Substrate modulation of cultured rabbit conjunctival epithelial cell differentiation and morphology.

abstract：:One hypothesized cause of low-tension glaucoma is chronic or intermittent ischemia of the optic nerve. Since the optic nerve and brain are both parts of the central nervous system and share a common blood supply, the authors wondered if patients with low-tension glaucoma might also have clinical or radiographic eviden...

journal_title：Investigative ophthalmology & visual science

authors： Corbett JJ,Phelps CD,Eslinger P,Montague PR

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To investigate whether signaling pathways that incorporate protein tyrosine kinases and phosphatases regulate PKC-sensitive, volume-sensitive Cl(-) currents (I(Cl,vol)) in cultured rabbit nonpigmented ciliary epithelial cells. METHODS:Activation of I(Cl,vol) in response to hyposmotic stimulation was recorded w...

journal_title：Investigative ophthalmology & visual science

authors： Shi C,Barnes S,Coca-Prados M,Kelly ME

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:This study was undertaken to improve understanding of the defective lens developmental changes induced by the transgenic overexpression of the Rho GDP dissociation inhibitor RhoGDIalpha. The study was focused on a single differentially expressed gene encoding ponsin, a cell adhesion interacting signaling adapto...

journal_title：Investigative ophthalmology & visual science

authors： Rao PV,Maddala R

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:(Photo)-oxidative stress is believed to play a role in the pathogenesis of age-related macular degeneration (AMD), with the threshold for retinal damage being lowest for short-wavelength (blue) light. Macular pigment (MP), consisting of the carotenoids lutein (L), zeaxanthin (Z) and meso-Z, has a maximum absorp...

journal_title：Investigative ophthalmology & visual science

authors： Nolan JM,O'Reilly P,Loughman J,Stack J,Loane E,Connolly E,Beatty S

更新日期：2009-10-01 00:00:00

abstract：Purpose:To report molecular genetic findings in six probands with congenital hereditary endothelial dystrophy (CHED) variably associated with hearing loss (also known as Harboyan syndrome). Furthermore, we developed a cellular model to determine if disease-associated variants induce aberrant SLC4A11 pre-mRNA splicing. ...

journal_title：Investigative ophthalmology & visual science

authors： Brejchova K,Dudakova L,Skalicka P,Dobrovolny R,Masek P,Putzova M,Moosajee M,Tuft SJ,Davidson AE,Liskova P

更新日期：2019-07-01 00:00:00

abstract：:It is possible to record a pattern electroretinogram (PERG) of near normal amplitude in a situation when the eye containing the active electrode is occluded. Because PERG recording requires high amplification and sensitive signal retrieval techniques, the electrode in the occluded eye records a distant potential from ...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to demonstrate the synthesis and cellular distribution of group II phospholipase A2 and lysozyme in the main and accessory lacrimal glands. METHODS:The authors studied samples of normal main lacrimal glands of seven autopsied subjects and accessory lacrimal glands of eight patients wh...

journal_title：Investigative ophthalmology & visual science

authors： Aho HJ,Saari KM,Kallajoki M,Nevalainen TJ

更新日期：1996-08-01 00:00:00

abstract：:Topical application of Prostaglandin F2 alpha (PGF2 alpha) to the eye reduces intraocular pressure (IOP) in all mammalian species studied thus far, including humans. The L-isopropylester derivative is currently the one most commonly used in experimental and clinical studies. Dose-response relationships were determined...

journal_title：Investigative ophthalmology & visual science

authors： Crawford KS,Kaufman PL

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:Cardiovascular risk factors such as smoking, hypertension, and atherosclerosis seem to play an important role in the development of choroidal neovascularization (CNV). Recent studies have also provided evidence suggesting that choroidal and retinal blood flow is decreased in patients with AMD. On the basis of t...

journal_title：Investigative ophthalmology & visual science

authors： Boltz A,Luksch A,Wimpissinger B,Maar N,Weigert G,Frantal S,Brannath W,Garhöfer G,Ergun E,Stur M,Schmetterer L

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：:Particulate fractions from fresh bovine corneal endothelium exhibited high affinity, specific binding by a potent muscarinic cholinergic radioligand, [3H]QNB. Particulate fraction binding sites exhibited half maximal binding at approximately 0.3 nM [3H]QNB and reached a maximal binding capacity of 820 fmoles/mg of pro...

