The development of the Melbourne low-vision ADL index: a measure of vision disability.

Abstract:

PURPOSE:To develop a new test of activities of daily living (ADLs) appropriate for the low-vision population: the Melbourne Low-Vision ADL Index (MLVAI). METHODS:The MLVAI was designed as a desk-based clinical assessment, comprising 18 observed items on complex ADLs in part (a) and 9 questions on broad self-care ADLs in part (b). Each item was rated on a five-level descriptive scale from 0 to 4, based on independence, speed, and accuracy of performance. It was designed to be administered under standardized conditions with regard to the instructions, illumination, and working distances. The validity and reliability of the new MLVAI was determined for 122 subjects who were representative of the general low-vision population, in a cross-sectional study. RESULTS:Two items were found to be redundant and were eliminated from the test. Thus, the final test comprised 25 items, with 100 being the highest possible score. Cronbach's alpha indicated an internal reliability of 0.96, and an intraclass correlation coefficient indicated an overall reliability of 0.95. The SE of measurement was 4.5. According to Spearman's correlation coefficient, the test-retest reliability was 0.94 (P < 0.001), and the interpractitioner reliability for five different pairs of practitioners was 0.90 or higher (P < 0.001). With regard to validity, there was a moderately high correlation with vision impairment (r = -0.68, P < 0.001). Using Rasch analysis, content validity was also demonstrated by good separation indexes (4.70 and 9.88) and high reliability scores (0.96 and 0.99) for the person and items parameters, respectively. Separate calculation of indexes and reliability scores for parts (a) and (b) indicated high content validity and reliability of each part. However, the separation indexes and reliability scores were higher for part (a) than for part (b). The correlation coefficient for part (a) and part (b) was 0.68. CONCLUSIONS:The MLVAI is a highly valid and reliable standardized test of ADL performance for the general low-vision population. It may be used to assess patients with low vision and has the potential to be used as a measure of low-vision rehabilitation outcomes.

authors

Haymes SA,Johnston AW,Heyes AD

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

1215-25

issue

6

eissn

0146-0404

issn

1552-5783

journal_volume

42

pub_type

杂志文章
  • Blue Multifocal Pupillographic Objective Perimetry in Glaucoma.

    abstract:PURPOSE:This study investigated multifocal pupillographic objective perimetry (mfPOP) stimuli that target the intrinsic photosensitivity of melanopsin retinal ganglion cells. The diagnostic potential for glaucoma is compared between stimuli biased toward either cone input to these cells or their melanopsin response. M...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-16029

    authors: Carle CF,James AC,Kolic M,Essex RW,Maddess T

    更新日期:2015-10-01 00:00:00

  • Corneal sensitivity following lacrimal gland excision in the rat.

    abstract:PURPOSE:Dry eye disease (DED) produces ocular pain and irritation, yet a detailed characterization of ocular sensitivity in a preclinical model of DED is lacking. The aim of the present study was to assess nociceptive behaviors in an aqueous tear deficiency model of DED in the rat. METHODS:Spontaneous blinking, cornea...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.15-16717

    authors: Meng ID,Barton ST,Mecum NE,Kurose M

    更新日期:2015-05-01 00:00:00

  • Role of swarming migration in the pathogenesis of bacillus endophthalmitis.

    abstract:PURPOSE:Bacillus cereus causes one of the most rapidly blinding forms of bacterial endophthalmitis. Migration of B. cereus throughout the eye during endophthalmitis is a unique aspect of this disease that may contribute to intraocular virulence. This study was conducted to analyze the contribution of swarming and intra...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0301

    authors: Callegan MC,Novosad BD,Ramirez R,Ghelardi E,Senesi S

    更新日期:2006-10-01 00:00:00

  • Development and evaluation of a contrast sensitivity perimetry test for patients with glaucoma.

    abstract:PURPOSE:To design a contrast sensitivity perimetry (CSP) protocol that decreases variability in glaucomatous defects while maintaining good sensitivity to glaucomatous loss. METHODS:Twenty patients with glaucoma and 20 control subjects were tested with a CSP protocol implemented on a monitor-based testing station. In ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.07-1205

    authors: Hot A,Dul MW,Swanson WH

    更新日期:2008-07-01 00:00:00

  • Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus.

