The Urokinase Receptor-Derived Peptide UPARANT Recovers Dysfunctional Electroretinogram and Blood-Retinal Barrier Leakage in a Rat Model of Diabetes.

abstract：:The morphologic effects on rabbit corneal endothelium of several common ophthalmic vehicle constituents were examined following subconjunctival administration. Profound dose-dependent changes consisting of intercellular vacuolization and thickening of the endothelial layer were noted within 1 day following administrat...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Wood I,Tomazzoli L,Alvarado J

更新日期：1986-04-01 00:00:00

abstract：PURPOSE:Folic acid is essential for DNA, RNA, and protein synthesis, and deficiencies in folate can lead to nutritional amblyopia and optic neuropathy. The transport of folate from the choroidal blood supply to the retina is only now beginning to be understood. The reduced-folate transporter was reported recently to be...

journal_title：Investigative ophthalmology & visual science

authors： Smith SB,Kekuda R,Gu X,Chancy C,Conway SJ,Ganapathy V

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：:Isotonic, neutral buffered solutions of benzalkonium chloride or chlorhexidine digluconate were applied topically to one eye of rabbits or human subjects. Contralateral control eyes received phosphate buffered saline as placebo. One-half hour later, the tear film of both eyes was loaded with nonpreserved sodium fluore...

journal_title：Investigative ophthalmology & visual science

authors： Burstein NL

更新日期：1984-12-01 00:00:00

abstract：PURPOSE:To determine the effect of age on the thickness of individual retinal layers, measured with spectral-domain optical coherence tomography (SD-OCT), in a population of healthy Caucasians. METHODS:One hundred and twenty subjects with an age ranging between 18 and 81 years were examined with SD-OCT. Mean layer thi...

journal_title：Investigative ophthalmology & visual science

authors： Demirkaya N,van Dijk HW,van Schuppen SM,Abràmoff MD,Garvin MK,Sonka M,Schlingemann RO,Verbraak FD

更新日期：2013-07-22 00:00:00

abstract：PURPOSE:To assess the impact of glaucoma-related vision loss on measures of out-loud reading, including time to say individual words, interval time between consecutive words, lexical errors, skipped words, and repetitions. METHODS:Glaucoma subjects (n = 63) with bilateral visual field loss and glaucoma suspect control...

journal_title：Investigative ophthalmology & visual science

authors： Mathews PM,Rubin GS,McCloskey M,Salek S,Ramulu PY

更新日期：2015-03-03 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the relationship between optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) and neuroretinal rim (NRR) in a nonhuman primate experimental glaucoma model, and in a population of clinical patients. METHODS:For nonhuman primates, normative da...

journal_title：Investigative ophthalmology & visual science

authors： Patel NB,Sullivan-Mee M,Harwerth RS

更新日期：2014-09-23 00:00:00

abstract：PURPOSE:The transdifferentiation of Tenon fibroblasts to myofibroblasts is a pivotal step in filtering bleb scarring. It is mediated by the cytokine TGF-beta, Rho-dependent contractility, and cell-matrix interactions in an interdependent fashion. HMG-CoA-reductase inhibitors (statins) have been shown to inhibit Rho-GTP...

journal_title：Investigative ophthalmology & visual science

authors： Meyer-Ter-Vehn T,Katzenberger B,Han H,Grehn F,Schlunck G

更新日期：2008-09-01 00:00:00

abstract：:Assays of cortisol-metabolizing enzymes in homogenates of human trabecular meshwork cells under optimal conditions revealed two defects in primary open-angle glaucoma (POAG): one is a marked increase in delta 4-reductase and the other is a decrease in 3-oxidoreductase. Experiments indicated that the differences in enz...

journal_title：Investigative ophthalmology & visual science

authors： Weinstein BI,Munnangi P,Gordon GG,Southren AL

更新日期：1985-06-01 00:00:00

abstract：PURPOSE:This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS:The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in ...

journal_title：Investigative ophthalmology & visual science

authors： Kojima T,Ishida R,Dogru M,Goto E,Takano Y,Matsumoto Y,Kaido M,Ohashi Y,Tsubota K

