Correlation of OCT characteristics and retinal sensitivity in neovascular age-related macular degeneration in the course of monthly ranibizumab treatment.

abstract：PURPOSE:To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS:The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Goldbaum MH,Chan K,Boden C,Lee TW,Vasile C,Boehm AG,Sejnowski T,Johnson CA,Weinreb RN

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To study the diameter response of retinal arterioles as a function of the arteriolar diameter. METHODS:Ten healthy young volunteers aged 22 to 33 years were subjected to diameter measurement of four successive segments of a retinal arteriole with a retinal vessel analyzer (RVA). At each of the segments, the di...

journal_title：Investigative ophthalmology & visual science

authors： Jeppesen P,Sanye-Hajari J,Bek T

更新日期：2007-01-01 00:00:00

abstract：:Purpose: To compare efficacy and safety between subconjunctival and intrascleral methods of mitomycin C (MMC) application during trabeculectomy Methods: This retrospective study included 165 eyes treated by trabeculectomy and compared clinical outcomes between eyes that received subconjunctival MMC (Group 1, 80 eyes, ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang M,Li B,Wang J,Liu W,Wu X

更新日期：2014-07-21 00:00:00

abstract：PURPOSE:AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL...

journal_title：Investigative ophthalmology & visual science

authors： Hidalgo-de-Quintana J,Evans RJ,Cheetham ME,van der Spuy J

更新日期：2008-07-01 00:00:00

abstract：:The distribution and organization of type I and type V collagens were studied in the embryonic chicken cornea using anti-collagen, type specific, monoclonal antibodies and immunoelectron microscopy. These studies were performed on lathyritic 17-day corneas treated at 4 degrees C or 37 degrees C. At the lower temperatu...

journal_title：Investigative ophthalmology & visual science

authors： Birk DE,Fitch JM,Linsenmayer TF

更新日期：1986-10-01 00:00:00

abstract：Purpose:To investigate the effect of the vascular adhesion protein-1 (VAP-1) inhibitor RTU-1096 on retinal morphologic changes and ocular inflammation after retinal laser photocoagulation in mice. Methods:C57BL/6JJcl mice were fed a diet containing RTU-1096, a specific inhibitor for VAP-1, or a control diet ad libitum...

journal_title：Investigative ophthalmology & visual science

authors： Matsuda T,Noda K,Murata M,Kawasaki A,Kanda A,Mashima Y,Ishida S

更新日期：2017-06-01 00:00:00

abstract：:Bovine corneal endothelial cells in culture synthesize predominantly type III collagen, unlike rabbit corneal endothelial cultures which synthesize type IV collagen. In an attempt to document whether this type III collagen synthesis by bovine cells is a tissue culture-specific phenomenon, collagens synthesized by orga...

journal_title：Investigative ophthalmology & visual science

authors： Kay EP,Oh S

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:To examine human corneal morphology and nerve recovery 5 years after photorefractive keratectomy (PRK). METHODS:Fourteen eyes of 14 patients (ages, 27-53 years) who underwent 6-mm diameter PRK for low to moderate myopia (spherical equivalent [SE] -2.5 to -8.0 D) were examined once 5 years after surgery. Nine h...

journal_title：Investigative ophthalmology & visual science

authors： Moilanen JA,Vesaluoma MH,Müller LJ,Tervo TM

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:This study explores the order of assembly of the lens fiber cell plasma membrane. Because the lens must synthesize most of its membrane components, our approach was to map directly the spatial distribution of cholesterol, fatty acid (reflecting phospholipid), and the main intrinsic protein, MP26, synthesis in t...

journal_title：Investigative ophthalmology & visual science

authors： Cenedella RJ

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting oxidative stress-induced damage to RPE...

journal_title：Investigative ophthalmology & visual science

authors： He Y,Leung KW,Ren Y,Pei J,Ge J,Tombran-Tink J

更新日期：2014-09-11 00:00:00

abstract：:The secretion of the aqueous humor has been proposed to occur as the result of active Na+ transport by a ouabain-sensitive Na-K ATPase. We have examined the localization of this enzyme in the epithelium of rabbit ciliary body pars plicata using [3H]ouabain autoradiography. Single ciliary processes were isolated and in...

journal_title：Investigative ophthalmology & visual science

authors： Usukura J,Fain GL,Bok D

更新日期：1988-04-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can infect the cornea and achieve ganglionic latency. HSV-1 can later be activated by a variety of effectors although the exact mechanism of reactivation is unknown. Rabbits harboring latent HSV-1 strain McKrae can be induced to shed virus by ocular iontophoresis of epinephrine to t...

journal_title：Investigative ophthalmology & visual science

authors： Rootman DS,Haruta Y,Hill JM,Kaufman HE

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:The inhibition of angiogenesis by angiostatic steroids has been demonstrated in a variety of systems, including rabbit and rat cornea. There is considerable interest in the therapeutic potential of this class of compounds for angiogenic ocular conditions such as diabetic retinopathy, macular degeneration, and r...

journal_title：Investigative ophthalmology & visual science

authors： Penn JS,Rajaratnam VS,Collier RJ,Clark AF

更新日期：2001-01-01 00:00:00

abstract：:A recent hypothesis for the cellular mechanism of fluid secretion by lacrimal acini has been based, in part, on the results of subcellular fractionation analyses of lacrimal gland fragments which had been incubated for a brief period in vitro. An important assumption in those studies was that the ion transporters and ...

