Conjunctival in vivo confocal scanning laser microscopy in patients with Sjögren syndrome.

abstract：:A method is presented for the rapid flow cytometric determination of epidermal growth factor (EGF) receptor densities on the surface of cultured ocular cells. The technique uses a biotinylated monoclonal antibody directed against the EGF receptor in conjunction with a streptavidin-bound fluorochrome and requires the s...

journal_title：Investigative ophthalmology & visual science

authors： Lopez JG,Chew SJ,Thompson HW,Malter JS,Insler MS,Beuerman RW

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To compare conventional pattern-reversal visual evoked potentials (cVEPs) with multifocal VEPs (mfVEPs). METHODS:mfVEPs and cVEPs were recorded during the same session in 12 normal subjects with an active electrode at Oz referenced to the inion (Oz-In) or to a midfrontal position, Fz (Oz-Fz). The mfVEP stimulu...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Hood DC

更新日期：2003-03-01 00:00:00

abstract：Purpose:We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model. Methods:Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], ...

journal_title：Investigative ophthalmology & visual science

authors： Cui RZ,Wang L,Qiao SN,Wang YC,Wang X,Yuan F,Weng SJ,Yang XL,Zhong YM

更新日期：2019-04-01 00:00:00

abstract：:This study demonstrated that growth and differentiation of rabbit conjunctival epithelial cells could be promoted by such substrata as collagen gel, matrigel or various mixtures of collagen and matrigel in a defined culture system. On conventional plastic or glass culture, the conjunctival epithelial cells adopted a m...

journal_title：Investigative ophthalmology & visual science

authors： Tsai RJ,Tseng SC

更新日期：1988-10-01 00:00:00

abstract：:The expression of receptors for Fc portion (FcR) of immunoglobulin G (IgG) and for a C3b component of complement (C3bR) by herpes simplex virus (HSV) was studied in primary cultures of rabbit corneal cells. Monolayer cultures of epithelial, stromal and endothelial cells of the rabbit cornea were infected with three st...

journal_title：Investigative ophthalmology & visual science

authors： Hatano H,Oh JO,Ou KH,Minasi P

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas. METHODS:This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); form...

journal_title：Investigative ophthalmology & visual science

authors： Saad A,Gatinel D

更新日期：2012-05-17 00:00:00

abstract：PURPOSE:To determine how the different stages of retinal processing change after photoreceptor degeneration in rabbits carrying the Pro347Leu rhodopsin mutation (Tg rabbits). METHODS:Cone electroretinograms (ERGs) were elicited by 150-ms duration stimuli from 13 Tg rabbits at 12 and 24 weeks of age. The ERG recordings...

journal_title：Investigative ophthalmology & visual science

authors： Nishimura T,Machida S,Kondo M,Terasaki H,Yokoyama D,Kurosaka D

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:A relationship has been reported between the presence of peripheral neuropathy and the density and shape of corneal nerve fibers. Peripheral neuropathy is a debilitating condition that arises from many common health problems, and its presence is often confirmed with an invasive clinical test called intramuscula...

journal_title：Investigative ophthalmology & visual science

authors： Holmes TJ,Pellegrini M,Miller C,Epplin-Zapf T,Larkin S,Luccarelli S,Staurenghi G

更新日期：2010-09-01 00:00:00

abstract：:Sodium iodate and sodium iodoacetate were employed as biological probes to evaluate component forces contributing to the strength of retinal adhesion to the retinal pigment epithelium (RPE). Iodate treatment produced a rapid reduction in the strength of adhesion, which was complete within 1 hr without evidence of conc...

journal_title：Investigative ophthalmology & visual science

authors： Ashburn FS Jr,Pilkerton AR,Rao NA,Marak GE

更新日期：1980-12-01 00:00:00

abstract：PURPOSE:The majority of patients with autosomal dominant optic atrophy (DOA) harbor pathogenic OPA1 mutations and certain missense mutations, mostly within the GTPase domain, have recently been shown to cause multiple mitochondrial DNA (mtDNA) deletions in skeletal muscle. This raises the possibility that the optic neu...

