Differential expression of chemokines by human retinal pigment epithelial cells infected with cytomegalovirus.

abstract：:Myeloid bodies are found in the retinal pigment epithelium of certain vertebrate species. They are organized structural forms of the smooth endoplasmic reticulum which are usually seen as stacks of flattened, smooth saccules having a circular or lens-shaped configuration. Our findings in the frog Rana pipiens suggest ...

journal_title：Investigative ophthalmology & visual science

authors： Matthes MT,Basinger SF

更新日期：1980-03-01 00:00:00

abstract：PURPOSE:Subjects with macular disorders need longer time to plan and execute a reaching and grasping task compared with normally sighted controls. In everyday life it is normal to perform reaching and grasping movements while simultaneously carrying out a cognitively demanding task. We investigated whether a simultaneo...

journal_title：Investigative ophthalmology & visual science

authors： Pardhan S,Zuidhoek S

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:To evaluate the rate and location of visual field (VF) progression before and after detection of disc hemorrhage (DH). METHODS:Disc photographs of consecutive patients with glaucoma with >or=5 SITA-Standard 24-2 VF in either eye were evaluated for the presence and location of DH. Exclusion criteria included di...

journal_title：Investigative ophthalmology & visual science

authors： De Moraes CG,Prata TS,Liebmann CA,Tello C,Ritch R,Liebmann JM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:We characterized fluorescent bone marrow cells (YFP(+) BMCs) in the thy1-YFP mouse and determine if they promote trigeminal ganglion (TG) cell neurite growth. METHODS:Excimer laser annular keratectomy was performed in thy1-YFP mice, and corneas were imaged. BMCs were harvested from femur and tibia, and the exp...

journal_title：Investigative ophthalmology & visual science

authors： Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S

更新日期：2013-09-03 00:00:00

abstract：PURPOSE:The objective of this systematic review was to examine the evidence on zinc intake from foods and supplements in the primary prevention and treatment of AMD. METHODS:Randomized controlled trials (RCTs), prospective cohort, retrospective cohort, and case-control studies that investigated zinc intake from foods ...

journal_title：Investigative ophthalmology & visual science

authors： Vishwanathan R,Chung M,Johnson EJ

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:To evaluate the consequences of the expression of a mutant mouse opsin gene on rod- and cone-mediated function. Experimental conditions were chosen to provide a basis of comparison to the results reported for patients with autosomal dominant retinitis pigmentosa (ADRP) in whom the proline at position 23 has bee...

journal_title：Investigative ophthalmology & visual science

authors： Goto Y,Peachey NS,Ripps H,Naash MI

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To investigate the discrepancy between grating and optotype visual acuity in children with visual impairment due to brain and/or ocular abnormalities. METHODS:Better eye acuity at 114 cm was studied in 81 patients (ages, 5-24 years) attending special schools for the visually handicapped. Fourteen patients had ...

journal_title：Investigative ophthalmology & visual science

authors： Stiers P,Vanderkelen R,Vandenbussche E

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration of light-exposed rats. METHODS:Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) received 60 minutes of TES, whereas SHAM (n = 15) received identical sham stimulation 2 hours before e...

journal_title：Investigative ophthalmology & visual science

authors： Schatz A,Arango-Gonzalez B,Fischer D,Enderle H,Bolz S,Röck T,Naycheva L,Grimm C,Messias A,Zrenner E,Bartz-Schmidt KU,Willmann G,Gekeler F

更新日期：2012-08-15 00:00:00

abstract：Purpose:Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts....

journal_title：Investigative ophthalmology & visual science

authors： Futakuchi A,Inoue T,Fujimoto T,Kuroda U,Inoue-Mochita M,Takahashi E,Ohira S,Tanihara H

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To explore changes in corneal sensitivity that develop in patients with dry eye and the relationship between sensibility and severity of the dry eye disease. METHODS:Experiments were performed in 44 patients with dry eye and 42 healthy individuals. Corneal sensitivity was measured with the Belmonte noncontact ...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,Acosta MC,Borderie V,Borrás F,Gallar J,Bury T,Laroche L,Belmonte C