    abstract::Herpes simplex virus type 1 (HSV-1) inoculated directly into the anterior chamber of the mouse eye induced an acute inflammatory process in both the injected eye and its uninjected (contralateral) counterpart. In the former, a rapid intense inflammatory reaction developed in the anterior segment (cornea, anterior cham...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Whittum JA,McCulley JP,Niederkorn JY,Streilein JW

    更新日期:1984-09-01 00:00:00

  • A connective tissue growth factor signaling receptor in corneal fibroblasts.

    abstract:PURPOSE:To biochemically characterize the receptor for connective tissue growth factor (CTGF) of human corneal fibroblasts (HCF). METHODS:Radiolabeled recombinant human CTGF was used to determine the specificity and time course of binding to low-passage cultures of HCF. The affinity and number of receptors present wer...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-9425

    authors: Blalock TD,Gibson DJ,Duncan MR,Tuli SS,Grotendorst GR,Schultz GS

    更新日期:2012-06-05 00:00:00

  • Retinal disease expression in Bardet-Biedl syndrome-1 (BBS1) is a spectrum from maculopathy to retina-wide degeneration.

    abstract:PURPOSE:To define the retinal phenotype in patients with the Bardet-Biedl syndrome and mutations in the BBS1 gene. METHODS:Ten patients (age range, 16-48 years), representing eight pedigrees, with BBS1 gene mutations were studied clinically and with kinetic perimetry, chromatic static perimetry, electroretinography (E...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0517

    authors: Azari AA,Aleman TS,Cideciyan AV,Schwartz SB,Windsor EA,Sumaroka A,Cheung AY,Steinberg JD,Roman AJ,Stone EM,Sheffield VC,Jacobson SG

    更新日期:2006-11-01 00:00:00

  • Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy?

    abstract:PURPOSE:To establish the regulatory roles that pericytes have in coordinating retinal endothelial cell (EC) growth and angiogenic potential. METHODS:Pericytes were derived from donor diabetic (DHuRP) or normal (NHuRP) human retinae, and characterized using vascular markers, coculture, contraction, morphogenesis, and p...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-13945

    authors: Durham JT,Dulmovits BM,Cronk SM,Sheets AR,Herman IM

    更新日期:2015-06-01 00:00:00

  • Contribution of mutation load to the intrafamilial genetic heterogeneity in a large cohort of Spanish retinal dystrophies families.

    abstract:PURPOSE:The aim of this study was to deepen our knowledge on the basis of intrafamilial genetic heterogeneity of inherited retinal dystrophies (RD) to further discern the contribution of individual alleles to the pathology. METHODS:Families with intrafamilial locus and/or allelic heterogeneity were selected from a coh...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-14938

    authors: Sánchez-Alcudia R,Cortón M,Ávila-Fernández A,Zurita O,Tatu SD,Pérez-Carro R,Fernandez-San Jose P,Lopez-Martinez MÁ,del Castillo FJ,Millan JM,Blanco-Kelly F,García-Sandoval B,Lopez-Molina MI,Riveiro-Alvarez R,Ayuso C

    更新日期:2014-10-23 00:00:00

  • Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis.

    abstract:PURPOSE:To determine the effect of pyrrolidine dithiocarbamate (PDTC), a nuclear factor (NF)-kappaB inhibitor, on chemokine and chemokine receptor expression and thus elucidate the role of NF-kappaB in the pathogenesis of experimental autoimmune anterior uveitis (EAAU). METHODS:Uveitis was induced in Lewis rats with t...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.04-0640

    authors: Yang CH,Fang IM,Lin CP,Yang CM,Chen MS

    更新日期:2005-04-01 00:00:00

  • Dilation of porcine retinal arterioles to cilostazol: roles of eNOS phosphorylation via cAMP/protein kinase A and AMP-activated protein kinase and potassium channels.

    abstract:PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-10115

    authors: Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

    更新日期:2013-02-19 00:00:00

  • Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension.

