Viscous corneal protection by sodium hyaluronate, chondroitin sulfate, and methylcellulose.

abstract：PURPOSE:The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb. METHODS:Thirty-seven patients (43 eyes) who had recently (<2 years) undergone ...

journal_title：Investigative ophthalmology & visual science

authors： Pfenninger L,Schneider F,Funk J

更新日期：2011-04-14 00:00:00

abstract：PURPOSE:The values of Heidelberg Retinal Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany) stereometric parameters depend on the reference plane (RP), the instability of which results in parameter variability. Identification of change depends on RP stability. This study was undertaken to evaluate the influen...

journal_title：Investigative ophthalmology & visual science

authors： Poli A,Strouthidis NG,Ho TA,Garway-Heath DF

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Patients with typical clinical features of retinitis pigmentosa were found to have the atypical electroretinographic finding of a negative waveform to a bright flash in the dark-adapted state. The full-field electroretinogram (ERG) was studied in seven such patients to understand better the pathophysiology. ME...

journal_title：Investigative ophthalmology & visual science

authors： Cideciyan AV,Jacobson SG

更新日期：1993-11-01 00:00:00

abstract：:The retinal blood vessels serve for nutrition of the retinal ganglion cells and their axons. This study was undertaken to evaluate the vessel diameter in normal and glaucoma eyes. The calibers of the superior temporal and inferior temporal retinal artery and vein were measured at the optic disc border and at a distanc...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nguyen XN,Naumann GO

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques and is believed to play a critical role in atherosclerosis. The purpose of this study was to identify and localize 7-ketocholesterol (7kCh) in the primate retina and to examine the potential consequences of its presence ...

journal_title：Investigative ophthalmology & visual science

authors： Moreira EF,Larrayoz IM,Lee JW,Rodríguez IR

更新日期：2009-02-01 00:00:00

abstract：:Five immunosuppressive and anti-inflammatory agents were tested for their effects on development of experimental autoimmune uveoretinitis (EAU) and immune responses to S-antigen in rats immunized with this retinal antigen. When administered daily from day 0-14 after immunization, cyclosporine at 5-20 mg/Kg was nontoxi...

journal_title：Investigative ophthalmology & visual science

authors： Mochizuki M,Nussenblatt RB,Kuwabara T,Gery I

更新日期：1985-02-01 00:00:00

abstract：Purpose:We recently reported that the glycosaminoglycan hyaluronan (HA), which promotes inflammatory angiogenesis in other vascular beds, is an abundant component of the limbal extracellular matrix. Consequently, we have explored the possibility that HA contributes to lymphangiogenesis in the inflamed cornea. Methods:...

journal_title：Investigative ophthalmology & visual science

authors： Sun M,Puri S,Mutoji KN,Coulson-Thomas YM,Hascall VC,Jackson DG,Gesteira TF,Coulson-Thomas VJ

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four...

journal_title：Investigative ophthalmology & visual science

authors： Keller KE,Kelley MJ,Acott TS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects. METHODS:Twenty-four young healthy women were grouped as vasospastic and nonvasospastic, based on their history of cold extremities and on the results of nailf...

journal_title：Investigative ophthalmology & visual science

authors： Gugleta K,Zawinka C,Rickenbacher I,Kochkorov A,Katamay R,Flammer J,Orgul S

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Cultured human corneal endothelial cells (cHCECs) are anticipated to become an alternative to donor corneas for the treatment of corneal endothelial dysfunction. However, cHCECs reportedly tend to exhibit chromosomal abnormality during in vitro cell division, thereby hampering their use in the clinical setting....

journal_title：Investigative ophthalmology & visual science

authors： Hamuro J,Ueno M,Toda M,Sotozono C,Montoya M,Kinoshita S

更新日期：2016-08-01 00:00:00

abstract：:On the assumption that myelin intrusion into the papilla and peripapillary region might occur with traumatic lesions of the optic nerve, a study was made of the clinical and histopathologic changes that might be expected. Nine monkey eyes were subjected to hemostat compression of the nerve close to the globe and studi...