更新日期：2005-07-01 00:00:00

abstract：:Purpose. Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an eye-targeted drug-delivery strategy to treat retinoblastoma, the most prevalent primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly...

journal_title：Investigative ophthalmology & visual science

authors： Steinle JJ,Zhang Q,Thompson KE,Toutounchian J,Yates CR,Soderland C,Wang F,Stewart CF,Haik BG,Williams JS,Jackson JS,Mandrell TD,Johnson D,Wilson MW

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:Cystinosis is caused by a deficiency in the lysosomal cystine transporter, cystinosin (CTNS gene), resulting in cystine crystal accumulation in tissues. In eyes, crystals accumulate in the cornea causing photophobia and eventually blindness. Hematopoietic stem progenitor cells (HSPCs) rescue the kidney in a mou...

journal_title：Investigative ophthalmology & visual science

authors： Rocca CJ,Kreymerman A,Ur SN,Frizzi KE,Naphade S,Lau A,Tran T,Calcutt NA,Goldberg JL,Cherqui S

更新日期：2015-11-01 00:00:00

abstract：:Tissue culture of retinal vessels from fetal calf eyes produced colonies of endothelium, pericytes, and smooth muscle. Identification of endothelial cells was based upon culture morphology, [3H]thymidine labeling of isolated vessels, and factor VIII immunofluorescence. Thimerosal added to the culture medium destroyed ...

journal_title：Investigative ophthalmology & visual science

authors： Buzney SM,Massicotte SJ

更新日期：1979-11-01 00:00:00

abstract：PURPOSE:Sildenafil (Viagra), a cGMP-specific phosphodiesterase type 5 inhibitor, is widely used for the treatment of erectile dysfunction and pulmonary hypertension. Clinical studies have reported transient visual impairments in patients after single-dose sildenafil use, suggesting neural involvement in several retinal...

journal_title：Investigative ophthalmology & visual science

authors： Martins J,Kolomiets B,Caplette R,Sahel JA,Castelo-Branco M,Ambrósio AF,Picaud S

更新日期：2015-04-01 00:00:00

abstract：:Purpose. To use optical coherence tomography (OCT) to evaluate the effect of punctal occlusion on tear meniscus volume in dry eye patients. Methods. Occlusion of both upper and lower puncta with collagen plugs was performed on one eye each in 20 dry eye patients and 20 normal subjects. The upper and lower tear menisci...

journal_title：Investigative ophthalmology & visual science

authors： Chen F,Shen M,Chen W,Wang J,Li M,Yuan Y,Lu F

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:We tested the hypothesis that retinal blood flow has a postocclusive reactive hyperemia response modulated by occlusion duration and metabolic activity, and that choroidal blood flow does not. METHODS:Anesthetized and paralyzed rats (n = 34) were studied. Retinal and choroidal blood flow was measured by laser ...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Kiel JW,Cardenas DP,De La Garza BH,Duong TQ

更新日期：2013-07-30 00:00:00

abstract：PURPOSE:Research to restore some degree of vision to patients suffering from retinal degeneration is becoming increasingly more promising. Several groups have chosen electrical stimulation of the remaining network of a degenerate retina as a means to generate discrete light percepts (phosphenes). Approaches vary signif...

journal_title：Investigative ophthalmology & visual science

authors： Matteucci PB,Chen SC,Tsai D,Dodds CW,Dokos S,Morley JW,Lovell NH,Suaning GJ

更新日期：2013-06-21 00:00:00

abstract：:We examined the sources of artifacts of vitreous fluorophotometry (VF), a technique used to assess the permeability of the blood-retinal barrier. By performing in vitro measurements in a model eye and in vivo readings in humans, we investigated the influence of various concentrations of fluorescein in the anterior cha...

journal_title：Investigative ophthalmology & visual science

authors： Zeimer RC,Cunha-Vaz JG,Johnson ME

更新日期：1982-05-01 00:00:00

abstract：:Interocular differences in apparent size (aniseikonia) are typically associated with interocular differences in refractive error (anisometropia). Aniseikonia is generally thought to reflect disparities in retinal image size that often accompany anisometropia. This assumption was examined with seven highly anisometropi...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Rabin J,Freeman RD

