Characterization of a novel family of ciliary body glycoproteins.

abstract：PURPOSE:To characterize reticular pseudodrusen (RPD) by using a point-to-point comparison of the reticular pattern on infrared reflectance (IR), autofluorescence (AF), and red-free (RF) images registered with en face sections of the choroid from spectral domain optical coherence tomography (SD-OCT) scans. METHODS:A cr...

journal_title：Investigative ophthalmology & visual science

authors： Sohrab MA,Smith RT,Salehi-Had H,Sadda SR,Fawzi AA

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:Point and null mutations in interphotoreceptor retinoid-binding protein (IRBP) cause retinal dystrophy in affected patients and IRBP-deficient mice with unknown mechanism. This study investigated whether IRBP protects cells from damages induced by all-trans-retinal (atRAL), which was increased in the Irbp(-/-) ...

journal_title：Investigative ophthalmology & visual science

authors： Lee M,Li S,Sato K,Jin M

更新日期：2016-04-01 00:00:00

abstract：:Ocular ultraviolet radiation (UVR) exposure was assessed in three occupational groups: fisherman, landscape workers and construction workers. The ratio of ocular exposure to ambient exposure was determined by placing UV-sensitive film (295-320 nm) between the eyes of the subjects and in a nearby open field. The mean o...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal FS,Phoon C,Bakalian AE,Taylor HR

更新日期：1988-04-01 00:00:00

abstract：PURPOSE:To describe a method for assessment and individualized compensation of anterior segment birefringence with scanning laser polarimetry. METHODS:A scanning laser polarimeter (GDx Nerve Fiber Analyzer; Laser Diagnostic Technologies, Inc., San Diego, CA) was modified to accommodate a variable compensator. The magn...

journal_title：Investigative ophthalmology & visual science

authors： Zhou Q,Weinreb RN

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To determine whether ciliary neurotrophic factor (CNTF) or brain-derived neurotrophic factor (BDNF) treatment leads to long-term photoreceptor survival in hereditary retinal degeneration. METHODS:An autosomal dominant feline model of rod-cone dystrophy was used throughout the study with two normal animals. In ...

journal_title：Investigative ophthalmology & visual science

authors： Chong NH,Alexander RA,Waters L,Barnett KC,Bird AC,Luthert PJ

更新日期：1999-05-01 00:00:00

abstract：:Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaris. Early changes are characterized by the appearance of platelet-fibrin thrombi within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative ch...

journal_title：Investigative ophthalmology & visual science

authors： Perry DD,Reddick RL,Risco JM

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:Since, to our knowledge, there are no reports on the prevalence of the blaNDM-1 gene among ocular isolates of Enterobacteriaceae, and only limited information on the prevalence of extended spectrum beta-lactamases (ESBLs) among ocular bacterial isolates are available, our study was undertaken. METHODS:A prospe...

journal_title：Investigative ophthalmology & visual science

authors： Sowmiya M,Malathi J,Madhavan HN

更新日期：2012-08-07 00:00:00

abstract：PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Weinreb RN

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:To test whether in an animal model of proliferative vitreoretinopathy (PVR) the Müller glial cells displayed an upregulation of purinergic P2 receptor-mediated responses. METHODS:PVR was induced by intravitreal injection of the proteolytic enzyme, dispase, in the eyes of adult rabbits. The developing PVR was e...

journal_title：Investigative ophthalmology & visual science

authors： Francke M,Weick M,Pannicke T,Uckermann O,Grosche J,Goczalik I,Milenkovic I,Uhlmann S,Faude F,Wiedemann P,Reichenbach A,Bringmann A

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:Photodynamic therapy (PDT) and the administration of compounds acting against vascular endothelial growth factor (anti-VEGF) are approved for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Experimental evidence that the combined use of both treatment opt...

journal_title：Investigative ophthalmology & visual science

authors： Zuluaga MF,Mailhos C,Robinson G,Shima DT,Gurny R,Lange N

更新日期：2007-04-01 00:00:00

abstract：:After viewing red vertical stripes and green horizontal stripes, the eye subsequently views white vertical stripes as greenish and white horizontal stripes as pinkish. It has been theorized that this phenomenon, known as the McCollough effect, is related to long-tern adaptation of cells tuned for both color and orient...

journal_title：Investigative ophthalmology & visual science

authors： Maguire WM,Meyer GE,Baizer JS

更新日期：1980-03-01 00:00:00

abstract：Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

journal_title：Investigative ophthalmology & visual science

authors： Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To explore the role in the eye of tenomodulin (TeM), a chondromodulin (ChM)-I-related glycoprotein, the expression, localization, and antiangiogenic potential of TeM were investigated. METHODS:Gene expression and protein localization of TeM in mouse eyes were examined by Northern blot analysis, in situ hybridi...

journal_title：Investigative ophthalmology & visual science

authors： Oshima Y,Shukunami C,Honda J,Nishida K,Tashiro F,Miyazaki J,Hiraki Y,Tano Y

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Under certain pathophysiologic conditions, the corneal endothelium can produce an abnormal posterior collagenous layer (PCL) that reduces light transmission. Previous studies suggest that formation of PCLs can result from transformation of endothelial cells to a proliferative myofibroblast phenotype. The purpos...

journal_title：Investigative ophthalmology & visual science

authors： Petroll WM,Jester JV,Bean JJ,Cavanagh HD

更新日期：1998-10-01 00:00:00

abstract：:Retinal leukocyte velocity and density were estimated using blue-field entoptic imaging techniques in a controlled double-masked study to determine the relative effects of oxygen and carbon dioxide on perimacular hemodynamics in single eyes of ten normal human subjects. Mild hypoxia (inspiration of 16% O2) did not sig...

