Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina.

abstract：PURPOSE:To characterize retinal functional consequences of elevated intraocular pressure (IOP) in a rat model of experimental glaucoma. METHODS:Unilateral elevation of IOP was produced by hypertonic saline injection into an episcleral vein in 20 adult male Brown-Norway rats. IOP was measured in both eyes of awake anim...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Bui BV,Morrison JC,Johnson EC,Dong J,Cepurna WO,Jia L,Barber S,Cioffi GA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To investigate the involvement of the p38 mitogen-activated protein (MAP) kinase and phosphatidylinositol-3 (PI-3) kinase-Akt signaling pathways after pathologic stimulation by N-methyl-D-aspartate (NMDA) receptors of retinal neurons in vivo. METHODS:NMDA (2-200 nmol), SB203580 (0.2-10 nmol, an inhibitor of p3...

journal_title：Investigative ophthalmology & visual science

authors： Manabe S,Lipton SA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：:Sodium iodate and sodium iodoacetate were employed as biological probes to evaluate component forces contributing to the strength of retinal adhesion to the retinal pigment epithelium (RPE). Iodate treatment produced a rapid reduction in the strength of adhesion, which was complete within 1 hr without evidence of conc...

journal_title：Investigative ophthalmology & visual science

authors： Ashburn FS Jr,Pilkerton AR,Rao NA,Marak GE

更新日期：1980-12-01 00:00:00

abstract：Purpose:We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods:The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography,...

journal_title：Investigative ophthalmology & visual science

authors： Alassane S,Binquet C,Arnould L,Fleck O,Acar N,Delcourt C,Bretillon L,Bron AM,Creuzot-Garcher C

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. METHODS:Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide a...

journal_title：Investigative ophthalmology & visual science

authors： Kim ET,Kim C,Lee SW,Seo JM,Chung H,Kim SJ

更新日期：2009-09-01 00:00:00

abstract：Purpose:To assess the effect of serous retinal detachment (SRD) on functional and anatomical outcomes in ranibizumab-treated patients with diabetic macular edema (DME). Methods:All consecutive ranibizumab-treated patients with SRD were included in this retrospective study. For each patient with SRD, a patient without ...

journal_title：Investigative ophthalmology & visual science

authors： Giocanti-Aurégan A,Hrarat L,Qu LM,Sarda V,Boubaya M,Levy V,Chaine G,Fajnkuchen F

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：:PURPOSE. Simple sphingolipids control crucial cellular processes in several cell types. Previous work demonstrated that sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate, are key mediators in the regulation of survival, differentiation, and proliferation of retina photoreceptors. Ceramide-1-pho...

journal_title：Investigative ophthalmology & visual science

authors： Miranda GE,Abrahan CE,Agnolazza DL,Politi LE,Rotstein NP

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:Pterygia are a common, benign, fibrovascular, and infiltrative process of the corneal-conjunctival junction of unknown pathogenesis. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes active against all components of the extracellular matrix, whose activity is specifically neutralized by tissu...

journal_title：Investigative ophthalmology & visual science

authors： Di Girolamo N,McCluskey P,Lloyd A,Coroneo MT,Wakefield D

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To compare the clinical outcomes of aberration-free ablation profiles based on the normal corneal vertex (CV) and the pupil center (PC) in relation to laser in situ keratomileusis. Aberration-free aspheric ablation treatments were performed in all cases. METHODS:Two myopic astigmatism groups (CV centered using...

journal_title：Investigative ophthalmology & visual science

authors： Arbelaez MC,Vidal C,Arba-Mosquera S

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to develop a murine model of allergic conjunctivitis induced by house dust mite (HDM) extract from Dermatophagoides pteronyssinus, a major allergen in humans. METHODS:Forty BALB/c mice were divided into five groups, immunized with placebo, ovalbumin (10 μg), or HDM extract followi...

journal_title：Investigative ophthalmology & visual science

authors： Lee YJ,Han SJ,Lee H,Kim JS,Seo KY

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Pathology in the primary drainage pathway for aqueous humor in the eye is responsible for ocular hypertension, the only treatable risk factor in patients with glaucoma. Unfortunately, the mechanisms that regulate pressure-dependent drainage of aqueous humor and thus intraocular pressure (IOP) are unknown. To be...

journal_title：Investigative ophthalmology & visual science

authors： Stamer WD,Lei Y,Boussommier-Calleja A,Overby DR,Ethier CR

更新日期：2011-12-09 00:00:00

abstract：Purpose:To define the functional roles of Grk1 and Grk7 in zebrafish cones in vivo. Methods:Genome editing was used to generate grk7a and grk1b knockout zebrafish. Electroretinogram (ERG) analyses of the isolated cone mass receptor potential and the b-wave were performed in dark-adapted zebrafish using a paired flash ...

journal_title：Investigative ophthalmology & visual science

authors： Chrispell JD,Dong E,Osawa S,Liu J,Cameron DJ,Weiss ER

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:The epidermal growth factor receptor (EGFR) appears in astrocytes after neural injury. The authors' laboratory has reported the presence of EGFR in glaucomatous optic nerves. The activation of EGFR is often associated with induction of cyclooxygenase (COX)-2. In this study, the induction of COX-2 pathway in rat...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Neufeld AH

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:Advanced glycation end products (AGEs) form irreversible cross-links with many macromolecules and have been shown to accumulate in tissues at an accelerated rate in diabetes. In the present study, AGE formation in vitreous was examined in patients of various ages and in patients with diabetes. Ex vivo investiga...

