Uveitis and arthritis induced by systemic injection of streptococcal cell walls.

abstract：PURPOSE:In several retinal complications, such as age-dependent macular degeneration (AMD), oxidative stress is increased and cytokine level is elevated. These are shown to alter the activation and expression of matrix metalloproteinase (MMP) both in human primary and immortalized retinal pigment epithelial (RPE) cells...

journal_title：Investigative ophthalmology & visual science

authors： Juuti-Uusitalo K,Nieminen M,Treumer F,Ampuja M,Kallioniemi A,Klettner A,Skottman H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study. METHODS:Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of ste...

journal_title：Investigative ophthalmology & visual science

authors： Healey PR,Mitchell P,Gilbert CE,Lee AJ,Ge D,Snieder H,Spector TD,Hammond CJ

更新日期：2007-06-01 00:00:00

abstract：Purpose:To assess interocular delays in amblyopes with stereopsis and to evaluate the relationship between interocular delays and the clinical characteristics. Methods:Twenty amblyopes with stereopsis (median, 400 arcseconds) and 20 controls with normal or corrected to normal visual acuity (≤0 logMAR) and normal stere...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Reynaud A,Tao C,Mao Y,He Z,Zhou J,Hess RF

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS). METHODS:Samples were collected from EIU-susceptible Lewis rats and EIU-re...

journal_title：Investigative ophthalmology & visual science

authors： de Vos AF,van Haren MA,Verhagen C,Hoekzema R,Kijlstra A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery. METHODS:A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After ...

journal_title：Investigative ophthalmology & visual science

authors： Jee JP,Choung HK,Kim CK,Hwang JM

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To study transition zones from normal to abnormal retina in Usher syndrome IB (USH1B) caused by myosin 7A (MYO7A) mutations. METHODS:Optical coherence tomography (OCT) scattering layers in outer retina were segmented in patients (n = 16, ages 2-42; eight patients had serial data, average interval 4.5 years) to...

journal_title：Investigative ophthalmology & visual science

authors： Sumaroka A,Matsui R,Cideciyan AV,McGuigan DB 3rd,Sheplock R,Schwartz SB,Jacobson SG

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. METHODS:Visible light-OCTA was used to study laser-induced CNV at differ...

journal_title：Investigative ophthalmology & visual science

authors： Shah RS,Soetikno BT,Yi J,Liu W,Skondra D,Zhang HF,Fawzi AA

更新日期：2016-07-01 00:00:00

abstract：:A method for assessing the inward permeability of the blood-retinal barrier by fluorophotometry is presented. The permeability value is calculated with the fluorophotometer computer from fluorophotometric scan values in vitreous and non-protein-bound fluorescein concentration values in plasma. No diffusion coefficient...

journal_title：Investigative ophthalmology & visual science

authors： Kappelhof JP,van Best JA,van Valenberg PL,Oosterhuis JA

更新日期：1987-04-01 00:00:00

abstract：Purpose:Growing evidence suggests the involvement of the macula even in early stages of glaucoma. However, little is known about the impact of glaucomatous macular damage on central pattern vision. Here we examine the contrast requirement for letter recognition and its relationship with retinal thickness in the macular...

journal_title：Investigative ophthalmology & visual science

authors： Chien L,Liu R,Girkin C,Kwon M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To develop a new test of activities of daily living (ADLs) appropriate for the low-vision population: the Melbourne Low-Vision ADL Index (MLVAI). METHODS:The MLVAI was designed as a desk-based clinical assessment, comprising 18 observed items on complex ADLs in part (a) and 9 questions on broad self-care ADLs ...

journal_title：Investigative ophthalmology & visual science

authors： Haymes SA,Johnston AW,Heyes AD

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate metabolic changes in aqueous humor from rabbit eyes exposed to either UV-A or -B radiation, by using (1)H nuclear magnetic resonance (NMR) spectroscopy and unsupervised pattern recognition METHODS:methods. Both eyes of adult albino rabbits were irradiated with UV-A (366 ...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Cejková J,Midelfart A

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:The values of Heidelberg Retinal Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany) stereometric parameters depend on the reference plane (RP), the instability of which results in parameter variability. Identification of change depends on RP stability. This study was undertaken to evaluate the influen...

journal_title：Investigative ophthalmology & visual science

authors： Poli A,Strouthidis NG,Ho TA,Garway-Heath DF

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:There is uncertainty in the published literature as to whether physical activity should be advocated for age-related macular degeneration (AMD) prevention. We aimed to assess prospectively the association between physical activity and the 15-year incidence of AMD in older adults. METHODS:We assessed AMD from r...

journal_title：Investigative ophthalmology & visual science

authors： Gopinath B,Liew G,Burlutsky G,Mitchell P

更新日期：2014-11-11 00:00:00

abstract：PURPOSE:Changes in gene expression were investigated after treatment of cultured human retinal pigment epithelial (RPE) cells with vitreous. This may have implications for proliferative diseases such as proliferative vitreoretinopathy. METHODS:Cells were cultured in the presence or absence of human vitreous, and gene ...

journal_title：Investigative ophthalmology & visual science

authors： Hunt DM,Chen WH,Hunt RC

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal dominant retinitis pigmentosa in a Chinese Family. METHODS:Families were ascertained and patients underwent complete ophthalmic examinations. Blood samples were collected and DNA was extracted. A linkage scan of genomic regions containing known ...