    abstract:Purpose:It has been suggested that arteriolar annuli localized in retinal arterioles regulate retinal blood flow acting as sphincters. Here, the morphology and protein expression profile of arteriolar annuli have been analyzed under physiologic conditions in the retina of wild-type, β-actin-Egfp, and Nestin-gfp transge...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.18-25000

    authors: Ramos D,Catita J,López-Luppo M,Valença A,Bonet A,Carretero A,Navarro M,Nacher V,Mendez-Ferrer S,Meseguer A,Casellas A,Mendes-Jorge L,Ruberte J

    更新日期:2019-02-01 00:00:00

  • Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.

    abstract:PURPOSE:There is a correlation between cell volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow. This study investigated the effects of the nitric oxide (NO)-independent activators of soluble guanylate cycl...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-3127

    authors: Dismuke WM,Sharif NA,Ellis DZ

    更新日期:2009-07-01 00:00:00

  • Cone visual cell degeneration in ground squirrel retina: disruption of morphology and cyclic nucleotide metabolism by lodoacetic acid.

    abstract::Photoreceptor degeneration was induced in the cone-dominant retina of the ground squirrel by intracardiac injection of iodoacetic acid. Morphology was examined and cyclic nucleotide levels were determined in retinas taken at various times between 35 min and 11 days after injection. Degenerating cone cells were first d...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Farber DB,Souza DW,Chase DG

    更新日期:1983-09-01 00:00:00

  • Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications.

    abstract:PURPOSE:To assess the reproducibility of the ocular response analyzer (ORA) in nonoperated eyes and the impact of corneal biomechanical properties on intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS:In the reliability study, two independent examiners obtained repeated ORA measurements i...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.07-0280

    authors: Moreno-Montañés J,Maldonado MJ,García N,Mendiluce L,García-Gómez PJ,Seguí-Gómez M

    更新日期:2008-03-01 00:00:00

  • Objective Ocular Discomfort: Noninvasive Evaluation by Functional Near-Infrared Ray Spectroscopy.

    abstract:Purpose:Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods:This ca...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.18-24840

    authors: Ono M,Takano Y,Haida M

    更新日期:2018-09-04 00:00:00

  • Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells.

    abstract:PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.15-16816

    authors: Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

    更新日期:2015-09-01 00:00:00

  • Response of the vestibulo-ocular reflex to differing programs of acceleration.

    abstract::The vestibulo-ocular reflex of normal monkeys was tested by a modified Bárány spinning test (B-test) and by sinosoidal rotation. The two tests gave concordant estimates of the time constant and corner frequency. Deviation from concordance was caused largely by modification of the reflex during the testing procedures. ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Blair S,Gavin M

    更新日期:1979-10-01 00:00:00

  • Mpdz null allele in an avian model of retinal degeneration and mutations in human leber congenital amaurosis and retinitis pigmentosa.

    abstract:PURPOSE:To identify the defective gene in the sex-linked, recessively inherited retinal dysplasia and degeneration (rdd) chicken and to search for the human equivalent disease. METHODS:Microsatellites from chicken chromosome Z were genotyped in 77 progeny of a carrier male (rdd/+) and an affected female (rdd/W), and c...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-7872

    authors: Ali M,Hocking PM,McKibbin M,Finnegan S,Shires M,Poulter JA,Prescott K,Booth A,Raashid Y,Jafri H,Ruddle JB,Mackey DA,Jacobson SG,Toomes C,Lester DH,Burt DW,Curry WJ,Inglehearn CF

    更新日期:2011-09-27 00:00:00

  • Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching.

    abstract:PURPOSE:Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0875

    authors: Keller KE,Kelley MJ,Acott TS

    更新日期:2007-03-01 00:00:00

  • A novel locus for autosomal dominant nuclear cataract mapped to chromosome 2p12 in a Pakistani family.

    abstract:PURPOSE:To map the disease locus in a four-generation, consanguineous Pakistani family affected by autosomal dominant congenital nuclear cataract (adNCat). All affected individuals had early onset of bilateral nuclear cataract. METHODS:Genomic DNA from family members was typed for alleles at more than 300 known polymo...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Khaliq S,Hameed A,Ismail M,Anwar K,Mehdi SQ

    更新日期:2002-07-01 00:00:00

  • Automated assessment of diabetic retinal image quality based on clarity and field definition.

