Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus.

abstract：PURPOSE:To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts. METHODS:The GJA8 gene was directly sequenced. Formation of functional channels was assessed by the two-microelectrode voltage-clamp METHOD:Connexin protein levels and distribu...

journal_title：Investigative ophthalmology & visual science

authors： Minogue PJ,Tong JJ,Arora A,Russell-Eggitt I,Hunt DM,Moore AT,Ebihara L,Beyer EC,Berthoud VM

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To examine the distribution of human heat shock proteins (HSPs) HSP90, inducible HSP70 (iHSP70), constitutive and inducible HSP70 (cHSP70), HSP65, and human HSP27 in conjunctival biopsy specimens of ocular cicatricial pemphigoid (OCP), atopic keratoconjunctivitis, and healthy persons with cataract. METHODS:Usi...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Dutt JE,Nouri M,Foster CS

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:Vitreous degeneration contributes to several age-related eye diseases, including retinal detachment, macular hole, macular traction syndrome, and nuclear cataracts. Remarkably little is understood about the molecular interactions responsible for maintaining vitreous structure. The purpose of this study was to m...

journal_title：Investigative ophthalmology & visual science

authors： Filas BA,Zhang Q,Okamoto RJ,Shui YB,Beebe DC

更新日期：2014-01-03 00:00:00

abstract：PURPOSE:The chaperone proteins, α-crystallins, also possess antiapoptotic properties. The purpose of the present study was to investigate whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides (α-crystallin mini-chaperone) are antiapoptotic, and to identify their putative transporters in human fetal RPE (hfR...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Chothe P,Sharma KK,Baid R,Kompella U,Spee C,Kannan N,Manh C,Ryan SJ,Ganapathy V,Kannan R,Hinton DR

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight pro...

journal_title：Investigative ophthalmology & visual science

authors： Weber BH,Lin B,White K,Kohler K,Soboleva G,Herterich S,Seeliger MW,Jaissle GB,Grimm C,Reme C,Wenzel A,Asan E,Schrewe H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the repeatability of manual measurements of choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using the enhanced depth imaging (EDI) technique. METHODS:Fifty consecutive, healthy, young, adult volunteers with no known e...

journal_title：Investigative ophthalmology & visual science

authors： Rahman W,Chen FK,Yeoh J,Patel P,Tufail A,Da Cruz L

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS:All family members underwent ophthalmic examination. Linkage analysis of candidate retinal dystrophy loci and a whole genome scan were perfo...

journal_title：Investigative ophthalmology & visual science

authors： van Lith-Verhoeven JJ,Hoyng CB,van den Helm B,Deutman AF,Brink HM,Kemperman MH,de Jong WH,Kremer H,Cremers FP

更新日期：2004-01-01 00:00:00

abstract：:Two distinct patterns of delayed-onset, cell-mediated hypersensitivity have been induced in the guinea pig eye with the same soluble protein antigen and two different methods of immunization. The predominant histologic feature of these reactions was the large number of eosinophils which infiltrated the uveal tract and...

journal_title：Investigative ophthalmology & visual science

authors： Friedlaender MH,Howes EL Jr,Hall JM,Krasnobrod H,Wormstead MA

更新日期：1978-04-01 00:00:00

abstract：:Ocular adenoviral infections occur worldwide, and currently, there is no ocular animal model for evaluating new antivirals or studying pathogenesis. With a paired-eye design, an ocular model was developed in 32 New Zealand rabbits following topical and intrastromal inoculation with a clinical isolate of adenovirus typ...

journal_title：Investigative ophthalmology & visual science

authors： Gordon YJ,Romanowski E,Araullo-Cruz T

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To determine whether caspase or cathepsin pathways are activated in human retinal pigment epithelial cells (ARPE-19) after exposure to 7-ketocholesterol (7kCh). METHODS:ARPE-19 cells were exposed to 7kCh with or without z-VAD-fmk, a pan-caspase inhibitor. Caspase-3, -8, and -9 activities were measured by a flu...

journal_title：Investigative ophthalmology & visual science

authors： Luthra S,Fardin B,Dong J,Hertzog D,Kamjoo S,Gebremariam S,Butani V,Narayanan R,Mungcal JK,Kuppermann BD,Kenney MC

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:There is a correlation between cell volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow. This study investigated the effects of the nitric oxide (NO)-independent activators of soluble guanylate cycl...

journal_title：Investigative ophthalmology & visual science

authors： Dismuke WM,Sharif NA,Ellis DZ

更新日期：2009-07-01 00:00:00

abstract：Purpose:To investigate transepidermal water loss (TEWL) from the ocular area in dry eye disease (DED) and evaluate the correlation between ocular TEWL and other DED parameters. Methods:Transepidermal water loss from the ocular area in 56 eyes with DED and 38 healthy eyes was measured using a Tewameter TM300 that was e...

journal_title：Investigative ophthalmology & visual science

authors： Jeon HS,Youn SW,Jeon HE,Kim JH,Hyon JY

更新日期：2016-09-01 00:00:00

abstract：Purpose:To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods:Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 K...

journal_title：Investigative ophthalmology & visual science

authors： Akaiwa K,Namekata K,Azuchi Y,Sano H,Guo X,Kimura A,Harada C,Mitamura Y,Harada T

更新日期：2018-04-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of stanniocalcin-1 (STC-1), a photoreceptor-protective glycoprotein, on the development of choroidal neovascularization (CNV) in relation to VEGF and its main receptor (VEGFR2) expression after laser injury. Methods:In rats, CNV was induced by laser photo...

