Intrinsically photosensitive (melanopsin) retinal ganglion cell function in glaucoma.

abstract：Purpose:We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model. Methods:Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], ...

journal_title：Investigative ophthalmology & visual science

authors： Cui RZ,Wang L,Qiao SN,Wang YC,Wang X,Yuan F,Weng SJ,Yang XL,Zhong YM

更新日期：2019-04-01 00:00:00

abstract：:The retinas of six pigmented rabbits (12 eyes) were irradiated with a cw-Nd:YAG laser using two different pulse forms, in conjunction with a constant pulse duration of 200 msec and a retinal focus diameter of 200 microns. The first pulse form (a) was characterized by an initial transient, lasting 15-20 msec, with a pe...

journal_title：Investigative ophthalmology & visual science

authors： van der Zypen E,Fankhauser F,Kwasniewska S,England C

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To determine the mechanisms underlying prostaglandin (PG) F(2)alpha-(,) carbachol (CCh)-, or latanoprost (a PGF(2)alpha analogue)-induced contraction of the pig iris sphincter muscle. METHODS:Effects of these agents on myofilament Ca(2+) sensitivity were evaluated and compared with the use of receptor-coupled ...

journal_title：Investigative ophthalmology & visual science

authors： Hasegawa Y,Nishimura J,Niiro N,Hirano K,Ishibashi T,Kanaide H

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To examine human corneal morphology and nerve recovery 5 years after photorefractive keratectomy (PRK). METHODS:Fourteen eyes of 14 patients (ages, 27-53 years) who underwent 6-mm diameter PRK for low to moderate myopia (spherical equivalent [SE] -2.5 to -8.0 D) were examined once 5 years after surgery. Nine h...

journal_title：Investigative ophthalmology & visual science

authors： Moilanen JA,Vesaluoma MH,Müller LJ,Tervo TM

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To assess the thickness and surface area of porcine sclera. METHODS:One hundred twenty-eight porcine globes were sectioned from the center of the cornea to the region of the optic nerve. Photographs of the sectioned sclera including a millimeter scale were taken. Photographic slides were projected onto blank p...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Sanderson S,Feng X,Hubbard WC

更新日期：2002-08-01 00:00:00

abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

journal_title：Investigative ophthalmology & visual science

authors： Soong H,Fischbarg J,Iwamoto T

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

journal_title：Investigative ophthalmology & visual science

authors： Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery. METHODS:A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After ...

journal_title：Investigative ophthalmology & visual science

authors： Jee JP,Choung HK,Kim CK,Hwang JM

更新日期：2006-06-01 00:00:00

abstract：:Corneas of fetal and young albino rabbits were examined by light and transmission electron microscopy. In addition, DNA and hydroxyproline content were measured in developing stroma. The results were compared with similar data from healing corneas in adult rabbits and from developing corneas of other animal species. I...

journal_title：Investigative ophthalmology & visual science

authors： Cintron C,Covington H,Kublin CL

更新日期：1983-05-01 00:00:00

abstract：:Cataracts were produced in cultured rat lenses by either 10 microM calcium ionophore A23187, 25 microM sodium selenite, or 30 mM xylose. E64, an inhibitor of cysteine proteases, such as calpain (EC, 3.4.22.17), reduced severity of cataract and proteolysis of crystallins when included at a 500 microM concentration in t...

journal_title：Investigative ophthalmology & visual science

authors： Shearer TR,Azuma M,David LL,Murachi T

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To investigate the role of N-cadherin and hepatocyte growth factor (HGF) in the invasion of collagen type I by human retinal pigment epithelial (RPE) cells. METHODS:RPE sheets from eight human eyes were used for characterization through Western blot analysis of the expression of cadherin in total lysates or af...

journal_title：Investigative ophthalmology & visual science

authors： Van Aken EH,De Wever O,Van Hoorde L,Bruyneel E,De Laey JJ,Mareel MM

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To investigate the dynamic effect of tear lipocalins (TLs), the major lipid-binding protein in tears, at aqueous-cornea and lipid-aqueous interfaces, and their potential contribution to surface tension in the tear film. METHODS:Human apo- and holo-TLs were applied to the aqueous subphase in a Langmuir trough, ...

journal_title：Investigative ophthalmology & visual science

authors： Glasgow BJ,Marshall G,Gasymov OK,Abduragimov AR,Yusifov TN,Knobler CM

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To study heterogeneity for chromosome 3 copy number in mixed choroidal melanoma with discrete populations of spindle and epithelioid cells using chromosome in situ hybridization (CISH) and to correlate chromosomal loss with cell type. METHODS:Twenty-two archival cases of choroidal melanoma with discrete popula...

journal_title：Investigative ophthalmology & visual science

authors： Sandinha T,Farquharson M,McKay I,Roberts F

更新日期：2006-12-01 00:00:00

abstract：Purpose:To assess clinical characteristics, foveal structure, mutation spectrum, and prevalence rate of Åland eye disease (AED)/incomplete congenital stationary night blindness (iCSNB). Methods:A retrospective survey included individuals diagnosed with AED at a national low-vision center from 1980 to 2014. A subset of...

