Effect of UV-A and UV-B irradiation on the metabolic profile of aqueous humor in rabbits analyzed by 1H NMR spectroscopy.

abstract：PURPOSE:Several studies have reported higher levels of macular pigment (MP) in association with reduced risk for age-related macular degeneration (ARMD), a disease to which there is a genetic predisposition. A classic twin study was performed to determine the heritability of MP in the healthy eye. METHODS:One hundred ...

journal_title：Investigative ophthalmology & visual science

authors： Liew SH,Gilbert CE,Spector TD,Mellerio J,Marshall J,van Kuijk FJ,Beatty S,Fitzke F,Hammond CJ

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Vergence eye movements undergo adaptive recalibration in response to a training stimulus in which the initial disparity is changed just after vergence begins (the double-step paradigm). In the present study the changes in the dynamic properties of convergence, speed and acceleration, were examined by using this...

journal_title：Investigative ophthalmology & visual science

authors： Takagi M,Oyamada H,Abe H,Zee DS,Hasebe H,Miki A,Usui T,Hasegawa S,Bando T

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：Purpose:Although normal function of the lacrimal gland is essential for vision (and thus for human well-being), the lacrimal gland remains rather poorly understood at a molecular level. The purpose of this study was to identify new genes and signaling cascades involved in lacrimal gland development. Methods:To identif...

journal_title：Investigative ophthalmology & visual science

authors： Dvoriantchikova G,Tao W,Pappas S,Gaidosh G,Tse DT,Ivanov D,Pelaez D

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The endothelium produces nitric oxide and endothelin (ET). This study was designed to investigate the endothelium-dependent regulation of the porcine ophthalmic microcirculation. METHODS:Isolated porcine eyes were perfused with a modified Langendorff setup (Hugo Sachs Elektronik KG, Freiburg, Germany) at a per...

journal_title：Investigative ophthalmology & visual science

authors： Meyer P,Flammer J,Lüscher TF

更新日期：1993-12-01 00:00:00

abstract：:The sequential electrophysiologic and pathologic changes in the retina in ceroid-lipofuscinosis were recorded in a time-course study in the ovine model. Over a relatively short period in the course of the disease, a severe reduction in both rod and cone b-wave amplitudes developed with rod b-wave changes preceeding th...

journal_title：Investigative ophthalmology & visual science

authors： Graydon RJ,Jolly RD

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:To determine the disease course of retinal dystrophy caused by recessive variants in the DRAM2 (damage-regulated autophagy modulator 2) gene. METHODS:Sixteen individuals with DRAM2-retinopathy were examined (six families; age range, 19-56 years, includes one pre-symptomatic case). The change in visual acuity o...

journal_title：Investigative ophthalmology & visual science

authors： Sergouniotis PI,McKibbin M,Robson AG,Bolz HJ,De Baere E,Müller PL,Heller R,El-Asrag ME,Van Schil K,Plagnol V,Toomes C,Uk Inherited Retinal Disease Consortium.,Ali M,Holder GE,Charbel Issa P,Leroy BP,Inglehearn CF,Webste

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve and leads to apoptotic retinal ganglion cell (RGC) death, which contributes to the persistence of visual loss. Currently, ON has no effective treatment. The goal was to determine the effectiven...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Brown L,Andrew S,Meza-Romero R,Burrows GG,Vandenbark AA

更新日期：2012-01-25 00:00:00

abstract：:The distribution and organization of type I and type V collagens were studied in the embryonic chicken cornea using anti-collagen, type specific, monoclonal antibodies and immunoelectron microscopy. These studies were performed on lathyritic 17-day corneas treated at 4 degrees C or 37 degrees C. At the lower temperatu...

journal_title：Investigative ophthalmology & visual science

authors： Birk DE,Fitch JM,Linsenmayer TF

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:Angiogenesis, the formation of new capillary blood vessels, is an essential biological process under physiological conditions, including embryonic development, reproduction, and wound repair. Under pathologic conditions, this process plays a critical role in a variety of diseases such as cancer, rheumatoid arth...