journal_title：Investigative ophthalmology & visual science

authors： Zhao M,Xie W,Tsai SH,Hein TW,Rocke BA,Kuo L,Rosa RH Jr

更新日期：2018-02-01 00:00:00

abstract：:The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

journal_title：Investigative ophthalmology & visual science

authors： Sakimoto G,Schwartz B

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in th...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2011-07-01 00:00:00

abstract：:The ability of human and rabbit ocular tissues to degrade prostaglandins (PGs) was compared by following the metabolic fate of PGF2 alpha. No metabolism was observed in vitro after 5.0 hr incubation with human cornea, iris/ciliary body, or sclera, as indicated by the absence of a decrease in [3H]-PGF2 alpha concentrat...

journal_title：Investigative ophthalmology & visual science

authors： Cheng-Bennett A,Poyer J,Weinkam RJ,Woodward DF

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Monkeys reared under conditions of alternating monocular occlusion during their first few months of life show large horizontal strabismus, "A" patterns, and dissociated vertical deviation. "A" patterns manifest as an inappropriate horizontal component in the deviated eye during vertical eye movements (cross-axi...

journal_title：Investigative ophthalmology & visual science

authors： Joshi AC,Das VE

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore. METHODS:Retinoid levels and photoreceptor functions of Rdh5-/-Rdh11-/- mice at a variety of l...

journal_title：Investigative ophthalmology & visual science

authors： Maeda A,Maeda T,Palczewski K

更新日期：2006-10-01 00:00:00

abstract：Purpose:To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscin-melanolipofuscin (LM), mitochondria, and nuclei. Methods:A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An...

journal_title：Investigative ophthalmology & visual science

authors： Pollreisz A,Neschi M,Sloan KR,Pircher M,Mittermueller T,Dacey DM,Schmidt-Erfurth U,Curcio CA

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Because of its role in cell cycle regulation and apoptosis, p53 may be involved in maintaining the post-mitotic state of the adult eye. To shed light on the role of p53 in retinal development and maintenance, this study investigated the pattern of expression of p53, its family members, and its regulators during...

journal_title：Investigative ophthalmology & visual science

authors： Vuong L,Brobst DE,Saadi A,Ivanovic I,Al-Ubaidi MR

更新日期：2012-07-20 00:00:00

abstract：PURPOSE:Rabbits are used commonly for the evaluation of drugs and surgery to lower intraocular pressure (IOP). The authors compared the accuracy and variability of three tonometers for measuring IOP in rabbits. METHODS:The anterior chamber of adult rabbits was cannulated with a 25-gauge needle connected to an elevated...

journal_title：Investigative ophthalmology & visual science

authors： Abrams LS,Vitale S,Jampel HD

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:Deposition of the macular pigment carotenoids lutein and zeaxanthin in the human retina occurs early in life. In this study, we examined the interrelationships of maternal carotenoid status and newborn infant macular pigment levels and systemic carotenoid status. As a secondary measure, we also evaluated the ef...

journal_title：Investigative ophthalmology & visual science

authors： Henriksen BS,Chan G,Hoffman RO,Sharifzadeh M,Ermakov IV,Gellermann W,Bernstein PS

更新日期：2013-08-15 00:00:00

abstract：PURPOSE:Environmental tobacco smoke (ETS) is widely regarded as a major modifiable risk factor for age-related macular degeneration (AMD). Yet, precisely how it exerts its pathologic effects is poorly understood. Since early-stage AMD is characterized by choroidal capillary loss, this study examined the effect of sides...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Scott HA,Ardekani S,Williams M,Talbot P,Ghosh K

更新日期：2014-04-08 00:00:00

abstract：:Retinoblastoma patients have cellular and humoral reactivity towards antigens expressed on retinoblastoma cells. We report the ultrastructural, cytogenetic, and immunologic features of four new retinoblastoma derived tissue culture cell lines. Studies with hybridoma produced monoclonal antibodies demonstrate that thes...

journal_title：Investigative ophthalmology & visual science

authors： Char DH,Wood IS,Huhta K,Rand N,Morita CT,Howes EL Jr

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Endothelin (ET)-1 is known to inhibit active NaK transport by as much as 50% in kidney tubule and other tissues. The presence of low levels of ET-1 in aqueous humor combined with the potential for release of ET-1 from ciliary processes suggests that the lens could be exposed to ET-1 in vivo. In this study, expe...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Delamere NA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Classically, acute and chronic inflammations are characterized by fibrin deposition and a dynamic influx of leukocytes. This leukocyte recruitment, and associated activation, is thought to be dependent on the generation of leukocyte chemotactic factors (LCF). Although the functional existence of LCF in ocular t...

journal_title：Investigative ophthalmology & visual science

authors： Ramsby ML,Kreutzer DL

更新日期：1994-11-01 00:00:00

abstract：:To investigate the accumulation of tear proteins on disposable extended-wear contact lenses (42% Etafilcon A and 58% hydration), a technique involving sodium dodecyl sulfate-polyacrylamide minigel electrophoresis combined with a sensitive silver-staining method was used. Besides the binding of large amounts of tear ly...

journal_title：Investigative ophthalmology & visual science

authors： Cheng KH,Kok JH,van Mil C,Kijlstra A

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Melanocyte is the major cell component in the uvea. Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1β and explored the relevant signal pathways. METHODS:Conditioned media and cells were collected ...

journal_title：Investigative ophthalmology & visual science

authors： Hu DN,Chen M,Zhang DY,Ye F,McCormick SA,Chan CC

更新日期：2011-06-01 00:00:00