Therapeutic Effect of MK2 Inhibitor on Experimental Murine Dry Eye.

abstract：Purpose:To evaluate the corneal endothelial characteristics across the primary angle closure (PAC) disease spectrum amongst patients diagnosed as PAC suspects (PACS), PAC, PAC glaucoma (PACG), and previous acute PAC (APAC). Methods:We analyzed a total of 529 subjects (51 PACS, 170 PAC, 234 PACG, and 74 with previous A...

journal_title：Investigative ophthalmology & visual science

authors： Verma S,Nongpiur ME,Husain R,Wong TT,Boey PY,Quek D,Perera SA,Aung T

更新日期：2018-09-04 00:00:00

abstract：:Purpose. Experimental autoimmune uveoretinitis (EAU), a Th1/Th17 cell-mediated autoimmune disease induced in mice, serves as a model of human endogenous uveitis. In this model, proinflammatory cytokines and various stimuli activate the transcriptional factor, nuclear factor-kappaB (NF-kappaB), in the retina. The thera...

journal_title：Investigative ophthalmology & visual science

authors： Iwata D,Kitaichi N,Miyazaki A,Iwabuchi K,Yoshida K,Namba K,Ozaki M,Ohno S,Umezawa K,Yamashita K,Todo S,Ishida S,Onoé K

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four...

journal_title：Investigative ophthalmology & visual science

authors： Keller KE,Kelley MJ,Acott TS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:To determine whether adenovirus vectors are capable of transferring a foreign active protein to the perfused anterior segment of the human eye. METHODS:Primary cultures from the human trabecular meshwork tissue were exposed to replication-deficient adenovirus Av1LacZ4 carrying the reporter beta-galactosidase g...

journal_title：Investigative ophthalmology & visual science

authors： Borrás T,Matsumoto Y,Epstein DL,Johnson DH

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To visualize and quantify the three-dimensional (3D) spatial relationships of the structures of the aqueous outflow system (AOS) within intact enucleated mouse eyes using spectral two-photon microscopy (TPM) techniques. METHODS:Spectral TPM, including two-photon autofluorescence (TPAF) and second-harmonic gene...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Liu N,Mak PU,Pun SH,Vai MI,Masihzadeh O,Kahook MY,Lei TC,Ammar DA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen in wet age-related macular degeneration (AMD), although the origin is still unknown; however, they reduced significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Framme C,Schweizer P,Imesch M,Wolf S,Wolf-Schnurrbusch U

更新日期：2012-08-24 00:00:00

abstract：PURPOSE:To elucidate the anatomy of the trabecular meshwork (TM) and its connection to ciliary muscle (CM) tendons with two photon excitation microscopic (TPEM) imaging. METHODS:The human aqueous outflow pathway was imaged in an unfixed and nonembeded state by using an inverted TPEM. Laser (Ti:Sapphire) was tuned at 8...

journal_title：Investigative ophthalmology & visual science

authors： Park CY,Lee JK,Kahook MY,Schultz JS,Zhang C,Chuck RS

更新日期：2016-03-01 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the efficacy of new viscous cysteamine hydrochloride (CH) eye drops (vCH 0.55%) compared with standard CH 0.10% drops treatment. Methods:This was an open-label, phase III, randomized, two-arm multicenter trial conducted at two centers in France. Cystinosis patients ≥2 ...

journal_title：Investigative ophthalmology & visual science

authors： Liang H,Labbé A,Le Mouhaër J,Plisson C,Baudouin C

更新日期：2017-04-01 00:00:00

abstract：Purpose:The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus. Methods:We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (T...

journal_title：Investigative ophthalmology & visual science

authors： Turnbull PR,Irani N,Lim N,Phillips JR

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of etomidate (ET) on axonal regeneration of retinal ganglion cells (RGCs) in adult rats. METHODS:The optic nerve was transected intraorbitally at 1 mm from the optic disc, and an autologous peripheral nerve was transplanted onto the ocular ON stump in adult rats. Then the animals were...

journal_title：Investigative ophthalmology & visual science

authors： Xu ZX,Qin SZ,Xu GZ,Hu JM,Ma LT

更新日期：2011-10-11 00:00:00

abstract：:Two distinct patterns of delayed-onset, cell-mediated hypersensitivity have been induced in the guinea pig eye with the same soluble protein antigen and two different methods of immunization. The predominant histologic feature of these reactions was the large number of eosinophils which infiltrated the uveal tract and...

journal_title：Investigative ophthalmology & visual science

authors： Friedlaender MH,Howes EL Jr,Hall JM,Krasnobrod H,Wormstead MA

更新日期：1978-04-01 00:00:00

abstract：PURPOSE:Inflammatory status of RPE cells induced by A2E is essential in the development of AMD. Recent research indicated T-cell immunity was involved in the pathological progression of AMD. This study was designed to investigate how A2E suppresses immunoregulatory function of RPE cells in T-cell immunity in vitro. ME...

journal_title：Investigative ophthalmology & visual science

authors： Shi Q,Wang Q,Li J,Zhou X,Fan H,Wang F,Liu H,Sun X,Sun X

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Ibuprofen and indomethacin are nonselective prostaglandin synthetase inhibitors that have been shown to improve oxygen-induced retinopathy in mice. Vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF)-I, and growth hormone (GH) are potent growth factors involved in retinal development. Th...

