TGFbeta1-dependent contraction of fibroblasts is mediated by the PDGFalpha receptor.

abstract：Purpose:To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods:This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20...

journal_title：Investigative ophthalmology & visual science

authors： Kiyota N,Shiga Y,Ichinohasama K,Yasuda M,Aizawa N,Omodaka K,Honda N,Kunikata H,Nakazawa T

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To quantify the role of anterior zonular tension on the optomechanical lens response during simulation of accommodation in primates. METHODS:Postmortem cynomolgus monkey eyes (n = 14; age range, 3.0-11.5 years) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, ...

journal_title：Investigative ophthalmology & visual science

authors： Nankivil D,Manns F,Arrieta-Quintero E,Ziebarth N,Borja D,Amelinckx A,Bernal A,Ho A,Parel JM

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the feasibility of using Cerenkov luminescence imaging (CLI) to facilitate plaque placement during episcleral brachytherapy of intraocular tumors. METHODS:Ruthenium-106 (Ru-106) decays to rhodium-106, which in turn emits high-energy beta particles. When the electrons ...

journal_title：Investigative ophthalmology & visual science

authors： Axelsson J,Krohn J

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy commonly associated with elevated intraocular pressure (IOP), leading to optic nerve head (ONH) cupping, axon loss, and apoptosis of retinal ganglion cells (RGCs), which could ultimately result in blindness. Brn3b is a class-4 POU domain transcription factor that plays a key role...

journal_title：Investigative ophthalmology & visual science

authors： Stankowska DL,Minton AZ,Rutledge MA,Mueller BH 2nd,Phatak NR,He S,Ma HY,Forster MJ,Yorio T,Krishnamoorthy RR

更新日期：2015-01-13 00:00:00

abstract：PURPOSE:To identify the retinal pigment epithelium (RPE) surface antigen recognized by the monoclonal antibody RET-PE2. METHODS:A lambda bacteriophage complementary DNA (cDNA) expression library, representing the rat RPE cell line RPE-J, was constructed and screened with the RET-PE2 monoclonal antibody. Transient tran...

journal_title：Investigative ophthalmology & visual science

authors： Finnemann SC,Marmorstein AD,Neill JM,Rodriguez-Boulan E

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:To develop a novel in vitro model to study the formation of Staphylococcus epidermidis biofilm on intraocular lenses (IOLs) from the primary-attachment phase to the biofilm-accumulation phase. The model was designed to replicate intraocular conditions especially by taking into account intraocular hydrodynamics....

journal_title：Investigative ophthalmology & visual science

authors： Baillif S,Casoli E,Marion K,Roques C,Pellon G,Hartmann DJ,Freney J,Burillon C,Kodjikian L

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To investigate spatial anisotropies in the peripheral visual field of axially myopic eyes, in an attempt to distinguish between models of isotropic and anisotropic ocular stretching. METHODS:Stimuli consisted of two high-contrast Gaussian patches presented in one of four orientations (90 degrees, 180 degrees, ...

journal_title：Investigative ophthalmology & visual science

authors： Vera-Diaz FA,McGraw PV,Strang NC,Whitaker D

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and ...

journal_title：Investigative ophthalmology & visual science

authors： Takamura Y,Tomomatsu T,Kubo E,Tsuzuki S,Akagi Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Glaucomatous optic neuropathy is characterized by remodeling of the extracellular matrix with disorganization of elastic fibers in the optic nerve head (ONH). There are significant differences in prevalence of glaucomatous optic neuropathy between African Americans (AAs) and Caucasian Americans (CAs). The goal ...

journal_title：Investigative ophthalmology & visual science

authors： Urban Z,Agapova O,Hucthagowder V,Yang P,Starcher BC,Hernandez MR

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Epidemiologic studies have linked UV-B exposure to development of cortical cataracts, but the underlying molecular mechanism(s) is unresolved. Here, we used a mouse model to examine the nature and distribution of DNA photolesions produced by ocular UV-B irradiation. METHODS:Anesthetized mice, eye globes, or is...

