当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice.

Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice.

Abstract：

PURPOSE:This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. METHODS:Visible light-OCTA was used to study laser-induced CNV at different time-points after laser injury to monitor CNV development and measure CNV lesion size. Measurements obtained from vis-OCTA angiograms were compared with histopathologic measurements from isolectin-stained choroidal flatmounts. RESULTS:Choroidal neovascularization area measurements between the vis-OCTA system and isolectin-stained choroidal flatmounts were significantly different in area for days 2 to 4 postlaser injury, and were not significantly different in area for days 5, 7, and 14. Choroidal neovascularization area measurements taken from the stained flatmounts were larger than their vis-OCTA counterparts for all time-points. Both modalities showed a similar trend of CNV size increasing from the day of laser injury until a peak of day 7 postlaser injury and subsequently decreasing by day 14. CONCLUSIONS:The earliest vis-OCTA can detect the presence of aberrant vessels in a mouse laser-induced CNV model is 5 days after laser injury. Visible light-OCTA was able to visualize the maximum of the CNV network 7 days postlaser injury, in accordance with choroidal flatmount immunostaining. Visible light-OCTA is a reliable tool in both detecting the presence of CNV development, as well as accurately determining the size of the lesion in a mouse laser-induced CNV model.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Shah RS,Soetikno BT,Yi J,Liu W,Skondra D,Zhang HF,Fawzi AA

doi

10.1167/iovs.15-18891

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

OCT86-95

issue

9

eissn

0146-0404

issn

1552-5783

pii

2534094

journal_volume

57

pub_type

杂志文章

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Ophthalmic phenotypes and the representativeness of twin data for the general population.

    abstract：PURPOSE:To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. METHODS:A series of birth, anthropometric, and 13 ocular biometric traits were ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-7258

    authors： Sanfilippo PG,Medland SE,Hewitt AW,Kearns LS,Ruddle JB,Sun C,Hammond CJ,Young TL,Martin NG,Mackey DA

    更新日期：2011-07-29 00:00:00

  • The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow.

    abstract：Purpose:To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods:This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.18-23872

    authors： Kiyota N,Shiga Y,Ichinohasama K,Yasuda M,Aizawa N,Omodaka K,Honda N,Kunikata H,Nakazawa T

    更新日期：2018-07-02 00:00:00

  • Retinal Nerve Fiber Layer Thickness in Children: The Gobi Desert Children Eye Study.

    abstract：Purpose:Because there is a paucity of population-based data on retinal nerve fiber layer thickness (RNFLT) for children, we measured the RNFLT and its associations in schoolchildren. Methods:The population-based Gobi Desert Children Eye Study included all schoolchildren aged 6 to 21 years living in Ejina, Inner Mongol...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.18-25418

    authors： Wang CY,Zheng YF,Liu B,Meng ZW,Hong F,Wang XX,Wang XJ,Du L,Wang IY,Zhu D,Tao Y,You QS,Jonas JB

    更新日期：2018-10-01 00:00:00

  • Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis.

    abstract：PURPOSE:Levels of some cytokines are significantly higher in the vitreous fluid of patients with acute uveitis than in normal vitreous fluid. The authors sought to determine which proinflammatory cytokines were upregulated in the vitreous fluid of patients with ocular sarcoidosis. METHODS:Samples of vitreous fluid wer...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-9244

    authors： Nagata K,Maruyama K,Uno K,Shinomiya K,Yoneda K,Hamuro J,Sugita S,Yoshimura T,Sonoda KH,Mochizuki M,Kinoshita S

    更新日期：2012-06-20 00:00:00

  • Reattachment of cultured human retinal pigment epithelium to extracellular matrix and human Bruch's membrane.

    abstract：PURPOSE:To determine the mechanism of reattachment of harvested human retinal pigment epithelium (RPE) to RPE-derived extracellular matrix and Bruch's membrane. METHODS:Confluent first-to third-passage human RPE were harvested from tissue culture and plated onto RPE-derived extracellular matrix or human Bruch's membra...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Ho TC,Del Priore LV

    更新日期：1997-05-01 00:00:00

  • Corneal epithelial basement membrane changes in diabetes.

    abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Taylor HR,Kimsey RA

    更新日期：1981-04-01 00:00:00

  • Distribution of amyloid precursor protein and amyloid-beta immunoreactivity in DBA/2J glaucomatous mouse retinas.

    abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-1249

    authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

    更新日期：2007-11-01 00:00:00

  • Aging and age-related diseases of the ocular lens and vitreous body.

    abstract：:Reduced quality of life and financial burden due to visual impairment and blindness begin to increase dramatically when individuals reach the age of 40. The major causes of age-related vision loss can be traced to changes to the structure and function of the lens, one of the tissues responsible for focusing light on t...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,评审

    doi：10.1167/iovs.13-12940

    authors： Petrash JM

    更新日期：2013-12-13 00:00:00

  • Preferential looking acuity obtained with a staircase procedure in pediatric patients.

