Distribution of amyloid precursor protein and amyloid-beta immunoreactivity in DBA/2J glaucomatous mouse retinas.

abstract：PURPOSE:The main purpose of this study was to develop a cell culture model of immortalized epithelium from the human cornea for drug permeability testing. METHODS:Immortalized human corneal epithelial (HCE) cells were grown on filters, with various filter materials and coating procedures. In the optimal case, HCE cell...

journal_title：Investigative ophthalmology & visual science

authors： Toropainen E,Ranta VP,Talvitie A,Suhonen P,Urtti A

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS:The type IV collagen chains present in the normal retina were determined immunohistoche...

journal_title：Investigative ophthalmology & visual science

authors： Savige J,Liu J,DeBuc DC,Handa JT,Hageman GS,Wang YY,Parkin JD,Vote B,Fassett R,Sarks S,Colville D

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To define the phenotypes of retinal degenerations associated with mutations in the gene encoding CRX (cone-rod homeobox), a photoreceptor-specific transcription factor. METHODS:Heterozygotes with the E168 [delta1 bp], E168 [delta2 bp], or G217 [delta1 bp] CRXgene mutation were studied clinically, with visual f...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Huang Y,Hanna DB,Freund CL,Affatigato LM,Carr RE,Zack DJ,Stone EM,McInnes RR

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To explore the effect of dominance and laterality on refractive error and axial length. METHODS:Ocular dominance was assessed with the hole-in-the-card test in 543 children during their 2006 follow-up visits for the Singapore Cohort study Of the Risk factors for Myopia (SCORM). Data were compared to cycloplegi...

journal_title：Investigative ophthalmology & visual science

authors： Chia A,Jaurigue A,Gazzard G,Wang Y,Tan D,Stone RA,Saw SM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Recently, RAP1 (Telomeric Repeat Binding Factor 2, Interacting Protein [TERF2IP]) was discovered as a modulator that selectively regulates nuclear factor light chain kappa enhancer of activated B cells (NFκB) signaling. The roles of RAP1 in regulation of inflammation and angiogenesis for corneal recovery follow...

journal_title：Investigative ophthalmology & visual science

authors： Poon MW,Yan L,Jiang D,Qin P,Tse HF,Wong IY,Wong DS,Tergaonkar V,Lian Q

更新日期：2015-01-08 00:00:00

abstract：PURPOSE:To visualize and quantify the three-dimensional (3D) spatial relationships of the structures of the aqueous outflow system (AOS) within intact enucleated mouse eyes using spectral two-photon microscopy (TPM) techniques. METHODS:Spectral TPM, including two-photon autofluorescence (TPAF) and second-harmonic gene...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Liu N,Mak PU,Pun SH,Vai MI,Masihzadeh O,Kahook MY,Lei TC,Ammar DA

更新日期：2016-06-01 00:00:00

abstract：:Parallel studies of the ionic balance and membrane permeability characteristics of normal human lenses were carried out in three countries (USA, England and Italy). Similar age-related changes were found in each laboratory. The lens membrane potential and resistance declined markedly with age while internal Na+ and fr...

journal_title：Investigative ophthalmology & visual science

authors： Duncan G,Hightower KR,Gandolfi SA,Tomlinson J,Maraini G

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:To evaluate the functional treatment response 3 months and 12 months after monthly ranibizumab in neovascular age-related macular degeneration (NAMD). METHODS:Twenty-six eyes showing treatment-naïve NAMD were examined with the Heidelberg Spectralis OCT (SD-OCT) and the Nidek MP-1 microperimeter (MP) at baselin...

journal_title：Investigative ophthalmology & visual science

authors： Sulzbacher F,Kiss C,Kaider A,Roberts P,Munk M,Kroh ME,Sayegh R,Schmidt-Erfurth U

