Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene.

abstract：PURPOSE:The secreted Ly6/uPAR-related protein-1 (Slurp1), associated with the hyperkeratotic disorder mal de Meleda, is abundantly expressed in corneas. Here, we examine its corneal expression and functions. METHODS:Gene expression was quantified by quantitative PCR (qPCR), immunoblots, and immunofluorescent staining....

journal_title：Investigative ophthalmology & visual science

authors： Swamynathan S,Buela KA,Kinchington P,Lathrop KL,Misawa H,Hendricks RL,Swamynathan SK

更新日期：2012-12-19 00:00:00

abstract：:Moiré fringes generated by two equal gratings in contact, looked at in Maxwellian view, are well suited for the assessment of retinal visual acuity. High-contrast fringes practically free from spatial harmonics (higher Fourier components) are obtained if, instead of the zero diffraction order, one first-order diffract...

journal_title：Investigative ophthalmology & visual science

authors： Lotmar W

更新日期：1980-04-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3'-kinase (PI3K) during corneal epithelial wound healing. METHODS:Epithelial debridement wounds in cultured porci...

journal_title：Investigative ophthalmology & visual science

authors： Xu KP,Yin J,Yu FS

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:The adult lacrimal gland (LG) is highly regenerative and is able to repair itself even after substantial damage; however, this ability to regenerate is lost with the development of dry eye conditions in chronically inflamed LGs.This study compares changes in the cell adhesion and cell matrix molecules and stem ...

journal_title：Investigative ophthalmology & visual science

authors： Umazume T,Thomas WM,Campbell S,Aluri H,Thotakura S,Zoukhri D,Makarenkova HP

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To characterize photoreceptor cell apoptosis and cell loss in a mouse model of experimental retinal detachment (RD), and to use the technology of mouse genetics to study the molecular mechanisms underlying RD-associated photoreceptor degeneration. METHODS:Retinal detachments were created in adult wild-type and...

journal_title：Investigative ophthalmology & visual science

authors： Yang L,Bula D,Arroyo JG,Chen DF

更新日期：2004-02-01 00:00:00

abstract：:Critical flicker frequency (CFF) was measured for stimuli varying in chromaticity only and in luminance only for patients with multiple sclerosis (MS) and for matched normal controls. The two CFF measurements showed different underlying linear interdependencies for the two groups, consistent with a greater loss of tem...

journal_title：Investigative ophthalmology & visual science

authors： Mason RJ,Snelgar RS,Foster DH,Heron JR,Jones RE

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:The objective of this systematic review was to examine the evidence on zinc intake from foods and supplements in the primary prevention and treatment of AMD. METHODS:Randomized controlled trials (RCTs), prospective cohort, retrospective cohort, and case-control studies that investigated zinc intake from foods ...

journal_title：Investigative ophthalmology & visual science

authors： Vishwanathan R,Chung M,Johnson EJ

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:Since, to our knowledge, there are no reports on the prevalence of the blaNDM-1 gene among ocular isolates of Enterobacteriaceae, and only limited information on the prevalence of extended spectrum beta-lactamases (ESBLs) among ocular bacterial isolates are available, our study was undertaken. METHODS:A prospe...

journal_title：Investigative ophthalmology & visual science

authors： Sowmiya M,Malathi J,Madhavan HN

更新日期：2012-08-07 00:00:00

abstract：:The metabolism of the polyunsaturated fatty acid, arachidonic acid (20:4, n-6) in rabbit cornea with varying severities of herpes simplex viral infection was investigated. The results indicate an active synthesis of the lipoxygenase and cyclooxygenase reaction products of arachidonic acid in central cornea and corneal...

journal_title：Investigative ophthalmology & visual science

authors： Birkle DL,Sanitato JJ,Kaufman HE,Bazan NG

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To characterize in SV40-immortalized human corneal epithelial cells (tHCEC) osmosensitive taurine transporter gene and protein expression as well as its functional activity. To evaluate whether medium supplementation with taurine improves cell viability during a hypertonic challenge. METHODS:tHCEC were preincu...

journal_title：Investigative ophthalmology & visual science

authors： Shioda R,Reinach PS,Hisatsune T,Miyamoto Y

更新日期：2002-09-01 00:00:00

abstract：:Monkeys eyes were fixed with glutaraldehyde in vivo at positive intraocular pressure of 35 or 25 mm Hg and compared with eyes fixed without a positive pressure gradient, with the use of light microscopy and transmission and scanning electron microscopy. The entire endothelial lining of the inner wall of Schlemm's cana...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone MA

更新日期：1979-01-01 00:00:00

abstract：Purpose:A shortage of human corneal endothelial cells (HCEC) for transplant and current methods of differentiation induction require chemical compounds, which might cast further influences after differentiation induction. Therefore, we developed a simple and straightforward approach to endothelial cell differentiation ...

journal_title：Investigative ophthalmology & visual science

authors： Chen X,Wu L,Li Z,Dong Y,Pei X,Huang Y,Wang L

更新日期：2018-06-01 00:00:00

abstract：Purpose:To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma. Methods:One hundred forty-six eyes of 95 glaucoma patients had optical coherence tomography ONH imaging and VF testing at a...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Lin C,Crowther M,Mak H,Yu M,Leung CK