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To determine whether anthocyanin-enriched bilberry extracts modulate pre- or posttranslational levels of oxidative stress defense enzymes heme-oxygenase (HO)-1 and glutathione S-transferase-pi (GST-pi) in cultured human retinal pigment epithelial (RPE) cells. METHODS:Confluent ARPE-19 cells were preincubated w...

journal_title：Investigative ophthalmology & visual science

authors： Milbury PE,Graf B,Curran-Celentano JM,Blumberg JB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

journal_title：Investigative ophthalmology & visual science

authors： Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina. Because gangliosides play an important role in neuronal cell differentiation and proliferation, this change in ganglioside profile may indicate retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Park EJ,Suh M,Clandinin MT

更新日期：2005-07-01 00:00:00

abstract：Purpose:High myopia (HM) is defined as a refractive error worse than -6.00 diopter (D). This study aims to update the phenotypic and genotypic landscape of nonsyndromic HM and to establish a biological link between the phenotypic traits and genetic deficiencies. Methods:A cross-sectional study involving 731 participan...

journal_title：Investigative ophthalmology & visual science

authors： Cai XB,Zheng YH,Chen DF,Zhou FY,Xia LQ,Wen XR,Yuan YM,Han F,Piao SY,Zhuang W,Lu F,Qu J,Yu AY,Jin ZB

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To identify the disease locus associated with autosomal dominant Fuchs corneal dystrophy (FCD) in a large family and to compare the progression of severity in families mapped to the FCD1 and FCD2 loci. METHODS:Seventeen individuals in a large family were examined by slit lamp biomicroscopy. Blood samples were ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Eghrari AO,Al-Saif A,Davey L,Meadows DN,Katsanis N,Gottsch JD

更新日期：2009-12-01 00:00:00

abstract：Purpose:To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods:We extended a previously published numerical model of the ONH to include 24 factors representing tissue anato...

journal_title：Investigative ophthalmology & visual science

authors： Hua Y,Voorhees AP,Sigal IA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To map the disease locus in a four-generation, consanguineous Pakistani family affected by autosomal dominant congenital nuclear cataract (adNCat). All affected individuals had early onset of bilateral nuclear cataract. METHODS:Genomic DNA from family members was typed for alleles at more than 300 known polymo...

journal_title：Investigative ophthalmology & visual science

authors： Khaliq S,Hameed A,Ismail M,Anwar K,Mehdi SQ

更新日期：2002-07-01 00:00:00

abstract：:Flicker sensitivity was measured in groups of younger and older adult observers to assess its mean values and the test-retest variability both between sessions and in a single session. Test-retest sensitivities differed by less than 15% but tended to decrease slightly in a session and increase slightly between session...

journal_title：Investigative ophthalmology & visual science

authors： Tyler CW

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:To measure changes in nuclear gene expression resulting from mitochondrial dysfunction in retinal pigment epithelial cells. METHODS:ARPE-19 retinal pigment epithelial cells were depleted of their mitochondrial (mt)DNA by passaging in a low concentration of ethidium bromide. Loss of mitochondrial DNA was determ...

journal_title：Investigative ophthalmology & visual science

authors： Miceli MV,Jazwinski SM

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To compare EyeCam (Clarity Medical Systems, Pleasanton, CA) imaging with gonioscopy for detecting angle closure. METHODS:In this prospective, hospital-based study, subjects underwent gonioscopy by a single observer and EyeCam imaging by a different operator. EyeCam images were graded by two masked observers. T...

journal_title：Investigative ophthalmology & visual science

authors： Perera SA,Baskaran M,Friedman DS,Tun TA,Htoon HM,Kumar RS,Aung T

更新日期：2010-06-01 00:00:00

abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

journal_title：Investigative ophthalmology & visual science

authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Diabetes reduces retinal and visual sensitivity to dim light flashes. However, the impact of diabetes on contrast sensitivity in dim light is unknown. Based on the lowered visual sensitivity previously observed, we hypothesized that contrast sensitivity would similarly be reduced. We therefore examined scotopic...