更新日期：2013-02-01 00:00:00

abstract：Purpose:Optical coherence tomography's (OCT) third outer retinal band has been attributed to the zone of interdigitation between RPE cells and cone outer segments. The purpose of this paper is to investigate the structure of this band with adaptive optics (AO)-OCT. Methods:Using AO-OCT, images were obtained from two s...

journal_title：Investigative ophthalmology & visual science

authors： Jonnal RS,Gorczynska I,Migacz JV,Azimipour M,Zawadzki RJ,Werner JS

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

journal_title：Investigative ophthalmology & visual science

authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

更新日期：2011-06-01 00:00:00

abstract：:Cataracts removed intracapsularly by cryoprobe technique from human diabetics were analyzed for sugars and polyols by gas liquid chromatography. The contents of sorbitol and fructose of lenses followed blood glucose levels at least up to 250 mg/dl. Studies indicate that human lens is capable of synthesizing substantia...

journal_title：Investigative ophthalmology & visual science

authors： Varma SD,Schocket SS,Richards RD

更新日期：1979-03-01 00:00:00

abstract：PURPOSE:To compare the effects of early, mid, and late subconjunctival injection of bevacizumab on corneal neovascularization (NV) and conjunctivalization in a rabbit limbal insufficiency model. METHODS:Limbal insufficiency was created surgically, and subconjunctival injections of 2.5 mg bevacizumab twice weekly for 1...

journal_title：Investigative ophthalmology & visual science

authors： Lin CT,Hu FR,Kuo KT,Chen YM,Chu HS,Lin YH,Chen WL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To assess the diagnostic validity of a fully automated image analysis algorithm of in vivo confocal microscopy images in quantifying corneal subbasal nerves to diagnose diabetic neuropathy. METHODS:One hundred eighty-six patients with type 1 and type 2 diabetes mellitus (T1/T2DM) and 55 age-matched controls un...

journal_title：Investigative ophthalmology & visual science

authors： Petropoulos IN,Alam U,Fadavi H,Marshall A,Asghar O,Dabbah MA,Chen X,Graham J,Ponirakis G,Boulton AJ,Tavakoli M,Malik RA

更新日期：2014-04-03 00:00:00

abstract：:Neuropeptide Y (NPY) is a recently discovered, amidated 36 amino acid residue neuropeptide present in many but not all sympathetic noradrenergic neurons. In the guinea-pig eye, NPY immunoreactive fibers were found to have the same distribution as noradrenergic fibers except that there were fewer at the iris dilator, i...

journal_title：Investigative ophthalmology & visual science

authors： Bruun A,Ehinger B,Sundler F,Tornqvist K,Uddman R

更新日期：1984-10-01 00:00:00

abstract：:The Early Treatment Diabetic Retinopathy Study (ETDRS) and other standardized classification schemes have laid a foundation for tremendous advances in the understanding and management of diabetic retinopathy (DR). However, technological advances in optics and image analysis, especially optical coherence tomography (OC...

journal_title：Investigative ophthalmology & visual science

authors： Abramoff MD,Fort PE,Han IC,Jayasundera KT,Sohn EH,Gardner TW

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To determine whether a novel peroxynitrite-based photosensitizer S-nitrosoglutathione (GSNO) can produce specific in vitro light-induced cell death of both standard animal lung and human Tenon's capsule (TC) fibroblasts and to compare this effect with that produced by the established photodynamic porphyrin prec...

journal_title：Investigative ophthalmology & visual science

authors： Tannous M,Hutnik CM,Tingey DP,Mutus B

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

journal_title：Investigative ophthalmology & visual science

authors： Dartt DA,Hodges RR

更新日期：2011-05-01 00:00:00

abstract：Purpose:To characterize the morphology of neovascularization at the disc (NVD) and neovascularization elsewhere (NVE) in treatment-naïve or previously treated proliferative diabetic retinopathy (PDR) patients using optical coherence tomography (OCT) angiography. Methods:En face OCT angiograms of NVD/NVE in 40 eyes of ...

