Plasma docosahexaenoic acid levels in various genetic forms of retinitis pigmentosa.

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:Myopia is a common complex trait that affects up to 60% of some populations. Its development is influenced by multiple genes and environmental factors. PAX6 and SOX2 are genes with fundamental roles in ocular growth and development, and they have been linked with myopia in a recent linkage study. The authors in...

journal_title：Investigative ophthalmology & visual science

authors： Simpson CL,Hysi P,Bhattacharya SS,Hammond CJ,Webster A,Peckham CS,Sham PC,Rahi JS

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00

abstract：:Electroretinograms (ERGs) were elicited by hemicircular (half-disc) stimuli to the upper, lower, temporal and nasal maculas of 26 normal subjects, and the amplitudes and implicit times of the ERGs from opposing macular regions were compared. The amplitudes of a-wave, b-wave and oscillatory potentials (OPs) were signif...

journal_title：Investigative ophthalmology & visual science

authors： Miyake Y,Shiroyama N,Horiguchi M,Ota I

更新日期：1989-08-01 00:00:00

abstract：:The retinal blood vessels serve for nutrition of the retinal ganglion cells and their axons. This study was undertaken to evaluate the vessel diameter in normal and glaucoma eyes. The calibers of the superior temporal and inferior temporal retinal artery and vein were measured at the optic disc border and at a distanc...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nguyen XN,Naumann GO

更新日期：1989-07-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the disease-causing mutations for retinitis pigmentosa (RP) patients and function of mutations. Methods:We recruited RP families and sporadic RP patients, and performed whole-exome sequencing (WES) to screen for sequence variations. Subsequently, we investigated the...

journal_title：Investigative ophthalmology & visual science

authors： Xiao X,Cao Y,Zhang Z,Xu Y,Zheng Y,Chen LJ,Pang CP,Chen H

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sunitinib in corneal neovascularization (NV). METHODS:Inflammatory corneal NV was induced by thermal cauterization applied in the central cornea of mice, to which sunitinib malate was daily administered by gavage or not. At...

journal_title：Investigative ophthalmology & visual science

authors： Detry B,Blacher S,Erpicum C,Paupert J,Maertens L,Maillard C,Munaut C,Sounni NE,Lambert V,Foidart JM,Rakic JM,Cataldo D,Noël A

更新日期：2013-05-03 00:00:00

abstract：PURPOSE:Excessive and continuously produced free radicals in the outer retina are implicated in retinal aging and the pathogenesis of sight-threatening retinopathies, yet measuring outer retinal oxidative stress in vivo remains a challenge. Here, we test the hypothesis that continuously produced paramagnetic free radic...

journal_title：Investigative ophthalmology & visual science

authors： Berkowitz BA,Bredell BX,Davis C,Samardzija M,Grimm C,Roberts R

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether human corneal epithelial cells and keratocytes synthesize both the soluble and membrane forms of the type II IL-1 receptor (IL-1RII). METHODS:Primary cell cultures of human corneal epithelial cells and keratocytes were established from human corneas. RT-PCR wa...

journal_title：Investigative ophthalmology & visual science

authors： Cubitt CL,Lausch RN,Oakes JE

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Abnormalities in the distribution of long-chain polyunsaturated fatty acids (LCPUFA) have been documented in plasma of patients with X-linked retinitis pigmentosa (XLRP). In this study, fatty acid profiles of red blood cells (RBC) were used as an index for LCPUFA metabolism in patients with XLRP because RBC lip...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman DR,Birch DG

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：Purpose:Global motion and global form perception have been found to be abnormal in the presence of amblyopia. How such deficits manifest in visual function reliant on the interactions between these two visual processing mechanisms has not been adequately explored. In the current study, we use dynamic Glass patterns (dG...

journal_title：Investigative ophthalmology & visual science

authors： Joshi MR,Simmers AJ,Jeon ST

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：Purpose:We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods:The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography,...

journal_title：Investigative ophthalmology & visual science

authors： Alassane S,Binquet C,Arnould L,Fleck O,Acar N,Delcourt C,Bretillon L,Bron AM,Creuzot-Garcher C

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To test whether the incidence of long-term drift to timolol can be reduced by a "pulsatile" treatment (6 months timolol-2 months dipivefrin). METHODS:In a randomized clinical trial, 100 consecutive subjects with ocular hypertension or high-tension primary open-angle glaucoma in at least one eye were randomly a...

journal_title：Investigative ophthalmology & visual science

authors： Gandolfi SA,Vecchi M

更新日期：1996-03-01 00:00:00

abstract：:Retinal cone photoreceptors are polarized cells with discrete functional compartments. Little is known of the membrane-skeleton components in cones responsible for the maintenance of cellular morphology and compartmentalization of integral membrane proteins. The authors describe a high density of the membrane-skeleton...