journal_title：Investigative ophthalmology & visual science

authors： Yiu SC,Wood RL,Mircheff AK

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：:Hypothesis-driven science is expected to result in a continuum of studies and findings along a discrete path. By comparison, serendipity can lead to new directions that branch into different paths. Herein, I describe a diverse series of findings that were motivated by hypotheses, but driven by serendipity. I summarize...

journal_title：Investigative ophthalmology & visual science

authors： Fischer AJ

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:The goal of this study was to determine the changes in the organization of the retinal cytoskeleton after experimental retinal detachment. METHODS:Cat retinas were detached from the retinal pigment epithelium and then processed for Western blot analysis and fluorescence microscopy. Proteins examined included g...

journal_title：Investigative ophthalmology & visual science

authors： Lewis GP,Matsumoto B,Fisher SK

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:To identify the disease locus associated with autosomal dominant Fuchs corneal dystrophy (FCD) in a large family and to compare the progression of severity in families mapped to the FCD1 and FCD2 loci. METHODS:Seventeen individuals in a large family were examined by slit lamp biomicroscopy. Blood samples were ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Eghrari AO,Al-Saif A,Davey L,Meadows DN,Katsanis N,Gottsch JD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to investigate whether leakage of aquaporin 5 (AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models. METHODS:Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)...

journal_title：Investigative ophthalmology & visual science

authors： Hirai S,Ishida N,Watanabe K,Mita S

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:Erythropoietin (EPO) modulates erythropoiesis by inhibiting apoptosis in erythrocyte progenitors. Recently, EPO has been shown to be protective in experimental models of mechanical trauma, neuroinflammation, cerebral and retinal ischemia, and even in a human stroke trial. However, little is known about EPO sign...

journal_title：Investigative ophthalmology & visual science

authors： Weishaupt JH,Rohde G,Pölking E,Siren AL,Ehrenreich H,Bähr M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of retinal nerve fiber layer (RNFL) defects associated with type II diabetes. METHODS:Forty nonglaucomatous eyes with type II diabetes and 54 eyes with early open angle glaucoma that exhibited a localized RNFL defect and 42 eyes from age- and sex-matched nondiabetic, nonglauc...

journal_title：Investigative ophthalmology & visual science

authors： Jeon SJ,Kwon JW,La TY,Park CK,Choi JA

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries ...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2013-09-09 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：Purpose:To compare the visual field (VF) progression among high tension glaucoma (HTG), primary angle closure glaucoma (PACG), and normal tension glaucoma (NTG) subjects in routine clinical care. Methods:All patients had ≥5 VF tests using HFA, 24-2, SITA-standard strategy. We compared the progression between glaucoma ...

journal_title：Investigative ophthalmology & visual science

authors： Ballae Ganeshrao S,Senthil S,Choudhari N,Sri Durgam S,Garudadri CS

更新日期：2019-03-01 00:00:00

abstract：Purpose:In many individuals with pattern strabismus, the vertical misalignment varies with horizontal eye position. It has been proposed that these cross-axis effects result from abnormal cross-talk between brainstem structures that would normally encode horizontal and vertical eye position and velocity. The nucleus pr...

journal_title：Investigative ophthalmology & visual science

authors： Pallus A,Walton MMG

更新日期：2020-05-11 00:00:00

abstract：:Albino rabbits were exposed to repeated microwave irradiations once daily for a month. Clinical examination was carried out for a period up to one year. No changes occurred below 300 mW./cm.2. At and above this level posterior subcapsular iridescence and posterior cortical cataracts were produced. The histologic findi...

journal_title：Investigative ophthalmology & visual science

authors： Hirsch SE,Appleton B,Fine BS,Brown PV

更新日期：1977-04-01 00:00:00

abstract：PURPOSE:Obstructive sleep apnea (OSA) syndrome generates hypertension, atherosclerosis, and endothelial and autonomic dysfunction, which may mutually interact with ocular vascular regulation. Exercise and posture changes can be used to manipulate blood pressure, ocular perfusion pressure (OPP), or both. It was hypothes...

journal_title：Investigative ophthalmology & visual science

authors： Khayi H,Pepin JL,Geiser MH,Tonini M,Tamisier R,Renard E,Baguet JP,Levy P,Romanet JP,Chiquet C

更新日期：2011-12-16 00:00:00

abstract：PURPOSE:Tests for ocular Chlamydia trachomatis have not been well characterized, because there is no gold standard test. Latent class analysis (LCA) was performed to estimate the sensitivity and specificity of laboratory and clinical tests for trachoma in the absence of a gold standard. METHODS:Individual data from pr...

journal_title：Investigative ophthalmology & visual science

authors： See CW,Alemayehu W,Melese M,Zhou Z,Porco TC,Shiboski S,Gaynor BD,Eng J,Keenan JD,Lietman TM

更新日期：2011-08-03 00:00:00

abstract：PURPOSE:To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dual-wavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS:Forty-three patients were divided into groups 1 (contro...

journal_title：Investigative ophthalmology & visual science

authors： Lima VC,Rosen RB,Maia M,Prata TS,Dorairaj S,Farah ME,Sallum J

更新日期：2010-11-01 00:00:00

abstract：:The existence of wide-band, phase-specific channels in the human visual system has been suggested in recent investigations. We used a number of adapting gratings to test for phase-specific adaptation effects. Observers were asked to discriminate between a simple 3 cpd sine-wave grating, (3), and a complex grating comp...

journal_title：Investigative ophthalmology & visual science

authors： Sansbury RV,Distelhorst J,Moore S

更新日期：1978-05-01 00:00:00