journal_title：Investigative ophthalmology & visual science

authors： Beharry KD,Modanlou HD,Hasan J,Gharraee Z,Abad-Santos P,Sills JH,Jan A,Nageotte S,Aranda JV

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To examine sex- and race-associated differences in macular thickness and foveal pit morphology by using spectral-domain optical coherence tomography (SD-OCT). METHODS:One hundred eighty eyes of 90 healthy patients (43 women, 47 men) underwent retinal imaging with spectral-domain OCT. The lateral scale of each ...

journal_title：Investigative ophthalmology & visual science

authors： Wagner-Schuman M,Dubis AM,Nordgren RN,Lei Y,Odell D,Chiao H,Weh E,Fischer W,Sulai Y,Dubra A,Carroll J

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Identification of causative mutations for retinal blinding disorders is often limited by restricted understanding of gene expression and underlying molecular mechanisms that trigger degenerative processes. This study was conducted to develop a catalog of canine retina-expressed genes that would provide a unique...

journal_title：Investigative ophthalmology & visual science

authors： Zangerl B,Sun Q,Pillardy J,Johnson JL,Schweitzer PA,Hernandez AG,Liu L,Acland GM,Aguirre GD

更新日期：2006-06-01 00:00:00

abstract：Purpose:To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods:The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The...

journal_title：Investigative ophthalmology & visual science

authors： Xiong S,Zhang B,Hong Y,He X,Zhu J,Zou H,Xu X

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in the identification and speciation of bacteria causing endophthalmitis. METHODS:PCR-RFLP was performed on 53 strains of 14 bacterial species (eight Gram positive and five Gram negative) collected from...

journal_title：Investigative ophthalmology & visual science

authors： Okhravi N,Adamson P,Matheson MM,Towler HM,Lightman S

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To investigate phenotype characteristics of fellow eyes in patients with early onset of neovascular age-related macular degeneration (NVAMD). METHODS:Patients with new-onset unilateral NVAMD between 50 and 65 years (n = 57, early-onset choroidal neovascularization [CNV] group) or >80 years (n = 47, late-onset ...

journal_title：Investigative ophthalmology & visual science

authors： Schick T,Ersoy L,Hoyng CB,Kirchhof B,Liakopoulos S

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity. METHODS:Retinal detachments were created in mice deficient for GFAP and vimentin (GFAP(-/-)vim(-/-)) and age-matched wild-type (wt) mice. The reactivity of the retina was studied by immunofluorescence and e...

journal_title：Investigative ophthalmology & visual science

authors： Verardo MR,Lewis GP,Takeda M,Linberg KA,Byun J,Luna G,Wilhelmsson U,Pekny M,Chen DF,Fisher SK

更新日期：2008-08-01 00:00:00

abstract：Purpose:Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). Methods:We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-...

journal_title：Investigative ophthalmology & visual science

authors： Kogo T,Muraoka Y,Iida Y,Ooto S,Murakami T,Kadomoto S,Iida-Miwa Y,Numa S,Miyake M,Miyata M,Uji A,Tsujikawa A

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS:The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlands. A total of 4822 subjects who at baseline were a...

journal_title：Investigative ophthalmology & visual science

authors： van Leeuwen R,Ikram MK,Vingerling JR,Witteman JC,Hofman A,de Jong PT

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:To test the hypothesis that subnormal retinal oxygenation response (DeltaPo2) found at 3 months of experimental diabetes is associated with cellular swelling and increased retinal thickness. METHODS:Two groups of animals were studied: control rats injected intraperitoneally with either 15% body weight of salin...

journal_title：Investigative ophthalmology & visual science

authors： Luan H,Roberts R,Sniegowski M,Goebel DJ,Berkowitz BA

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:We measured the aqueous humor levels of matrix metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP) TIMP-1, TIMP-2, and TIMP-3 in patients with myopia or cataract, and investigated the relationship between their levels and axial length (AL). METHODS:We measure...

journal_title：Investigative ophthalmology & visual science

authors： Jia Y,Hu DN,Zhu D,Zhang L,Gu P,Fan X,Zhou J

更新日期：2014-05-29 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：PURPOSE:To investigate whether the detection of apoptosing retinal cells (DARC) could detect cells undergoing apoptosis in a laser model of retinal damage. METHODS:Laser lesions were placed, with the use of a frequency-doubled Nd:YAG laser, on the retina in 34 eyes of anesthetized Dark Agouti rats. Lesion size and las...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz-Valckenberg S,Guo L,Maass A,Cheung W,Vugler A,Moss SE,Munro PM,Fitzke FW,Cordeiro MF

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure. METHODS:A population-based study was conducted in Beaver Dam, Wisconsin (n=4926, age range, 43-84 years). Retinal photographs of right eyes taken at the baseline examination (1988-90) were...

journal_title：Investigative ophthalmology & visual science

authors： Wong TY,Klein R,Klein BE,Meuer SM,Hubbard LD

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

journal_title：Investigative ophthalmology & visual science

authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00