journal_title：Investigative ophthalmology & visual science

authors： Pakneshan P,Birsner AE,Adini I,Becker CM,D'Amato RJ

更新日期：2008-09-01 00:00:00

abstract：:The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

journal_title：Investigative ophthalmology & visual science

authors： Sakimoto G,Schwartz B

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:One of the difficulties in modeling visual field (VF) data is the sometimes large and correlated measurement errors in the point-wise sensitivity estimates. As these errors affect all locations of the same VF, we propose to model them as global visit effects (GVE). We evaluate this model and show the effect it ...

journal_title：Investigative ophthalmology & visual science

authors： Bryan SR,Eilers PH,Lesaffre EM,Lemij HG,Vermeer KA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To study binding of retinoids to human tear lipocalin (TL) to assess factors influencing ligand affinity and delivery. Mechanistic features of retinoid interactions with TL were investigated, including the influence of the retinoid functional group on ligand affinity, the relative affinity of retinol versus fat...

journal_title：Investigative ophthalmology & visual science

authors： Gasymov OK,Abduragimov AR,Yusifov TN,Glasgow BJ

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:The organization of scleral collagen helps to determine the eye's biomechanical response to intraocular pressure (IOP), and may therefore be important in glaucoma. This study provides a quantitative assessment of changes in scleral collagen fibril organization in bead-induced murine experimental glaucoma. METH...

journal_title：Investigative ophthalmology & visual science

authors： Pijanka JK,Kimball EC,Pease ME,Abass A,Sorensen T,Nguyen TD,Quigley HA,Boote C

更新日期：2014-09-16 00:00:00

abstract：PURPOSE:Transforming growth factor beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expands on our p...

journal_title：Investigative ophthalmology & visual science

authors： Courtney DG,Poulsen ET,Kennedy S,Moore JE,Atkinson SD,Maurizi E,Nesbit MA,Moore CB,Enghild JJ

更新日期：2015-07-01 00:00:00

abstract：:An automated Minigel electrophoresis system (PhastSystem, Pharmacia, Uppsala, Sweden) was tested for human tear protein analysis. Tear samples were treated under nonreducing or reducing conditions before sodium dodecyl sulphate polyacryl amide gel electrophoresis (SDS-PAGE). Micro-amounts of tears (2 microliters) were...

journal_title：Investigative ophthalmology & visual science

authors： Kuizenga A,van Haeringen NJ,Kijlstra A

更新日期：1991-02-01 00:00:00

abstract：:The retinal blood vessels serve for nutrition of the retinal ganglion cells and their axons. This study was undertaken to evaluate the vessel diameter in normal and glaucoma eyes. The calibers of the superior temporal and inferior temporal retinal artery and vein were measured at the optic disc border and at a distanc...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nguyen XN,Naumann GO

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To determine the sensitivity to change and specificity achieved when published test-retest variability (TRV) data are used to determine whether measured changes in ETDRS logarithm of the minimum angle of resolution (logMAR) visual acuity reflect true clinical change or are attributable to measurement error alon...

journal_title：Investigative ophthalmology & visual science

authors： Rosser DA,Cousens SN,Murdoch IE,Fitzke FW,Laidlaw DA

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To prepare binary transgenic mouse lines that overexpress reporter genes in a corneal-epithelium-specific manner when induced by doxycycline. METHODS:A gene-targeting construct containing an internal ribosomal entry site-reverse tetracycline transcription activator (IRES-rtTA) cassette was inserted into the Kr...

journal_title：Investigative ophthalmology & visual science

authors： Chikama T,Hayashi Y,Liu CY,Terai N,Terai K,Kao CW,Wang L,Hayashi M,Nishida T,Sanford P,Doestchman T,Kao WW

