Proteomic Alterations in Aqueous Humor From Patients With Primary Open Angle Glaucoma.

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects. METHODS:Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed wi...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz B,Schaefer T,Krick CM,Reith W,Backens M,Käsmann-Kellner B

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:The authors examine the effect of retinal branch vein occlusion (BVO), a common retinal vascular disorder, on protein tyrosine phosphorylation, production of angiogenic growth factors, and activation of signal proteins in the tyrosine kinase pathways in the retina. METHODS:Retinal branch vein occlusion was ind...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi A,Imai K,Kim HC,de Juan E Jr

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:To examine the expression of five prostaglandin (PG) receptors, EP(1), EP(2), EP(3), EP(4), and FP and their corresponding mRNA transcripts in human sclera and cultured human scleral fibroblasts (HSFs). METHODS:Primary cultures of HSFs were established from donor eyes. Also, sclera from human donor eyes was sn...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Aihara M,Weinreb RN

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:Oxidative stress has been proposed as a major pathogenic factor in age-related macular degeneration (AMD), the leading cause of vision loss among elderly people of western European ancestry. Lutein (LUT) and zeaxanthin (ZEA), major components in macular pigment, are among the retinal antioxidants. Though xantho...

journal_title：Investigative ophthalmology & visual science

authors： Chucair AJ,Rotstein NP,Sangiovanni JP,During A,Chew EY,Politi LE

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:A number of protocols have been published to induce retinal determination from human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). Although all these studies have shown some degree of expression of markers of retinal cells, fewer than 30 markers are typically used to characterize the ES...

journal_title：Investigative ophthalmology & visual science

authors： Lamba DA,Reh TA

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:Angiogenesis, the formation of new capillary blood vessels, is an essential biological process under physiological conditions, including embryonic development, reproduction, and wound repair. Under pathologic conditions, this process plays a critical role in a variety of diseases such as cancer, rheumatoid arth...

journal_title：Investigative ophthalmology & visual science

authors： Pakneshan P,Birsner AE,Adini I,Becker CM,D'Amato RJ

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To isolate and characterize ciliary body epithelial antigens reactive with a monoclonal antibody, 2B4.14.1. METHODS:A mouse monoclonal antibody generated against human corneal endothelium, 2B4.14.1 reacts with nonpigmented epithelium of human and guinea pig ciliary bodies. The ciliary body proteins reactive wi...

journal_title：Investigative ophthalmology & visual science

authors： Howell DN,Ross JR,Miller SE,Sanfilippo FP

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor (HGF), HGF receptor (MET), keratinocyte growth factor (KGF), KGF receptor, and fibroblast growth factor (FGF) receptor-2 were produced in primary cultures of human corneal epithelial, stromal fibroblast, and end...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Walker JW,Chwang EL,He YG

更新日期：1993-07-01 00:00:00

abstract：:The impact of aging on cell loss in the human retina was examined in foveal and temporal equatorial regions in eyes from 35 donors with ages spanning a 78-yr period from the second to the ninth decade of life. Equatorial cones and retinal pigment epithelial cells (RPE) decreased at uniform rates from the second to the...

journal_title：Investigative ophthalmology & visual science

authors： Gao H,Hollyfield JG

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure. METHODS:A population-based study was conducted in Beaver Dam, Wisconsin (n=4926, age range, 43-84 years). Retinal photographs of right eyes taken at the baseline examination (1988-90) were...

journal_title：Investigative ophthalmology & visual science

authors： Wong TY,Klein R,Klein BE,Meuer SM,Hubbard LD

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:To investigate the effect of high glucose on the proliferation of human retinal endothelial cells (HRECs) and to elucidate the possible mechanisms of antiangiogenic activity of curcumin, a diferuloylmethane. METHODS:Human retinal endothelial cells were isolated from the retinal tissue obtained from human donor...

journal_title：Investigative ophthalmology & visual science

authors： Premanand C,Rema M,Sameer MZ,Sujatha M,Balasubramanyam M

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To examine the histologic and ultrastructural changes in Bruch's membrane (BM) in apolipoprotein E deficient [ApoE(-)] mice in comparison with age-matched control animals. METHODS:Two-month-old (group 1) and 8-month-old (group 2) normal control C57BL/6 mice and 2-month-old (group 3) and 8-month-old (group 4) A...

journal_title：Investigative ophthalmology & visual science

authors： Dithmar S,Curcio CA,Le NA,Brown S,Grossniklaus HE

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To learn whether locally expressed and systemic mediators might modulate the cholinergically induced transepithelial Cl(-) fluxes that underlie lacrimal fluid production. METHODS:Reconstituted epithelial monolayers were exposed to a submaximal dose of the muscarinic agonist, carbachol (CCh), or to one of sever...

