Parstatin suppresses ocular neovascularization and inflammation.

abstract：PURPOSE:In corneal endothelial cells, intercellular Ca(2+) waves elicited by a mechanical stimulus involve paracrine intercellular communication, mediated by ATP release via connexin hemichannels, as well as gap junctional intercellular communication. Both mechanisms are inhibited by thrombin, which activates RhoA and ...

journal_title：Investigative ophthalmology & visual science

authors： D'hondt C,Srinivas SP,Vereecke J,Himpens B

更新日期：2007-04-01 00:00:00

abstract：Purpose:To investigate the chromatic characteristics and intensity-response function of light-induced reflex lacrimation and its correlation with the melanopsin-driven postillumination pupil response (PIPR). Methods:Eleven visually normal participants completed the experiment. Lacrimation was measured in one eye by pl...

journal_title：Investigative ophthalmology & visual science

authors： Lei S,Goltz HC,Chen X,Zivcevska M,Wong AM

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Mutations in the genes that control cell proliferation in cutaneous melanoma are generally uncommon in uveal melanoma. Despite the absence of known activating mutations, the RAF-MEK-ERK, or mitogen-activated protein kinase (MAPK), pathway is usually activated in uveal melanoma. An assay with increased potential...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Kilic E,Luyten GP,de Klein A,Jager MJ,Gruis NA,Van der Velden PA

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Recent studies suggest that photoreceptor cells regulate local inflammation in the retina in diabetes. The purpose of this study was to determine if photoreceptor cells themselves produce inflammatory proteins in diabetes and if soluble factors released by photoreceptors in elevated glucose induce inflammatory ...

journal_title：Investigative ophthalmology & visual science

authors： Tonade D,Liu H,Kern TS

更新日期：2016-08-01 00:00:00

abstract：:The metabolic disorder in diabetics often results in progressive retinopathy with severe visual impairment. Changes in metabolism can influence corneal autofluorescence. This has led to speculation that diabetic retinopathy might be associated with changes in corneal autofluorescence. Corneal autofluorescence of both ...

journal_title：Investigative ophthalmology & visual science

authors： Stolwijk TR,van Best JA,Oosterhuis JA,Swart W

更新日期：1992-01-01 00:00:00

abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...

journal_title：Investigative ophthalmology & visual science

authors： Ferdousi M,Petropoulos IN,Kalteniece A,Azmi S,Ponirakis G,Efron N,Soran H,Malik RA

更新日期：2018-11-01 00:00:00

abstract：:The authors' study of the viscosities of various concentrations of sodium hyaluronate, chondroitin sulfate, and methylcellulose revealed that sodium hyaluronate and methylcellulose are pseudoplastic fluids in contrast to chondroitin sulfate, which is a Newtonian fluid. Pseudoplastic fluids are ideal for maintaining th...

journal_title：Investigative ophthalmology & visual science

authors： Hammer ME,Burch TG

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:To quantify the role of anterior zonular tension on the optomechanical lens response during simulation of accommodation in primates. METHODS:Postmortem cynomolgus monkey eyes (n = 14; age range, 3.0-11.5 years) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, ...

journal_title：Investigative ophthalmology & visual science

authors： Nankivil D,Manns F,Arrieta-Quintero E,Ziebarth N,Borja D,Amelinckx A,Bernal A,Ho A,Parel JM

更新日期：2009-08-01 00:00:00

abstract：Purpose:To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes. Methods:Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, sex, and axia...

journal_title：Investigative ophthalmology & visual science

authors： Lee SH,Kim TW,Lee EJ,Girard MJ,Mari JM

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:This study observed biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus in contact lens cases and investigated the inhibitory effects of 2,2'-dipyridyl (2DP) and 1,2,3,4,6-penta-O-galloyl-b-D-glucopyranose (PGG). METHODS:Biofilm formation of P. aeruginosa ATCC 9027 and S. aureus ATCC 25923 an...

journal_title：Investigative ophthalmology & visual science

authors： Cho P,Shi GS,Boost M

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS:In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative fa...

journal_title：Investigative ophthalmology & visual science

authors： Pandian A,Sankaridurg PR,Naduvilath T,O'Leary D,Sweeney DF,Rose K,Mitchell P

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Levels of some cytokines are significantly higher in the vitreous fluid of patients with acute uveitis than in normal vitreous fluid. The authors sought to determine which proinflammatory cytokines were upregulated in the vitreous fluid of patients with ocular sarcoidosis. METHODS:Samples of vitreous fluid wer...

journal_title：Investigative ophthalmology & visual science

authors： Nagata K,Maruyama K,Uno K,Shinomiya K,Yoneda K,Hamuro J,Sugita S,Yoshimura T,Sonoda KH,Mochizuki M,Kinoshita S

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas. METHODS:This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); form...

journal_title：Investigative ophthalmology & visual science

authors： Saad A,Gatinel D

更新日期：2012-05-17 00:00:00

abstract：Purpose:To describe the pathology of AMD in eyes with geographic atrophy (GA) using confocal scanning laser ophthalmoscopy (SLO) blue light autofluorescence (BAF), and near-infrared (IR) AF and to correlate it with the histology and immunohistochemistry analysis at the margins of the GA lesion. Methods:Enucleated, fix...

journal_title：Investigative ophthalmology & visual science

authors： Bonilha VL,Bell BA,Hu J,Milliner C,Pauer GJ,Hagstrom SA,Radu RA,Hollyfield JG

