Anion channels in the apical membrane of mammalian corneal epithelium primary cultures.

abstract：Purpose:We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. We hypothesized that this protective effect varies with running intensity. To test this, mice undergoing LIRD were run at different treadmill speeds and retinal function ...

journal_title：Investigative ophthalmology & visual science

authors： Mees LM,Coulter MM,Chrenek MA,Motz CT,Landis EG,Boatright JH,Pardue MT

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:To assess if the in vivo mechanical displacement of the anterior laminar cribrosa surface (ALCS) as a response of an acute elevation in intraocular pressure (IOP) differs in individuals of European (ED) and African descent (AD). METHODS:Spectral-domain optical coherence tomography (SDOCT) scans were obtained f...

journal_title：Investigative ophthalmology & visual science

authors： Fazio MA,Johnstone JK,Smith B,Wang L,Girkin CA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:To investigate the role of angiopoietin-1 (Ang1) in choroidal neovascularization (CNV) and vascular leakage. METHODS:We generated laser-induced CNV in mice and measured the size of CNV and vascular leakage after intravitreal administration of Ang1. The expressions and distributions of endothelial junctional pr...

journal_title：Investigative ophthalmology & visual science

authors： Lee J,Park DY,Park DY,Park I,Chang W,Nakaoka Y,Komuro I,Yoo OJ,Koh GY

更新日期：2014-04-07 00:00:00

abstract：PURPOSE:The chaperone proteins, α-crystallins, also possess antiapoptotic properties. The purpose of the present study was to investigate whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides (α-crystallin mini-chaperone) are antiapoptotic, and to identify their putative transporters in human fetal RPE (hfR...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Chothe P,Sharma KK,Baid R,Kompella U,Spee C,Kannan N,Manh C,Ryan SJ,Ganapathy V,Kannan R,Hinton DR

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

更新日期：2007-11-01 00:00:00

abstract：:The overall morphology of corneal fibroblasts in the rat was examined by scanning electron microscopy after removal of stromal connective tissue elements by tryptic digestion and HCl hydrolysis. Fibroblasts thus exposed were flattened and stellate cells with a diameter of about 10 micron and had a number of ramified c...

journal_title：Investigative ophthalmology & visual science

authors： Nishida T,Yasumoto K,Otori T,Desaki J

更新日期：1988-12-01 00:00:00

abstract：:Previous studies have used Badal laser optometry to demonstrate significant variance in the distribution of tonic (or "dark-focus") resting positions of accommodation (TA) for groups of observers. This study investigates whether individual differences in TA are due to individual differences in autonomic tone of the ci...

journal_title：Investigative ophthalmology & visual science

authors： Gilmartin B,Hogan RE

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:Müller cells are the principal glial cells of the retina. They span the entire thickness of the neural retina, and they are in close contact with neurons. Müller cells grow very slowly, and they undergo senescence with increasing passages. Moreover, successful primary cultures of Müller cells can be obtained on...

journal_title：Investigative ophthalmology & visual science

authors： Lupien CB,Salesse C

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to characterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene ablation and to analyze the allelic selection of the keratin 12 (Krt12) gene during corneal type-epithelium differentiation. METHODS:Knock-in mice were generated by gene targeting. The authors exa...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi Y,Call MK,Liu CY,Hayashi M,Babcock G,Ohashi Y,Kao WW

更新日期：2010-09-01 00:00:00

abstract：Purpose:To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes. Methods:Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, sex, and axia...

journal_title：Investigative ophthalmology & visual science

authors： Lee SH,Kim TW,Lee EJ,Girard MJ,Mari JM

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to compare the accommodative performance of the amblyopic eye of children with unilateral amblyopia to that of their nonamblyopic eye, and also to that of children without amblyopia, during both monocular and binocular viewing. METHODS:Modified Nott retinoscopy was used to measure...