更新日期：2017-03-01 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:The mouse has become an important wound healing model with which to study corneal fibrosis, a frequent complication of refractive surgery. The aim of the current study was to quantify changes in stromal ultrastructure and light scatter that characterize fibrosis in mouse corneal debridement wounds. METHODS:Epi...

journal_title：Investigative ophthalmology & visual science

authors： Boote C,Du Y,Morgan S,Harris J,Kamma-Lorger CS,Hayes S,Lathrop KL,Roh DS,Burrow MK,Hiller J,Terrill NJ,Funderburgh JL,Meek KM

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:The objective of the study was to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on the multifocal electroretinogram (mfERG) following an induced branch retinal vein occlusion (BRVO) in pigs. METHODS:Electrophysiological examination of the retina was performed in 20 pigs with stan...

journal_title：Investigative ophthalmology & visual science

authors： Ejstrup R,Cour Ml,Kyhn MV,Heegaard S,Kiilgaard JF

更新日期：2012-09-14 00:00:00

abstract：:PURPOSE. To investigate the effects and possible mechanisms of rat bone marrow mesenchymal stem cell (BMSC) transplantation on the light-damaged retinal structure and the apoptosis of photoreceptors. METHODS. DAPI-labeled BMSCs were transplanted into the subretinal space of light-damaged Sprague-Dawley rats 10 days af...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Wang W

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To search for proprioceptive nerve terminals in human ciliary muscle. METHODS:In 48 human donor eyes, histologic and ultrathin sections cut in different planes and wholemounts of the ciliary muscle were studied. Immunohistochemical staining with antibodies against pan-neuronal antigens and antigens reported as...

journal_title：Investigative ophthalmology & visual science

authors： Flügel-Koch C,Neuhuber WL,Kaufman PL,Lütjen-Drecoll E

更新日期：2009-12-01 00:00:00

abstract：:To investigate the pathogenesis of ocular cytomegalovirus infections, 3-week-old BALB/c mice were inoculated with 10(4) plaque-forming units of murine cytomegalovirus (MCMV) by the right anterior chamber and studied sequentially with the use of virus assays and in situ nucleic acid hybridization methods. During acute ...

journal_title：Investigative ophthalmology & visual science

authors： Bale JF Jr,O'Neil ME,Lyon B,Perlman S

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:Glial cells are structurally and functionally linked to neuronal tissues. Pathologically, the cells may be activated and characterized by increased size and number and altered cellular properties. In glaucoma, pathologic mechanisms within the anterior optic nerve may include glial activation. This study examine...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Cioffi GA,Cull G,Dong J,Fortune B

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:Reading a text requires vergence angle adjustments, so that the images in the two eyes fall on corresponding retinal areas. Vergence adjustments bring the two retinal images into Panum's fusional area and therefore, small remaining errors or regulations do not lead to double vision. The present study evaluated ...

journal_title：Investigative ophthalmology & visual science

authors： Jainta S,Dehnert A,Heinrich SP,Jaschinski W

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:To assess if the in vivo mechanical displacement of the anterior laminar cribrosa surface (ALCS) as a response of an acute elevation in intraocular pressure (IOP) differs in individuals of European (ED) and African descent (AD). METHODS:Spectral-domain optical coherence tomography (SDOCT) scans were obtained f...

journal_title：Investigative ophthalmology & visual science

authors： Fazio MA,Johnstone JK,Smith B,Wang L,Girkin CA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the express...

journal_title：Investigative ophthalmology & visual science

authors： Alge CS,Priglinger SG,Neubauer AS,Kampik A,Zillig M,Bloemendal H,Welge-Lussen U

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:Recent studies demonstrated that short peptides derived from activity-dependent neurotrophic factor (ADNF) and activity-dependent neuroprotective protein (ADNP) are neuroprotective at femtomolar concentrations. We evaluated these findings in cultures of purified rat retinal ganglion cells (RGCs) using two such ...

journal_title：Investigative ophthalmology & visual science

authors： Lagrèze WA,Pielen A,Steingart R,Schlunck G,Hofmann HD,Gozes I,Kirsch M

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP). METHODS:Paired explants were used as control versus VIP (10 nM)-treated before storage in corne...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Gloria D,Molloy J

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To better understand ocular hypertension-induced early molecular alterations that may determine the initiation of neurodegeneration in human glaucoma, this study analyzed retinal proteomic alterations in the ocular hypertensive human retina. METHODS:Retina samples were obtained from six human donors with ocula...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Hondur G,Li M,Cai J,Klein JB,Kuehn MH,Tezel G

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is an inherited retinal disease that causes early-onset severe visual impairment. To evaluate the mutation spectrum in the Chinese population, we performed a mutation screen in 145 Chinese LCA families. METHODS:First, we performed direct Sanger sequencing of 7 LCA disease genes...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Wang X,Zou X,Xu S,Li H,Soens ZT,Wang K,Li Y,Dong F,Chen R,Sui R

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00