    abstract:PURPOSE:To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. METHODS:Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose,...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.05-1155

    authors: Fleming AD,Philip S,Goatman KA,Olson JA,Sharp PF

    更新日期:2006-03-01 00:00:00

  • Photoreceptor Degeneration Accompanies Vascular Changes in a Zebrafish Model of Diabetic Retinopathy.

    abstract:Purpose:Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness worldwide in the working-age population, and the incidence is rising. Until now it has been difficult to define initiating events and disease progression at the molecular level, as available diabetic rodent models do not present the...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.61.2.43

    authors: Ali Z,Zang J,Lagali N,Schmitner N,Salvenmoser W,Mukwaya A,Neuhauss SCF,Jensen LD,Kimmel RA

    更新日期:2020-02-07 00:00:00

  • Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study.

    abstract:Purpose:To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A). Methods:In this case-control retrospective observational study, patients with atrophic NAION (at least 3 months after onset of sy...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.17-22996

    authors: Augstburger E,Zéboulon P,Keilani C,Baudouin C,Labbé A

    更新日期:2018-02-01 00:00:00

  • Selective binding of a 30-kilodalton protein to disposable hydrophilic contact lenses.

    abstract::To investigate the accumulation of tear proteins on disposable extended-wear contact lenses (42% Etafilcon A and 58% hydration), a technique involving sodium dodecyl sulfate-polyacrylamide minigel electrophoresis combined with a sensitive silver-staining method was used. Besides the binding of large amounts of tear ly...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Cheng KH,Kok JH,van Mil C,Kijlstra A

    更新日期:1990-11-01 00:00:00

  • Impairments of contrast discrimination and contrast adaptation in glaucoma.

    abstract:PURPOSE:Contrast detection is commonly measured clinically; however, discrimination between contrasts is also important for natural vision. Furthermore, optimal performance requires the visual system to adapt to ambient contrast conditions. Recent studies of primate neurophysiology demonstrate significant retinal invol...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-3332

    authors: McKendrick AM,Sampson GP,Walland MJ,Badcock DR

    更新日期:2010-02-01 00:00:00

  • Differential expression of chemokines by human retinal pigment epithelial cells infected with cytomegalovirus.

    abstract:PURPOSE:To evaluate the effects of human cytomegalovirus (HCMV) infection on chemokine gene expression and secretion by human retinal pigment epithelial (HRPE) cell cultures. METHODS:HRPE cells were infected with HCMV (strain AD169) at an MOI of 5. Culture supernatants, collected at various postinoculation days, were ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.02-0980

    authors: Momma Y,Nagineni CN,Chin MS,Srinivasan K,Detrick B,Hooks JJ

    更新日期:2003-05-01 00:00:00

  • Protein-related abnormalities in keratoconus.

    abstract::Two-dimensional electrophoretic maps of extracts from eleven normal and eleven keratoconus corneas were compared. Of the eleven corneas analyzed, eight were pooled and the remaining three were analyzed individually. Several differences were demonstrated between electrophoretic patterns of normal and keratoconus cornea...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Panjwani N,Drysdale J,Clark B,Alberta J,Baum J

    更新日期:1989-12-01 00:00:00

  • Retinal Thy-1 expression during development.

    abstract:PURPOSE:To evaluate the developmental expression of Thy-1 in the retina. Thy-1, the most abundant mammalian neuronal surface glycoprotein, is likely to play a significant role in retinal development. In the mammalian retina, it is found predominantly, if not exclusively, on retinal ganglion cells. METHODS:Rat retinae ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Liu CJ,Chaturvedi N,Barnstable CJ,Dreyer EB

    更新日期:1996-06-01 00:00:00

  • Preface: The aging eye: normal changes, age-related diseases, and sight-saving approaches.

    abstract::This volume presents articles based on a workshop held June 14 to 16, 2013 in Rancho Palos Verde, CA sponsored by the Ocular Research Symposia Foundation (ORSF). The mission of the ORSF is to focus attention on unmet needs and current research opportunities in eye research with the objective of accelerating translatio...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章,评审

    doi:10.1167/iovs.13-12993

    authors: Chader GJ,Taylor A

    更新日期:2013-12-13 00:00:00