journal_title：Investigative ophthalmology & visual science

authors： Manh V,Chen AM,Tarczy-Hornoch K,Cotter SA,Candy TR

更新日期：2015-01-27 00:00:00

abstract：PURPOSE:Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition. METHODS:This phase III, double-masked, noninferiority study randomized patients with mild to moderate endogeno...

journal_title：Investigative ophthalmology & visual science

authors： Sheppard JD,Toyos MM,Kempen JH,Kaur P,Foster CS

更新日期：2014-05-06 00:00:00

abstract：Purpose:To examine the association between intraocular pressure (IOP) and the prevalence of glaucomatous optic neuropathy (GON) in high myopia. Methods:The hospital-based observational study consisted of patients treated in the Tokyo High Myopia Clinics and for whom fundus photographs and IOP readings were available. ...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nagaoka N,Fang YX,Weber P,Ohno-Matsui K

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To evaluate by vector analysis the corneal astigmatic changes occurring in keratoconic corneas during a 3-year follow-up and to determine the relationship between these changes and other clinical changes. METHODS:Keratoconic eyes (n = 114) of 75 patients ranging in age from 14 to 70 years were retrospectively ...

journal_title：Investigative ophthalmology & visual science

authors： Piñero DP,Alio JL,Tomás J,Maldonado MJ,Teus MA,Barraquer RI

更新日期：2011-06-08 00:00:00

abstract：Purpose:To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods:First, sc...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda Y,Nishiguchi KM,Miya F,Shimozawa N,Funatsu J,Nakatake S,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Yasutomi Y,Tsunoda T,Nakazawa T,Ishibashi T,Sonoda KH

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate a DNA dot hybridization assay (DHA) for assessing bacterial bioburden in orthokeratology lens (OK) storage cases. METHODS:Forty-one OK wearers participated in this study. The dot hybridization assay was used to assess the bacterial bioburden of OK after removal and 6-hour ...

journal_title：Investigative ophthalmology & visual science

authors： Kuo MT,Chien CC,Lo J,Hsiao CC,Tseng SL,Lai YH,Fang PC,Chang TC

更新日期：2014-12-23 00:00:00

abstract：PURPOSE:The current study was done to determine the role of lipocalin-2 (LCN2) in the pathogenesis of demyelinating optic neuritis using an experimental autoimmune optic neuritis (EAON) model. METHODS:The EAON was induced by subcutaneous immunization with an emulsified mixture of myelin oligodendrocyte glycoprotein (M...

journal_title：Investigative ophthalmology & visual science

authors： Chun BY,Kim JH,Nam Y,Huh MI,Han S,Suk K

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Bayesian estimators allow the frequency of visual field progression rates in the population (the prior distribution) to constrain rate estimates for individuals. We examined the benefits of a prior distribution accounting for one of progression's major risk factors--whether intraocular pressure is treated--to g...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ,Johnson CA

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Fundus autofluorescence (FAF), as an index of lipofuscin accumulation in the retinal pigment epithelium (RPE), provides indirect information on the level of metabolic activity of the RPE and thus the integrity of the RPE/photoreceptor complex. To investigate whether the photoreceptor/RPE complex is still viable...

journal_title：Investigative ophthalmology & visual science

authors： Scholl HP,Chong NH,Robson AG,Holder GE,Moore AT,Bird AC

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:There is considerable variation in the degree of form-deprivation myopia (FDM) induced in chickens by a uniform treatment regimen. Sex and pretreatment eye size have been found to be predictive of the rate of FD-induced eye growth. Therefore, this study was undertaken to test whether the greater rate of myopic ...

journal_title：Investigative ophthalmology & visual science

authors： Chen YP,Prashar A,Hocking PM,Erichsen JT,To CH,Schaeffel F,Guggenheim JA

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To demonstrate the conjunctival alterations in patients with Sjögren's (SSDE) and non-Sjögren's syndrome dry eye (NSSDE) using a new generation confocal microscope (HRTII/ RCM; Heidelberg Engineering, Heidelberg, Germany), in a prospective controlled study. METHODS:Twenty-eight right eyes of 28 patients with S...