    abstract：:Visual acuity of infants and young children with ophthalmologic disorders was assessed by adapting a transformed up-down staircase to preferential looking (PL) procedures. Eighty-five percent of pediatric patients between 11 days and 5 years of age were tested successfully. Acuity of infants and young children with no...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Mayer DL,Fulton AB,Hansen RM

    更新日期：1982-10-01 00:00:00

  • RDS gene mutations causing retinitis pigmentosa or macular degeneration lead to the same abnormality in photoreceptor function.

    abstract：PURPOSE:To investigate functional abnormalities in mutations in the peripherin (RDS) gene leading to different clinical types of autosomal dominant retinal disease--macular degeneration and retinitis pigmentosa. METHODS:Patients from two families, one with a mutation in codon 167 (Gly167Asp) leading to macular degener...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Kemp CM,Jacobson SG,Cideciyan AV,Kimura AE,Sheffield VC,Stone EM

    更新日期：1994-07-01 00:00:00

  • Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants.

    abstract：Purpose:Activation of proteolytic enzymes, calpains and caspases, have been observed in many models of retinal disease. We previously demonstrated calpain activation in monkey retinal explants cultured under hypoxia. However, cellular responses are often species-specific. The purpose of the present study was to determi...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.61.13.13

    authors： Kobayashi-Otsugu M,Orihara K,Nakajima E,Shearer TR,Azuma M

    更新日期：2020-11-02 00:00:00

  • Clinicopathologic effects of the Q64ter rhodopsin mutation in retinitis pigmentosa.

    abstract：PURPOSE:To correlate retinal histopathology with functional changes caused by the rhodopsin Q64ter mutation. METHODS:A 50-year-old female heterozygote was evaluated clinically and with psychophysical and electroretinographic measurements of rod and cone function. The retinas obtained after death were examined microsco...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Milam AH,Li ZY,Cideciyan AV,Jacobson SG

    更新日期：1996-04-01 00:00:00

  • A method for preparing a viable corneal endothelial layer, completely denuded of overlying stroma.

    abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Soong H,Fischbarg J,Iwamoto T

    更新日期：1978-11-01 00:00:00

  • The effect of complete tenotomy on blood flow to the anterior segment of the canine eye.

    abstract：:The relative importance of the anterior ciliary arteries to blood flow to the anterior segment and the quadrant distribution of blood to the iris, ciliary body, and ciliary processes were determined in canines with the use of 15 +/- 3 mum 103Ru microspheres with the reference blood flow method. Recti muscles were isol...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Keough EM,Wilcox LM,Connolly RJ,Hotte CE

    更新日期：1980-11-01 00:00:00

  • Nighttime Driving in Older Adults: Effects of Glare and Association With Mesopic Visual Function.

    abstract：Purpose:To examine the associations between nighttime driving performance of older drivers and photopic, mesopic, and glare-based tests of visual function. Methods:Participants included 26 older drivers (71.8 ± 6.3 years), with minimal or no eye disease, but who reported vision-related nighttime driving difficulties. ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-21219

    authors： Kimlin JA,Black AA,Wood JM

    更新日期：2017-05-01 00:00:00

  • Triamcinolone acetonide inhibits IL-6- and VEGF-induced angiogenesis downstream of the IL-6 and VEGF receptors.

    abstract：PURPOSE:To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and whether this inhibition is through antagonism of the IL-6 or the VEGF receptor 2. METHODS:A rat cornea micropocket assay was used to initiate IL-6- and VEGF-mediated angiogenesis. The ability of TA or neutralizing VE...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-1651

    authors： Ebrahem Q,Minamoto A,Hoppe G,Anand-Apte B,Sears JE

    更新日期：2006-11-01 00:00:00

  • Oscillatory eye movements resembling pendular nystagmus in normal juvenile macaques.

    abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-5903

    authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

    更新日期：2011-06-01 00:00:00

  • Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis.

    abstract：PURPOSE:To evaluate the effect of chemical chaperones on the trafficking of secretion-incompetent primary open-angle glaucoma-associated mutant myocilin and the possibility to rescue cells coexpressing mutant and wild-type myocilin from endoplasmic reticulum (ER) stress and apoptosis. METHODS:CHO-K1, HEK293 and human ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-0943

    authors： Yam GH,Gaplovska-Kysela K,Zuber C,Roth J

    更新日期：2007-04-01 00:00:00

  • Tear film osmolarity: determination of a referent for dry eye diagnosis.

    abstract：PURPOSE:To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. METHOD:A meta-analysis was performed on published data for tear osmolarity in samples of normal eyes and various subty...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,meta分析

    doi：10.1167/iovs.05-1504

    authors： Tomlinson A,Khanal S,Ramaesh K,Diaper C,McFadyen A

    更新日期：2006-10-01 00:00:00

  • Prolactins are natural inhibitors of angiogenesis in the retina.

    abstract：PURPOSE:Disruption of the normally antiangiogenic environment of the retina leads to aberrant angiogenesis, the major cause of vision loss throughout the world. Prolactin (PRL), the hormone originally associated with milk production, can be proteolytically processed to 16K-PRL, a 16 kDa N-terminal PRL fragment with pot...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0173

    authors： Aranda J,Rivera JC,Jeziorski MC,Riesgo-Escovar J,Nava G,López-Barrera F,Quiróz-Mercado H,Berger P,Martínez de la Escalera G,Clapp C