journal_title：Investigative ophthalmology & visual science

authors： Li N,Mei H,MacDonald IM,Jiao X,Hejtmancik JF

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To evaluate the nerve growth factor (NGF) plasma concentration in patients with vernal keratoconjunctivitis and to correlate it with the histopathology and immunopathology of the disease. METHODS:An immunoenzymatic assay was performed to measure NGF plasma levels in patients with vernal keratoconjunctivitis an...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Bonini S,Micera A,Magrini L,Bracci-Laudiero L,Aloe L

更新日期：1995-09-01 00:00:00

abstract：Purpose:To improve the transparency of the acellular dermal matrix (ADM) and investigate the optical, mechanical and histologic properties and biocompatibility of transparent ADM (TADM) in lamellar keratoplasty. Methods:A stepwise sectioning strategy was applied to determine the transparency distribution of the ADM, a...

journal_title：Investigative ophthalmology & visual science

authors： Wang Y,Ma J,Jiang X,Liu Z,Yang J,Li X

更新日期：2020-01-23 00:00:00

abstract：Purpose:To assess the feasibility of macular integrity assessment (MAIA) microperimetry (MP) in children. Also to establish representative outcome measures (differential light sensitivity, fixation stability, test-retest reliability) for children without visual impairment. Methods:Thirty-three adults and 33 children (...

journal_title：Investigative ophthalmology & visual science

authors： Jones PR,Yasoubi N,Nardini M,Rubin GS

更新日期：2016-11-01 00:00:00

abstract：Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic m...

journal_title：Investigative ophthalmology & visual science

authors： Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

更新日期：2021-02-01 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:The role of macular pigment (MP) in age-related maculopathy (ARM) is still not clearly understood. Recent studies have reported on variations in the spatial distribution of MP optical density (MPOD) including a secondary peak ("ring") in the slope of the MPOD profile. The authors investigated in a cross-section...

journal_title：Investigative ophthalmology & visual science

authors： Dietzel M,Zeimer M,Heimes B,Pauleikhoff D,Hense HW

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:To screen polymorphisms in complement factor-H (CFH), toll-like receptor 4 (TLR4), and APOE genes as potential risk factors for age-related macular degeneration (AMD) in Indian patients. METHODS:One hundred patients with AMD and 120 normal control subjects were screened for the polymorphisms by restriction dig...

journal_title：Investigative ophthalmology & visual science

authors： Kaur I,Hussain A,Hussain N,Das T,Pathangay A,Mathai A,Hussain A,Nutheti R,Nirmalan PK,Chakrabarti S

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Mice (Pdegtm1/Pdegtm1) homozygous for a mutant allele of the gamma subunit of retinal cyclic guanosine monophosphate phosphodiesterase (PDE gamma) suffer a severe photoreceptor degeneration. To determine whether the antiapoptotic BCL2 gene is effective in delaying the cell death pathway in this new strain of mu...

journal_title：Investigative ophthalmology & visual science

authors： Tsang SH,Chen J,Kjeldbye H,Li WS,Simon MI,Gouras P,Goff SP

更新日期：1997-04-01 00:00:00

abstract：:Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate. ...

journal_title：Investigative ophthalmology & visual science

authors： Podos SM,Lee PY,Severin C,Mittag T

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SD-OCT) in healthy individuals. METHODS:In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear ...

journal_title：Investigative ophthalmology & visual science

authors： Celebi AR,Mirza GE

更新日期：2013-12-11 00:00:00

abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to modify and functionalize the surface of synthetic poly-ε-caprolactone (PCL) nanofibrous scaffolds to improve their biocompatibility in order to provide better "cell-substrate" interaction. METHODS:Poly-ε-caprolactone solution was electrospun and its surface functionality was mo...

journal_title：Investigative ophthalmology & visual science

authors： Sharma S,Gupta D,Mohanty S,Jassal M,Agrawal AK,Tandon R

更新日期：2014-02-12 00:00:00

abstract：PURPOSE:This study was performed to investigate motion perception in patients with glaucoma. METHODS:A random dot motion test was used to measure three aspects of central motion perception: minimum displacement threshold (Dmin), maximum displacement threshold (Dmax), and coherence threshold (signal to noise). Motion p...

journal_title：Investigative ophthalmology & visual science

authors： Bullimore MA,Wood JM,Swenson K

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:To investigate the slow phase in latent/manifest latent nystagmus (LMLN) by producing long eye-drift intervals devoid of fast phases (extended slow phases [ESPs]) and to relate ESP metrics to clinical findings. METHODS:Ten patients with LMLN had eye movements recorded while attending to paired visual and audit...

journal_title：Investigative ophthalmology & visual science

authors： Gradstein L,Goldstein HP,Wizov SS,Reinecke RD

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:To determine whether the intact isolated ciliary epithelial bilayer retains the alpha-2 and beta adrenergic receptor activation and interaction described for whole ciliary processes and whether this pure epithelial bilayer displays bioelectric parameters sensitive to alterations in cyclic adenosine Monophosphat...

journal_title：Investigative ophthalmology & visual science

authors： Horio B,Sears M,Mead A,Matsui H,Bausher L

更新日期：1996-03-01 00:00:00