journal_title：Investigative ophthalmology & visual science

authors： Umino Y,Solessio E

更新日期：2013-02-28 00:00:00

abstract：PURPOSE:To determine how the different stages of retinal processing change after photoreceptor degeneration in rabbits carrying the Pro347Leu rhodopsin mutation (Tg rabbits). METHODS:Cone electroretinograms (ERGs) were elicited by 150-ms duration stimuli from 13 Tg rabbits at 12 and 24 weeks of age. The ERG recordings...

journal_title：Investigative ophthalmology & visual science

authors： Nishimura T,Machida S,Kondo M,Terasaki H,Yokoyama D,Kurosaka D

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:To assess the neuroprotective effects of ketorolac administration, in solution or delivered from biodegradable microspheres, on the survival of axotomized retinal ganglion cells (RGCs). METHODS:Retinas were treated intravitreally with a single injection of tromethamine ketorolac solution and/or with ketorolac-...

journal_title：Investigative ophthalmology & visual science

authors： Nadal-Nicolás FM,Rodriguez-Villagra E,Bravo-Osuna I,Sobrado-Calvo P,Molina-Martínez I,Villegas-Pérez MP,Vidal-Sanz M,Agudo-Barriuso M,Herrero-Vanrell R

更新日期：2016-03-01 00:00:00

abstract：:In 150 retinoblastomas the authors found a uniform thickness of the cuff of viable retinoblastoma cells that surrounds blood vessels. The mean thickness was 98.7 microns with a standard deviation of 11.9 microns. The cross-sectional area of the cuff was negatively correlated with the mitotic activity in the cuff and p...

journal_title：Investigative ophthalmology & visual science

authors： Burnier MN,McLean IW,Zimmerman LE,Rosenberg SH

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is a group of childhood-onset retinal diseases characterized by severe visual impairment or blindness. One form is caused by mutations in the RPE65 gene, which encodes the retinal pigment epithelium (RPE) isomerase. In this study, the retinal structure and expression of molecula...

journal_title：Investigative ophthalmology & visual science

authors： Hernández M,Pearce-Kelling SE,Rodriguez FD,Aguirre GD,Vecino E

更新日期：2010-12-01 00:00:00

abstract：:Accurate assessment of ocular alignment in monkeys is difficult because typical clinical methods require extensive cooperation by the subject or provide only a rough estimate of the misalignment. Recently, Brodie derived a geometrical model for determining the Hirschberg ratio in humans, and validated it photographica...

journal_title：Investigative ophthalmology & visual science

authors： Quick MW,Boothe RG

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore. METHODS:Retinoid levels and photoreceptor functions of Rdh5-/-Rdh11-/- mice at a variety of l...

journal_title：Investigative ophthalmology & visual science

authors： Maeda A,Maeda T,Palczewski K

更新日期：2006-10-01 00:00:00

abstract：:The susceptibility of Candida albicans to topical amphotericin B and natamycin was evaluated in a model of stromal keratitis in Dutch-belted rabbits and compared with minimal inhibitory concentrations in vitro. Treatment was delayed 24 hr to allow invasive disease to occur and was then continued for 5 days. Ten strain...

journal_title：Investigative ophthalmology & visual science

authors： O'Day DM,Ray WA,Robinson RD,Head WS,Savage AM

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To investigate the molecular mechanism of Rho-associated kinase (ROCK) inhibitors Y-27632 and Y-39983 on corneal endothelial cell (CEC) proliferation and their wound-healing effect. METHODS:The expression of G1 proteins of the cell cycle and expression of phosphorylated Akt in monkey CECs (MCECs) treated with ...

journal_title：Investigative ophthalmology & visual science

authors： Okumura N,Nakano S,Kay EP,Numata R,Ota A,Sowa Y,Sakai T,Ueno M,Kinoshita S,Koizumi N

更新日期：2014-01-15 00:00:00