journal_title：Investigative ophthalmology & visual science

authors： Stitt AW,Moore JE,Sharkey JA,Murphy G,Simpson DA,Bucala R,Vlassara H,Archer DB

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characteriz...

journal_title：Investigative ophthalmology & visual science

authors： Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

更新日期：2015-02-26 00:00:00

abstract：PURPOSE:To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death, mitochondrial bioenergetics, and senescence. METHODS:Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal microscopy. Human RP...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Ishikawa K,Spee C,Mehta HH,Wan J,Yen K,Cohen P,Kannan R,Hinton DR

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To elucidate the anatomy of the trabecular meshwork (TM) and its connection to ciliary muscle (CM) tendons with two photon excitation microscopic (TPEM) imaging. METHODS:The human aqueous outflow pathway was imaged in an unfixed and nonembeded state by using an inverted TPEM. Laser (Ti:Sapphire) was tuned at 8...

journal_title：Investigative ophthalmology & visual science

authors： Park CY,Lee JK,Kahook MY,Schultz JS,Zhang C,Chuck RS

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To characterize the phagocytosis of extracellular matrix components by retinal pigment epithelial cells and to determine which receptors and signal transduction pathways are involved. METHODS:Fluorescent latex beads were coated with fibronectin (FN), collagen type I or IV, or thrombospondin and incubated with ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao MW,Jin ML,He S,Spee C,Ryan SJ,Hinton DR

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:To characterize the molecular properties, cellular distribution, and subcellular distribution of bovine rom-1 and its interaction with peripherin/rds in photoreceptor cells as an important step toward elucidating the role of rom-1 in photoreceptor outer segment structure-function relationships and in inherited ...

journal_title：Investigative ophthalmology & visual science

authors： Moritz OL,Molday RS

更新日期：1996-02-01 00:00:00

abstract：Purpose:To investigate by optical coherence tomography angiography (OCT-A) the choroidal vascular response to experimentally increased blood pressure in patients with central serous chorioretinopathy (CSCR). Methods:For this multicenter, observational, case-control study, we enrolled 35 patients with an established di...

journal_title：Investigative ophthalmology & visual science

authors： Cardillo Piccolino F,Lupidi M,Cagini C,Fruttini D,Nicolò M,Eandi CM,Tito S

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To investigate macular changes in acute retinopathy of prematurity (ROP). METHODS:Fifty-four premature infants with ROP and 20 controls underwent routine ROP screening with indirect ophthalmoscopy and imaging. A tabletop spectral domain optical coherence tomography (SD-OCT) scanner (Spectralis; Heidelberg Engi...

journal_title：Investigative ophthalmology & visual science

authors： Vinekar A,Avadhani K,Sivakumar M,Mahendradas P,Kurian M,Braganza S,Shetty R,Shetty BK

更新日期：2011-07-15 00:00:00

abstract：Purpose:To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD). Methods:The qAF imaging was performed on eyes of 26 rhesus macaques (me...

journal_title：Investigative ophthalmology & visual science

authors： Tran TM,Kim S,Lin KH,Chung SH,Park S,Sazhnyev Y,Wang Y,Cunefare D,Farsiu S,Thomasy SM,Moshiri A,Yiu G

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Scleral proteoglycans were characterized from human donor eyes aged 2 months to 94 years to identify age-related changes in the synthesis and/or accumulation of these extracellular matrix components. METHODS:Newly synthesized proteoglycans (previously radiolabeled with 35SO4) and total accumulated scleral prot...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Achen VR,Penugonda S,Schmidt RW,Mount BA

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHODS:In an earlier study, it was shown that a model using vB-ICA-mm...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Boden C,Zhang Z,Pascual J,Lee TW,Zangwill LM,Weinreb RN,Crowston JG,Hoffmann EM,Medeiros FA,Sejnowski T,Goldbaum M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To explore connexin43 (Cx43) knockdown as an efficient treatment for corneal endothelial injury in an in vivo rat corneal scrape injury model. METHODS:Scrape injury was induced in the corneal endothelium, and immunolabeling (ZO-1, alpha-SMA, Cx43) was performed to analyze changes in Cx43 expression during woun...

journal_title：Investigative ophthalmology & visual science

authors： Nakano Y,Oyamada M,Dai P,Nakagami T,Kinoshita S,Takamatsu T

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:This study investigated a novel motion-on-color paradigm to functionally isolate the magnocellular pathway and evaluate its diagnostic value in preperimetric glaucoma patients. METHODS:Thirty patients with preperimetric primary open-angle glaucoma and 30 controls participated in this study. They were tested in...

journal_title：Investigative ophthalmology & visual science

authors： Wen W,Zhang P,Liu T,Zhang T,Gao J,Sun X,He S

更新日期：2015-07-01 00:00:00

abstract：Purpose:High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreore...

journal_title：Investigative ophthalmology & visual science

authors： Takeuchi M,Taguchi M,Sato T,Karasawa K,Sakurai Y,Harimoto K,Ito M

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To investigate the induction of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) gene expression by prostaglandin E2 (PGE2) in cultured rat Müller cells and to study the mechanism of the induction. METHODS:Müller cells were obtained from neonatal Sprague-Dawley rat retinas an...

journal_title：Investigative ophthalmology & visual science

authors： Cheng T,Cao W,Wen R,Steinberg RH,LaVail MM

更新日期：1998-03-01 00:00:00