Gender-related differences in the morphology of the lacrimal gland.

abstract：PURPOSE:To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS:The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats a...

journal_title：Investigative ophthalmology & visual science

authors： LeDoux MS,Zhou Q,Murphy RB,Greene ML,Ryan P

更新日期：2001-10-01 00:00:00

abstract：Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

journal_title：Investigative ophthalmology & visual science

authors： Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

更新日期：2019-07-01 00:00:00

abstract：:The therapeutic effect of citrate on alkali-burned eyes is thought to be the result of inhibition of PMN activities while ascorbate apparently stimulates the production of new collagen by scorbutic fibroblasts. Attachment of PMNs to the vascular endothelium is the initial PMN response to mediators and must occur befor...

journal_title：Investigative ophthalmology & visual science

authors： Pfister RR,Haddox JL,Snyder TL

更新日期：1988-06-01 00:00:00

abstract：PURPOSE:Although primary congenital glaucoma (PCG)-associated CYP1B1 mutations in the heterozygous state have been evaluated for association with primary open-angle glaucoma (POAG) in several small studies, their contribution to the occurrence of POAG is still controversial. The present study was conducted to determine...

journal_title：Investigative ophthalmology & visual science

authors： Pasutto F,Chavarria-Soley G,Mardin CY,Michels-Rautenstrauss K,Ingelman-Sundberg M,Fernández-Martínez L,Weber BH,Rautenstrauss B,Reis A

更新日期：2010-01-01 00:00:00

abstract：:Posterior eye cups of the frog Rana ridibunda were prefixed in the presence of tannic acid, osmicated and stained en bloc with uranyl acetate. Electron microscopy revealed the following features of membrane traffic in cells of the retinal pigment epithelium (RPE): (1) intracellular membranes with increased electron de...

journal_title：Investigative ophthalmology & visual science

authors： Rungger-Brändle E,Englert U,Leuenberger PM

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS). METHODS:Samples were collected from EIU-susceptible Lewis rats and EIU-re...

journal_title：Investigative ophthalmology & visual science

authors： de Vos AF,van Haren MA,Verhagen C,Hoekzema R,Kijlstra A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Activity in regions of the visual cortex corresponding to central scotomas in subjects with macular degeneration (MD) is considered evidence for functional reorganization in the brain. Three unresolved issues related to cortical activity in subjects with MD were addressed: Is the cortical response to stimuli pr...

journal_title：Investigative ophthalmology & visual science

authors： Liu T,Cheung SH,Schuchard RA,Glielmi CB,Hu X,He S,Legge GE

更新日期：2010-12-01 00:00:00

abstract：Purpose:To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods:Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology. Hematoxylin and eosin staining of retinal...

journal_title：Investigative ophthalmology & visual science

authors： Bales KL,Bentley MR,Croyle MJ,Kesterson RA,Yoder BK,Gross AK

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:To characterize the static blood flow autoregulation in the optic nerve head (ONH), and to investigate its role in hemodynamic changes in experimental glaucoma (EG). METHODS:Unilateral elevation of intraocular pressure (IOP) was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork....

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Burgoyne CF,Cull G,Thompson S,Fortune B

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:To compare spectral-domain optical coherence tomography (SD-OCT) standard structural measures and a new three-dimensional (3D) volume optic nerve head (ONH) change detection method for detecting change over time in severely advanced-glaucoma (open-angle glaucoma [OAG]) patients. METHODS:Thirty-five eyes of 35 ...

journal_title：Investigative ophthalmology & visual science

authors： Belghith A,Medeiros FA,Bowd C,Liebmann JM,Girkin CA,Weinreb RN,Zangwill LM

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:This study was conducted to validate a recently described technique for measuring the rates of visual field (VF) decay in glaucoma. METHODS:A pointwise exponential regression (PER) model was used to calculate average rates of faster and slower deteriorating VF components, and that of the entire VF. Rapid progr...

journal_title：Investigative ophthalmology & visual science

authors： Azarbod P,Mock D,Bitrian E,Afifi AA,Yu F,Nouri-Mahdavi K,Coleman AL,Caprioli J

更新日期：2012-08-09 00:00:00

abstract：PURPOSE:To investigate the effect of hydrogen peroxide on the epithelial cells of cultured rabbit lenses. METHODS:Lenses were cultured in minimum essential medium containing a single dose of 0.03, 0.1, or 0.2 mM H2O2. Three hours later the medium was replaced with peroxide-free minimum essential medium. Lenses were al...

journal_title：Investigative ophthalmology & visual science

authors： Reddan JR,Giblin FJ,Dziedzic DC,Wirebaugh BM,Peters JL

更新日期：1995-02-01 00:00:00

abstract：:An arterial connection between the two internal ophthalmic arteries in the rabbit was confirmed. The consensual response to ocular injury and its relationship to this interconnecting artery was examined by transecting the interconnecting vessel and creating a monocular injury by anterior chamber paracentesis. In the r...

