Abstract：
PURPOSE:The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was investigated. METHODS:The ophthalmic artery was catheterized through the external carotid system using a fluoroscopy-monitored, transfemoral, endovascular approach in 12 pigs (mean weight, 70 kg). The effects were evaluated using angiography and multifocal electroretinography. RESULTS:Occlusion of arteries supplying the retina was established using endovascular coiling. Coiling in the proximal part of the ophthalmic artery caused no or little ischemia, presumably because of collateral blood supply. Coiling in the distal part of the ophthalmic artery, over the branching of the main ciliary artery, caused more severe retinal ischemia. Multifocal electroretinography recordings, which reflect retinal function in an area close to the visual streak, showed decreased amplitudes and increased implicit times after distal occlusion, but not after proximal occlusion of the ophthalmic artery. The responses were similar 1 hour and 72 hours after coiling, indicating that a permanent ischemic injury was established. CONCLUSIONS:The porcine ophthalmic artery can be occluded using an endovascular coiling technique. This provides an experimental animal model of retinal ischemia in which occlusion at different sites of the vasculature produces different degrees of severity of the ischemic damage.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö Mdoi
10.1167/iovs.11-7628subject
Has Abstractpub_date
2011-07-01 00:00:00pages
4880-5issue
7eissn
0146-0404issn
1552-5783pii
iovs.11-7628journal_volume
52pub_type
杂志文章abstract：:Pattern ERGs in response to pattern-reversal stimuli varying in spatial frequency (range: 0.2-9.03 cycles/deg) and contrast (range: 0.03-0.93) were recorded from two normal male subjects. At most spatial frequencies the response amplitude increased linearly up to the highest contrast without saturation. From the ampli...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated ...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：Purpose:The purpose of this work was to test whether palisade endings express structural and molecular features of exocytotic machinery, and are associated with acetylcholine receptors, and enzymes for neurotransmitter breakdown. Methods:Extraocular rectus muscles from six cats were studied. Whole-mount preparations o...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.61.14.31
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abstract：PURPOSE:Ischemia is a risk factor for eye diseases like ocular vein occlusion or glaucoma. To investigate effects of ischemia-reperfusion (I/R) a lot of different animal models are used, studying one or two different cell types, which creates heterogeneity of data. The aim of this study was to investigate the function ...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.13-13372
更新日期：2014-04-28 00:00:00
abstract：Purpose:Mutations in CACNA2D4, encoding the α2δ4 subunit of retinal voltage-gated calcium channels (Cav), cause a rare type of retinal dysfunction in human, mainly affecting cone vision. Here, we investigate the role of CACNA2D4 in targeting of Cav, its influence on cone-mediated signal transmission, and the cellular a...
journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.19-26759
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.08-2934
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.16-20802
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:Fibrillins are the major constituent of tissue microfibrils, which form the ocular zonule. In Marfan syndrome (MFS), FBN1 mutations lead to ectopia lentis. The goal of this work was to investigate zonule composition and formation in fibrillin-deficient and wild-type mice. METHODS:Immunofluorescence staining of...
journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.13-13121
更新日期：2013-12-23 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.07-0214
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journal_title：Investigative ophthalmology & visual science
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更新日期：1997-03-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：PURPOSE:To develop structural markers of early glaucomatous optic nerve damage with confocal scanning laser ophthalmoscopy. METHODS:Custom software was developed to analyze the images of 53 patients with open-angle glaucoma and 43 healthy subjects (matched for age, race, and refractive error), with images acquired wit...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:The metabolism of the polyunsaturated fatty acid, arachidonic acid (20:4, n-6) in rabbit cornea with varying severities of herpes simplex viral infection was investigated. The results indicate an active synthesis of the lipoxygenase and cyclooxygenase reaction products of arachidonic acid in central cornea and corneal...
journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：1986-10-01 00:00:00
abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...
journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.13-12801
更新日期：2013-12-03 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To characterize the effect of postural IOP elevation and pharmacological IOP lowering on retinal ganglion cell (RGC) function in the DBA/2J mouse model of glaucoma. METHODS:Four groups of DBA/2J mice (3 months old, n = 7; 5 months old, n = 7; 10 months old, n = 7; and 11 months old, n = 8) were anesthetized by...
journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.07-0582
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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更新日期：1979-12-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2001-03-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2002-01-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：1983-09-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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doi：
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2001-01-01 00:00:00
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更新日期：2015-02-05 00:00:00