更新日期：1983-04-01 00:00:00

abstract：:Horseradish peroxidase has been injected into the dorsal lateral geniculate nucleus of macaque monkeys to label ganglion cells of the retina by retrograde axoplasmic transport. Displaced ganglion cells, with somata in the inner nuclear layer and dendrites in the inner plexiform layer, were detected by virtue of their ...

journal_title：Investigative ophthalmology & visual science

authors： Bunt AH,Minckler DS

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:The authors investigated whether trigeminal sensitization occurs in response to bright light with the retina disconnected from the rest of the central nervous system by optic nerve section. METHODS:In urethane-anesthetized rats, trigeminal reflex blinks were evoked with air puff stimuli directed at the cornea ...

journal_title：Investigative ophthalmology & visual science

authors： Dolgonos S,Ayyala H,Evinger C

更新日期：2011-10-04 00:00:00

abstract：PURPOSE:To examine the effects of methylcobalamin on glutamate-induced neurotoxicity in the cultured retinal neurons. METHODS:Primary cultures obtained from the fetal rat retina (gestation days 16 to 19) were used for the experiment. The neurotoxicity was assessed quantitatively using the trypan blue exclusion method....

journal_title：Investigative ophthalmology & visual science

authors： Kikuchi M,Kashii S,Honda Y,Tamura Y,Kaneda K,Akaike A

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate metabolic changes in aqueous humor from rabbit eyes exposed to either UV-A or -B radiation, by using (1)H nuclear magnetic resonance (NMR) spectroscopy and unsupervised pattern recognition METHODS:methods. Both eyes of adult albino rabbits were irradiated with UV-A (366 ...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Cejková J,Midelfart A

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:The scarified cornea keratitis model was modified to study Pseudomonas aeruginosa infection of healing corneal epithelium. The new model was then used to study the role of ExsA, a transcriptional activator of P. aeruginosa, in bacterial penetration through injured and healing corneal epithelia. METHODS:Scratch...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Evans DJ,Fleiszig SM

更新日期：2003-12-01 00:00:00

abstract：:Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaris. Early changes are characterized by the appearance of platelet-fibrin thrombi within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative ch...

journal_title：Investigative ophthalmology & visual science

authors： Perry DD,Reddick RL,Risco JM

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a history of cataract and cataract surgery (self-report and for a sibling), and to determine which demographic, cognitive, and medical factors are predictive of an accurate history. METHODS:All participants in the Salisbury Eye Evaluation (SEE) project and their locally resident si...

journal_title：Investigative ophthalmology & visual science

authors： Bowie H,Congdon NG,Lai H,West SK

更新日期：2003-07-01 00:00:00

abstract：:This study demonstrated that growth and differentiation of rabbit conjunctival epithelial cells could be promoted by such substrata as collagen gel, matrigel or various mixtures of collagen and matrigel in a defined culture system. On conventional plastic or glass culture, the conjunctival epithelial cells adopted a m...

journal_title：Investigative ophthalmology & visual science

authors： Tsai RJ,Tseng SC

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:To determine whether a novel peroxynitrite-based photosensitizer S-nitrosoglutathione (GSNO) can produce specific in vitro light-induced cell death of both standard animal lung and human Tenon's capsule (TC) fibroblasts and to compare this effect with that produced by the established photodynamic porphyrin prec...

journal_title：Investigative ophthalmology & visual science

authors： Tannous M,Hutnik CM,Tingey DP,Mutus B

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Cortical cataract in humans is associated with Ca2+ overload and protein loss, and although animal models of cataract have implicated Ca2+-activated proteases in this process, it remains to be determined whether the human lens responds in this manner to conditions of Ca2+ overload. The purpose of these experime...

journal_title：Investigative ophthalmology & visual science

authors： Sanderson J,Marcantonio JM,Duncan G

更新日期：2000-07-01 00:00:00