journal_title：Investigative ophthalmology & visual science

authors： Forster S,Mead A,Sears M

更新日期：1979-02-01 00:00:00

abstract：PURPOSE:To examine the potential of a broad-spectrum kinase inhibitor as a means of neutralizing the effects of contraction promoters on ocular cells. METHODS:The inhibitory effects of a broad-spectrum kinase inhibitor were examined and characterized using an in vitro assay of extracellular matrix contraction by choro...

journal_title：Investigative ophthalmology & visual science

authors： Guidry C,Hardwick C

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：:To determine whether glaucoma selectively injures a particular size of optic nerve fiber (and its cell body), we induced chronic experimental glaucoma in one eye each of ten monkeys. With automated image analysis, the number and diameter of optic nerve fibers were compared between each glaucomatous eye and its normal ...

journal_title：Investigative ophthalmology & visual science

authors： Quigley HA,Sanchez RM,Dunkelberger GR,L'Hernault NL,Baginski TA

更新日期：1987-06-01 00:00:00

abstract：PURPOSE:To assess the role of vitamin E (VE) in age-related changes in the retinal tissues by using a mouse model of severe VE deficiency. METHODS:Pups of alpha-tocopherol transfer protein null (a-TTP(-)(/)(-)) mice were fed a VE-deficient diet for 4 or 18 months (VE (-) group). Wild-type C57BL/6 mice were fed a 0.002...

journal_title：Investigative ophthalmology & visual science

authors： Tanito M,Yoshida Y,Kaidzu S,Chen ZH,Cynshi O,Jishage K,Niki E,Ohira A

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To image and analyze anatomical differences at the temporal raphe between normal and glaucomatous eyes using adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography (OCT), and to relate these differences to visual field measurements. METHODS:Nine glaucomatous eyes of 9 patients (...

journal_title：Investigative ophthalmology & visual science

authors： Huang G,Luo T,Gast TJ,Burns SA,Malinovsky VE,Swanson WH

更新日期：2015-06-01 00:00:00

abstract：:Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4....

journal_title：Investigative ophthalmology & visual science

authors： Braakman R,van der Valk P,van Delft JL,de Wolff-Rouendaal D,Oosterhuis JA

更新日期：1989-05-01 00:00:00

abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

journal_title：Investigative ophthalmology & visual science

authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy...

journal_title：Investigative ophthalmology & visual science

authors： van Essen TH,Bronkhorst IH,Maat W,Verduyn W,Roelen DL,Luyten GP,Jager MJ

更新日期：2012-05-04 00:00:00

abstract：PURPOSE:To quantify the role of anterior zonular tension on the optomechanical lens response during simulation of accommodation in primates. METHODS:Postmortem cynomolgus monkey eyes (n = 14; age range, 3.0-11.5 years) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, ...

journal_title：Investigative ophthalmology & visual science

authors： Nankivil D,Manns F,Arrieta-Quintero E,Ziebarth N,Borja D,Amelinckx A,Bernal A,Ho A,Parel JM

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The aim of the present study was to use an in vivo model of retinal excitotoxicity to investigate the neuroprotective effect of somatostatin (SRIF)-ergic agents. METHODS:Adult Sprague-Dawley rats (weight range, 250-300 g) intravitreally received (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyd...

journal_title：Investigative ophthalmology & visual science

authors： Kiagiadaki F,Thermos K

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To compare psychophysical Naka-Rushton parameters in retinitis pigmentosa (RP) patients and healthy controls using a flash-on-flash increment threshold paradigm, and to measure changes of these parameters with RP progression. METHODS:Sixty-six RP patients and 10 normal subjects were tested, and their maximum r...

journal_title：Investigative ophthalmology & visual science

authors： Dagnelie G,Massof RW

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To test the validity of the color component subtraction method, a new objective technique of measuring nuclear cataract, and to correlate the tangent values of the different degrees of nuclear opacities to their corresponding subjective nuclear cataract grading using the Lens Opacities Classification System II ...

journal_title：Investigative ophthalmology & visual science

authors： Khu PM,Kashiwagi T

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure. METHODS:A population-based study was conducted in Beaver Dam, Wisconsin (n=4926, age range, 43-84 years). Retinal photographs of right eyes taken at the baseline examination (1988-90) were...

journal_title：Investigative ophthalmology & visual science

authors： Wong TY,Klein R,Klein BE,Meuer SM,Hubbard LD

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:We tested the hypotheses that the mismatch between the clinical disc margin (CDM) and Bruch's membrane opening (BMO) is a function of BMO area (BMOA) and is affected by the presence of glaucoma. METHODS:A total of 45 normal eyes (45 subjects) and 53 glaucomatous eyes (53 patients) were enrolled and underwent r...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Miraftabi A,Henry S,Chung N,Nowroozizadeh S,Caprioli J,Nouri-Mahdavi K

更新日期：2016-03-01 00:00:00