journal_title：Investigative ophthalmology & visual science

authors： Yu-Wai-Man P,Davies VJ,Piechota MJ,Cree LM,Votruba M,Chinnery PF

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:There is some evidence to suggest that thrombolysis has a beneficial effect in retinal vessel occlusion. However, there is concern that this therapeutic approach carries the risk of hemorrhage. Retrograde cannulation of the supraorbital arteries followed by irrigation with fibrinolytic agents may have the poten...

journal_title：Investigative ophthalmology & visual science

authors： Schwenn OK,Wüstenberg EG,Konerding MA,Hattenbach LO

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To determine whether the uniform field and pattern ERGs that are reduced in macaque eyes with experimental glaucoma have the same inner-retinal origins. METHODS:ERGs were recorded from 14 anesthetized adult macaques using DTL electrodes. Six monkeys had laser-induced experimental glaucoma, and two others recei...

journal_title：Investigative ophthalmology & visual science

authors： Viswanathan S,Frishman LJ,Robson JG

更新日期：2000-08-01 00:00:00

abstract：:Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-depe...

journal_title：Investigative ophthalmology & visual science

authors： Tang LQ,Krupin T,Milner M,Woods D,Miller K,Carré DA,Civan MM

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:To investigate the slow phase in latent/manifest latent nystagmus (LMLN) by producing long eye-drift intervals devoid of fast phases (extended slow phases [ESPs]) and to relate ESP metrics to clinical findings. METHODS:Ten patients with LMLN had eye movements recorded while attending to paired visual and audit...

journal_title：Investigative ophthalmology & visual science

authors： Gradstein L,Goldstein HP,Wizov SS,Reinecke RD

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:The authors' previous models predicted local formation of diabetic retinopathy (DR) in adults with diabetes and existing retinopathy. Here they derived a multivariate model for local prediction of DR onset in patients with no previous retinopathy. METHODS:Seventy-eight eyes from 41 diabetes patients were teste...

journal_title：Investigative ophthalmology & visual science

authors： Harrison WW,Bearse MA Jr,Ng JS,Jewell NP,Barez S,Burger D,Schneck ME,Adams AJ

更新日期：2011-02-09 00:00:00

abstract：:A single injection of an aqueous suspension of group A streptococcal peptidoglycan-polysaccharide complexes (PG-PS) when injected intraperitoneally into Lewis rats induced a self-limiting bilateral uveitis with associated perpetuating polyarthritis. The uveitis was characterized clinically during the first 72 h by iri...

journal_title：Investigative ophthalmology & visual science

authors： Wells A,Pararajasegaram G,Baldwin M,Yang CH,Hammer M,Fox A

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:To evaluate the functional treatment response 3 months and 12 months after monthly ranibizumab in neovascular age-related macular degeneration (NAMD). METHODS:Twenty-six eyes showing treatment-naïve NAMD were examined with the Heidelberg Spectralis OCT (SD-OCT) and the Nidek MP-1 microperimeter (MP) at baselin...

journal_title：Investigative ophthalmology & visual science

authors： Sulzbacher F,Kiss C,Kaider A,Roberts P,Munk M,Kroh ME,Sayegh R,Schmidt-Erfurth U

更新日期：2013-02-01 00:00:00

abstract：:The role of heterozygous galactokinase deficiency in the development of presenile cataracts is presently undetermined. Erythrocyte galactokinase activity was measured from 95 normal Caucasian subjects and from 39 Caucasian patients who had developed idiopathic bilateral cataracts between ages 20 and 55. The diagnosis ...