journal_title：Investigative ophthalmology & visual science

authors： Walkenbach RJ,Ye GS

更新日期：1990-04-01 00:00:00

abstract：:In order to investigate the effect of traction of the vasculature on induction or acceleration of neovascularization, the chorioallantoic membranes (CAMs) of the developing chick embryo were placed under tension with 10-0 nylon sutures and subsequently examined histologically. In the initial phase of the study, CAMs f...

journal_title：Investigative ophthalmology & visual science

authors： Yamashita H,Hori S,Yamamoto T

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:Beta-adrenergic receptor (AR) antagonists are frequently prescribed ophthalmic drugs, yet previous investigations into how catecholamines affect corneal wound healing have yielded conflicting RESULTS:With the use of an integrated pharmacologic and genetic approach, the authors investigated how the beta-AR impa...

journal_title：Investigative ophthalmology & visual science

authors： Ghoghawala SY,Mannis MJ,Pullar CE,Rosenblatt MI,Isseroff RR

更新日期：2008-05-01 00:00:00

abstract：Purpose:We assessed changes in age-specific prevalence of refractive error at the time of starting school, by comparing preschool and school age cohorts in Shanghai, China. Methods:A cross-sectional study was done in Jiading District, Shanghai during November and December 2013. We randomly selected 7 kindergartens and...

journal_title：Investigative ophthalmology & visual science

authors： Ma Y,Qu X,Zhu X,Xu X,Zhu J,Sankaridurg P,Lin S,Lu L,Zhao R,Wang L,Shi H,Tan H,You X,Yuan H,Sun S,Wang M,He X,Zou H,Congdon N

更新日期：2016-11-01 00:00:00

abstract：:Visual fixation of a small, stationary target was measured in 12 young observers (mean age = 22 yr) and in 12 older observers (mean age = 70 yr). The two groups' fixation behavior did not differ on various dimensions of fixation stability: mean fixation area, intra-subject variability, or changes in fixation over succ...

journal_title：Investigative ophthalmology & visual science

authors： Kosnik W,Fikre J,Sekuler R

更新日期：1986-12-01 00:00:00

abstract：:Although aqueous outflow is most likely a passive, nonenergy-dependent process, alterations in cellular function in the trabecular meshwork presumably are involved in the development of some types of glaucoma. Accordingly, it seems important to define both the normal and abnormal biochemistry of this tissue. The autho...

journal_title：Investigative ophthalmology & visual science

authors： Anderson PJ,Karageuzian LN,Cheng HM,Epstein DL

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:Allopregnanolone is a neurosteroid and powerful modulator of neuronal excitability. The neuroprotective effects of allopregnanolone involve potentiation of γ-aminobutyric acid (GABA) inhibitory responses. Although glutamate excitotoxicity contributes to ganglion cell death in glaucoma, the role of GABA in glauc...

journal_title：Investigative ophthalmology & visual science

authors： Ishikawa M,Yoshitomi T,Zorumski CF,Izumi Y

更新日期：2014-11-18 00:00:00

abstract：PURPOSE:To evaluate the visual and refractive outcome for four wavefront-guided surface ablation (WGSA) techniques (LASEK, LASEK flap-off [LASEK FO], Epi-LASIK, and Epi-LASIK flap-off [Epi-LASIK FO]) in a large myopic population. METHODS:This retrospective review included 1000 myopic eyes (spherical equivalent [SE] -1...

journal_title：Investigative ophthalmology & visual science

authors： Kulkarni SV,AlMahmoud T,Priest D,Taylor SE,Mintsioulis G,Jackson WB

更新日期：2013-01-21 00:00:00

abstract：PURPOSE:Classically, acute and chronic inflammations are characterized by fibrin deposition and a dynamic influx of leukocytes. This leukocyte recruitment, and associated activation, is thought to be dependent on the generation of leukocyte chemotactic factors (LCF). Although the functional existence of LCF in ocular t...

