The effects of iodate and iodoacetate on the retinal adhesion.

Abstract:

:Sodium iodate and sodium iodoacetate were employed as biological probes to evaluate component forces contributing to the strength of retinal adhesion to the retinal pigment epithelium (RPE). Iodate treatment produced a rapid reduction in the strength of adhesion, which was complete within 1 hr without evidence of concurrent structural change. The adhesive strength reduction produced by iodoacetate required 8 to 12 hr, corresponding to the appearance of early structural changes in the photoreceptor outer segments, although delayed metabolic disturbances in the RPE might also have been involved. The study suggests that metabolic activity in the RPE may account for a portion of the strength of adhesion and that structural changes in the photoreceptor outer segments may also contribute to the forces of adhesion.

authors

Ashburn FS Jr,Pilkerton AR,Rao NA,Marak GE

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

1427-32

issue

12

eissn

0146-0404

issn

1552-5783

journal_volume

19

pub_type

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