journal_title：Investigative ophthalmology & visual science

authors： Mesa R,Bassnett S

更新日期：2013-10-17 00:00:00

abstract：PURPOSE:To investigate the effect of the tissue origin of stromal fibroblasts and epithelial cells on reconstructed corneas in vitro. METHODS:Four types of constructs were produced by the self-assembly approach using the following combinations of human cells: corneal fibroblasts/corneal epithelial cells, corneal fibro...

journal_title：Investigative ophthalmology & visual science

authors： Carrier P,Deschambeault A,Audet C,Talbot M,Gauvin R,Giasson CJ,Auger FA,Guérin SL,Germain L

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and whether this inhibition is through antagonism of the IL-6 or the VEGF receptor 2. METHODS:A rat cornea micropocket assay was used to initiate IL-6- and VEGF-mediated angiogenesis. The ability of TA or neutralizing VE...

journal_title：Investigative ophthalmology & visual science

authors： Ebrahem Q,Minamoto A,Hoppe G,Anand-Apte B,Sears JE

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Many retinal imaging instruments use infrared wavelengths to reduce the risk of light damage. However, we have discovered that exposure to infrared illumination causes a long-lasting reduction in infrared autofluorescence (IRAF). We have characterized the dependence of this effect on radiant exposure and invest...

journal_title：Investigative ophthalmology & visual science

authors： Masella BD,Williams DR,Fischer WS,Rossi EA,Hunter JJ

更新日期：2014-05-20 00:00:00

abstract：Purpose:To quantify the effect of induced stray light on halo size, luminance threshold, and contrast sensitivity. Methods:Retinal stray light was induced in five healthy subjects using different photographic filters. The stray light induced ranged from levels observed in intraocular lenses (IOLs) with glistenings (lo...

journal_title：Investigative ophthalmology & visual science

authors： van der Mooren M,Rosén R,Franssen L,Lundström L,Piers P

更新日期：2016-10-01 00:00:00

abstract：Purpose:There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanic...

journal_title：Investigative ophthalmology & visual science

authors： Blackburn BJ,Gu S,Ford MR,de Stefano V,Jenkins MW,Dupps WJ Jr,Rollins AM

更新日期：2019-01-02 00:00:00

abstract：:Purpose. Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an eye-targeted drug-delivery strategy to treat retinoblastoma, the most prevalent primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly...

journal_title：Investigative ophthalmology & visual science

authors： Steinle JJ,Zhang Q,Thompson KE,Toutounchian J,Yates CR,Soderland C,Wang F,Stewart CF,Haik BG,Williams JS,Jackson JS,Mandrell TD,Johnson D,Wilson MW

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS:The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in ...

journal_title：Investigative ophthalmology & visual science

authors： Kojima T,Ishida R,Dogru M,Goto E,Takano Y,Matsumoto Y,Kaido M,Ohashi Y,Tsubota K

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To test the hypothesis that retinal hypoxia is present during vascular development in normal rat pups and in a newborn rat model of retinopathy of prematurity (ROP). METHODS:Preretinal vitreous PO(2) measurements were made during room air breathing using (19)F magnetic resonance spectroscopy (MRS) and a perflu...

journal_title：Investigative ophthalmology & visual science

authors： Zhang W,Ito Y,Berlin E,Roberts R,Berkowitz BA

更新日期：2003-07-01 00:00:00

abstract：:Monoclonal antibody to HSV glycoprotein D was derivatized with palmitic acid and incorporated into liposomes. These immunoliposomes bound specifically to intact mouse corneas infected with HSV-1 in vitro. Furthermore, in yield reduction assays, anti-gD immunoliposomes loaded with acyclovir proved far more effective at...