journal_title：Investigative ophthalmology & visual science

authors： Wakamatsu TH,Sato EA,Matsumoto Y,Ibrahim OM,Dogru M,Kaido M,Ishida R,Tsubota K

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Sarcoidosis is a heterogeneous and multisystem granulomatous disorder. The etiology still is uncertain, but the disease currently is thought to be triggered by various genetic as well as environmental factors. Recently, an association between sarcoidosis and the butyrophilin-like 2 (BTNL2) gene located in close...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki H,Ota M,Meguro A,Katsuyama Y,Kawagoe T,Ishihara M,Asukata Y,Takeuchi M,Ito N,Shibuya E,Nomura E,Uemoto R,Nishide T,Namba K,Kitaichi N,Morimoto S,Kaburaki T,Ando Y,Takenaka S,Nakamura J,Saeki K,Ohno S,In

更新日期：2012-10-11 00:00:00

abstract：PURPOSE:Visibility of low-spatial frequency stimuli improves when their contrast is modulated at 5 to 10 Hz compared with stationary stimuli. Therefore, temporal modulations of visual objects could enhance the performance of low vision patients who primarily perceive images of low-spatial frequency content. We investig...

journal_title：Investigative ophthalmology & visual science

authors： Watson LM,Strang NC,Scobie F,Love GD,Seidel D,Manahilov V

更新日期：2012-09-06 00:00:00

abstract：PURPOSE:Previous studies have demonstrated a role for the retinal pigment epithelium (RPE) in the development and maintenance of the choroidal vasculature, suggesting that RPE serves a trophic role for the choroidal vessels. The goal of this study was to determine the expression pattern of vascular endothelial growth f...

journal_title：Investigative ophthalmology & visual science

authors： Saint-Geniez M,Maldonado AE,D'Amore PA

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To determine whether retinal progenitor cells in the inner nuclear layer give rise to regenerated cones after laser ablation of photoreceptors in adult goldfish retina. METHODS:Using a technique developed previously in this laboratory, photoreceptors in the retina of adult goldfish were ablated with an argon l...

journal_title：Investigative ophthalmology & visual science

authors： Wu DM,Schneiderman T,Burgett J,Gokhale P,Barthel L,Raymond PA

更新日期：2001-08-01 00:00:00

abstract：Purpose:To determine the effects of narrowband light exposure on choroidal thickness and the pupil response in humans. Methods:Twenty subjects, ages 21 to 43 years, underwent 1 hour of exposure to broadband, short wavelength "blue," or long wavelength "red" light, or darkness. Choroidal thickness, imaged with spectral...

journal_title：Investigative ophthalmology & visual science

authors： Lou L,Ostrin LA

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To map the canine rcd2 retinal degeneration locus. Rod-cone dysplasia type 2 (rcd2), an early-onset autosomal recessive form of progressive retinal atrophy (PRA), is phenotypically similar to early-onset forms of retinitis pigmentosa collectively termed Leber congenital amaurosis and segregates naturally in the...

journal_title：Investigative ophthalmology & visual science

authors： Kukekova AV,Nelson J,Kuchtey RW,Lowe JK,Johnson JL,Ostrander EA,Aguirre GD,Acland GM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The outcome of glaucoma filtration surgery is affected by subconjunctival wound healing. The effects of the antiglaucoma drug latanoprost on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel were investigated. METHODS:HTFs were cultured in a type I collagen gel wi...

journal_title：Investigative ophthalmology & visual science

authors： Liu Y,Ko JA,Yanai R,Kimura K,Chikama T,Sagara T,Nishida T

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To evaluate the importance of lens epithelial cell death in age-related cataract. To determine whether the large percentage of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)-positive lens epithelial cells previously reported in human capsulotomy specimens results from apopto...

journal_title：Investigative ophthalmology & visual science

authors： Harocopos GJ,Alvares KM,Kolker AE,Beebe DC

更新日期：1998-12-01 00:00:00