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

journal_title：Investigative ophthalmology & visual science

authors： Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

更新日期：1999-03-01 00:00:00

abstract：:Class II (DR or Ia) alloantigens are potent inducers of cell-mediated immune responses. However, the expression of Class II alloantigens on corneal cells, except for Langerhans cells within the limbal epithelium, has not previously been described. We have induced Ia expression on cultured rabbit corneal endothelial ce...

journal_title：Investigative ophthalmology & visual science

authors： Donnelly JJ,Li WY,Rockey JH,Prendergast RA

更新日期：1985-04-01 00:00:00

abstract：PURPOSE:Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening of the outer segments, concomitant with AV form...

journal_title：Investigative ophthalmology & visual science

authors： Kunchithapautham K,Coughlin B,Lemasters JJ,Rohrer B

更新日期：2011-05-05 00:00:00

abstract：PURPOSE:We investigated the hypothesis that cyclic adenosine monophosphate (cAMP) modifies the basolateral membrane chloride conductance of chick retinal pigment epithelium (RPE). METHODS:Placing freshly dissected chick retina-RPE-choroid tissues in a perfusion chamber that allows separate perfusion of its retinal and...

journal_title：Investigative ophthalmology & visual science

authors： Kuntz CA,Crook RB,Dmitriev A,Steinberg RH

更新日期：1994-02-01 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:The phenotype of specialized cells arises, in part, from their characteristic gene expression patterns. Retinal ganglion cells (RGCs) are of wide interest in neuroscience and die in glaucoma and other optic neuropathies. In this study the genes expressed by RGCs were profiled by expressed sequence tag (EST) ana...

journal_title：Investigative ophthalmology & visual science

authors： Farkas RH,Qian J,Goldberg JL,Quigley HA,Zack DJ

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:Subretinal drusenoid deposits (SDD) have been associated with the progression to late age-related macular degeneration (AMD). To determine whether SDD in eyes in normal macular health increases risk for early AMD, this study examined the association between presence of SDD at baseline in a cohort of older adult...

journal_title：Investigative ophthalmology & visual science

authors： Huisingh C,McGwin G Jr,Neely D,Zarubina A,Clark M,Zhang Y,Curcio CA,Owsley C

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:We investigated whether the tear interferometric pattern was able to identify differences in tear film kinetics among clinical subtypes of dry eye. METHODS:A total of 138 eyes of 76 subjects (38 men and 38 women; mean age ± SD, 61.6 ± 16.2 years) with or without dry eye who visited Itoh Clinic from May to Augu...

journal_title：Investigative ophthalmology & visual science

authors： Arita R,Morishige N,Fujii T,Fukuoka S,Chung JL,Seo KY,Itoh K

更新日期：2016-07-01 00:00:00

abstract：:The outer horizontal cell (OHC) of the frog Rana pipiens was studied by light and electron microscopy of Golgi-stained and horseradish peroxidase-injected cells. Responses of OHCs were recorded with intracellular electrodes. The OHCs are probably axonless cells. Their dendritic terminals are lateral processes at synap...

journal_title：Investigative ophthalmology & visual science

authors： Ogden TE,Mascetti GG,Pierantoni R

更新日期：1985-05-01 00:00:00

abstract：Purpose:Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small inf...

journal_title：Investigative ophthalmology & visual science

authors： Derafshi Z,Kunzer BE,Mugler EM,Rokhmanova N,Park DW,Tajalli H,Shetty K,Ma Z,Williams JC,Hetling JR

更新日期：2017-06-01 00:00:00

abstract：Purpose:To evaluate the contribution of fixational saccades toward fixation instability in strabismic monkeys. Methods:Binocular eye movements were measured as six experimental monkeys (five strabismic monkeys and one monkey with downbeat nystagmus) and one normal monkey fixated targets of two shapes (Optotype, Disk) ...

journal_title：Investigative ophthalmology & visual science

authors： Upadhyaya S,Pullela M,Ramachandran S,Adade S,Joshi AC,Das VE

更新日期：2017-11-01 00:00:00