Abstract:
PURPOSE:To investigate spatial anisotropies in the peripheral visual field of axially myopic eyes, in an attempt to distinguish between models of isotropic and anisotropic ocular stretching. METHODS:Stimuli consisted of two high-contrast Gaussian patches presented in one of four orientations (90 degrees, 180 degrees, 45 degrees, or 135 degrees). For each orientation, perceived separation was established relative to that for all other orientations. The experiment was conducted with central fixation and at 15 degrees in the nasal and inferior visual fields. Eleven myopes and nine emmetropes participated in the study. Biometric data were collected from all subjects. RESULTS:For foveal fixation, the magnitude of the spatial anisotropy (approximately 5%) was consistent with the well-documented horizontal-vertical illusion (HVI), and unrelated to axial length. In the nasal visual field, much larger misperceptions were found (approximately 19%), the magnitude of which increased significantly with increasing axial length. Inferiorly, a reversal of the traditional HVI is found in most subjects (approximately 7%), with a tendency for a larger reversed illusion with increasing axial length. Differences between nasal and inferior misperceptions were significantly correlated with axial length. CONCLUSIONS:Isotropic stretching, such as globe expansion, should preserve the aspect ratios of receptive fields, predicting a separation misperception which is independent of axial length. In contrast, the magnitude of the misperception is significantly correlated with axial length, supporting anisotropic stretching models of myopic growth.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Vera-Diaz FA,McGraw PV,Strang NC,Whitaker Ddoi
10.1167/iovs.04-0127keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
758-63issue
2eissn
0146-0404issn
1552-5783pii
46/2/758journal_volume
46pub_type
杂志文章abstract:PURPOSE:The existence of an organic cation transport process in rabbit cornea and conjunctiva that mediates absorption of carnitine has previously been suggested. This study was conducted to determine the expression and localization of the carnitine/organic cation transporter (OCTN1 and OCTN2) in corneal or conjunctiva...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.07-1528
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:Previous studies have shown that insulin-like growth factor-binding protein (IGFBP)-2 is markedly upregulated in senescent RPE cells in vitro, and might therefore be a marker of senescent cells in vivo. This study was conducted to determine whether IGFBP-2 expression in human RPE cells from the macula and perip...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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abstract:PURPOSE:To determine the influence of specific regions within Lp82 calpain on protein stability, enzymatic activity, and localization within lens and to test the influence of an Lp82 knockout mouse on normal maturational proteolysis in lens. METHODS:DNA constructs for Lp82 and Lp82-related proteins were subcloned into...
journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:2000-12-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:1994-03-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2014-10-28 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:To investigate the role of the gap junction protein connexin43 (Cx43), which is predominantly expressed in lens epithelial cells in the control of lens development and organization. METHODS:Newborn mice in which the Cx43 gene was disrupted by homologous recombination were used. Lenses from Cx43 (-/-) mice and ...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2011-05-17 00:00:00
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journal_title:Investigative ophthalmology & visual science
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