journal_title：Investigative ophthalmology & visual science

authors： Cogan DG,Yee RD

更新日期：1977-05-01 00:00:00

abstract：:Collagen deposition is largely responsible for scar information, an undesirable outcome of glaucoma filtering surgery. Because interferon-gamma (IFN-gamma) has been reported to inhibit collagen synthesis in a variety of cells, the authors examined its effect on collagen synthesis by Tenon's capsule fibroblasts culture...

journal_title：Investigative ophthalmology & visual science

authors： Low SQ,Kitada S,Lee DA

更新日期：1991-10-01 00:00:00

abstract：PURPOSE:To test whether in an animal model of proliferative vitreoretinopathy (PVR) the Müller glial cells displayed an upregulation of purinergic P2 receptor-mediated responses. METHODS:PVR was induced by intravitreal injection of the proteolytic enzyme, dispase, in the eyes of adult rabbits. The developing PVR was e...

journal_title：Investigative ophthalmology & visual science

authors： Francke M,Weick M,Pannicke T,Uckermann O,Grosche J,Goczalik I,Milenkovic I,Uhlmann S,Faude F,Wiedemann P,Reichenbach A,Bringmann A

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 during the eye-opening stage when the goblet cells first appear. METHODS:Laser microdissection (LMD) was used to collect conjunctival forniceal cells from postnatal (PN) day 9, PN14 and PN20 wild-type...

journal_title：Investigative ophthalmology & visual science

authors： Gupta D,Harvey SA,Kaminski N,Swamynathan SK

更新日期：2011-07-01 00:00:00

abstract：:The histological distribution of R-cognin in chick retinas was determined from embryonic day 8 through 13 wk post-hatching by indirect immunofluorescence using polyclonal anticognin. On embryonic day 8, at a developmental stage without distinct retina layers, most of the cells within the tissue exhibited fluorescence....

journal_title：Investigative ophthalmology & visual science

authors： Dobi ET,Troccoli NM,Hausman RE

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:Macular pigment (MP) may protect against age-related macular degeneration. This study was conducted to determine the extent of changes in the macular pigment density as a consequence of oral supplementation with lutein. A second purpose was to compare two objective measurement techniques. METHODS:In the first ...

journal_title：Investigative ophthalmology & visual science

authors： Berendschot TT,Goldbohm RA,Klöpping WA,van de Kraats J,van Norel J,van Norren D

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:Because several polypeptide growth factors are known to influence capillary endothelial cell mitogenesis, the authors investigated the presence of some of these molecules in choroidal neovascular membranes (CNVMs) removed surgically from human subjects with age-related macular degeneration (ARMD). METHODS:The ...

journal_title：Investigative ophthalmology & visual science

authors： Amin R,Puklin JE,Frank RN

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:To characterize the differential expression of intraocular inflammatory cytokines in eyes with branch retinal vein occlusion (BRVO) and to assess their roles as prognostic determinants of BRVO. METHODS:A prospective cohort study of 38 eyes with BRVO. Aqueous humor samples were collected just before the intravi...

journal_title：Investigative ophthalmology & visual science

authors： Kaneda S,Miyazaki D,Sasaki S,Yakura K,Terasaka Y,Miyake K,Ikeda Y,Funakoshi T,Baba T,Yamasaki A,Inoue Y

更新日期：2011-05-06 00:00:00

abstract：PURPOSE:To identify the tyrosine-phosphorylated protein(s) in bovine rod outer segments (ROS) that are associated with phosphatidylinositol 3-kinase (PI3K). METHODS:Glutathione-S-transferase (GST) fusion proteins containing two SH2 domains of the p85 regulatory subunit of PI3K-GST-p85 (N-SH2), GST-p85 (C-SH2), and res...

journal_title：Investigative ophthalmology & visual science

authors： Rajala RV,Anderson RE

更新日期：2001-12-01 00:00:00

abstract：Purpose:To evaluate the contribution of fixational saccades toward fixation instability in strabismic monkeys. Methods:Binocular eye movements were measured as six experimental monkeys (five strabismic monkeys and one monkey with downbeat nystagmus) and one normal monkey fixated targets of two shapes (Optotype, Disk) ...