journal_title：Investigative ophthalmology & visual science

authors： Ishibazawa A,Nagaoka T,Yokota H,Takahashi A,Omae T,Song YS,Takahashi T,Yoshida A

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS:A subset of males (n = 24) participating in a larger natural history ...

journal_title：Investigative ophthalmology & visual science

authors： Bennett LD,Wang YZ,Klein M,Pennesi ME,Jayasundera T,Birch DG

更新日期：2016-02-01 00:00:00

abstract：Purpose:The subbasal nerve plexus (SNP) is the densest and most recognizable component of the mammalian corneal innervation; however, the anatomical configuration of the SNP in most animal models remains incompletely described. The purpose of the current study is to describe in detail the SNP architecture in eight diff...

journal_title：Investigative ophthalmology & visual science

authors： Marfurt C,Anokwute MC,Fetcko K,Mahony-Perez E,Farooq H,Ross E,Baumanis MM,Weinberg RL,McCarron ME,Mankowski JL

更新日期：2019-12-02 00:00:00

abstract：PURPOSE:Although the murine alphaA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao H,Yang Y,Rizo CM,Overbeek PA,Robinson ML

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:In addition to photoreceptor degeneration, excessive light causes degenerative alterations in the inner retina and ganglion cell death. A disturbance in osmohomeostasis may be one causative factor for the alterations in the inner retina. Because Müller cells mediate inner retinal osmohomeostasis (mainly through...

journal_title：Investigative ophthalmology & visual science

authors： Iandiev I,Wurm A,Hollborn M,Wiedemann P,Grimm C,Remé CE,Reichenbach A,Pannicke T,Bringmann A

更新日期：2008-08-01 00:00:00

abstract：:Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma...

journal_title：Investigative ophthalmology & visual science

authors： Liu SH,Tagawa Y,Prendergast RA,Franklin RM,Silverstein AM

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Oxidative stress and cellular senescence are known to contribute to the development of AMD; however, the mechanism is not fully understood. This study investigated the role of TGF-β-activated kinase 1 (TAK1) in the senescence of RPE cells as a model for the development of dry AMD. METHODS:Cultured human RPE ce...

journal_title：Investigative ophthalmology & visual science

authors： Dvashi Z,Green Y,Pollack A

更新日期：2014-08-12 00:00:00

abstract：PURPOSE:To evaluate the effects of human cytomegalovirus (HCMV) infection on chemokine gene expression and secretion by human retinal pigment epithelial (HRPE) cell cultures. METHODS:HRPE cells were infected with HCMV (strain AD169) at an MOI of 5. Culture supernatants, collected at various postinoculation days, were ...

journal_title：Investigative ophthalmology & visual science

authors： Momma Y,Nagineni CN,Chin MS,Srinivasan K,Detrick B,Hooks JJ

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Lee KM,Kim H,Kim TW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. METHODS:Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide a...

journal_title：Investigative ophthalmology & visual science

authors： Kim ET,Kim C,Lee SW,Seo JM,Chung H,Kim SJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To evaluate quantitatively the relationship between the displacement of anterior visual pathway structures by pituitary tumors and visual field damage with the goal of improving diagnosis and management. METHODS:Subjects had pituitary macroadenomas and both magnetic resonance imaging (MRI) and static perimetry...

journal_title：Investigative ophthalmology & visual science

authors： Boland MV,Lee IH,Zan E,Yousem DM,Miller NR

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To understand the pathophysiology of human retinal degenerations caused by mutations in the peripherin/RDS gene. METHODS:Three families with autosomal dominant retinal degeneration were found to have mutations in the peripherin/RDS gene. There were two frameshift mutations: a 1-base pair (bp) insertion at codo...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Kemp CM,Sheffield VC,Stone EM

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degene...

journal_title：Investigative ophthalmology & visual science

authors： Leveziel N,Yu Y,Reynolds R,Tai A,Meng W,Caillaux V,Calvas P,Rosner B,Malecaze F,Souied EH,Seddon JM

更新日期：2012-07-27 00:00:00