journal_title：Investigative ophthalmology & visual science

authors： Sponsel WE,DePaul KL,Zetlan SR

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:The mouse has become an important wound healing model with which to study corneal fibrosis, a frequent complication of refractive surgery. The aim of the current study was to quantify changes in stromal ultrastructure and light scatter that characterize fibrosis in mouse corneal debridement wounds. METHODS:Epi...

journal_title：Investigative ophthalmology & visual science

authors： Boote C,Du Y,Morgan S,Harris J,Kamma-Lorger CS,Hayes S,Lathrop KL,Roh DS,Burrow MK,Hiller J,Terrill NJ,Funderburgh JL,Meek KM

更新日期：2012-05-14 00:00:00

abstract：:Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized b...

journal_title：Investigative ophthalmology & visual science

authors： Iso T,Uda K,Yamauchi H,Nakajima N,Suda H

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:Vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are members of a large group of homologous peptides identified as the VEGF family. Although VEGF-A is known to act as a potent angiogenic peptide in the retina, the vasoactive function of PlGF in this tissue is less well defined. Thi...

journal_title：Investigative ophthalmology & visual science

authors： Feeney SA,Simpson DA,Gardiner TA,Boyle C,Jamison P,Stitt AW

更新日期：2003-02-01 00:00:00

abstract：:Chloride ion (Cl-) secretion by the rabbit corneal epithelium involves a catecholamine-stimulated Cl- conductance at the apical membrane, but the characteristics of the ion channel(s) responsible are unknown. A primary cell culture system was developed that induces stratified epithelial differentiation of rat and rabb...

journal_title：Investigative ophthalmology & visual science

authors： Marshall WS,Hanrahan JW

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:To investigate the effect of retinal eccentricity on the phenomenon of dichoptic suppression of the mfVEP amplitude and to examine the relationship between the degree of simulated unilateral visual impairment and the possible release of dichoptic suppression in the contralateral eye. METHOD:Eight subjects with...

journal_title：Investigative ophthalmology & visual science

authors： Leaney J,Klistorner A,Arvind H,Graham SL

更新日期：2010-12-01 00:00:00

abstract：Purpose:To compare the changes in human tear proteome and clinical effects following topical cyclosporine A (CsA) 0.05% or diquafosol tetrasodium (DQS) 3% treatment of dry eye disease (DED), and to identify biomarkers for determining disease severity and treatment effectiveness in DED. Methods:A total of 18 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Ji YW,Kim HM,Ryu SY,Oh JW,Yeo A,Choi CY,Kim MJ,Song JS,Kim HS,Seo KY,Kim KP,Lee HK

更新日期：2019-12-02 00:00:00

abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

journal_title：Investigative ophthalmology & visual science

authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

更新日期：2014-12-02 00:00:00

abstract：:The capacities of porcine choroidal fibroblasts, retinal glial cells, and retinal pigment epithelial cells to contract collagen gels in vitro were compared. Experiments with varied cell numbers indicated that glial cells are the most effective, followed by choroidal fibroblasts and retinal pigment epithelial cells. An...

journal_title：Investigative ophthalmology & visual science

authors： Guidry C,McFarland RJ,Morris R,Witherspoon CD,Hook M

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:An alteration in corneal innervation has been described in dry eye associated with diabetes mellitus, contact lens use, and LASIK. The purpose of this study was to evaluate whether dry eye not related to Sjögren's syndrome (NSDE) and dry eye related to primary Sjögren's syndrome (PSDE) are associated with an al...

journal_title：Investigative ophthalmology & visual science

authors： Benítez-Del-Castillo JM,Acosta MC,Wassfi MA,Díaz-Valle D,Gegúndez JA,Fernandez C,García-Sánchez J

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To investigate the role of N-cadherin and hepatocyte growth factor (HGF) in the invasion of collagen type I by human retinal pigment epithelial (RPE) cells. METHODS:RPE sheets from eight human eyes were used for characterization through Western blot analysis of the expression of cadherin in total lysates or af...

journal_title：Investigative ophthalmology & visual science

authors： Van Aken EH,De Wever O,Van Hoorde L,Bruyneel E,De Laey JJ,Mareel MM

更新日期：2003-02-01 00:00:00

abstract：:It is possible to record a pattern electroretinogram (PERG) of near normal amplitude in a situation when the eye containing the active electrode is occluded. Because PERG recording requires high amplification and sensitive signal retrieval techniques, the electrode in the occluded eye records a distant potential from ...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:To evaluate the nerve growth factor (NGF) plasma concentration in patients with vernal keratoconjunctivitis and to correlate it with the histopathology and immunopathology of the disease. METHODS:An immunoenzymatic assay was performed to measure NGF plasma levels in patients with vernal keratoconjunctivitis an...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Bonini S,Micera A,Magrini L,Bracci-Laudiero L,Aloe L

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:To study the spatial distribution of posterior pole choroidal thickness (CT) in healthy eyes using spectral domain optical coherence tomography (SD-OCT). METHODS:Fifty-nine eyes from 30 subjects with no retinal or choroidal disease were examined with high-definition (HD) OCT using macular volume cube scanning ...

journal_title：Investigative ophthalmology & visual science

authors： Ouyang Y,Heussen FM,Mokwa N,Walsh AC,Durbin MK,Keane PA,Sanchez PJ,Ruiz-Garcia H,Sadda SR

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy is shown to share many similarities with chronic inflammatory disease, and in diabetes, accelerated apoptosis of retinal capillary cells is evident before histopathology can be seen. The purpose of this study was to examine the effect of interleukin (IL)-1beta on capillary cell apoptosis in...

journal_title：Investigative ophthalmology & visual science

authors： Kowluru RA,Odenbach S

更新日期：2004-11-01 00:00:00