journal_title：Investigative ophthalmology & visual science

authors： Spencer M,Moon RT,Milam AH

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To determine the accommodative accuracy of infants and young children before they had had any form of clinical intervention or treatment, in an attempt to determine the difference between 'normal' and 'abnormal' visual experience for these individuals. METHODS:Nott retinoscopy was performed on 111 subjects in ...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Gray KH,Hohenbary CC,Lyon DW

更新日期：2012-01-17 00:00:00

abstract：PURPOSE:Oxygen-induced retinopathy (OIR) is a model for human retinopathy of prematurity (ROP). In OIR mice, this study determined whether blockade of β-adrenergic receptors (β-ARs) with propranolol influences retinal levels of proangiogenic factors, retinal vascularization, and blood-retinal barrier (BRB) breakdown. ...

journal_title：Investigative ophthalmology & visual science

authors： Ristori C,Filippi L,Dal Monte M,Martini D,Cammalleri M,Fortunato P,la Marca G,Fiorini P,Bagnoli P

更新日期：2011-01-05 00:00:00

abstract：PURPOSE:To investigate the slow phase in latent/manifest latent nystagmus (LMLN) by producing long eye-drift intervals devoid of fast phases (extended slow phases [ESPs]) and to relate ESP metrics to clinical findings. METHODS:Ten patients with LMLN had eye movements recorded while attending to paired visual and audit...

journal_title：Investigative ophthalmology & visual science

authors： Gradstein L,Goldstein HP,Wizov SS,Reinecke RD

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Keratoconus is characterized by thinning and scarring of the central region of the cornea. Previous research showed that, in corneas obtained from patients with keratoconus, lysosomal enzyme activities are elevated, whereas levels of protease inhibitors such as alpha1-proteinase inhibitor are reduced. This stud...

journal_title：Investigative ophthalmology & visual science

authors： Zhou L,Sawaguchi S,Twining SS,Sugar J,Feder RS,Yue BY

更新日期：1998-06-01 00:00:00

abstract：:The cornea of one eye was opacified in two young macaque monkeys by multiple stromal injections of a suspension of polystyrene particles (latex). Ultrasound measurements showed that the eye with opaque cornea grew at a faster rate, so that after 1 year it was more than 1 mm longer than the normal eye. This difference ...

journal_title：Investigative ophthalmology & visual science

authors： Wiesel TN,Raviola E

更新日期：1979-12-01 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Strabismic amblyopia is typically associated with several visual deficits, including loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision. Binocular summation ratios (BSRs) are usually assessed by comparing contrast sensitivity for binocular stimuli (sens(BIN)) with that measured in t...

journal_title：Investigative ophthalmology & visual science

authors： Baker DH,Meese TS,Mansouri B,Hess RF

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:A prior study showed that cholinergic agonists activate phospholipase D (PLD). The purpose of this study was to determine whether cholinergic agonists use the PLD pathway to alter protein secretion and to identify the molecular signaling components of this pathway in rat lacrimal gland acini. METHODS:Rat lacri...

journal_title：Investigative ophthalmology & visual science

authors： Hodges RR,Guilbert E,Shatos MA,Natarajan V,Dartt DA

更新日期：2011-04-06 00:00:00

abstract：PURPOSE:To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS). METHODS:Eleven macaque monkeys, including four controls and...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Patel NB,Harwerth RS,Frishman LJ

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To determine the roles played by toll-like receptor 9 (TLR9) in cultured human corneal endothelial (HCEn) cells after herpes simplex virus type 1 (HSV-1) infection and to characterize the TLR9-mediated antiviral responses. METHOD:Immortalized HCEn cells were examined for TLR expression. The upregulation of inf...

journal_title：Investigative ophthalmology & visual science

authors： Takeda S,Miyazaki D,Sasaki S,Yamamoto Y,Terasaka Y,Yakura K,Yamagami S,Ebihara N,Inoue Y

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:Angiotensin-converting-enzyme (ACE) catalyses the formation of angiotensin II (ANGII), which presumably acts as a central neurotransmitter/modulator. ANGII-related effects have also been observed in the retina. Present in vivo experiments were designed to investigate further ANGII-related effects on retinal neu...

journal_title：Investigative ophthalmology & visual science

authors： Jacobi PC,Osswald H,Jurklies B,Zrenner E

更新日期：1994-03-01 00:00:00

abstract：Purpose:To validate the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) in a cohort of patients treated at the University of California-San Francisco (UCSF). Methods:A retrospective chart review was performed of 390 patients treated between 2002 and 2007 for choroidal melanoma at UCSF. Similar patients (n = 117...

journal_title：Investigative ophthalmology & visual science

authors： DeParis SW,Taktak A,Eleuteri A,Enanoria W,Heimann H,Coupland SE,Damato B

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00