journal_title：Investigative ophthalmology & visual science

authors： Stambolian D,Scarpino-Myers V,Eagle RC Jr,Hodes B,Harris H

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:To learn whether locally expressed and systemic mediators might modulate the cholinergically induced transepithelial Cl(-) fluxes that underlie lacrimal fluid production. METHODS:Reconstituted epithelial monolayers were exposed to a submaximal dose of the muscarinic agonist, carbachol (CCh), or to one of sever...

journal_title：Investigative ophthalmology & visual science

authors： Selvam S,Mircheff AK,Yiu SC

更新日期：2013-04-26 00:00:00

abstract：Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

journal_title：Investigative ophthalmology & visual science

authors： Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To identify the prognostic value of extraocular extension in enucleated uveal melanoma (UM) patients and to correlate extraocular extension to chromosomal aberrations, metastasis-free survival (MFS), and clinico-histopathological risk factors. METHODS:Retrospective study of patients with UM treated with enucle...

journal_title：Investigative ophthalmology & visual science

authors： van Beek JG,Koopmans AE,Vaarwater J,de Rooi JJ,Paridaens D,Naus NC,de Klein A,Verdijk RM,Kiliç E

更新日期：2014-03-04 00:00:00

abstract：PURPOSE:To identify the tyrosine-phosphorylated protein(s) in bovine rod outer segments (ROS) that are associated with phosphatidylinositol 3-kinase (PI3K). METHODS:Glutathione-S-transferase (GST) fusion proteins containing two SH2 domains of the p85 regulatory subunit of PI3K-GST-p85 (N-SH2), GST-p85 (C-SH2), and res...

journal_title：Investigative ophthalmology & visual science

authors： Rajala RV,Anderson RE

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:This study explored the role of the left posterior parietal cortex (PPC) in saccades, vergence, and combined saccade-vergence movements by means of transcranial magnetic stimulation (TMS) in humans. METHODS:TMS was applied over the left PPC for 80, 90, or 100 ms after target onset. In a control experiment, TMS...

journal_title：Investigative ophthalmology & visual science

authors： Yang Q,Kapoula Z

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：Purpose:Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods:This ca...

journal_title：Investigative ophthalmology & visual science

authors： Ono M,Takano Y,Haida M

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:To examine the relation between grating acuity at age 1 year and Snellen acuity and grating acuity at 5.5 years, in preterm children with birth weights less than 1251 g. METHODS:Subjects were participants in the multicenter study of Cryotherapy for Retinopathy of Prematurity. The Teller acuity card (TAC; Viste...

journal_title：Investigative ophthalmology & visual science

authors： Dobson V,Quinn GE,Siatkowski RM,Baker JD,Hardy RJ,Reynolds JD,Trese MT,Tung B

更新日期：1999-02-01 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：:While using cobalt (Co2+) to block synaptic transmission in an in vitro preparation of chick retina, the authors observed significant changes in the DC electroretinogram (DC ERG). Cobalt (3.0 mM) increased the amplitudes of all three photoreceptor-dependent responses of the retinal pigment epithelium (RPE): the c-wave...

journal_title：Investigative ophthalmology & visual science

authors： Gallemore RP,Steinberg RH

更新日期：1991-11-01 00:00:00

abstract：PURPOSE:Oxidative stress has been proposed as a major pathogenic factor in age-related macular degeneration (AMD), the leading cause of vision loss among elderly people of western European ancestry. Lutein (LUT) and zeaxanthin (ZEA), major components in macular pigment, are among the retinal antioxidants. Though xantho...

journal_title：Investigative ophthalmology & visual science

authors： Chucair AJ,Rotstein NP,Sangiovanni JP,During A,Chew EY,Politi LE

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations. METHODS:Thirty-six subjects (19 male, 17 female; mean SD, age 51 13 years) were recruited into this single-masked placebo-controlled study, and were ...

journal_title：Investigative ophthalmology & visual science

authors： Loughman J,Nolan JM,Howard AN,Connolly E,Meagher K,Beatty S

更新日期：2012-11-29 00:00:00