journal_title：Investigative ophthalmology & visual science

authors： Selvam S,Mircheff AK,Yiu SC

更新日期：2013-04-26 00:00:00

abstract：PURPOSE:Tendency-oriented perimetry (TOP) is a new strategy designed to estimate the sensitivity of the visual field quickly, by using linear interpolation between test locations. This study determined the spatial resolution characteristics of TOP. METHODS:A Monte-Carlo technique was used to simulate visual fields, an...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To conduct clinical and genetic studies in a European family with autosomal dominant Stargardt-like macular dystrophy (adSTGD-like MD) and to investigate the functional consequences of a novel ELOVL4 mutation. METHODS:Ophthalmic examination and mutation screening by direct sequencing of the ELOVL4 gene was per...

journal_title：Investigative ophthalmology & visual science

authors： Maugeri A,Meire F,Hoyng CB,Vink C,Van Regemorter N,Karan G,Yang Z,Cremers FP,Zhang K

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS:This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (C...

journal_title：Investigative ophthalmology & visual science

authors： Yang D,Fu J,Hou R,Liu K,Jonas JB,Wang H,Chen W,Li Z,Sang J,Zhang Z,Liu S,Cao Y,Xie X,Ren R,Lu Q,Weinreb RN,Wang N

更新日期：2014-04-15 00:00:00

abstract：:Critical flicker frequency (CFF) was measured for stimuli varying in chromaticity only and in luminance only for patients with multiple sclerosis (MS) and for matched normal controls. The two CFF measurements showed different underlying linear interdependencies for the two groups, consistent with a greater loss of tem...

journal_title：Investigative ophthalmology & visual science

authors： Mason RJ,Snelgar RS,Foster DH,Heron JR,Jones RE

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:MRL/Mp-lpr/lpr mice (MRL/lpr) spontaneously develop lacrimal gland inflammatory lesions and are a model for the human disease Sjögren's syndrome. Therapy with monoclonal antibodies (mAb) to CD4 ameliorates the autoimmune renal, vasculitic, and intraocular inflammatory lesions in MRL/lpr mice. The effect of anti...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Burns WH,Prendergast RA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To determine the levels of free UV filters and selected amino acids in cataract lenses compared with normal lenses. METHODS:Indian cataract lenses (n=39) and normal lenses (n=6) were examined by HPLC to quantify levels of UV filter compounds, the UV filter precursor amino acid tryptophan (Trp), as well as tyro...

journal_title：Investigative ophthalmology & visual science

authors： Streete IM,Jamie JF,Truscott RJ

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) trigger signaling through reactive oxygen species (ROS) and whether the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway lead to intravitreous neovascularization (IVNV) in an oxygen-induced ret...

journal_title：Investigative ophthalmology & visual science

authors： Byfield G,Budd S,Hartnett ME

更新日期：2009-07-01 00:00:00

abstract：:The integrity of the RPE barrier function in retinal detachment was studied in vitro. The retinal pigment epithelium (RPE)-choroid tissue was isolated from cynomolgus monkey eyes with acute (less than 1 hr), subacute (1-2 weeks), and chronic (8-20 months) retinal detachments, and clamped between Ussing-type chambers. ...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE,Toris CB

更新日期：1987-11-01 00:00:00

abstract：PURPOSE:The immediate early gene Egr-1 is thought to form part of the pathway that mediates abnormal ocular growth. This study investigated whether the mRNA expression levels of Egr-1 in a mammalian retina are modulated differentially, depending on the direction of ocular growth. METHODS:To induce accelerated growth a...

journal_title：Investigative ophthalmology & visual science

authors： Ashby RS,Zeng G,Leotta AJ,Tse DY,McFadden SA

更新日期：2014-07-22 00:00:00

abstract：PURPOSE:How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood. This study sought to identify vitamin A-responsive genes in ocular surface epithelia using gene microarray analysis of cultures of a human conjunctival epithelial (HCjE) cell line grown with ...

journal_title：Investigative ophthalmology & visual science

authors： Hori Y,Spurr-Michaud SJ,Russo CL,Argüeso P,Gipson IK

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:To develop and characterize a feline model of retinal degeneration induced by intravitreal injection of adenosine triphosphate (ATP). METHODS:Nineteen normally sighted adult cats received 100 μL intravitreal injections of ATP with a final concentration of 11, 22, or 55 mM at the retina. Four animals were eutha...

journal_title：Investigative ophthalmology & visual science

authors： Aplin FP,Luu CD,Vessey KA,Guymer RH,Shepherd RK,Fletcher EL

更新日期：2014-11-25 00:00:00

abstract：:Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the opt...

journal_title：Investigative ophthalmology & visual science

authors： Rao NA,Guy J,Sheffield PS

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:To examine the behavior of fibroblasts and retinal pigment epithelial cells after attachment to the retinal surface in vitro to elucidate the pathobiology of the early stages of epiretinal membrane formation. METHODS:Human retinal pigment epithelial (HRPE) cells and bovine Tenon's capsule fibroblasts (BTFs) we...

journal_title：Investigative ophthalmology & visual science

authors： Allamby D,Foreman D,Carrington L,McLeod D,Boulton M

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To design a contact lens to treat and prevent fungal ocular infections. METHODS:Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in p...

journal_title：Investigative ophthalmology & visual science

authors： Ciolino JB,Hudson SP,Mobbs AN,Hoare TR,Iwata NG,Fink GR,Kohane DS

更新日期：2011-08-09 00:00:00