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The goal of this study was to functionally evaluate three previously uncharacterized heat shock factor protein 4 (HSF4) mutations (c.595_599delGGGCC, c.1213C>T, c.1327+4A>G) encoding mutant HSF4 proteins (G199EfsX15, R405X, and M419GfsX29) with missing C-terminal ends. These HSF4 mutations were previously ident...

journal_title：Investigative ophthalmology & visual science

authors： Merath K,Ronchetti A,Sidjanin DJ

更新日期：2013-10-11 00:00:00

abstract：PURPOSE:To establish an experimental mouse model of retinal detachment (RD) created by corneal puncture (CP). METHODS:Mouse corneas were punctured with a 30.5-gauge beveled needle, and the anterior chamber was penetrated. Histologic and functional changes of the retina were examined by light microscopy and electroreti...

journal_title：Investigative ophthalmology & visual science

authors： Zeng R,Zhang Y,Shi F,Kong F

更新日期：2012-03-26 00:00:00

abstract：PURPOSE:In humans, mutations in the gene encoding myosin VIIa can cause Usher syndrome type 1b (USH1B), a disease characterized by deafness and retinitis pigmentosa. Myosin VIIa is also the gene responsible for the inner ear abnormalities at the shaker1 (sh1) locus in mice. To date, none of the sh1 alleles examined hav...

journal_title：Investigative ophthalmology & visual science

authors： Libby RT,Steel KP

更新日期：2001-03-01 00:00:00

abstract：:Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma...

journal_title：Investigative ophthalmology & visual science

authors： Liu SH,Tagawa Y,Prendergast RA,Franklin RM,Silverstein AM

更新日期：1981-01-01 00:00:00

abstract：:Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outsi...

journal_title：Investigative ophthalmology & visual science

authors： Panda S,Jonas JB

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of high glucose on the proliferation of human retinal endothelial cells (HRECs) and to elucidate the possible mechanisms of antiangiogenic activity of curcumin, a diferuloylmethane. METHODS:Human retinal endothelial cells were isolated from the retinal tissue obtained from human donor...

journal_title：Investigative ophthalmology & visual science

authors： Premanand C,Rema M,Sameer MZ,Sujatha M,Balasubramanyam M

更新日期：2006-05-01 00:00:00

abstract：Purpose:To investigate the effects of tear film instability (TFI) induced by sustained tear exposure (STARE) on sensory responses to corneal cold, mechanical, and chemical stimuli. Methods:Fifteen normal subjects were enrolled. TFI was induced during 10 repeated trials of STARE. Pneumatic cold, mechanical, and chemica...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Begley CG,Simpson TL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Although the murine alphaA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao H,Yang Y,Rizo CM,Overbeek PA,Robinson ML

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT). METHODS:Laser photocoagulation was applied to the mouse fundus using a 532-nm diode laser (100, 150, and 200 mW; 100-μm diameter, 0.1-second duration). SD-O...

journal_title：Investigative ophthalmology & visual science

authors： Giani A,Thanos A,Roh MI,Connolly E,Trichonas G,Kim I,Gragoudas E,Vavvas D,Miller JW

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Nerve growth factor (NGF) is a neuropeptide essential for the development, survival, growth, and differentiation of corneal cells. Its effects are mediated by both TrkA and p75 receptors. Clinically relevant use of NGF was introduced to treat neurotrophic ulcerations in patients. Herein, we examine the mechanis...

journal_title：Investigative ophthalmology & visual science

authors： Blanco-Mezquita T,Martinez-Garcia C,Proença R,Zieske JD,Bonini S,Lambiase A,Merayo-Lloves J

更新日期：2013-06-04 00:00:00

abstract：PURPOSE:To assess the thickness and surface area of porcine sclera. METHODS:One hundred twenty-eight porcine globes were sectioned from the center of the cornea to the region of the optic nerve. Photographs of the sectioned sclera including a millimeter scale were taken. Photographic slides were projected onto blank p...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Sanderson S,Feng X,Hubbard WC

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:The inherited early-onset macular degenerative disease known as malattia leventinese (ML) and Doyne honeycomb retinal dystrophy (DHRD) have been linked to a missense mutation leading to production of a mutant fibulin-3 protein (R345W). R345W is poorly secreted and accumulates in the RPE of ML/DHRD retinas. Accu...

journal_title：Investigative ophthalmology & visual science

authors： Roybal CN,Marmorstein LY,Vander Jagt DL,Abcouwer SF

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Aquaporin (AQP) is a hexahelical integral membrane protein that functions as a constitutive channel for water and regulated channel for cations in fluid transporting tissues, including many in the eye. Although AQP1 has been cloned from a cDNA library prepared from cultures of retinal pigment epithelial (RPE) c...

journal_title：Investigative ophthalmology & visual science

authors： Stamer WD,Bok D,Hu J,Jaffe GJ,McKay BS

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Vision restoration is a fast-approaching reality for some people with profound vision loss. In order to reliably determine treatment efficacy, accurate assessment of baseline residual visual function is critical. The purpose of this study was to compare residual function as detected on Goldman visual field (GVF...

journal_title：Investigative ophthalmology & visual science

authors： Ayton LN,Apollo NV,Varsamidis M,Dimitrov PN,Guymer RH,Luu CD

更新日期：2014-03-06 00:00:00

abstract：PURPOSE:The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. METHODS:Occludin expression was inhibited in the human retina...

journal_title：Investigative ophthalmology & visual science

authors： Phillips BE,Cancel L,Tarbell JM,Antonetti DA

更新日期：2008-06-01 00:00:00