journal_title：Investigative ophthalmology & visual science

authors： Ramsby ML,Kreutzer DL

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells are known to express ionotropic P2X(7) receptors for ATP. Stimulation of these receptors in other cells can elevate Ca(2+) and sometimes lead to cell death. This study asked whether P2X(7) receptor stimulation alters the Ca(2+) levels and viability of retinal ganglion cells. METHODS:P2X(...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Zhang M,Laties AM,Mitchell CH

更新日期：2005-06-01 00:00:00

abstract：:Tendon and cornea of 17-day-old chick embryos primarily synthesize type I collagen as the major collagenous component nd type V collagen as a minor collagenous component. Matrix-free cells isolated from cornea and tendon synthesize and secrete mainly type I procollagen. A short lag period for the secretion of collagen...

journal_title：Investigative ophthalmology & visual science

authors： Kao WW,Mai SH,Chou KL

更新日期：1982-12-01 00:00:00

abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

journal_title：Investigative ophthalmology & visual science

authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

更新日期：2019-10-01 00:00:00

abstract：Purpose:Aging is a critical risk factor for the development of retinal diseases, but how aging perturbs ocular homeostasis and contributes to disease is unknown. We identified transmembrane protein 135 (Tmem135) as a gene important for regulating retinal aging and mitochondrial dynamics in mice. Overexpression of Tmem1...

journal_title：Investigative ophthalmology & visual science

authors： Landowski M,Grindel S,Shahi PK,Johnson A,Western D,Race A,Shi F,Benson J,Gao M,Santoirre E,Lee WH,Ikeda S,Pattnaik BR,Ikeda A

更新日期：2020-10-01 00:00:00

abstract：Purpose:The subbasal nerve plexus (SNP) is the densest and most recognizable component of the mammalian corneal innervation; however, the anatomical configuration of the SNP in most animal models remains incompletely described. The purpose of the current study is to describe in detail the SNP architecture in eight diff...

journal_title：Investigative ophthalmology & visual science

authors： Marfurt C,Anokwute MC,Fetcko K,Mahony-Perez E,Farooq H,Ross E,Baumanis MM,Weinberg RL,McCarron ME,Mankowski JL

更新日期：2019-12-02 00:00:00

abstract：:In 188 patients from separate families with various forms of retinitis pigmentosa (RP) and 91 normal subjects, plasma fatty acids were measured as a percentage of total plasma fatty acids, and their concentrations were determined using capillary-column gas-liquid chromatography. After controlling for the effects of ag...

journal_title：Investigative ophthalmology & visual science

authors： Gong J,Rosner B,Rees DG,Berson EL,Weigel-DiFranco CA,Schaefer EJ

更新日期：1992-08-01 00:00:00

abstract：PURPOSE:Angiotensin II (AII) has been shown to play a role in many vascular diseases. In the study described, the effect of AII on vascular endothelial growth factor (VEGF) expression and related intracellular signaling mechanism was investigated in bovine retinal microcapillary pericytes. METHODS:Cultured bovine reti...

journal_title：Investigative ophthalmology & visual science

authors： Otani A,Takagi H,Oh H,Suzuma K,Matsumura M,Ikeda E,Honda Y

更新日期：2000-04-01 00:00:00

abstract：Purpose:To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods:Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RT...

journal_title：Investigative ophthalmology & visual science

authors： Lin Y,Jiang H,Liu Y,Rosa Gameiro G,Gregori G,Dong C,Rundek T,Wang J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:EGF-induced activation of the epigenetic CCCTC binding factor (CTCF) plays an important role in corneal epithelial cell proliferation by suppressing the Pax6 gene. The present study focused on further understanding the role of CTCF in mediating EGF-induced migration of immortalized human corneal epithelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Deng SX,Lu L

更新日期：2012-02-23 00:00:00

abstract：PURPOSE:We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries ...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2013-09-09 00:00:00

abstract：PURPOSE:Glaucomatous optic neuropathy is characterized by remodeling of the extracellular matrix with disorganization of elastic fibers in the optic nerve head (ONH). There are significant differences in prevalence of glaucomatous optic neuropathy between African Americans (AAs) and Caucasian Americans (CAs). The goal ...

journal_title：Investigative ophthalmology & visual science

authors： Urban Z,Agapova O,Hucthagowder V,Yang P,Starcher BC,Hernandez MR

更新日期：2007-07-01 00:00:00