journal_title：Investigative ophthalmology & visual science

authors： Upadhyaya S,Pullela M,Ramachandran S,Adade S,Joshi AC,Das VE

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To evaluate a novel objective perimetry using multifocal chromatic pupil light reflex in normal participants and patients with photoreceptor dysfunction, and to relate this new technique with subjective dark-adapted chromatic Goldmann perimetry. METHODS:Thirty-two eyes of 17 retinitis pigmentosa (RP) or cone-r...

journal_title：Investigative ophthalmology & visual science

authors： Skaat A,Sher I,Kolker A,Elyasiv S,Rosenfeld E,Mhajna M,Melamed S,Belkin M,Rotenstreich Y

更新日期：2013-04-17 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the express...

journal_title：Investigative ophthalmology & visual science

authors： Alge CS,Priglinger SG,Neubauer AS,Kampik A,Zillig M,Bloemendal H,Welge-Lussen U

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To describe a software program developed to provide an objective assessment of the amount of posterior capsular opacification (PCO) in high-resolution digital images of the posterior capsule after cataract surgery. METHODS:Images are analyzed by a set protocol of defining the area of the posterior capsule, rem...

journal_title：Investigative ophthalmology & visual science

authors： Barman SA,Hollick EJ,Boyce JF,Spalton DJ,Uyyanonvara B,Sanguinetti G,Meacock W

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To isolate all constituent mucins from human conjunctival mucus. METHODS:Mucins were extracted from human conjunctiva in guanidine hydrochloride and protease inhibitors. The mucins were isolated by density gradient centrifugation, gel filtration, and ion exchange chromatography. Throughout purification, the mu...

journal_title：Investigative ophthalmology & visual science

authors： Berry M,Ellingham RB,Corfield AP

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:Ca(2+) is a major regulator of cell function. In the retinal pigment epithelium (RPE), intracellular free Ca(2+) concentration ([Ca(2+)](i)) is essential for the maintenance of normal retinal function. Therefore, accurate control of [Ca(2+)](i) is vital in these cells. Because Ca(2+) is permanently extruded fro...

journal_title：Investigative ophthalmology & visual science

authors： Wimmers S,Strauss O

更新日期：2007-12-01 00:00:00

abstract：Purpose:Primary open angle glaucoma (POAG) is the most prevalent form of glaucoma, accounting for approximately 90% of all cases. The aqueous humor (AH), a biological fluid in the anterior and posterior chambers of the eye, is involved in a multitude of functions including the maintenance of IOP and ocular homeostasis....

journal_title：Investigative ophthalmology & visual science

authors： Sharma S,Bollinger KE,Kodeboyina SK,Zhi W,Patton J,Bai S,Edwards B,Ulrich L,Bogorad D,Sharma A

更新日期：2018-05-01 00:00:00

abstract：:In 188 patients from separate families with various forms of retinitis pigmentosa (RP) and 91 normal subjects, plasma fatty acids were measured as a percentage of total plasma fatty acids, and their concentrations were determined using capillary-column gas-liquid chromatography. After controlling for the effects of ag...

journal_title：Investigative ophthalmology & visual science

authors： Gong J,Rosner B,Rees DG,Berson EL,Weigel-DiFranco CA,Schaefer EJ

更新日期：1992-08-01 00:00:00

abstract：Purpose:Aging is a critical risk factor for the development of retinal diseases, but how aging perturbs ocular homeostasis and contributes to disease is unknown. We identified transmembrane protein 135 (Tmem135) as a gene important for regulating retinal aging and mitochondrial dynamics in mice. Overexpression of Tmem1...

journal_title：Investigative ophthalmology & visual science

authors： Landowski M,Grindel S,Shahi PK,Johnson A,Western D,Race A,Shi F,Benson J,Gao M,Santoirre E,Lee WH,Ikeda S,Pattnaik BR,Ikeda A

更新日期：2020-10-01 00:00:00