journal_title：Investigative ophthalmology & visual science

authors： Norley SG,Sendele D,Huang L,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:To evaluate a novel objective perimetry using multifocal chromatic pupil light reflex in normal participants and patients with photoreceptor dysfunction, and to relate this new technique with subjective dark-adapted chromatic Goldmann perimetry. METHODS:Thirty-two eyes of 17 retinitis pigmentosa (RP) or cone-r...

journal_title：Investigative ophthalmology & visual science

authors： Skaat A,Sher I,Kolker A,Elyasiv S,Rosenfeld E,Mhajna M,Melamed S,Belkin M,Rotenstreich Y

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of retinal neurons with implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety and efficacy of a wireless intraocular retinal implant (EPIRET3) in six volunteers ...

journal_title：Investigative ophthalmology & visual science

authors： Roessler G,Laube T,Brockmann C,Kirschkamp T,Mazinani B,Goertz M,Koch C,Krisch I,Sellhaus B,Trieu HK,Weis J,Bornfeld N,Röthgen H,Messner A,Mokwa W,Walter P

更新日期：2009-06-01 00:00:00

abstract：Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

journal_title：Investigative ophthalmology & visual science

authors： Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) die as a result of axonal injury in a variety of optic neuropathies, including glaucoma. Reactive oxygen species (ROS) act as intracellular signaling molecules and initiate apoptosis in nerve growth factor-deprived sympathetic neurons and axotomized RGCs. Determination of the role ...

journal_title：Investigative ophthalmology & visual science

authors： Schlieve CR,Lieven CJ,Levin LA

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:Extracellular microRNAs (miRNAs) in aqueous humor were suggested to have a role in transcellular signaling and may serve as disease biomarkers. The authors adopted next-generation sequencing (NGS) techniques to further characterize the miRNA profile in single samples of 60 to 80 μL human aqueous humor. METHODS...

journal_title：Investigative ophthalmology & visual science

authors： Wecker T,Hoffmeier K,Plötner A,Grüning BA,Horres R,Backofen R,Reinhard T,Schlunck G

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To examine retinal function using the full-field electroretinogram (ERG) during and after acute intraocular pressure (IOP) elevation in wild-type mice. METHODS:IOP was elevated by anterior chamber cannulation in wild-type C57/BL6 mice. The pressure-function relationship was determined by IOP elevation in steps...

journal_title：Investigative ophthalmology & visual science

authors： Kong YX,Crowston JG,Vingrys AJ,Trounce IA,Bui VB

更新日期：2009-12-01 00:00:00

abstract：:In orbital exenteration specimens from 14 rats, 93% of the mast cells were found in the lids, the limbus, and the conjunctiva, 5% in the orbital tissues, and less than 1% in the globe. The density of mast cells was highest in lid (2843/mm3), limbus (2822/mm3), and orbit (2184/mm3) and lowest in bulbar conjunctiva (794...

journal_title：Investigative ophthalmology & visual science

authors： Allansmith MR,Baird RS,Kashima K,Bloch KJ

更新日期：1979-08-01 00:00:00

abstract：PURPOSE:A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk for primary open-angle glaucoma (POAG) in whites. The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese ...

journal_title：Investigative ophthalmology & visual science

authors： How AC,Aung T,Chew X,Yong VH,Lim MC,Lee KY,Toh JY,Li Y,Liu J,Vithana EN

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Lens case hygiene practices are important in maintaining safe contact lens wear. However, the effectiveness of various lens case cleaning practices have not been evaluated and compared. This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by len...

journal_title：Investigative ophthalmology & visual science

authors： Wu YT,Zhu H,Willcox M,Stapleton F

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To characterize the cellular expression patterns of antiangiogenic factors differentially regulated in the fetal human macula. METHODS:RNA was extracted from macular, nasal, and surround biopsies of three human fetal retinas at midgestation. Relative levels of expression of pigment epithelium-derived factor (P...

journal_title：Investigative ophthalmology & visual science

authors： Kozulin P,Natoli R,Bumsted O'Brien KM,Madigan MC,Provis JM

更新日期：2010-08-01 00:00:00