expressed and systemic mediators might modulate the cholinergically induced transepithelial Cl(-) fluxes that underlie lacrimal fluid production. METHODS:Reconstituted epithelial monolayers were exposed to a submaximal dose of the muscarinic agonist, carbachol (CCh), or to one of sever...

journal_title：Investigative ophthalmology & visual science

authors： Selvam S,Mircheff AK,Yiu SC

更新日期：2013-04-26 00:00:00

abstract：Purpose:To investigate diurnal variation in the length of mouse rod outer segments in vivo. Methods:The lengths of rod inner and outer segments (RIS, ROS) of dark-adapted albino mice maintained on a 12-hour dark:12-hour light cycle with light onset 7 AM were measured at prescribed times (6:30 AM, 11 AM, 3:30 PM) durin...

journal_title：Investigative ophthalmology & visual science

authors： Zhang P,Shibata B,Peinado G,Zawadzki RJ,FitzGerald P,Pugh EN Jr

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To relate the oxygen environment of the retina to photoreceptor stability, protection, and function in the P23H rat. METHODS:Heterozygote P23H-3 (Line 3) rats were studied. Photoreceptor death rates were assessed with the TUNEL technique for detection of fragmenting DNA, in a developmental series from postnata...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Cringle S,Valter K,Walsh N,Lee D,Stone J

更新日期：2004-06-01 00:00:00

abstract：Purpose:The activation of the urokinase-type plasminogen activator and its receptor system is associated with retinal diseases. Among peptide inhibitors of this system, UPARANT acts by preventing the onset of pathologic signs of neovascular ocular diseases. We investigated whether systemic UPARANT may act in a therapeu...

journal_title：Investigative ophthalmology & visual science

authors： Cammalleri M,Locri F,Marsili S,Dal Monte M,Pisano C,Mancinelli A,Lista L,Rusciano D,De Rosa M,Pavone V,Bagnoli P

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To compare action spectra for visual discomfort in the fovea and the parafovea and to determine the effect of macular pigment (MP). METHODS:Visual discomfort thresholds to lights from 440 to 600 nm were obtained for six young (<35 y), visually normal subjects with a wide range of MP densities (0.10-0.71 at 30'...

journal_title：Investigative ophthalmology & visual science

authors： Stringham JM,Snodderly DM

更新日期：2013-09-19 00:00:00

abstract：:Prism induced shift of fixation was measured in 12 cooperative patients utilizing electro-oculography. These recordings were compared with a voluntary shift in fixation of the same eye. No differences were noted when comparing voluntary movements with prism induced movements. Trial of the prism induced eye movement fo...

journal_title：Investigative ophthalmology & visual science

authors： Metz HS

更新日期：1984-10-01 00:00:00