journal_title：Investigative ophthalmology & visual science

authors： Hove MN,Kilic-Biyik KZ,Trotter A,Grønskov K,Sander B,Larsen M,Carroll J,Bech-Hansen T,Rosenberg T

更新日期：2016-12-01 00:00:00

abstract：Purpose:To evaluate the relationship between refractive error, circadian phase, and melatonin with consideration of prior light exposure, physical activity, and sleep. Methods:Healthy young myopic (spherical equivalent refraction [SER] ≤-0.50DS) and emmetropic adults underwent noncycloplegic autorefraction and axial l...

journal_title：Investigative ophthalmology & visual science

authors： Flanagan SC,Cobice D,Richardson P,Sittlington JJ,Saunders KJ

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：Purpose:This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Methods:Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRNA (...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Han X,Kunz E,Hartnett ME

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To investigate the role of anti-vascular endothelial growth factor (VEGF)-C therapy in corneal graft survival and concomitant suppression of hem- and lymph-angiogenesis. METHODS:Corneal suture model in BALB/c mice was placed and immunohistochemical staining was performed with CD31/PECAM-1 and LYVE-1 to quantif...

journal_title：Investigative ophthalmology & visual science

authors： Hajrasouliha AR,Funaki T,Sadrai Z,Hattori T,Chauhan SK,Dana R

更新日期：2012-03-09 00:00:00

abstract：:The outer horizontal cell (OHC) of the frog Rana pipiens was studied by light and electron microscopy of Golgi-stained and horseradish peroxidase-injected cells. Responses of OHCs were recorded with intracellular electrodes. The OHCs are probably axonless cells. Their dendritic terminals are lateral processes at synap...

journal_title：Investigative ophthalmology & visual science

authors： Ogden TE,Mascetti GG,Pierantoni R

更新日期：1985-05-01 00:00:00

abstract：PURPOSE:To compare the effects of early, mid, and late subconjunctival injection of bevacizumab on corneal neovascularization (NV) and conjunctivalization in a rabbit limbal insufficiency model. METHODS:Limbal insufficiency was created surgically, and subconjunctival injections of 2.5 mg bevacizumab twice weekly for 1...

journal_title：Investigative ophthalmology & visual science

authors： Lin CT,Hu FR,Kuo KT,Chen YM,Chu HS,Lin YH,Chen WL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial (ICE) syndrome. METHODS:Corneas diagnosed with ICE syndrome and removed during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies t...

journal_title：Investigative ophthalmology & visual science

authors： Hirst LW,Bancroft J,Yamauchi K,Green WR

更新日期：1995-04-01 00:00:00

abstract：:The retinal pigment epithelium (RPE)-choroid was isolated from cynomolgus monkey eyes with experimental retinal detachments and the volume flow was determined in vitro using Ussing-type chambers. With zero pressure difference across the membrane, retina-to-choroid volume flow was 5.0 microliter/hr/cm2 in eyes with sub...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:To design a contrast sensitivity perimetry (CSP) protocol that decreases variability in glaucomatous defects while maintaining good sensitivity to glaucomatous loss. METHODS:Twenty patients with glaucoma and 20 control subjects were tested with a CSP protocol implemented on a monitor-based testing station. In ...

journal_title：Investigative ophthalmology & visual science

authors： Hot A,Dul MW,Swanson WH

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To determine the influence of specific regions within Lp82 calpain on protein stability, enzymatic activity, and localization within lens and to test the influence of an Lp82 knockout mouse on normal maturational proteolysis in lens. METHODS:DNA constructs for Lp82 and Lp82-related proteins were subcloned into...

journal_title：Investigative ophthalmology & visual science

authors： Ma H,Shih M,Fukiage C,Azuma M,Duncan MK,Reed NA,Richard I,Beckmann JS,Shearer TR

更新日期：2000-12-01 00:00:00

abstract：:On the assumption that myelin intrusion into the papilla and peripapillary region might occur with traumatic lesions of the optic nerve, a study was made of the clinical and histopathologic changes that might be expected. Nine monkey eyes were subjected to hemostat compression of the nerve close to the globe and studi...

journal_title：Investigative ophthalmology & visual science

authors： Cogan DG,Yee RD

更新日期：1977-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:To examine the effects of modification of immune effector cells, including macrophages, in the pathogenesis of herpes simplex virus retinitis in BALB/c mice. METHODS:Two intravitreal injections (2 microliters each) of anti-CD11b monoclonal antibody (mAb) [13 micrograms/microliters] were administered to the con...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Rodriguez A,Heiligenhaus A,Pazos B,Van Rooijen N,Foster CS

更新日期：1994-06-01 00:00:00

abstract：:Previous research has demonstrated that distinct, gender-related differences exist in the morphology of the rat lacrimal gland. The purpose of the present study was to determine whether this sexual dimorphism is unique to the rat, or extends as well to other species. Lacrimal glands were collected from adult male and ...

journal_title：Investigative ophthalmology & visual science

authors： Cornell-Bell AH,Sullivan DA,Allansmith MR

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a major cause of visual impairment in developed countries. While DR has been described classically as a microvascular disease, recent evidence suggests that changes to retinal microglia are an early feature of retinopathy. In our study, we assessed changes in microglial distribution...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chen X,Rakoczy EP,McMenamin PG

更新日期：2013-01-30 00:00:00