    更新日期：2005-08-01 00:00:00

  • Bacterial Coaggregation Among the Most Commonly Isolated Bacteria From Contact Lens Cases.

    abstract：Purpose:To examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. Methods:Four or five strains each of commonly isolated bacteria from contact lens cases, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Serratia marcescens, were grown, wash...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-20593

    authors： Datta A,Stapleton F,Willcox MD

    更新日期：2017-01-01 00:00:00

  • Photodynamic therapy using Lu-Tex induces apoptosis in vitro, and its effect is potentiated by angiostatin in retinal capillary endothelial cells.

    abstract：PURPOSE:To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cel...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Renno RZ,Delori FC,Holzer RA,Gragoudas ES,Miller JW

    更新日期：2000-11-01 00:00:00

  • Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years.

    abstract：:Advanced macular degeneration is an important cause of vision loss in the United States with over 2 million people affected by the disease. Despite substantial progress in the development of new therapies for wet AMD, the severe visual impairment associated with geographic atrophy in dry AMD or Stargardt disease remai...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,评审

    doi：10.1167/iovs.15-18681

    authors： Schwartz SD,Tan G,Hosseini H,Nagiel A

    更新日期：2016-04-01 00:00:00

  • Changes in gene expression by trabecular meshwork cells in response to mechanical stretching.

    abstract：PURPOSE:Trabecular meshwork (TM) cells appear to sense changes in intraocular pressure (IOP) as mechanical stretching. In response, they make homeostatic corrections in the aqueous humor outflow resistance, partially by increasing extracellular matrix (ECM) turnover initiated by the matrix metalloproteinases. To unders...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0075

    authors： Vittal V,Rose A,Gregory KE,Kelley MJ,Acott TS

    更新日期：2005-08-01 00:00:00

  • Decrease of anterior ciliary arterial pressure with increased ocular pressure.

    abstract：:The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Sakimoto G,Schwartz B

    更新日期：1984-08-01 00:00:00

  • Ultrastructural immunocytochemical analysis of elastin in the human lamina cribrosa. Changes in elastic fibers in primary open-angle glaucoma.

    abstract：:The elastic fiber consists of several components: a central core of alpha-elastin and a microfibrillar sheath containing three components: fibrillin, microfibril-associated glycoprotein, and a 35-kD protein with amine oxidase activity. Elastin is a major component of the elastic fibers of the extracellular matrix (ECM...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Hernandez MR

    更新日期：1992-09-01 00:00:00

  • Regional differences in the fine structure of the ciliary epithelium related to accommodation.

    abstract：:The ciliary bodies of five monkey eyes and one human eye were subdivided into five zones. The ciliary epithelium with its bordering stroma was investigated electron microscopically. The number of cell organelles of the nonpigmented (NPE) and pigmented (PE) epithelium (mitochondria, rough endoplasmic reticulum, Golgi c...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Ober M,Rohen JW

    更新日期：1979-07-01 00:00:00

  • Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells.

    abstract：PURPOSE:To investigate the intracellular mechanisms that induce amyloid beta (Abeta) accumulation and angiogenesis in the human retinal pigment epithelial cell line ARPE19. METHODS:The authors used two endoplasmic reticulum (ER) stress-inducing reagents, thapsigargin (TG), which inhibits the sarcoplasmic/endoplasmic c...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1067

    authors： Koyama Y,Matsuzaki S,Gomi F,Yamada K,Katayama T,Sato K,Kumada T,Fukuda A,Matsuda S,Tano Y,Tohyama M

    更新日期：2008-06-01 00:00:00

  • Molecular Mechanisms Mediating Antiangiogenic Action of the Urokinase Receptor-Derived Peptide UPARANT in Human Retinal Endothelial Cells.

    abstract：Purpose:To investigate the molecular mechanisms of the antiangiogenic activity of UPARANT, an antagonist of the urokinase-type plasminogen activator receptor (uPAR), on primary human retinal endothelial cells (HREC) as a model of in vitro angiogenesis. Methods:The antiangiogenic activity of UPARANT was evaluated on en...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-19909

    authors： Motta C,Lupo G,Rusciano D,Olivieri M,Lista L,De Rosa M,Pavone V,Anfuso CD

    更新日期：2016-10-01 00:00:00

  • Extending the Spectrum of EYS-Associated Retinal Disease to Macular Dystrophy.

    abstract：Purpose:To assess the phenotypic variability and natural course of inherited retinal diseases (IRDs) caused by EYS mutations. Methods:Multiethnic cohort study (N = 30) with biallelic EYS variants from a clinical IRD database (retinitis pigmentosa [RP], N = 27; cone-rod dystrophy [CRD], N = 1; and macular dystrophy, N ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,多中心研究

    doi：10.1167/iovs.18-25531

    authors： Pierrache LHM,Messchaert M,Thiadens AAHJ,Haer-Wigman L,de Jong-Hesse Y,van Zelst-Stams WAG,Collin RWJ,Klaver CCW,van den Born LI

    更新日期：2019-05-01 00:00:00